Familial Transmission of Suicidal Behavior
Open accessAbstract
Adoption and twin studies show that familial transmission of suicidal behavior is partly attributable to genetic factors. Transmission of suicidal behavior is mediated by transmission of impulsive aggression or neuroticism and neurocognitive deficits. The most plausible explanations for nongenetic familial transmission are the intergenerational transmission of abuse and adverse familial environments. Bereavement and relationship disruption contribute to suicidal risk via the development of complicated grief, although long-term effects may be mediated by a complex chain of interrelated events. Imitation may contribute to suicidal risk, at least in attempted suicide. However, so-called family environmental factors often are related to risk factors that are heritable. Conversely, genetic factors exert their impact on depression and suicidal behavior via interaction with a stressful environment.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Personal and family history of suicidal thoughts and behaviors (PSH and FSH, respectively) are significant risk factors associated with future suicide events.
“Personal and family history of suicidal thoughts and behaviors (PSH and FSH, respectively) are significant risk factors associated with future suicide events.”
From Deep learning for identifying personal and family history of suicidal thoughts and behaviors from EHRs (2024) · cites this paper as [9]
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965 · see citing works
Toward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791 · see citing works
A component analysis of cognitive-behavioral treatment for depression.
Jacobson, N. S., Dobson, K. S., Truax, P. A., Addis, M. E., Koerner, K., Gollan, J. K., Gortner, E., & Prince, S. E. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.2.295 · Cited by 1,413 · see citing works
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260 · see citing works
Qin, P., Agerbo, E., & Mortensen, P. B. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.765 · Cited by 954 · see citing works
FERGUSSON, D. M., HORWOOD, L. J., & LYNSKEY, M. T. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00024 · Cited by 826 · see citing works
FERGUSSON, D. M., LYNSKEY, M. T., & HORWOOD, L. J. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199610000-00023 · Cited by 483 · see citing works
Devlin, B., Daniels, M., & Roeder, K. (1997) · Nature · doi:10.1038/41319 · Cited by 478 · see citing works
Suicidal behaviour: an epidemiological and genetic study
STATHAM, D. J., HEATH, A. C., MADDEN, P. A. F., BUCHOLZ, K. K., BIERUT, L., DINWIDDIE, S. H., SLUTSKE, W. S., DUNNE, M. P., & MARTIN, N. G. (1998) · Psychological Medicine · doi:10.1017/s0033291798006916 · Cited by 471 · see citing works
Latham, A. E., & Prigerson, H. G. (2004) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.34.4.350.53737 · Cited by 448 · see citing works
Is Suicide Bereavement Different? A Reassessment of the Literature
Jordan, J. R. (2001) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.31.1.91.21310 · Cited by 433 · see citing works
Toward a comprehensive developmental model for major depression in men
Kendler, K. S., Gardner, C. O., & Prescott, C. A. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.115 · Cited by 411 · see citing works
Zalsman, G., Huang, Y.-Y., Oquendo, M. A., Burke, A. K., Hu, X.-Z., Brent, D. A., Ellis, S. P., Goldman, D., & Mann, J. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1588 · Cited by 371 · see citing works
Self-citationQin, P., Agerbo, E., & Mortensen, P. B. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11197-4 · Cited by 352 · see citing works
Family history of suicide among suicide victims.
