Haematopoietic stem cells in perisinusoidal niches are protected from ageing
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With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. However, whether ageing also affects the HSC niche, and thereby impairs its capacity to support HSC function, is still widely debated. Here, by using in-vivo long-term label-retention assays we demonstrate that aged label-retaining HSCs, which are, in old mice, the most quiescent HSC subpopulation with the highest regenerative capacity and cellular polarity, reside predominantly in perisinusoidal niches. Furthermore, we demonstrate that sinusoidal niches are uniquely preserved in shape, morphology and number on ageing. Finally, we show that myeloablative chemotherapy can selectively disrupt aged sinusoidal niches in the long term, which is linked to the lack of recovery of endothelial Jag2 at sinusoids. Overall, our data characterize the functional alterations of the aged HSC niche and unveil that perisinusoidal niches are uniquely preserved and thereby protect HSCs from ageing.
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In bone marrow from old mice, a pool of quiescent HSCs located close to sinusoids may be protected from some ageing effects.
“Likewise, in bone marrow from old mice, a pool of quiescent HSCs located close to sinusoids (FIG. 1b) may be protected from some ageing effects38.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [38]
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Chen, J., Hendriks, M., Chatzis, A., Ramasamy, S. K., & Kusumbe, A. P. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4171 · Cited by 175 · see citing works
“A subpopulation of HSCs with high regenerative capacity, active Notch signaling, and cellular polarity resides predominantly in perisinusoidal niches in the aged mice.((103))”
BackgroundMicroenvironmental contributions to hematopoietic stem cell aging
Ho, Y., & Méndez‐Ferrer, S. (2019) · Haematologica · doi:10.3324/haematol.2018.211334 · Cited by 149 · see citing works
“Overexpression of the Notch ligand Dll4 in vascular endothelial cells can prevent myeloid skewing of hematopoietic progenitors(73) but cannot completely rescue HSC aging,(70) perhaps consistent with the finding of another study in which Dll4 was unchanged in the aged murine BM.(40) A common finding is reduced endostea…”
BackgroundResultSelf-citationHarnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M. Z., Wei, Y., Wang, L., Liao, Y., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.03.005 · Cited by 140 · see citing works
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“41 By contrast, Tom+ oMkPs were substantially different from both GFP+ yMkPs (1,071 DEGs) and oMkPs (187 DEGs, Table S2) and associated with Gene Ontology (GO) terms such as regulation of response to stress and immune response (Figure 2B).”
BackgroundThe Hematopoietic Bone Marrow Niche Ecosystem
Fröbel, J., Landspersky, T., Perçin, G. I., Schreck, C., Rahmig, S., Ori, A., Nowak, D., Essers, M. A. G., Waskow, C., & Oostendorp, R. A. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705410 · Cited by 97 · see citing works
Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells
Kandarakov, O. F., Belyavsky, A. V., & Semenova, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084462 · Cited by 97 · see citing works
“With age, degeneration of arteries and arterioles occurs [197], they become disorganized, which impairs their ability to maintain HSC quiescence and affects function of the latter [188,198].”
BackgroundKokkaliaris, K. D., Kunz, L., Cabezas‐Wallscheid, N., Christodoulou, C., Renders, S., Camargo, F. D., Trumpp, A., Scadden, D. T., & Schroeder, T. (2020) · Blood · doi:10.1182/blood.2020006574 · Cited by 93 · see citing works
Self-citationMolecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
Zhang, L., Mack, R. M., Breslin, P., & Zhang, J. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00994-z · Cited by 78 · see citing works
Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases
Stücker, S., Chen, J., Watt, F. E., & Kusumbe, A. P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602269 · Cited by 68 · see citing works
“These functional HSC alterations correlate with an agerelated relocation of HSCs away from endosteal arteriolar niches, favoring non-endosteal sinusoidal BM niches in the central BM (Maryanovich et al., 2018; Ho et al., 2019; Saçma et al., 2019).”
BackgroundInflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis
Zioni, N., Bercovich, A. A., Chapal-Ilani, N., Bacharach, T., Rappoport, N., Solomon, A., Avraham, R., Kopitman, E., Porat, Z., Sacma, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36906-1 · Cited by 67 · see citing works
Self-citationAging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
Matteini, F., Mulaw, M. A., & Florian, M. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738204 · Cited by 58 · see citing works
“So far, megakaryocytes (MKs) are the ones mainly implied in HSC regulation and young HSCs are often found in close proximity to MKs (39, 40), which is interestingly not observed upon aging (40, 41).”
