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PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking

Troyano-Rodriguez, Eva, Mann, Shivani, Ullah, Raja, Ahmad, Mohiuddin·2019·Molecular and Cellular Neuroscience
DOI 10.1016/j.mcn.2019.06.008
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Abstract

AMPA-type glutamate receptors (AMPAR) are one of the principal mediators of fast excitatory synaptic transmission in the brain. These receptors associate with multiple integral membrane proteins which influence their trafficking and channel properties. Proline-rich transmembrane protein 1 (PRRT1) is a membrane protein and an understudied component of native AMPAR complexes. In order to understand the regulation of AMPARs by PRRT1, we have performed electrophysiological and biochemical investigations on acute hippocampal slices derived from PRRT1 knockout mice. Our results show that PRRT1 controls the levels of AMPARs at the cell surface, though it is dispensable for synaptic transmission. PRRT1 has differential effects on the stability of AMPAR GluA1 subunit phosphorylated at S845 and at S831, two residues at which the phosphorylation status has major influences on receptor trafficking. Furthermore, PRRT1 is required for NMDA receptor-dependent long-term depression (LTD) and proper NMDA-induced AMPAR trafficking. These findings position PRRT1 as an important regulator of AMPAR stabilization and trafficking in different subcellular pools under basal conditions and during synaptic plasticity.

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Metadata

Authors
Troyano-Rodriguez, E., Mann, S., Ullah, R., & Ahmad, M.
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2019-07
Volume
98
Pages
155-163
ISSN
1044-7431
DOI
10.1016/j.mcn.2019.06.008
Cited by
35
References
13
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Oklahoma Center for the Advancement of Science and Technology (HR16-116)
  • College of Medicine Alumni Association Fund

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