Runeson, B., & Åsberg, M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1525 · Cited by 250 · see citing works
A twin study of genetic and environmental influences on suicidality in men
FU, Q., HEATH, A. C., BUCHOLZ, K. K., NELSON, E. C., GLOWINSKI, A. L., GOLDBERG, J., LYONS, M. J., TSUANG, M. T., JACOB, T., TRUE, M. R., et al. (2002) · Psychological Medicine · doi:10.1017/s0033291701004846 · Cited by 245 · see citing works
Agerbo, E. (2005) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2004.024950 · Cited by 180 · see citing works
Social support and suicidal ideation in older adults using home healthcare services
Rowe, J. L., Conwell, Y., Schulberg, H. C., & Bruce, M. L. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000218324.78202.25 · Cited by 153 · see citing works
Suicide‐Bereaved Children and Adolescents: A Controlled Longitudinal Examination
CEREL, J., FRISTAD, M. A., WELLER, E. B., & WELLER, R. A. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199906000-00013 · Cited by 142 · see citing works
The Impact of Adolescent Suicide on Siblings and Parents: A Longitudinal Follow‐Up
Brent, D. A., Moritz, G., Bridge, J., Perper, J., & Canobbio, R. (1996) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.1996.tb00610.x · Cited by 107 · see citing works
Self-citationBRENT, D. A., OQUENDO, M., BIRMAHER, B., GREENHILL, L., KOLKO, D., STANLEY, B., ZELAZNY, J., BRODSKY, B., MELHEM, N., ELLIS, S. P., et al. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000135619.38392.78 · Cited by 99 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Suicide and suicidal behaviour
Turecki, G., & Brent, D. A. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00234-2 · Cited by 2,338 · see citing works
Self-citationAggression, Impulsivity, and Suicide Behavior: A Review of the Literature
Gvion, Y., & Apter, A. (2011) · Archives of Suicide Research · doi:10.1080/13811118.2011.565265 · Cited by 426 · see citing works
Candidate endophenotypes for genetic studies of suicidal behavior
Mann, J. J., Arango, V. A., Avenevoli, S., Brent, D. A., Champagne, F. A., Clayton, P., Currier, D., Dougherty, D. M., Haghighi, F., Hodge, S. E., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.021 · Cited by 398 · see citing works
Self-citationKetamine for rapid reduction of suicidal ideation: a randomized controlled trial
Murrough, J. W., Soleimani, L., DeWilde, K. E., Collins, K. A., Lapidus, K. A., Iacoviello, B. M., Lener, M., Kautz, M., Kim, J., Stern, J. B., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715001506 · Cited by 297 · see citing works
Cognitive-Behavioral Therapy for Adolescent Depression and Suicidality
Spirito, A., Esposito-Smythers, C., Wolff, J., & Uhl, K. (2011) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2011.01.012 · Cited by 140 · see citing works
Familial Pathways to Early-Onset Suicide Attempt: A 5.6-Year Prospective Study
Brent, D. A., Melhem, N. M., Oquendo, M., Burke, A., Birmaher, B., Stanley, B., Biernesser, C., Keilp, J., Kolko, D., Ellis, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2141 · Cited by 138 · see citing works
Self-citationWetherall, K., Cleare, S., Eschle, S., Ferguson, E., O'Connor, D. B., O'Carroll, R. E., & O'Connor, R. C. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.074 · Cited by 131 · see citing works
Wedig, M. M., Silverman, M. H., Frankenburg, F. R., Reich, D. B., Fitzmaurice, G., & Zanarini, M. C. (2012) · Psychological Medicine · doi:10.1017/s0033291712000517 · Cited by 137 · see citing works
Strawbridge, R. J., Ward, J., Ferguson, A., Graham, N., Shaw, R. J., Cullen, B., Pearsall, R., Lyall, L. M., Johnston, K. J. A., Niedzwiedz, C. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.005 · Cited by 112 · see citing works
Antecedents and sex/gender differences in youth suicidal behavior
Rhodes, A. E. (2014) · World Journal of Psychiatry · doi:10.5498/wjp.v4.i4.120 · Cited by 124 · see citing works
Fehling, K. B., & Selby, E. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.499980 · Cited by 94 · see citing works
Postvention is prevention—The case for suicide postvention
Jordan, J. R. (2017) · Death Studies · doi:10.1080/07481187.2017.1335544 · Cited by 75 · see citing works
Spillane, A., Larkin, C., Corcoran, P., Matvienko-Sikar, K., Riordan, F., & Arensman, E. (2017) · BMC Public Health · doi:10.1186/s12889-017-4930-3 · Cited by 67 · see citing works
Pre- and postloss features of adolescent suicide bereavement: A systematic review
Andriessen, K., Draper, B., Dudley, M., & Mitchell, P. B. (2016) · Death Studies · doi:10.1080/07481187.2015.1128497 · Cited by 67 · see citing works
“© 2016 Taylor & Francis Heller, 2008; Insel & Gould, 2008), and/or biological through a vulnerability for impulsivity, aggression, and suicidal feelings (Andriessen & Videtic-Paska, 2015; Brent & Melhem, 2008; Hawton, Saunders, & O’Connor, 2012).”
