CoChat
Sign Up
Cited by 162Ovarian function and disordersHypothalamic control of reproductive hormonesDiabetes, Cardiovascular Risks, and Lipoproteins

Sensitization to Insulin Induces Ovulation in Nonobese Adolescents with Anovulatory Hyperandrogenism

Ibáñez, Lourdes, Valls, Carme, Ferrer, Angela, Marcos, Maria Victoria, Rodriguez-Hierro, Francisco, de Zegher, Francis·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.8.7756
Open this paper in CoChat — free account

Abstract

In nonobese girls with an adolescent variant of polycystic ovary syndrome, insulin-sensitizing treatment reduces hyperinsulinism, dyslipidemia, and hyperandrogenism and restores eumenorrhea; however, the effect on anovulation is unknown. We assessed whether metformin treatment is capable of inducing ovulation in nonobese adolescents with anovulatory hyperandrogenism after precocious pubarche. The study population consisted of 18 adolescents (mean age, 16 yr; body mass index, 21.4 kg/m2; 3-7 yr beyond menarche) with hyperinsulinemic hyperandrogenism. All girls received metformin for 6 months in a daily dose of 1275 mg. Before inclusion, persistent anovulation was documented by weekly serum progesterone measurements less than 4 ng/ml (months -3 and -1); the ovulation rate was assessed similarly after 2, 4 and 6 months on metformin; a premenstrual progesterone level greater than 8 ng/ml was used as ovulation marker. Regular menses were reported by 16 of 18 girls within 4 months on metformin, and all girls were eumenorrheic after 6 months on metformin. Of the 18 girls, 1 (6%) ovulated after 2 months on metformin, 7 (39%) after 4 months, and 14 (78%) after 6 months; ovulation induction failed in the girls with the lowest birth weight or most severe hyperandrogenism. Metformin treatment was well tolerated. In conclusion, sensitization to insulin was found to be an effective approach to induce ovulation in nonobese adolescents with anovulatory hyperandrogenism.

Integrity signals

Registry

Crossref · 10.1210/jcem.86.8.7756

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Rapid postnatal catch-up growth and adiposity seem to increase the risk of excessive androgen secretion and precocious pubarche with a higher predilection to develop features suggestive of polycystic ovary syndrome in adolescence.

    “Rapid postnatal catch-up growth and adiposity seem to increase the risk of excessive androgen secretion and precocious pubarche with a higher predilection to develop features suggestive of PCOS in adolescence [4,140,141]”

    From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [141]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ibáñez, L., Valls, C., Ferrer, A., Marcos, M. V., Rodriguez-Hierro, F., & de Zegher, F.
Affiliations
  • Endocrinology Unit (L.I., A.F., F.R-H.), 08950 Esplugues, Barcelona, Spain
  • Universitat de Barcelona (ES)
  • Endocrinology Unit (M.V.M.), Consorci Hospitalari de Terrassa, 08227 Terrassa, Spain
  • Department of Paediatrics (F.d.Z.), University of Leuven, 3000 Leuven, Belgium
ORCID
Valls, Carme
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-08-01
Volume
86
Issue
8
Pages
3595-3598
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.8.7756
OpenAlex
W2022056436
Cited by
162
References
44
Citations by year
2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 3
FWCI
18.41
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
metformin, insulin sensitization, ovulation induction, polycystic ovary syndrome, adolescent girls, hyperinsulinemia, precocious pubarche, eumenorrhea, birth weight
MeSH terms
Adolescent, Adult, Androgens, Anovulation, Estradiol, Female, Follicle Stimulating Hormone, Humans, Hyperinsulinism, Hypoglycemic Agents, Insulin, Luteinizing Hormone, Menstrual Cycle, Metformin, Ovulation, Progesterone, Sex Hormone-Binding Globulin, Time Factors, Hyperandrogenism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review