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Cited by 31Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyExercise and Physiological Responses

Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle

Koshinaka, Keiichi, Sano, Akiko, Howlett, Kirsten F., Yamazaki, Takako, Sasaki, Maiko, Sakamoto, Kei, Kawanaka, Kentaro·2008·Metabolism
DOI 10.1016/j.metabol.2008.01.014
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Abstract

A bout of prolonged aerobic exercise can enhance the sensitivity of muscle glucose uptake to insulin, and this may be mediated by activation of 5'-adenosine monophosphate-activated protein kinase (AMPK). The aim of this study was to examine whether high-intensity short-term exercise resulting in a significantly greater increase in the activation of AMPK is more effective in enhancing muscle insulin sensitivity compared with low-intensity prolonged aerobic exercise. We measured insulin sensitivity after high-intensity intermittent swimming (HIS) or low-intensity continuous swimming (LIS) exercise in rat epitrochlearis muscle. During HIS, the rats underwent eight 20-second bouts of swimming with a weight equal to 18% of body weight. The LIS rats swam with no load for 3 hours. High-intensity intermittent swimming increased (P < .05) 2-deoxyglucose uptake approximately 8-fold, whereas LIS increased it (P < .05) approximately 2-fold immediately after exercise compared with rested muscle. This response was associated with an increase (P < .05) in phosphorylation of AMPK Thr(172) and its downstream target acetyl-coenzyme A carboxylase (ACC) Ser(79) in HIS (13- and 6-fold, respectively) and LIS (2.8- and 2-fold, respectively) immediately after exercise. In contrast, submaximal (30 microU/mL) insulin-stimulated 2-deoxyglucose uptake measured 4 hours after exercise was 73% and 46% higher (P < .05) in LIS and HIS, respectively, compared with rest. The HIS exercise resulted in a greater activation of AMPK compared with LIS, but insulin sensitivity was higher after LIS compared with HIS. The results suggest that HIS is not more effective in enhancing insulin sensitivity than LIS. Thus, AMPK activation immediately after exercise may not be the only factor that determines the magnitude of the exercise-induced increase in insulin sensitivity in rat epitrochlearis muscle.

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Crossref · 10.1016/j.metabol.2008.01.014

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  • AMPK activation increased with exercise intensity, but there were not greater improvements in insulin sensitivity when HIT was compared to LIT exercise groups.

    “Koshinaka et al. [143] found that whilst AMPK activation increased with exercise intensity, there were not greater improvements in insulin sensitivity when HIT was compared to LIT exercise groups.”

    From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [143]

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Authors
Koshinaka, K., Sano, A., Howlett, K. F., Yamazaki, T., Sasaki, M., Sakamoto, K., & Kawanaka, K.
Affiliations
  • Niigata University of Health and Welfare (JP)
  • Deakin University (AU)
  • University of Dundee (GB)
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2008-06
Volume
57
Issue
6
Pages
749-756
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2008.01.014
OpenAlex
W2143269619
Cited by
31
References
47
Citations by year
2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 2
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
high-intensity intermittent exercise, AMPK activation, acetyl-CoA carboxylase, epitrochlearis muscle, muscle glucose uptake, 2-deoxyglucose uptake
MeSH terms
Acetyl-CoA Carboxylase, Adenylate Kinase, Animals, Glucose, Glycogen, Insulin, Male, Phosphorylation, Physical Conditioning, Animal, Swimming, Rats, Wistar, Muscle, Skeletal, p38 Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Glucose Transporter Type 4, Rats

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