Fanelli, G., & Serretti, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.007 · Cited by 52 · see citing works
Genome-wide association studies of suicidal behaviors: a review
Sokolowski, M., Wasserman, J., & Wasserman, D. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.08.006 · Cited by 48 · see citing works
An overview of the neurobiology of suicidal behaviors as one meta-system
Sokolowski, M., Wasserman, J., & Wasserman, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.101 · Cited by 50 · see citing works
Calderaro, M., Baethge, C., Bermpohl, F., Gutwinski, S., Schouler-Ocak, M., & Henssler, J. (2022) · The British Journal of Psychiatry · doi:10.1192/bjp.2021.158 · Cited by 50 · see citing works
Burrell, L. V., Mehlum, L., & Qin, P. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.09.023 · Cited by 41 · see citing works
Complicated Grief and Suicidality: <i>The Impact of Subthreshold Mood Symptoms</i>
Dell'Osso, L., Carmassi, C., Rucci, P., Ciapparelli, A., Conversano, C., & Marazziti, D. (2011) · CNS Spectrums · doi:10.1017/s1092852912000090 · Cited by 38 · see citing works
Self-harm and violent criminality linked with parental death during childhood
Carr, M. J., Mok, P. L. H., Antonsen, S., Pedersen, C. B., & Webb, R. T. (2020) · Psychological Medicine · doi:10.1017/s0033291719001193 · Cited by 32 · see citing works
Sokolowski, M., Wasserman, J., & Wasserman, D. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32694 · Cited by 30 · see citing works
Yrondi, A., Vaiva, G., Walter, M., D Amato, T., Bellivier, F., Bennabi, D., Bougerol, T., Camus, V., Doumy, O., Genty, J.-B., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.055 · Cited by 21 · see citing works
Adekkanattu, P., Furmanchuk, A., Wu, Y., Pathak, A., Patra, B. G., Bost, S., Morrow, D., Wang, G. H.-M., Yang, Y., Forrest, N. J., et al. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01266-7 · Cited by 12 · see citing works
- Authors
- Brent, D. A., & Melhem, N.
- Corresponding author
- Brent, David A.
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 31
- Issue
- 2
- Pages
- 157-177
- ISSN
- 0193-953X (ISSN-L)
- PMC
- PMC2440417
- OpenAlex
- W2045150555
- Cited by
- 329
- References
- 23
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 20 · 2023: 21 · 2022: 14 · 2021: 25 · 2020: 29 · 2019: 18 · 2018: 26 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 25 · 2013: 10 · 2012: 18
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01mh043366-06)
- National Institute of Mental Health (MH 62185, MH 77930, K01MH077930, MH-66371, MH56390, MH 43366, P30MH055123, MH 6612, R01MH056612, P30MH066371, R01MH056390, P50MH062185)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- suicidal behavior, family transmission, genetic factors, twin studies, adoption studies, impulsive aggression, neuroticism, neurocognitive impairment, intergenerational abuse, complicated grief, bereavement, relationship disruption, imitation, suicide attempts, depression, gene-environment interaction, heritability
- MeSH terms
- Adoption, Bereavement, Family, Humans, Risk Factors, Suicide, Twin Studies as Topic, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review