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The WNT signaling pathways in wound healing and fibrosis

Burgy, Olivier, Königshoff, Melanie·2018·Matrix Biology
DOI 10.1016/j.matbio.2018.03.017
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Abstract

The WNT signaling pathways are major regulators of organ development. Ample research over the past few decades revealed that these pathways are critically involved in adult tissue homeostasis and stem cell function as well as the development of chronic diseases, such as cancer and fibrosis. In this review, we will describe the different WNT signal pathways, summarize the current evidence of WNT signal involvement in wound healing and fibrosis, and highlight potential novel therapeutic options for fibrotic disorders targeting WNT signaling pathways.

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Metadata

Authors
Burgy, O., & Königshoff, M.
Venue
Matrix Biology
Publisher
Elsevier BV
Published
2018-08
Volume
68-69
Pages
67-80
ISSN
0945-053X
DOI
10.1016/j.matbio.2018.03.017
Cited by
175
References
12
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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