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Cited by 569Dementia and Cognitive Impairment ResearchTreatment of Major DepressionNeurological Disease Mechanisms and Treatments

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Depression and dementia: Cause, consequence or coincidence?

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Bennett, Sophia, Thomas, Alan J.·2014·Maturitas
DOI 10.1016/j.maturitas.2014.05.009
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Abstract

The relationship between depression and dementia is complex and still not well understood. A number of different views exist regarding how the two conditions are linked as well as the underlying neurobiological mechanisms at work. This narrative review examined longitudinal and cross sectional studies in the existing literature and determined the evidence supporting depression being a risk factor, a prodrome, a consequence, or an independent comorbidity in dementia. Overall there is convincing evidence to support both the notion that early life depression can act as a risk factor for later life dementia, and that later life depression can be seen as a prodrome to dementia. There is also evidence to support both conditions showing similar neurobiological changes, particularly white matter disease, either indicating shared risk factors or a shared pattern of neuronal damage. These findings highlight the need to examine if effective treatment of depressive episodes has any effect in reducing the prevalence of dementia, as well as clinicians being vigilant for late life depression indicating the incipient development of dementia, and therefore carefully following up these individuals for future cognitive impairment.

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Metadata

Authors
Bennett, S., & Thomas, A. J.
Affiliations
Newcastle University (GB)
Corresponding author
Thomas, Alan J.
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
2014-10
Volume
79
Issue
2
Pages
184-190
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/j.maturitas.2014.05.009
OpenAlex
W2097522066
Cited by
569
References
3
Citations by year
2026: 34 · 2025: 61 · 2024: 75 · 2023: 64 · 2022: 60 · 2021: 60 · 2020: 74 · 2019: 48 · 2018: 35 · 2017: 21 · 2016: 24 · 2015: 9 · 2014: 3
FWCI
2.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
depression, dementia, geriatric depression, dementia risk factors, comorbidities, white matter disease, neurobiological mechanisms, cognitive impairment
MeSH terms
Cognition Disorders, Cross-Sectional Studies, Dementia, Depression, Depressive Disorder, Humans, Risk Factors, Comorbidity, Prevalence, Treatment Outcome

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