Inflammatory Proteins and Muscle Strength in Adolescents: The AVENA Study
Abstract
OBJECTIVES: To examine the associations between inflammatory proteins and muscle strength and to determine whether this association varies between overweight and nonoverweight adolescents. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 416 Spanish adolescents (230 boys and 186 girls) aged 13 to 18(1/2) years. MAIN EXPOSURES: Muscle strength score was computed as the mean of the handgrip and standing broad jump standardized values. The adolescents were categorized as overweight (including obese) or nonoverweight according to body mass index. Body fat and fat-free mass were derived from skinfold thickness. OUTCOME MEASURES: C-reactive protein, complement factors C3 and C4, ceruloplasmin, and prealbumin levels. RESULTS: The results of the regression analysis showed that C-reactive protein, C3, and ceruloplasmin were negatively associated with muscle strength after controlling for sex, age, pubertal status, weight, height, socioeconomic status, and cardiorespiratory fitness. Moreover, C-reactive protein and prealbumin levels were associated with muscle strength in overweight adolescents after controlling for potential confounders, including body fat and fat-free mass. CONCLUSIONS: Low-grade inflammation is negatively associated with muscle strength in adolescents. The patterns of these associations seem more relevant in overweight adolescents, suggesting that having high levels of muscle strength may counteract the negative consequences ascribed to body fat.
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Fe is important in immune/inflammatory responses including neutrophil activation, macrophage effector functions, and Th1/Th2 patterns.
“Fe is important in immune/inflammatory responses including neutrophil activation, macrophage effector functions, and T-helper cell type-1 and -2 (Th1/Th2) patterns (reviewed in Weiss (695) ).”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [695]
Cites
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Establishing a standard definition for child overweight and obesity worldwide: international survey
Cole, T. J. (2000) · BMJ · doi:10.1136/bmj.320.7244.1240 · Cited by 16,500 · see citing works
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
Tanner, J. M., & Whitehouse, R. H. (1976) · Archives of Disease in Childhood · doi:10.1136/adc.51.3.170 · Cited by 3,137 · see citing works
Skinfold equations for estimation of body fatness in children and youth.
Slaughter, M. H., Lohman, T. G., Boileau, R. A., Horswill, C. A., Stillman, R. J., Loan, M. D. V., & Bemben, D. A. (1988) · PubMed · Cited by 2,712 · see citing works
The multistage 20 metre shuttle run test for aerobic fitness
Léger, L., Mercier, D., Gadoury, C., & Lambert, J. (1988) · Journal of Sports Sciences · doi:10.1080/02640418808729800 · Cited by 2,539 · see citing works
The underappreciated role of muscle in health and disease
Wolfe, R. R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.475 · Cited by 1,561 · see citing works
Novel Risk Factors for Systemic Atherosclerosis
Ridker, P. M., Stampfer, M. J., & Rifai, N. (2001) · JAMA · doi:10.1001/jama.285.19.2481 · Cited by 1,300 · see citing works
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294 · see citing works
Resistance Exercise in Individuals With and Without Cardiovascular Disease
Pollock, M. L., Franklin, B. A., Balady, G. J., CHAITMAN, B. R., Fleg, J. L., Fletcher, B. J., Limacher, M. C., Piña, I. L., Stein, R. A., Williams, M. A., et al. (2000) · Circulation · doi:10.1161/01.cir.101.7.828 · Cited by 1,054 · see citing works
Inflammatory markers and loss of muscle mass (sarcopenia) and strength
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047 · see citing works
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m242 · Cited by 901 · see citing works
Ferrucci, L., Penninx, B. W. J. H., Volpato, S., Harris, T. B., Bandeen‐Roche, K., Balfour, J., Leveille, S. G., Fried, L. P., & Md, J. M. G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50605.x · Cited by 618 · see citing works
Cook, D. G., Mendall, M. A., Whincup, P. H., Carey, I. M., Ballam, L., Morris, J. E., Miller, G. J., & Strachan, D. P. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00312-3 · Cited by 446 · see citing works
Ibañez, J., Izquierdo, M., Argüelles, I., Forga, L., Larrión, J. L., García-Unciti, M., Idoate, F., & Gorostiaga, E. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.3.662 · Cited by 442 · see citing works
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438 · see citing works
Physical Fitness and Physical Activity in Obese and Nonobese Flemish Youth
Deforche, B. I., Lefevre, J., Bourdeaudhuij, I. D., Hills, A. P., Duquet, W., & Bouckaert, J. J. (2003) · Obesity Research · doi:10.1038/oby.2003.59 · Cited by 376 · see citing works
Association of Muscular Strength with Incidence of Metabolic Syndrome in Men
Jurča, R., LaMonte, M. J., Barlow, C. E., Kampert, J. B., Church, T. S., & Blair, S. N. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000175865.17614.74 · Cited by 372 · see citing works
The metabolic syndrome: role of skeletal muscle metabolism.