BackgroundInfluentialSelf-citationAcute Myeloid Leukemia: Aging and Epigenetics
Zjablovskaja, P., & Florian, M. C. (2019) · Cancers · doi:10.3390/cancers12010103 · Cited by 60 · see citing works
“Indeed, some recent reports highlighted profound alterations in the BM microenvironment on aging which might play important roles in disease progression, or it might be critical to tailor the chemotherapeutic approach for the elderly [16,17,83,84].”
BackgroundSelf-citationInflammation, Aging and Hematopoiesis: A Complex Relationship
Bousounis, P., Bergo, V., & Trompouki, E. (2021) · Cells · doi:10.3390/cells10061386 · Cited by 58 · see citing works
The role of the haematopoietic stem cell niche in development and ageing
Cain, T. L., Derecka, M., & McKinney‐Freeman, S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00770-8 · Cited by 59 · see citing works
“Although JAG1 is reduced in aged endothelium, JAG2 is maintained at steady state 183 .”
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis
SanMiguel, J. M., Young, K. A., & Trowbridge, J. J. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.197 · Cited by 58 · see citing works
Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
Yang, D., & de Haan, G. (2021) · Cells · doi:10.3390/cells10081849 · Cited by 52 · see citing works
“For example, it has been shown that HSCs are re-localized in the aging niche, where aged HSCs are away from arterioles or megakaryocytes but close to perivascular Nestin-GFPdim cells and sinusoids compared to young counterparts [62,64].”
BackgroundAguilar-Navarro, A. G., Meza-León, B., Gratzinger, D. A., Juárez-Aguilar, F. G., Chang, Q., Ornatsky, O., Tsui, H., Gómez, R. E., Hernández-Ramírez, A., Xie, S. Z.-J., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.011 · Cited by 46 · see citing works
“Stem Cell This is an open access article under the C to remain stable in mouse BM with aging (Maryanovich et al., 2018; Saçma et al., 2019).”
BackgroundOgrodnik, M. B., & Gladyshev, V. N. (2023) · Nature Aging · doi:10.1038/s43587-023-00447-5 · Cited by 46 · see citing works
Bone marrow niches for hematopoietic stem cells: Life span dynamics and adaptation to acute stress
Hofmann, J., & Kokkaliaris, K. D. (2024) · Blood · doi:10.1182/blood.2023023788 · Cited by 45 · see citing works
The Importance of Computational Modeling in Stem Cell Research
del Sol, A., & Jung, S. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.07.006 · Cited by 45 · see citing works
“To date, a few computational approaches have been developed that explicitly consider niche effects [20 – 23].”
BackgroundMechanisms involved in hematopoietic stem cell aging
Fujino, T., Asada, S., Goyama, S., & Kitamura, T. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04356-5 · Cited by 45 · see citing works
“Consistent with these observations, aged HSCs detach from endosteal and arteriolar regions, whereas their proximity to the sinusoidal niche are preserved [184, 188, 189].”
BackgroundThe roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies
Zhang, H., Liesveld, J. L., Calvi, L. M., Lipe, B. C., Xing, L., Becker, M. W., Schwarz, E. M., & Yeh, S.-C. A. (2023) · Bone Research · doi:10.1038/s41413-023-00249-w · Cited by 46 · see citing works
Biomechanical cues as master regulators of hematopoietic stem cell fate
Li, H., Luo, Q., Shan, W., Cai, S., Tie, R., Xu, Y., Lin, Y., Qian, P., & Huang, H. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03882-y · Cited by 43 · see citing works
“The spatial variations of BM niche in cellular and extracellular matrix (ECM) components, soluble, physical, and biomechanical factors are intertwined to create functional niches [1, 79] (Fig.”
