Cited by 86Treatment of Major DepressionAntioxidant Activity and Oxidative StressTryptophan and brain disorders

Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice

Abdel-Wahab, Basel A., Salama, Ragaa H.·2011·Pharmacology Biochemistry and Behavior

Abstract

Unlabelled Venlafaxine (VLF) is an approved antidepressant that is claimed to have superior clinical efficacy to comparable drugs. Recently, many studies showed the relationship between depression and increased oxidative stress. This study investigated the relationship between the antidepressant effect of VLF and its ability to protect animals against stress-induced oxidative lipid peroxidation and DNA damage induced during antidepressant testing.Methods The antidepressant effect of long-term treatment (21 days) of VLF in doses 5, 10 and 20mg/kg/day, i.p. was tested using forced swimming test (FST) and tail suspension test (TST). The effects of VLF on hippocampal lipid peroxidation (MDA), nitric oxide (NO), glutathione (GSH), total antioxidant (TAC) levels and glutathione-S-transferase (GST) activity were tested. Furthermore, the corresponding changes in serum and hippocampal 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured.Results Long-term VLF treatment showed a significant, antidepressant effect in both FST and TST. VLF could decrease the hippocampal MDA and NO and to increase hippocampal GSH and TAC levels and GST activity in the tested animals. Only GSH and TAC levels were increased by VLF in the non-tested animals. In addition, both serum and hippocampal 8-OHdG levels were significantly reduced by VLF in animals exposed to antidepressant tests.Conclusion Long-term VLF treatment in the effective antidepressant doses can protect against stress-induced oxidative cellular and DNA damage. This action may be through antagonizing the oxidative stress and enhancing the antioxidant defense mechanisms. Consequently, pharmacological modulation of stress-induced oxidative DNA damage as a possible stress-management approach should be an important avenue of further research.

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Crossref · 10.1016/j.pbb.2011.07.015

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Authors
Abdel-Wahab, B. A., & Salama, R. H.
Affiliations
Assiut University (EG)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2011-11
Volume
100
Issue
1
Pages
59-65
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2007039285
Cited by
86
References
64
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 11 · 2013: 5 · 2012: 7
FWCI
5.39
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
venlafaxine, antidepressant effects, oxidative DNA damage, hippocampus, oxidative stress, lipid peroxidation, 8-hydroxy-2'-deoxyguanosine, glutathione, antioxidant defense, nitric oxide, forced swim test, tail suspension test, depression
MeSH terms
Venlafaxine Hydrochloride, Animals, Antidepressive Agents, Cyclohexanols, Depression, DNA Damage, Hippocampus, Male, Random Allocation, Stress, Psychological, Oxidative Stress, Mice

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