Cited by 155Medication Adherence and ComplianceBlood Pressure and Hypertension StudiesPharmacy and Medical Practices

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Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group

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Gwadry-Sridhar, Femida H., Manias, Elizabeth, Lal, Lincy, Salas, Maribel, Hughes, Dyfrig A., Ratzki-Leewing, Alexandria, Grubisic, Maja·2013·Value in Health

DOI 10.1016/j.jval.2013.03.1631

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Abstract

Objectives To systematically review the evidence on the impact of interventions to improve medication adherence in adults prescribed antihypertensive medications.Methods An electronic search was undertaken of articles published between 1979 and 2009, without language restriction, that focused on interventions to improve antihypertensive medication adherence among patients (≥18 years) with essential hypertension. Studies must have measured adherence as an outcome of the intervention. We followed standard guidelines for the conduct and reporting of the review and conducted a narrative synthesis of reported data.Results Ninety-seven articles were identified for inclusion; 35 (35 of 97, 36.1%) examined interventions to directly improve medication adherence, and the majority (58 of 97, 59.8%) were randomized controlled trials. Thirty-four (34 of 97, 35.1%) studies reported a statistically significant improvement in medication adherence.Discussion/conclusions Interventions aimed at improving patients' knowledge of medications possess the greatest potential clinical value in improving adherence with antihypertensive therapy. However, we identified several limitations of these studies, and advise future researchers to focus on using validated adherence measures, well-designed randomized controlled trials with relevant adherence and clinical outcomes, and guidelines on the appropriate design and analysis of adherence research.

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Sorted by citations

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
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Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association
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See all 155

Authors: Gwadry-Sridhar, F. H., Manias, E., Lal, L., Salas, M., Hughes, D. A., Ratzki-Leewing, A., & Grubisic, M.
Affiliations: Western University (CA)
The University of Melbourne (AU)
AstraZeneca (United States) (US)
Bangor University (GB)
Corresponding author: Gwadry-Sridhar, Femida H.
ORCID: Manias, Elizabeth
Lal, Lincy
Salas, Maribel
Hughes, Dyfrig A.
Venue: Value in Health
Publisher: Elsevier BV
Published: 2013-07
Volume: 16
Issue: 5
Pages: 863-871
ISSN: 1098-3015 (ISSN-L)
DOI: 10.1016/j.jval.2013.03.1631
OpenAlex: W2042085280
Cited by: 155
References: 147
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 20 · 2020: 18 · 2019: 17 · 2018: 24 · 2017: 12 · 2016: 12 · 2015: 16 · 2014: 4 · 2013: 1
FWCI: 1.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Value in Health (publishedVersion)
PubMed (publishedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
Keywords: medication adherence, essential hypertension, antihypertensive therapy, adherence interventions, blood pressure control, medication knowledge, adherence measurement
MeSH terms: Essential Hypertension, Antihypertensive Agents, Blood Pressure, Humans, Hypertension, Health Knowledge, Attitudes, Practice, Patient Education as Topic, Reminder Systems, Medication Adherence

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Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension: A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group

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