BackgroundClonal hematopoiesis and its impact on the aging osteo-hematopoietic niche
Winter, S., Götze, K. S. S., Hecker, J. S., Metzeler, K. H., Guezguez, B., Woods, K., Medyouf, H., Schäffer, A., Schmitz, M., Wehner, R., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02226-6 · Cited by 39 · see citing works
Sarachakov, A., Varlamova, A., Svekolkin, V., Galkin, I., Valencia, I., Unkenholz, C., Pannellini, T., Akaeva, A., Smirnova, S., Ovcharov, P., et al. (2023) · Blood · doi:10.1182/blood.2023021280 · Cited by 41 · see citing works
Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration
Hirakawa, H., Gao, L., Tavakol, D. N., Vunjak‐Novakovic, G., & Ding, L. (2023) · Nature Genetics · doi:10.1038/s41588-023-01528-2 · Cited by 40 · see citing works
Grockowiak, É., Korn, C., Rak, J. M., Lysenko, V., Hallou, A., Panvini, F. M., Williams, M., Fielding, C., Fang, Z., Khatib-Massalha, E., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00607-x · Cited by 36 · see citing works
“Reduced endosteal and increased central BM niches promote myeloid cell expansion during aging 28,29 .”
Self-citationCXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens
Wang, J., Xie, J., Wang, D., Han, X. N., Chen, M., Shi, G., Jiang, L., & Zhao, M. L. (2022) · eLife · doi:10.7554/elife.78662 · Cited by 35 · see citing works
“…2009; Olson et al., 2013), 31 non-myelinating Schwann cells (Jiang et al., 2018; Yamazaki et al., 2011), and blood 32 vessels (Avecilla et al., 2004; Sacma et al., 2019) to further influence the attraction and 33 retention of hematopoietic stem and progenitor cells during homeostasis and stress.”
BackgroundDecoding Aging Hallmarks at the Single-Cell Level
Ma, S., Chi, X., Cai, Y., Ji, Z., Wang, S., Ren, J., & Liu, G. (2023) · Annual Review of Biomedical Data Science · doi:10.1146/annurev-biodatasci-020722-120642 · Cited by 37 · see citing works
Bruserud, Ø., Vo, A. K., & Reikvam, H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030706 · Cited by 37 · see citing works
Cellular crosstalk in the bone marrow niche
Huang, Z., Iqbal, Z., Zhao, Z., Liu, J., Alabsi, A. M., Shabbir, M., Mahmood, A., Liang, Y., Li, W., & Deng, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05900-6 · Cited by 34 · see citing works
Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice
Montserrat‐Vazquez, S., Ali, N., Matteini, F., Lozano-Bartolomé, J., Tu, Z., Mejía-Ramírez, E., Marka, G., Vollmer, A., Soller, K., Saçma, M., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00275-y · Cited by 35 · see citing works
Self-citationBioengineering the Bone Marrow Vascular Niche
Bessy, T., Itkin, T., & Passaro, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645496 · Cited by 34 · see citing works
“Recent advances in whole tissue imaging and deep learning (Saçma et al., 2019) in mouse models have allowed to study the BM vascular network with unprecedent resolution, and specific endothelial cells lining specialized vessels have been defined as central actors of bone remodeling and cellular exchanges in homeostasi…”
BackgroundEndothelial heterogeneity in bone marrow: insights across development, adult life and leukemia
Boueya, I. L., Sandhow, L., Albuquerque, J. R. P., Znaidi, R., & Passaro, D. (2024) · Leukemia · doi:10.1038/s41375-024-02453-x · Cited by 33 · see citing works
The Notch signaling pathway involvement in innate lymphoid cell biology
Golub, R. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.12.004 · Cited by 31 · see citing works
“In situ hybridization of E12 through E17 murine fetal liver evidenced widespread expression of Jag1 and Dll1 ligands [21].”
BackgroundInfluentialA Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells
Tiwari, R. L., Mishra, P., Martin, N., George, N. O., Sakk, V., Soller, K., Nalapareddy, K., Nattamai, K., Scharffetter‐Kochanek, K., Florian, M. C., et al. (2021) · Aging · doi:10.18632/aging.202694 · Cited by 31 · see citing works
“regenerative capacity, similar to what is here reported for HFSCs [38].”
