Remission in depressed outpatients: More than just symptom resolution?

Zimmerman, Mark; McGlinchey, Joseph B.; Posternak, Michael A.; Friedman, Michael; Boerescu, Daniela; Attiullah, Naureen

doi:10.1016/j.jpsychires.2007.09.004

Cited by 98Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionMental Health Research Topics

Remission in depressed outpatients: More than just symptom resolution?

Zimmerman, Mark, McGlinchey, Joseph B., Posternak, Michael A., Friedman, Michael, Boerescu, Daniela, Attiullah, Naureen·2008·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2007.09.004

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Abstract

Objective In treatment studies of depression remission is defined according to scores on symptom severity scales. Normalization of functioning has often been mentioned as an important component of the definition of remission, though it is not used to identify remitted patients in studies of treatment efficacy. Conceptually, the return of normal functioning should be as fundamental to the concept of remission as is symptom resolution because the presence of both symptoms and impaired functioning are core constructs in the diagnosis of mental disorders. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project we examined the independent and additive association between level of severity of depressive symptoms and functional impairment in predicting depressed patients' subjective evaluation of their remission status.Methods Five hundred and fourteen depressed psychiatric outpatients filled out a questionnaire on which they rated the severity of the symptoms of depression, the level of impairment due to depression, and their quality of life.Results Symptom severity, functional impairment from depression, and quality of life were significantly and highly intercorrelated, and each was significantly associated with remission status. The results of a logistic regression analysis indicated that each of the three variables was a significant, independent, predictor of remission status.Discussion In treatment studies of depression remission is narrowly defined in terms of symptom resolution. Our results support broadening the concept of remission beyond symptom levels to include assessments of functioning and quality of life.

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These findings support the idea that deficits in functioning and other longstanding consequences of MDEs (i.e., changes in self-perception) may remit slower than acute MDE symptoms and contribute to the resurgence of residual symptoms and MDE recurrence through means of FoDR.
“These findings support the idea that deficits in functioning and other longstanding consequences of MDEs (i.e., changes in self-perception) may remit slower than acute MDE symptoms and contribute to the resurgence of residual symptoms and MDE recurrence through means of FoDR [57, 58].”
From Fear of depression recurrence among individuals with remitted depression: a qualitative interview study (2024) · cites this paper as [58]

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Additional file 2 of Fear of depression recurrence among individuals with remitted depression: a qualitative interview study
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Authors: Zimmerman, M., McGlinchey, J. B., Posternak, M. A., Friedman, M., Boerescu, D., & Attiullah, N.
Affiliations: Brown University (US)
Corresponding author: Zimmerman, Mark
ORCID: Zimmerman, Mark
Friedman, Michael
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2008-08
Volume: 42
Issue: 10
Pages: 797-801
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2007.09.004
OpenAlex: W2083048235
Cited by: 98
References: 32
Citations by year: 2026: 4 · 2025: 9 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 6
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: depression remission, functional disability, quality of life, depression severity, psychiatric outpatients, MIDAS project, predictors of remission
MeSH terms: Activities of Daily Living, Adult, Aged, Aged, 80 and over, Ambulatory Care, Culture, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Social Adjustment, Outcome Assessment, Health Care

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Remission in depressed outpatients: More than just symptom resolution?

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