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Cited by 21Suicide and Self-Harm StudiesChild Abuse and TraumaPersonality Disorders and Psychopathology

Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report

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Yrondi, Antoine, Vaiva, Guillaume, Walter, Michel, D Amato, Thierry, Bellivier, Frank, Bennabi, Djamila, Bougerol, Thierry, Camus, Vincent +84 more·2021·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2020.12.055
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Abstract

OBJECTIVE: In addition to heredity, exposure to early-life adversity is an important predisposing risk factor of suicidal behaviour. Although the association between Childhood Trauma (CT) and suicide risk is well documented, interactions between CT and suicidal behaviour in Treatment-Resistant Depression (TRD) populations have received little coverage. This study aimed to evaluate i) association between CT and suicidal behaviour in a TRD population, and ii) the role of personality traits and impulsiveness as potential factors of mediation in these associations. METHODS: Patients were recruited from a cohort of the French network of TRD expert centers. Depressive symptom severity, CT, suicidal behaviour, personality traits, and impulsiveness were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Childhood Trauma Questionnaire (CTQ), the Columbia Suicide Severity Rating Scale (CSSRS), the Structured Clinical Interview for DSM-IV, the Big Five Inventory, and the Barratt Impulsivness Scale (BIS) respectively. RESULTS: Among the 256 patients with a baseline CTQ, in relation to suicide risk for the current depressive episode, we found an association with the total CTQ scores mediated by the intensity of the current episode in a model adjusted for age and sex (total effect: β = 0.171; p = 0.011, direct effect: β = 0.135; p = 0.043; indirect effect: β = 0.036; p = 0.048). Focusing on CT subtypes, we detected an association between suicide risk and physical neglect in a model adjusted for age and sex (β = 0.301; p = 0.002), without any mediation by the intensity of the current episode. There was no mediation effect from personality traits nor impulsiveness. With regards to CSSRS to assess suicidal ideation, we did not find any association with the total CTQ score and CT subtype scores. CONCLUSION: We report a strong association between suicidal behaviour and CT (in particular childhood physical neglect) in a TRD population.

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  • Life stress events are directly associated with a poorer response to commonly prescribed antidepressants, as well as with a greater occurrence of suicidal behavior and comorbidities and a greater severity of symptoms.

    “More in general, life stress events have been directly associated with a poorer response to commonly prescribed antidepressants, as well as with a greater occurrence of suicidal behavior and comorbidities and a greater severity of symptoms”

    From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [128]

    The Discussion and Conclusion report an association between childhood trauma—particularly physical neglect—and suicide risk in patients with treatment-resistant depression. The Introduction also reports an association between childhood trauma and clinical severity in that population. The paper does not establish that life stress events generally cause poorer responses to commonly prescribed antidepressants or more comorbidities; its treatment-response discussion proposes a biological explanation rather than testing that association. (LLM, conf=0.88)

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  1. BARRATT, E. S. (1985). Impulsiveness subtraits : Arousal and information processing. In J. T. Spence & C. E. hard (Eds.), Mofivation, emotion, andpersonality (pp. 137-146). North-Holland : Elsevier Science. In Motivation, emotion, and personnality (J. T. Spence&C. E. hard, p. 137-146). Elsevier Science.
  2. Fergusson, D. M., Woodward, L. J., & Horwood, L. J. (2000b). Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychological Medicine, 30(1), 23-39.

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Authors
Yrondi, A., Vaiva, G., Walter, M., D Amato, T., Bellivier, F., Bennabi, D., Bougerol, T., Camus, V., Doumy, O., Genty, J.-B., Haffen, E., Holtzmann, J., Horn, M., Lançon, C., Leboyer, M., Llorca, P.-M., Maruani, J., Moirand, R., Molière, F., Petrucci, J., Richieri, R., Samalin, L., Schmitt, L., Stephan, F., Courtet, P., El-Hage, W., Aouizerate, B., Aouizerate, B., Bennabi, D., Leboyer, M., Haffen, E., Llorca, P. M., Barteau, V., Bensalem, S., Laouamri, H., Souryis, K., Mallet, L., Yon, L., Petrucci, J., Genty, J. B., Yrondi, A., Pierre, D., Schmitt, L., Sarrail, M., Haffen, E., Bennabi, D., Ryff, I., Beuchet, E., Tio, G., Cappe, C., Clerc, E., Llorca, P. M., Garnier, M., Honciuc, R. M., Allauze, E., Blanc, O., Bellivier, F., Allaili, N., Nieto, I., Meheust, J., Sunthavy, Y., Maruani, J., Bougerol, T., Polosan, M., Courvoisier, P., Holtzmann, J., Fredembach, B., Foubert-Andreani, S., Camus, V., El Hage, W., D’Amato, T., Haesebaert, F., Dubien, C., Lefebvre, M., Meznad, A., Brunelin, J., Moirand, R., Aouizerate, B., Doumy, O., Lancon, C., Richieri, R., Peri, P., Faugere, M., Faget-Agius, C., Courtet, P., Boulenger, J. P., Moliere, F., Stephan, F., Walter, M., Mesmeur, C., Vaiva, G., & Horn, M.
Affiliations
  • Fondation FondaMental (FR)
  • Université Clermont Auvergne (FR)
  • Université Toulouse III - Paul Sabatier (FR)
  • Université de Bordeaux (FR)
  • Hôpital de la Conception (FR)
  • Inserm (FR)
  • Université Paris-Est Créteil (FR)
  • Lyon 1 Université (FR)
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2021-03
Volume
135
Pages
20-27
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2020.12.055
OpenAlex
W3114084339
Cited by
21
References
73
Citations by year
2026: 2 · 2025: 6 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 2
FWCI
1.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Psychiatric Research (acceptedVersion, other-oa)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
  • HAL Portal Artxiker (Hindustan Aeronautics Limited (India)) (submittedVersion)
  • Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
Agence Nationale de la Recherche
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
childhood trauma, suicidal behavior, treatment-resistant depression, suicide risk, physical neglect, personality traits, impulsivity, mediation, suicidal ideation, childhood adversity
MeSH terms
Depression, Humans, Surveys and Questionnaires, Risk Factors, Violence, Suicidal Ideation, Depressive Disorder, Treatment-Resistant

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