Stump, C. S., Henriksen, E. J., Wei, Y., & Sowers, J. R. (2006) · Annals of Medicine · doi:10.1080/07853890600888413 · Cited by 362 · see citing works
Effects of Resistance Training on Insulin Sensitivity in Overweight Latino Adolescent Males
Shaibi, G. Q., Cruz, M. L., Ball, G. D. C., Weigensberg, M. J., Salem, G. J., Crespo, N. C., & Goran, M. I. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000227304.88406.0f · Cited by 328 · see citing works
Inflammatory Markers and Incident Mobility Limitation in the Elderly
Penninx, B. W. J. H., Kritchevsky, S. B., Newman, A. B., Nicklas, B. J., Simonsick, E. M., Rubin, S., Nevitt, M., Visser, M., Harris, T., & Pahor, M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52308.x · Cited by 326 · see citing works
Associations of Muscle Strength and Fitness with Metabolic Syndrome in Men
Jurča, R., LaMonte, M. J., Church, T. S., Earnest, C. P., FitzGerald, S. J., Barlow, C. E., JORDAN, A. N., Kampert, J. B., & Blair, S. N. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000135780.88930.a9 · Cited by 323 · see citing works
Elevated Serum C-Reactive Protein Levels and Early Arterial Changes in Healthy Children
Järvisalo, M. J., Harmoinen, A. P. T., Hakanen, M., Paakkunainen, U., Viikari, J. S. A., Hartiala, J., Lehtimäki, T. J., Simell, O., & Raitakari, O. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000024222.06463.21 · Cited by 315 · see citing works
Kelly, A. S., Wetzsteon, R. J., Kaiser, D. R., Steinberger, J., Bank, A. J., & Dengel, D. R. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.08.004 · Cited by 297 · see citing works
Ruiz, J. R., Ortega, F. B., Rizzo, N., Villa, I., Hurtig‐Wennlöf, A., Oja, L., & Sjöstróm, M. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e318030d1bd · Cited by 220 · see citing works
Self-citationCardiorespiratory Fitness and C-Reactive Protein Among a Tri-Ethnic Sample of Women
LaMonte, M. J., Durstine, J. L., Yanowitz, F. G., Lim, T. H., DuBose, K. D., Davis, P. G., & Ainsworth, B. E. (2002) · Circulation · doi:10.1161/01.cir.0000025425.20606.69 · Cited by 207 · see citing works
Moreno, L. A., Joyanes, M., Mesana, M. I., González‐Gross, M., Gil, C. M., Sarría‐Santamera, A., Gutiérrez, Á., Garaulet, M., Pérez-Prieto, R., Sánchez, M. B., et al. (2003) · Nutrition · doi:10.1016/s0899-9007(03)00040-6 · Cited by 205 · see citing works
Self-citationOrtega, F. B., Ruiz, J. R., Castillo, M. J., Moreno, L. A., González‐Gross, M., Wärnberǵ, J., & Gutiérrez, Á. (2005) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60372-1 · Cited by 203 · see citing works
Self-citationOverweight, Obesity and Body Fat Composition in Spanish Adolescents
Moreno, L. A., Mesana, M. I., Fleta, J., Ruiz, J. R., González‐Gross, M., Sarría, A., Marcos, A., & Bueno, M. (2005) · Annals of Nutrition and Metabolism · doi:10.1159/000084738 · Cited by 203 · see citing works
Self-citationAdipocytokines, Body Composition, and Fitness in Children
Nemet, D., Wang, P., Funahashi, T., Matsuzawa, Y., Tanaka, S., Engelman, L., & Cooper, D. M. (2003) · Pediatric Research · doi:10.1203/00006450-200301000-00025 · Cited by 192 · see citing works
Ortega, F. B., Ruiz, J. R., Castillo, M. J., Moreno, L. A., González‐Gross, M., Wärnberǵ, J., & Gutiérrez, Á. (2005) · Revista Española de Cardiología · doi:10.1157/13078126 · Cited by 188 · see citing works
Self-citationCruz, M. L., Shaibi, G. Q., Weigensberg, M. J., Spruijt‐Metz, D., Ball, G. D. C., & Goran, M. I. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092625 · Cited by 177 · see citing works
Wärnberǵ, J., Nova, E., Moreno, L. A., Romeo, J., Mesana, M. I., Ruiz, J. R., Ortega, F. B., Sjöstróm, M., Sánchez, M. B., & Marcos, A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.505 · Cited by 172 · see citing works
Self-citationKlimčáková, E., Polak, J., Moro, C., Hejnová, J., Majercik, M., Viguerie, N., Berlan, M., Langin, D., & Štich, V. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0382 · Cited by 163 · see citing works
Kim, J., Shen, W., Gallagher, D., Jones, A., Wang, Z., Wang, J., Heshka, S., & Heymsfield, S. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1014 · Cited by 146 · see citing works
Influence of resistance exercise training on glucose control in women with type 2 diabetes