ResultSelf-citationCdc42-Borg4-Septin7 axis regulates HSC polarity and function
Kandi, R., Senger, K., Grigoryan, A., Soller, K., Sakk, V., Schuster, T., Eiwen, K., Menon, M. B., Gaestel, M., Zheng, Y., et al. (2021) · EMBO Reports · doi:10.15252/embr.202152931 · Cited by 30 · see citing works
Self-citationOsteoblast Lineage Support of Hematopoiesis in Health and Disease
Kim, M., Valderrábano, R. J., & Wu, J. Y. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4678 · Cited by 28 · see citing works
“Age-related changes in the bone marrow microenvironment include alterations in the vasculature((129)) and depletion of lymphoid and Osx osteogenic progenitors.((68)) The number of Osteolectin-expressing BMSCs also declines with age and is associated with a decline in CLPs, CMPs, and myeloid-erythroid progenitors (MEPs…”
BackgroundThe biology of hematopoietic stem cells and its clinical implications
Skulimowska, I., Sośniak, J., Gońka, M., Szade, A., Józkowicz, A., & Szade, K. (2021) · FEBS Journal · doi:10.1111/febs.16192 · Cited by 26 · see citing works
Bone marrow adipocytes: key players in vascular niches, aging, and disease
Fan, Y., El-Khalek, M. K. A., Zhang, Y., Liu, L., Tian, Q., Chueakula, N., Ramasamy, S. K., Dalan, R., Habib, S. J., & Kusumbe, A. P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1633801 · Cited by 26 · see citing works
Loss of epigenetic polarity is a hallmark of hematopoietic stem cell aging
Mejía-Ramírez, E., Geiger, H., & Florian, M. C. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa189 · Cited by 24 · see citing works
Self-citationThe extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging
Raja, E., Changarathil, G., Oinam, L., Ngo, Y. X., Tsunezumi, J., Ishii, R., Sasaki, T., Imanaka‐Yoshida, K., Yanagisawa, H., & Sada, A. (2022) · EMBO Reports · doi:10.15252/embr.202255478 · Cited by 22 · see citing works
Haematopoietic ageing in health and lifespan
Andersson, R., Mejía-Ramírez, E., & Florian, M. C. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01739-1 · Cited by 24 · see citing works
“…the HSCs that conserve the highest capa city for self-renewal and balanced differentiation after transplantation reside predominantly in selected perisinusoidal niches, whose shape, morphology and number are uniquely preserved, in contrast to the decline of the arteriolar compartment 37 .”
InfluentialSelf-citationPrasad, P., & Cancelas, J. A. (2024) · Cells · doi:10.3390/cells13110910 · Cited by 21 · see citing works
“High LepR-expressing MSCs that co-express a high amount of SCF reside close to the sinusoids where the long-term HSCs are majorly found [34,35].”
BackgroundExtracellular Vesicles and Hematopoietic Stem Cell Aging
Goldberg, L. R. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314643 · Cited by 20 · see citing works
Hernandez-Valladares, M., Aasebø, E., Berven, F. S., Selheim, F., & Bruserud, Ø. (2020) · Aging · doi:10.18632/aging.202361 · Cited by 20 · see citing works
Rodrigues, C. P., & Akhtar, A. (2021) · Science Advances · doi:10.1126/sciadv.abi5987 · Cited by 20 · see citing works
Arai, F., Stumpf, P. S., Ikushima, Y. M., Hosokawa, K., Roch, A., Lutolf, M. P., Suda, T., & MacArthur, B. D. (2020) · Cell Systems · doi:10.1016/j.cels.2020.11.004 · Cited by 19 · see citing works
Landspersky, T., Saçma, M., Rivière, J., Hecker, J. S., Hettler, F., Hameister, E., Brandstetter, K., Istvánffy, R., Marquez, S. R., Ludwig, R., et al. (2021) · Blood · doi:10.1182/blood.2021011775 · Cited by 19 · see citing works
Self-citationShi, G., Chang, Z., Zhang, P., Zou, X., Zheng, X., Liu, X., Yan, J., Xu, H., Tian, Z., Zhang, N., et al. (2024) · Cell Proliferation · doi:10.1111/cpr.13715 · Cited by 17 · see citing works
Stem cell aging: The upcoming era of proteins and metabolites
Schüler, S. C., Gebert, N., & Ori, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111288 · Cited by 18 · see citing works
“It was found that HSCs lose their proximity to most niche cells (Saçma et al., 2019),”
Fotopoulou, F., Rodriguez-Correa, E., Dussiau, C., & Milsom, M. D. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104698 · Cited by 17 · see citing works
Self-citationThe Role and Mechanism of the Vascular Endothelial Niche in Diseases: A Review
Lei, Z., Hu, X., Wu, Y., Fu, L., Lai, S., Lin, J., Li, X., & Lv, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.863265 · Cited by 17 · see citing works
“A lack of Jag2 in the perisinusoidal endothelial niche accelerated aging of hematopoietic stem cells (Saçma et al., 2019).”
