Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report
Abstract
Objective There is an emerging body of data suggesting that oxidative stress may be associated with the pathophysiology of bipolar disorder (BD). In the present study we investigated the oxidative stress profile in two monozygotic twins during a manic episode.Methods Two monozygotic twins diagnosed as currently manic by the Structured Clinical Interview for DSM-IV were studied. Serum thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and catalase (CAT) were measured as parameters of oxidative stress. DNA damage was assessed using the single cell gel electrophoresis technique (Comet Assay). All biochemical measures were conducted at baseline and after a 6-week treatment.Results Bipolar twins had higher TBARS, SOD and DNA damage, and lower CAT than the healthy control. TBARS and SOD were normalized after mood stabilization, whereas CAT and DNA damage remained altered at week 6.Conclusions These findings support that oxidative stress may play a role in the pathophysiology of BD and that pharmacological treatment may exert antioxidant effects. Studies with larger samples are warranted to further clarify this issue.
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Oxidative unbalance in social phobia patients can be corrected after eight weeks of citalopram administration.
“Additionally, it seems that oxidative unbalance in social phobia patients can be corrected after eight weeks of citalopram administration [256].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [256]
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Self-citation
- Authors
- Frey, B. N., Andreazza, A. C., Kunz, M., Gomes, F. A., Quevedo, J., Salvador, M., Gonçalves, C. A., & Kapczinski, F.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Universidade do Extremo Sul Catarinense (BR)
- Universidade de Caxias do Sul (BR)
- Corresponding author
- Kapczinski, Flávio
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 31
- Issue
- 1
- Pages
- 283-285
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2087799748
- Cited by
- 120
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 8 · 2015: 13 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, oxidative stress, DNA damage, monozygotic twins, manic episodes, TBARS, superoxide dismutase, catalase, mood stabilizers, antioxidant activity, pathophysiology
- MeSH terms
- Bipolar Disorder, Catalase, Chlorpromazine, DNA Damage, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Superoxide Dismutase, Antipsychotic Agents, Twins, Lithium Carbonate, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Antimanic Agents, Comet Assay
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