Involvement of the Bed Nucleus of the Stria Terminalis in Tonic Regulation of Paraventricular Hypothalamic CRH and AVP mRNA Expression
Abstract
The bed nucleus of the stria terminalis (BNST) occupies a central position in pathways regulating hypothalamo-pituitary-adrenocortical (HPA) stress regulation. The potential role of the BNST in tonic neural control of HPA function was assessed by examining effects of selective BNST lesions on expression of ACTH secretagogues in HPA-integrative neurons of the medial parvocellular paraventricular nucleus. Anterior BNST lesions (ABN) involved major portions of the anteromedial, anterolateral, ventromedial, ventrolateral, dorsolateral and juxtacapsular subnuclei. These lesions resulted in significant (30%) decreases in corticotropin-releasing hormone (CRH) mRNA expression across the rostrocaudal extent of the medial parvocellular PVN, with no accompanying changes in basal arginine vasopressin (AVP) mRNA levels. Posterior BNST (PBN) lesions involved large but subtotal damage to the posterior intermediate, posterior medial, posterior lateral and preoptic subnuclei; these lesions resulted in small but significant changes in CRH mRNA and slight increases in number of AVP mRNA-producing parvocellular neurons. PBN effects on CRH mRNA expression were most pronounced at the caudal extent of the medial parvocellular zone, suggesting a topographic input from the posterior BNST to the PVN that is only partially compromised by PBN lesions. Analysis of individual cases revealed a correlation between damage of the anterolateral BNST and decreased CRH mRNA levels, and damage of the posterior in…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A subpopulation of parvocellular PVN OT and AVP neurons, along with ERβ and coordinating input from the BnST, is thought to be involved in the stress response, supporting the possibility that EDCs may influence the hypothalamic-pituitary-adrenal axis.
“Finally, a subpopulation of parvocellular PVN OT and AVP neurons, along with ERβ and coordinating input from the BnST, is thought to be involved in the stress response (135, 139, 140) supporting the possibility that EDCs may influence the hypothalamic–pituitary–adrenal axis.”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [139]
Cited by
Sorted by citations
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Self-citationHerman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Self-citationLimbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
Self-citationStressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926 · see citing works
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Walker, D. L., Toufexis, D. J., & Davis, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01282-2 · Cited by 838 · see citing works
Functional Cross‐Talk Between the Hypothalamic‐Pituitary‐Gonadal and ‐Adrenal Axes
Viau, V. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00798.x · Cited by 744 · see citing works
Dong, H., Petrovich, G. D., Watts, A. G., & Swanson, L. W. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1079 · Cited by 521 · see citing works
Sheng, J. A., Bales, N. J., Myers, S. A., Bautista, A. I., Roueinfar, M., Hale, T. M., & Handa, R. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601939 · Cited by 418 · see citing works
Role of endogenous opioid system in the regulation of the stress response
Drolet, G., Dumont, É. C., Gosselin, I., Kinkead, R., Laforest, S., & Trottier, J.-F. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00161-0 · Cited by 421 · see citing works
Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis
Handa, R. J., & Weiser, M. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.001 · Cited by 408 · see citing works
Choi, D. C., Furay, A. R., Evanson, N. K., Ostrander, M. M., Ulrich-Lai, Y. M., & Herman, J. P. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4301-06.2007 · Cited by 392 · see citing works
Self-citationNeural circuits mediating stress
López, J. F., Akil, H., & Watson, S. J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00266-8 · Cited by 373 · see citing works
Self-citationLowry, C. A. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00861.x · Cited by 362 · see citing works
Richardson, H. N., Lee, S. Y., O’Dell, L. E., Koob, G. F., & Rivier, C. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06455.x · Cited by 294 · see citing works
Local circuit regulation of paraventricular nucleus stress integration
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00681-5 · Cited by 274 · see citing works
Makino, S., Hashimoto, K., & Gold, P. W. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00791-8 · Cited by 260 · see citing works
Olive, M. F., Koenig, H. N., Nannini, M. A., & Hodge, C. W. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00748-1 · Cited by 237 · see citing works
Stress Activation of Cortex and Hippocampus Is Modulated by Sex and Stage of Estrus
Figueiredo, H. F., Dolgas, C. M., & Herman, J. P. (2002) · Endocrinology · doi:10.1210/endo.143.7.8888 · Cited by 237 · see citing works
Self-citationForray, M. I., & Gysling, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.011 · Cited by 191 · see citing works
Neural Regulation of the Stress Response: The Many Faces of Feedback
Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175 · see citing works
“…regions of the BST inhibit HPA axis responses to stress whereas anterior BST neurons provide excitatory input to the PVN, a heterogeneity that may be related to differential limbic innervation of these regions (Herman et al. 1994; Dong et al. 2001b; Dong and Swanson 2004b, 2006; Choi et al. 2007).”