BackgroundGhosh, J., Koussa, R. E., Mohamad, S., Liu, J., Kacena, M. A., & Srour, E. F. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000656 · Cited by 17 · see citing works
Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -
Torres, L. S., Asada, N., Weiss, M. J., Trumpp, A., Suda, T., Scadden, D. T., & Ito, K. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.06.004 · Cited by 16 · see citing works
Self-citationRole of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches
Lévesque, J.-P., SUMMERS, K. M., Millard, S. M., Bisht, K., Winkler, I. G., & Pettit, A. R. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.07.001 · Cited by 15 · see citing works
Targeting the Hematopoietic Stem Cell Niche in β-Thalassemia and Sickle Cell Disease
Aprile, A., Sighinolfi, S., Raggi, L., & Ferrari, G. (2022) · Pharmaceuticals · doi:10.3390/ph15050592 · Cited by 15 · see citing works
“Moreover, the damaged SS-RBCs and activated ECs can produce a proinflammatory environment that is exacerbated during episodes of crisis.”
BackgroundInfluentialLee, S., Wong, H., Castiglione, M. A., Murphy, M. M., Kaushansky, K., & Zhan, H. (2022) · Stem Cells · doi:10.1093/stmcls/sxac005 · Cited by 12 · see citing works
Du, L., Freitas-Cortez, M. A., Zhang, J., Xue, Y., Veettil, R. T., Zhao, Z., & Morrison, S. J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412317122 · Cited by 12 · see citing works
“Perisinusoidal niches for HSCs are preserved during aging ( 20 ), but the identity of the cells that produce SCF for HSC maintenance has not been functionally tested during aging and we have limited insight into how stromal cells change their properties during aging.”
Human hematopoietic microenvironments
Kristensen, H. B., Andersen, T. L., Patriarca, A., Kallenbach, K., MacDonald, B., Sikjær, T., Ejersted, C., & Delaissé, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250081 · Cited by 12 · see citing works
“Because of the evidence regarding the influence of aging on the HSPC microenvironment [14,56], we investigated whether it was possible to find any correlations between aging and HSPC localization; which we were not able to find.”
BackgroundTargeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells
Mejía-Ramírez, E., Picazo, P. I., Walter, B., Montserrat‐Vazquez, S., Affuso, F., Wieser, S., Pezzano, F., Reymond, L., Castillo‐Robles, J., Matteini, F., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-01014-w · Cited by 14 · see citing works
Self-citationPlasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression.
Jibril, A. S., Hellmich, C., Wojtowicz, E. E., Hampton, K., Maynard, R. S., Silva, R. D., Fowler-Shorten, D. J., Mistry, J. J., Moore, J. A., Bowles, K. M., et al. (2023) · Blood · doi:10.1182/blood.2022018711 · Cited by 11 · see citing works
Xinyi, Y., Vladimirovich, R. I., Beeraka, N. M., Satyavathi, A., Kamble, D., Nikolenko, V. N., Lakshmi, A. N., Basappa, B., Padmanabha Reddy, Y., Fan, R., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04008-4 · Cited by 11 · see citing works
“As the age increases, the alterations occur in the vasculature, marked by the decline in CD31 high Endomu-cin −/low arterioles [147, 151, 208].”
BackgroundWatt, S. M. (2022) · PubMed Central · doi:10.12336/biomatertransl.2022.01.005 · Cited by 11 · see citing works
Proliferation: Driver of HSC aging phenotypes?
