A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents
Open accessAbstract
BACKGROUND: Evidence is lacking to recommend one diet over another when treating polycystic ovary syndrome (PCOS). OBJECTIVES: To obtain preliminary data, comparing the impact of a low-glycaemic load (LGL) vs. low-fat (LF) diet on biochemical hyperandrogenism in overweight and obese adolescents with PCOS. To ascertain feasibility of recruiting study participants, in partnership with an adolescent clinic, and implementing dietary interventions. METHODS: Randomized controlled trial of 19 overweight and obese adolescents with PCOS and not using hormonal contraceptives (HCs). Interventions comprised nutrition education, dietary counselling and cooking workshops to foster adherence to a LGL (45% carbohydrate, 35% fat, 20% protein) or LF (55% carbohydrate, 25% fat, 20% protein) diet over 6 months. Serum bioavailable testosterone was the primary outcome. RESULTS: Sixteen (LGL, n = 7; LF, n = 9) participants completed the study. Body fat percentage decreased (P < 0.05) in response to the interventions, with no difference between the LGL and LF groups (-1.2% vs. -2.2%; P = 0.16). Bioavailable testosterone did not change for either group (-0.4 vs. -1.8 ng dL(-1) ; P = 0.35). Regarding feasibility, recruiting adolescents posed a challenge, and use of HCs was a main reason for ineligibility. Participants attended 5.9 of 6 in-person visits and 2.6 of 3 cooking workshops, completed 4.9 of 6 telephone counselling calls, and reported high satisfaction with the diets and cooking workshops (≥8 on a 10-cm scale). CONCLUSIONS: Dietary interventions were beneficial for weight control but did not attenuate biochemical hyperandrogenism. Innovative strategies are needed to recruit adolescents for studies aimed at assessing independent effects of diet on features of PCOS.
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A low-carbohydrate diet (20 to 40 g/d) and a hypocaloric diet (<40 g of fat per day) during 12 weeks improved weight and menstrual irregularities with no difference between the diets.
“A low-carbohydrate diet (20 to 40 g/d) and a hypocaloric diet (<40 g of fat per day) during 12 weeks improved weight and menstrual irregularities with no difference between the diets.”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [168]
Both low-glycemic load and low-fat diets during 6 months improved weight with no difference between diets.
“Similarly, both low–glycemic load and low-fat diets during 6 months improved weight with no difference between diets [168].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [168]
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BackgroundMethodLifestyle changes in women with polycystic ovary syndrome
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BackgroundInfluentialInternational evidence-based recommendations for polycystic ovary syndrome in adolescents
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Polycystic Ovary Syndrome in Adolescence: From the Cradle to the Grave
Haghollahi, F., Heidary, Z., Bagheri, M., Masoumi, M., & Ghaemi, M. (2022) · Fertility Gynecology and Andrology · doi:10.5812/fga-129248 · Cited by 2 · see citing works
EFFICACY OF LOW LEVEL LASER THERAPY TO TREAT OBESITY
Amin, T. I. (2017) · International Journal Of Medical Science And Clinical Invention · doi:10.18535/ijmsci/v4i8.04
Abdolahian, S., Tehrani, F. R., Ghodsi, D., Jafari, M., Majd, H. A., & Nahidi, F. (2020) · JMIR Research Protocols · doi:10.2196/22538
The Relationship between Polycystic Ovary Syndrome and Psychological Symptoms
Pınar, G. (2021) · Journal of Clinical Research and Reports · doi:10.31579/2642-9756/040
“In the same studies also showed that women with PCOS are at risk for disorganized eating behavior, impaired self-esteem and sleeping problems [6,8-1013,36,41-44].”
BackgroundInfluentialAbdolahian, S., Tehrani, F. R., Ghodsi, D., Jafari, M., Majd, H. A., & Nahidi, F. (2020) · doi:10.2196/preprints.22538
Pengaruh Asupan Nutrisi Dan Pola Makan Pada Pasien Dengan Sindrom Ovarium Polikistik
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Polycystic ovary syndrome: pathogenic mechanisms and nutritional therapeutic strategies
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To assess the impact of imparting nutrition education on knowledge gain of young women with PCOS
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“Consumption of low-glycemic load versus low-fat diets on biochemical hyperandrogenism and cardiovascular risk factors has a beneficial effect on BMI of overweight and obese PCOS women (Wong et al. 2016).”
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Structured Exercise Protocol on Adolescent with Polycystic Ovarian Syndrome
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- Authors
- Wong, J. M. W., Gallagher, M., Gooding, H., Feldman, H. A., Gordon, C. M., Ludwig, D. S., & Ebbeling, C. B.
- Affiliations
- Boston Children's Hospital (US)
- Hasbro Children's Hospital (US)
- Corresponding author
- Ebbeling, C. B.
- Venue
- Pediatric Obesity
- Publisher
- Wiley
- Published
- 2015-07
- Volume
- 11
- Issue
- 3
- Pages
- 210-220
- ISSN
- 2047-6302 (ISSN-L)
- 2047-6310
- PMC
- PMC4698106
- OpenAlex
- W2167025774
- Cited by
- 50
- References
- 31
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 3 · 2017: 2 · 2016: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Thrasher Research Fund
- New Balance Foundation
- Harvard Catalyst (TR001102)
- Harvard University
- National Institute of Diabetes and Digestive and Kidney Diseases (K24 DK082730)
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, adolescents, low-fat diet, dietary intervention, hyperandrogenism, bioavailable testosterone, obesity, overweight, weight management, nutrition education, nutrition counseling, cooking workshops, participant recruitment, feasibility
- MeSH terms
- Glycemic Load, Adolescent, Adult, Body Composition, Cooking, Counseling, Diet, Female, Humans, Insulin Resistance, Obesity, Patient Education as Topic, Pilot Projects, Polycystic Ovary Syndrome, Diet, Fat-Restricted, Overweight
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