Cited by 519Edible Oils Quality and AnalysisEssential Oils and Antimicrobial ActivityPhytochemicals and Antioxidant Activities

Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves

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Pereira, Ana Paula, Ferreira, Isabel CFR, Marcelino, Filipa, Valentão, Patricia, Andrade, Paula B, Seabra, Rosa, Estevinho, Leticia, Bento, Albino +1 more·2007·Molecules

Abstract

We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds.

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  1. Samuelsson, G. The blood pressure lowering factor in leaves of Olea europaea. Farmacevtisk Revy 1951, 15, 229-239.
  2. Benavente-García, O.; Castillo, J.; Lorente, J.; Ortuño, A.; Del Rio, J.A. Antioxidant activity of phenolics from Olea europaea L. leaves. Food Chem. 2000, 68, 457-462.
  3. Markin, D.; Duek, L.; Berdicevsky, I. In vitro antimicrobial activity of olive leaves. Mycoses 2003, 46, 132-136.
  4. Verduyn-Lunel, F.M.; Meis, J.F.; Voss, A. Nosocomial fungal infections: candidaemia. Diagn. Microbiol. Infect. Dis. 1999, 34, 213-220.

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Authors
Pereira, A. P., Ferreira, I. C., Marcelino, F., Valentão, P., Andrade, P. B., Seabra, R., Estevinho, L., Bento, A., & Pereira, J. A.
Affiliations
  • Universidade Politécnica de Bragança (PT)
  • REQUIMTE / Serviço de Farmacognosia, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal
  • Universidade do Porto (PT)
  • CIMO / Escola Superior Agrária, Instituto Politécnico de Bragança, Campus Sta Apolónia, Apt. 1172, 5301-855 Bragança, Portugal
Corresponding author
Pereira, José Alberto
Venue
Molecules
Publisher
MDPI AG
Published
2007-05-26
Volume
12
Issue
5
Pages
1153-1162
ISSN
1420-3049 (ISSN-L)
OpenAlex
W2146146382
Cited by
519
References
26
Citations by year
2026: 16 · 2025: 28 · 2024: 38 · 2023: 19 · 2022: 44 · 2021: 34 · 2020: 46 · 2019: 38 · 2018: 34 · 2017: 33 · 2016: 33 · 2015: 36 · 2014: 29 · 2013: 20 · 2012: 19
FWCI
6.30
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Interreg
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
olive leaves, Olea europaea, phenolic compounds, antimicrobial activity, antibacterial activity, antifungal activity, caffeic acid, verbascoside, oleuropein, luteolin glycosides, rutin, apigenin glycosides, nutraceuticals, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Candida albicans, Cryptococcus neoformans
MeSH terms
Anti-Infective Agents, Chromatography, High Pressure Liquid, Microbial Sensitivity Tests, Phenols, Molecular Structure, Plant Leaves, Olea

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