Yanai, H., & Beerman, I. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111331 · Cited by 9 · see citing works
Xiao, M., Hong, S., Peng, P., Cai, S., Huang, Y., Liang, J., Bai, X., Bao, Q., Li, W., Cheng, G., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155978 · Cited by 9 · see citing works
The aging hematopoietic stem cell niche: a mini review
Gao, X., Zhang, J., & Tamplin, O. J. (2025) · Frontiers in Hematology · doi:10.3389/frhem.2025.1525132 · Cited by 9 · see citing works
“Some have observed that endosteal ECs, like arterioles and TZVs, are reduced during aging, but overall EC volume and area occupancy are unchanged, leading to the conclusion that BM sinusoids are preserved upon aging (15).”
Yang, F., Nourse, C., Helgason, G. V., & Kirschner, K. (2023) · HemaSphere · doi:10.1097/hs9.0000000000000895 · Cited by 9 · see citing works
“59 61 However, the expression of the cell surface receptor LepR increases in human MSCs with increased age.”
El‐naseery, N. I., Elewa, Y. H. A., El-behery, E., & Dessouky, A. A. (2023) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2023.152131 · Cited by 9 · see citing works
Hematopoietic Stem Cells and Their Bone Marrow Niches
Pinho, S., & Zhao, M. L. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_2 · Cited by 8 · see citing works
Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice
Yang, D., Skinder, N., Kao, Y.-R., Chen, J., Thiruthuvanathan, V. J., Svendsen, A. F., Zhang, C., Dethmers-Ausema, B., Weersing, E., Maryanovich, M., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00880-8 · Cited by 8 · see citing works
The role of the stem cell epigenome in normal aging and rejuvenative therapy
Jayarajan, J., & Milsom, M. D. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa167 · Cited by 8 · see citing works
Self-citationSaçma, M., Matteini, F., Mulaw, M. A., Hageb, A., Bogeska, R., Sakk, V., Vollmer, A., Marka, G., Soller, K., Milsom, M. D., et al. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101483 · Cited by 8 · see citing works
Self-citation3D In Vitro Models of the Bone Marrow Niche
Scala, P., Serio, B., & Giudice, V. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01421 · Cited by 7 · see citing works
Skinder, N., Fernández, I. S., Dethmers-Ausema, A., Weersing, E., & de Haan, G. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023011585 · Cited by 7 · see citing works
Current Trends on Hemopoietic Stem Cells
Okeke, C., Silas, U., Okeke, C., & Chikwendu, C. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15999200729162021 · Cited by 6 · see citing works
Omatsu, Y., Higaki, K., & Nagasawa, T. (2021) · Current topics in microbiology and immunology · doi:10.1007/978-3-030-86016-5_2 · Cited by 6 · see citing works
Dissecting dormancy and quiescence in hematopoietic stem cells
Ibneeva, L., & Grinenko, T. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1401713 · Cited by 6 · see citing works
Meeting Report: Aging Research and Drug Discovery
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Functional Specialization of the Calvarial Bone Marrow
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Self-citation
- Authors
- Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K., Marka, G., Vollmer, A., Karns, R., Cabezas-Wallscheid, N., Trumpp, A., Méndez-Ferrer, S., Milsom, M. D., Mulaw, M. A., Geiger, H., & Florian, M. C.
- Affiliations
- Universität Ulm (DE)
- German Cancer Research Center (DE)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Florian, Maria Carolina
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2019-11
- Volume
- 21
- Issue
- 11
- Pages
- 1309-1320
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2986117925
- Cited by
- 133
- References
- 81
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 23 · 2022: 19 · 2021: 26 · 2020: 21 · 2019: 2
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Deutsche Forschungsgemeinschaft (FL 921/1-1, FOR2674, SFB1074)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- hematopoietic stem cells, aging, HSC quiescence, myeloablative chemotherapy, bone marrow microenvironment
- MeSH terms
- Jagged-2 Protein, Aging, Animals, Bone Marrow, Capillaries, Cell Differentiation, Cell Division, Doxycycline, Fluorouracil, Gene Expression Regulation, Hematopoietic Stem Cells, Histones, Homeostasis, Mice, Inbred C57BL, Mice, Transgenic, Cell Polarity, Genes, Reporter, Hematopoietic Stem Cell Transplantation, Myeloablative Agonists, Green Fluorescent Proteins, Mice, Stem Cell Niche, Cell Tracking
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