Cited by 322Ovarian function and disordersReproductive Biology and FertilityDiabetes, Cardiovascular Risks, and Lipoproteins

Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome

Wang, Juan, Wu, Daichao, Guo, Hui, Li, Meixiang·2019·Life Sciences

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive endocrine diseases, which has a variety of effects on a woman's health. Because of the involvement of multiple pathways and the lack of common clues, PCOS demonstrates multifactorial properties and heterogeneity of symptoms. Recent studies have demonstrated that the core etiology and primary endocrine characteristics of PCOS are hyperandrogenemia (HA) and insulin resistance (IR). HA and IR are the main causes of PCOS and they can interplay each other in the occurrence and development of PCOS. Just because of this, the study about the effects of HA and IR on pathophysiology of various related symptoms of PCOS is very important to understand the pathogenesis of PCOS. This paper reviews the main symptoms of PCOS, including neuroendocrine disorders, reproductive processes, dyslipidemia, obesity, hypertension, nonalcoholic fatty liver disease (NAFLD), and sleep disordered breathing, which seriously affect the physical and mental health of PCOS women. The increasing knowledge of the development pattern of HA and IR in PCOS suggests that changes in diet and lifestyle, and the discovery of potential therapeutic agents may improve PCOS. However, further studies are needed to clarify the mutual influence and relation of HA and IR in development of PCOS. This review provides an overview of the current knowledge about the effects of HA and IR on PCOS.

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Crossref · 10.1016/j.lfs.2019.116940

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Authors
Wang, J., Wu, D., Guo, H., & Li, M.
Affiliations
University of South China (CN)
Corresponding author
Li, Meixiang
Venue
Life Sciences
Publisher
Elsevier BV
Published
2019-11
Volume
236
Pages
116940
ISSN
0024-3205 (ISSN-L)
OpenAlex
W2980249081
Cited by
322
References
113
Citations by year
2026: 27 · 2025: 53 · 2024: 75 · 2023: 69 · 2022: 44 · 2021: 37 · 2020: 15 · 2012: 1
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Key Lab for Clinical Anatomy and Reproductive Medicine of Hengyang City (2017KJ182)
  • Natural Science Foundation of Hunan Province (2017SJ353, CX20190753, 2015JJ2128)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, hyperandrogenemia, insulin resistance, PCOS pathogenesis, neuroendocrine disorders, dyslipidemia, obesity, hypertension, non-alcoholic fatty liver disease, sleep-disordered breathing, PCOS treatment, lifestyle intervention
MeSH terms
Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Risk Factors, Hyperandrogenism

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