Self-citationSterrenburg, L., Gaszner, B., Boerrigter, J., Santbergen, L., Bramini, M., Elliott, E., Chen, A., Peeters, B. W. M. M., Roubos, E. W., & Kozicz, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028128 · Cited by 149 · see citing works
Ciccocioppo, R., Fedeli, A., Economidou, D., Policani, F., Weiss, F., & Massi, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09445.2003 · Cited by 137 · see citing works
Fenoglio, K. A., Chen, Y., & Baram, T. Z. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4080-05.2006 · Cited by 124 · see citing works
Inputs to the ventrolateral bed nucleus of the stria terminalis
Shin, J., Geerling, J. C., & Loewy, A. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21870 · Cited by 115 · see citing works
Regev, L., Neufeld-Cohen, A., Tsoory, M., Kuperman, Y., Getselter, D., Gil, S., & Chen, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.64 · Cited by 110 · see citing works
Warne, J. P. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.036 · Cited by 112 · see citing works
Resstel, L. B. M., Alves, F. H. F., Reis, D. G., Crestani, C. C., Corrêa, F. M. A., & Guimarães, F. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.007 · Cited by 107 · see citing works
Regev, L., Tsoory, M., Gil, S., & Chen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.036 · Cited by 93 · see citing works
Gomes, F. V., Reis, D. G., Alves, F. H., Corrêa, F. M., Guimarães, F. S., & Resstel, L. B. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881110389095 · Cited by 97 · see citing works
Nijsen, M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00167-6 · Cited by 92 · see citing works
Noradrenergic control of the bed nucleus of the stria terminalis in stress and reward
Flavin, S. A., & Winder, D. G. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.013 · Cited by 62 · see citing works
Weiser, M. J., Foradori, C. D., & Handa, R. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.098 · Cited by 66 · see citing works
The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse
Kash, T. L. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.12.004 · Cited by 58 · see citing works
“Shown on the diagram are the lateral hypothalamus (LH), periacqueductal grey (PAG), locus coeruleus (LC), nucleus tractus solitaries (NTS), ventral tegmental area (VTA), the paraventricular nucleus of the hypothalamus (PVN) and the dorsal raphe (DR).”
InfluentialLesion of the bed nucleus of the stria terminalis enhances learned despair
Schulz, D., & Canbeyli, R. S. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00235-5 · Cited by 57 · see citing works
Endocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works
“Finally, a subpopulation of parvocellular PVN OT and AVP neurons, along with ERβ and coordinating input from the BnST, is thought to be involved in the stress response (135, 139, 140) supporting the possibility that EDCs may influence the hypothalamic–pituitary–adrenal axis.”
BackgroundDent, G., Choi, D. C., Herman, J. P., & Levine, S. (2007) · Brain Research · doi:10.1016/j.brainres.2006.04.082 · Cited by 44 · see citing works
Self-citation
- Authors
- Herman, J. P., Cullinan, W. E., & Watson, S. J.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Herman, James P.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1994-08
- Volume
- 6
- Issue
- 4
- Pages
- 433-442
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2140661504
- Cited by
- 235
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 14 · 2012: 9
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH49698, MH 42251, P01MH042251)
- National Institute on Drug Abuse (DA 05452)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- bed nucleus of the stria terminalis, paraventricular nucleus, corticotropin-releasing factor, vasopressin, hypothalamic-pituitary-adrenal axis, stress regulation, CRH mRNA expression, parvocellular neurons
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Corticosterone, Corticotropin-Releasing Hormone, Ibotenic Acid, Male, Paraventricular Hypothalamic Nucleus, RNA, Messenger, Thalamus, Gene Expression, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
