A study of wrist-worn activity measurement as a potential real-world biomarker for late-life depression
Open accessAbstract
BACKGROUND: Late-life depression (LLD) is associated with a decline in physical activity. Typically this is assessed by self-report questionnaires and, more recently, with actigraphy. We sought to explore the utility of a bespoke activity monitor to characterize activity profiles in LLD more precisely. METHOD: The activity monitor was worn for 7 days by 29 adults with LLD and 30 healthy controls. Subjects underwent neuropsychological assessment and quality of life (QoL) (36-item Short-Form Health Survey) and activities of daily living (ADL) scales (Instrumental Activities of Daily Living Scale) were administered. RESULTS: Physical activity was significantly reduced in LLD compared with controls (t = 3.63, p < 0.001), primarily in the morning. LLD subjects showed slower fine motor movements (t = 3.49, p < 0.001). In LLD patients, activity reductions were related to reduced ADL (r = 0.61, p < 0.001), lower QoL (r = 0.65, p < 0.001), associative learning (r = 0.40, p = 0.036), and higher Montgomery-Åsberg Depression Rating Scale score (r = -0.37, p < 0.05). CONCLUSIONS: Patients with LLD had a significant reduction in general physical activity compared with healthy controls. Assessment of specific activity parameters further revealed the correlates of impairments associated with LLD. Our study suggests that novel wearable technology has the potential to provide an objective way of monitoring real-world function.
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O'Brien et al. (45) documented that physical activity was low among individuals with late life depression related to healthy controls.
“O'Brien et al. (45) documented that physical activity was low among individuals with late life depression related to healthy controls”
From Monitoring Changes in Depression Severity Using Wearable and Mobile Sensors (2020) · cites this paper as [45]
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- Authors
- O'Brien, J. T., Gallagher, P., Stow, D., Hammerla, N., Ploetz, T., Firbank, M., Ladha, C., Ladha, K., Jackson, D., McNaney, R., Ferrier, I. N., & Olivier, P.
- Affiliations
- University of Cambridge (GB)
- University of Newcastle Australia (AU)
- Open Lab, Newcastle University
- Corresponding author
- Gallagher, P.
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-09-26
- Volume
- 47
- Issue
- 1
- Pages
- 93-102
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC5197921
- OpenAlex
- W2527625754
- Cited by
- 76
- References
- 42
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 1 · 2018: 9 · 2017: 1
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Psychological Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- Apollo (cc-by)
- Funders
- National Institute for Health and Care Research (NF-SI-0510-10065, SPCR-S-057)
- University of Cambridge
- Newcastle University
- Cambridge University Hospitals
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Medical Research Council (G1001828/1)
- Engineering and Physical Sciences Research Council (EP/M023001/1, EP/G066019/1)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Context-Aware Activity Recognition Systems
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- geriatric depression, wrist-worn activity monitors, physical activity, wearable devices, biomarkers, actigraphy, activities of daily living, quality of life, fine motor movements, associative learning, objective functional assessment
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Aging, Depressive Disorder, Female, Humans, Male, Biomarkers, Exercise, Actigraphy
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