Fenicchia, L. M., Kanaley, J. A., Azevedo, J. L., Miller, C. S., Weinstock, R. S., Carhart, R. L., & Ploutz-Snyder, L. L. (2004) · Metabolism · doi:10.1016/j.metabol.2003.10.007 · Cited by 146 · see citing works
Wells, J. C. K., Fewtrell, M. S., Williams, J. E., Haroun, D., Lawson, M. S., & Cole, T. J. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803402 · Cited by 135 · see citing works
Isasi, C. R., Deckelbaum, R. J., Tracy, R. P., Starc, T. J., Berglund, L., & Shea, S. (2003) · PEDIATRICS · doi:10.1542/peds.111.2.332 · Cited by 129 · see citing works
Anthropometric body fat composition reference values in Spanish adolescents. The AVENA Study
Moreno, L. A., Mesana, M. I., González‐Gross, M., Gil, C. M., Fleta, J., Wärnberǵ, J., Ruiz, J. R., Sarría, A., Marcos, A., Bueno, M., et al. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602285 · Cited by 117 · see citing works
Self-citationGonzález‐Gross, M., Castillo, M. J., Moreno, L. A., Nova, E., González‐Lamuño, D., Pérez‐Llamas, F., Gutiérrez, Á., Garaulet, M., Joyanes, M., Leiva, A. V., et al. (2003) · Hispana · Cited by 105 · see citing works
Self-citationRuiz, J. R., Rizzo, N., Ortega, F. B., Loit, H. ‐., Veidebaum, T., & Sjöstróm, M. (2007) · Diabetologia · doi:10.1007/s00125-007-0678-0 · Cited by 80 · see citing works
Self-citationDernellis, J. M., & Panaretou, M. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.027 · Cited by 70 · see citing works
González‐Gross, M., Castillo, M. J., Moreno, L. A., Nova, E., González‐Lamuño, D., Pérez‐Llamas, F., Gutiérrez, A., Garaulet, M., Joyanes, M., Leiva, A. V., et al. (2003) · PubMed · Cited by 59 · see citing works
Self-citationEffects of physical training and its cessation on the hemostatic system of obese children
Ferguson, M. A., Gutin, B., Owens, S., Barbeau, P., Tracy, R. P., & Litaker, M. S. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1130 · Cited by 52 · see citing works
C-reactive protein and cardiorespiratory fitness in young adults
Williams, M. J. A., Milne, B. J., Hancox, R. J., & Poulton, R. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000166453.15722.7b · Cited by 48 · see citing works
Cardiovascular Fitness Is Negatively Associated With Homocysteine Levels in Female Adolescents
Ruiz, J. R., Sola, R., González‐Gross, M., Ortega, F. B., Vicente‐Rodríguez, G., García‐Fuentes, M., Gutiérrez, Á., Sjöstróm, M., Pietrzik, K. F., & Castillo, M. J. (2007) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.161.2.166 · Cited by 44 · see citing works
Self-citationThe effect of starvation on skeletal muscle function in man.
Lennmarken, C., Sandstedt, S., Schenck, H., & Larsson, J. (1986) · Clinical Nutrition · doi:10.1016/0261-5614(86)90015-4 · Cited by 37 · see citing works
Ruiz, J. R., Ortega, F. B., Tresaco, B., et al. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-956503 · Cited by 27 · see citing works
Self-citationReference values for serum lipids and lipoproteins in Spanish adolescents: the AVENA study
Ruiz, J. R., Ortega, F. B., Moreno, L. A., et al. (2006) · Sozial- und Präventivmedizin · doi:10.1007/s00038-005-0021-9 · Cited by 21 · see citing works
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Self-citation
- Authors
- Ruiz, J. R., Ortega, F. B., Wärnberg, J., Moreno, L. A., Carrero, J. J., Gonzalez-Gross, M., Marcos, A., Gutierrez, A., & Sjöström, M.
- Affiliations
- Karolinska Institutet (SE)
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2008-05-01
- Volume
- 162
- Issue
- 5
- Pages
- 462
- ISSN
- 1072-4710 (ISSN-L)
- OpenAlex
- W2110368649
- Cited by
- 78
- References
- 51
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 11 · 2012: 5
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- inflammatory proteins, muscle strength, adolescents, overweight, obesity, C-reactive protein, complement C3, complement C4, ceruloplasmin, prealbumin, low-grade inflammation, grip strength, standing long jump, fat mass, fat-free mass
- MeSH terms
- Adolescent, C-Reactive Protein, Ceruloplasmin, Complement C3, Complement C4, Cross-Sectional Studies, Female, Humans, Immunoproteins, Male, Physical Fitness, Prealbumin, Regression Analysis, Overweight, Muscle Strength
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