Cited by 329Suicide and Self-Harm StudiesHomicide, Infanticide, and Child AbuseGenetic Associations and Epidemiology

Familial Transmission of Suicidal Behavior

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Brent, David A., Melhem, Nadine·2008·Psychiatric Clinics of North America

Abstract

Adoption and twin studies show that familial transmission of suicidal behavior is partly attributable to genetic factors. Transmission of suicidal behavior is mediated by transmission of impulsive aggression or neuroticism and neurocognitive deficits. The most plausible explanations for nongenetic familial transmission are the intergenerational transmission of abuse and adverse familial environments. Bereavement and relationship disruption contribute to suicidal risk via the development of complicated grief, although long-term effects may be mediated by a complex chain of interrelated events. Imitation may contribute to suicidal risk, at least in attempted suicide. However, so-called family environmental factors often are related to risk factors that are heritable. Conversely, genetic factors exert their impact on depression and suicidal behavior via interaction with a stressful environment.

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Crossref · 10.1016/j.psc.2008.02.001

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Authors
Brent, D. A., & Melhem, N.
Corresponding author
Brent, David A.
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2008-06
Volume
31
Issue
2
Pages
157-177
ISSN
0193-953X (ISSN-L)
OpenAlex
W2045150555
Cited by
329
References
23
Citations by year
2026: 12 · 2025: 21 · 2024: 20 · 2023: 21 · 2022: 14 · 2021: 25 · 2020: 29 · 2019: 18 · 2018: 26 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 25 · 2013: 10 · 2012: 18
FWCI
2.47
Type
journal article
Language
en
Open access
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01mh043366-06)
  • National Institute of Mental Health (MH 62185, MH 77930, K01MH077930, MH-66371, MH56390, MH 43366, P30MH055123, MH 6612, R01MH056612, P30MH066371, R01MH056390, P50MH062185)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
suicidal behavior, family transmission, genetic factors, twin studies, adoption studies, impulsive aggression, neuroticism, neurocognitive impairment, intergenerational abuse, complicated grief, bereavement, relationship disruption, imitation, suicide attempts, depression, gene-environment interaction, heritability
MeSH terms
Adoption, Bereavement, Family, Humans, Risk Factors, Suicide, Twin Studies as Topic, Genetic Predisposition to Disease

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