Actigraphy in patients with treatment-resistant depression undergoing electroconvulsive therapy
Abstract
Depressive disorder is frequently accompanied by changes in psychomotor activity and disturbances of the sleep-wake cycle. The chronobiological effects of electroconvulsive therapy (ECT) in patients with treatment-resistant depression (TRD) are largely unknown. The objective of the current study was to measure the influence of ECT on patients' activity and sleep. 15 patients with unipolar TRD were treated with ECT. Activity levels were measured with wrist actigraphy before and after ECT. Remission rate (score on the 17-item Hamilton Depression Rating Scale lower than 8 points) was 40.0%. Remitters had increases of 56.0% on light activity, 49.8% on total activity, and 70.2% on circadian amplitude, while there was no significant change of these variables in subjects who did not experience remission. The circadian acrophase and actigraphic sleep-parameters were not significantly affected by treatment.
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In TRD patients receiving ECT, individuals who reached remission experienced notable enhancements in light activity, overall activity, and circadian amplitude.
“They observed that Individuals who reached remission experienced notable enhancements in light activity, overall activity, and circadian amplitude”
From A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms (2023) · cites this paper as [36]
ECT had a limited impact on the timing of peak activity or actigraphic sleep measurements in TRD patients.
“and ECT had a limited impact on the timing of peak activity or actigraphic sleep measurements.”
From A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms (2023) · cites this paper as [36]
Digital biomarkers, including motor function, have demonstrated effectiveness in tracking shifts in depression severity during treatment.
“The demonstrated effectiveness of digital biomarkers, including motor function, in tracking shifts in depression severity during treatment is a significant step forward (33, 36).”
From A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms (2023) · cites this paper as [36]
Winkler et al. found an increase in light activity and circadian amplitude in patients with remission after ECT.
“Increase in light activity and circadian amplitude in patients with remission after ECT”
From A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms (2023) · cites this paper as [36]
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- Authors
- Winkler, D., Pjrek, E., Lanzenberger, R., Baldinger, P., Eitel, D., Kasper, S., & Frey, R.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Winkler, Dietmar
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 57
- Pages
- 96-100
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2026729768
- Cited by
- 21
- References
- 48
- Citations by year
- 2023: 4 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medizinische Universität Wien
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- actigraphy, treatment-resistant depression, electroconvulsive therapy, chronobiology, circadian rhythm, sleep-wake cycle, psychomotor activity, circadian amplitude, depression remission
- MeSH terms
- Adult, Major Depressive Disorder, Electroconvulsive Therapy, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Recurrence, Sleep, Treatment Outcome, Young Adult, Actigraphy, Depressive Disorder, Treatment-Resistant
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