3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

Maximum Likelihood from Incomplete Data Via the EM Algorithm

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Structures of the holo CRISPR RNA-guided transposon integration complex

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Structural features of nucleosomes in interphase and metaphase chromosomes

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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

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DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage

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Conformational motions and ligand-binding underlying gating and regulation in IP3R channel

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Mechanism of glycogen synthase inactivation and interaction with glycogenin

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Structure and interactions of the endogenous human Commander complex

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The PfRCR complex bridges malaria parasite and erythrocyte during invasion

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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

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Structural basis for plasmid restriction by SMC JET nuclease

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Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules

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Genome expansion by a CRISPR trimmer-integrase

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Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III

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Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex

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Structure of mycobacterial respiratory complex I

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Molecular mechanism of phospholipid transport at the bacterial outer membrane interface

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Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney

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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway

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Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy

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CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets

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Architecture of the RNF1 complex that drives biological nitrogen fixation

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Atomic structures of a bacteriocin targeting Gram-positive bacteria

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Structural basis of 3′-tRNA maturation by the human mitochondrial RNase Z complex

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Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors

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Structure of the recombinant RNA polymerase from African Swine Fever Virus

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Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

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Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex

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Conformational space exploration of cryo-EM structures by variability refinement

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Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome

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Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria

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Structure and activation mechanism of a Lamassu phage and plasmid defense system

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Structure of a membrane tethering complex incorporating multiple SNAREs

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Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate

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Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport

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Building molecular model series from heterogeneous CryoEM structures using Gaussian mixture models and deep neural networks

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The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems

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Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor

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Conformational landscapes of a class I ribonucleotide reductase complex during turnover reveal intrinsic dynamics and asymmetry

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SNARE disassembly requires Sec18/NSF side loading

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Structure and regulation of full-length human leucine-rich repeat kinase 1

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Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G

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Nucleosome structural variations in interphase and metaphase chromosomes

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Molecular exaptation by the integrin αI domain

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A cryo-electron microscopy structure of yeast Pex5 in complex with a cargo uncovers a novel binding interface

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Curvature Generation and Engineering Principles from Shewanella oneidensis Multi-flagellin Flagellum

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Structural insights into cobalamin loading and reactivation of human methionine synthase

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Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage λP helicase loader

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Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation

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Analysis of the heterogenous structural states of the hexameric ATPase PilU of the type IV pili from Vibrio cholerae

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Structure of the human CTF18−RFC clamp loader bound to PCNA

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