Intercellular communication and conjugation are mediated by ESX secretion systems in mycobacteria
Open accessAbstract
Conseting mycobacteria: Mycobacteria encompass several slow-growing pathogens, including organisms that cause leprosy and tuberculosis. Mycobacteria use a component of their ESX (or Type VII) secretion system for a distinctive form of genetic exchange called distributive conjugal DNA transfer. Gray et al. investigated a quicker-growing model species, Mycobacterium smegmatis. They found that the secretory apparatus, ESX-4, is essential for DNA transfer into the recipient but is not required for donor cells to pass along their DNA. The ESX-1 secretory apparatus was required in the recipient for ESX-4 induction, but it did not appear to provide the physical channel for DNA. Rather, ESX-1 may secrete cell-surface “mating factor” receptors. More research will be needed to understand the details of this intriguing means of DNA exchange in mycobacteria. Science , this issue p. 347
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RNA-seq analysis demonstrated that donor and recipient cells have specific transcriptional responses to direct contact with the opposite mating type.
“RNA-seq analysis demonstrated that donor and recipient cells have specific transcriptional responses to direct contact with the opposite mating type.”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [58]
The RNA-profiling passage (indexed under Abstract; page unavailable) describes strain-specific analysis of donor and recipient cells in coculture. The contact-separation passage shows that direct cell-cell contact is required for the recipient’s esx4 transcriptional response, but it does not establish that donor transcriptional responses require direct contact. (LLM, conf=0.86)
Experimental — accuracy not yet measuredContact-dependent activation of ESX-4 in the recipient is regulated by ESX-1 activity in the donor, providing the first direct evidence for mycobacterial cell-cell communication.
“This contact-dependent activation of ESX-4 in the recipient is regulated by ESX-1 activity in the donor providing the first direct evidence for mycobacterial cell-cell communication (58).”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [58]
The ESX-4 secretion system is transcriptionally activated in the recipient on donor contact and is essential for DCT.
“Notably, the ESX-4 secretion system is transcriptionally activated in the recipient on donor contact and is essential for DCT (58).”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [58]
The ESX-4 system of M. smegmatis is also involved in this DCT procedure.
“This procedure apparently also involves the ESX-4 system of M. smegmatis (53).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [53]
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Cites
Type VII secretion — mycobacteria show the way
Abdallah, A. M., Gey van Pittius, N. C., DiGiuseppe Champion, P. A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., & Bitter, W. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1773 · Cited by 763 · see citing works
The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria
Gey van Pittius, N. C., Gamieldien, J., Hide, W., Brown, G. D., Siezen, R. J., & Beyers, A. D. (2001) · Genome Biology · doi:10.1186/gb-2001-2-10-research0044 · Cited by 375 · see citing works
Systematic Genetic Nomenclature for Type VII Secretion Systems
Bitter, W., Houben, E. N. G., Bottai, D., Brodin, P., Brown, E. J., Cox, J. S., Derbyshire, K., Fortune, S. M., Gao, L.-Y., Liu, J., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000507 · Cited by 307 · see citing works
Self-citationESX/type VII secretion systems and their role in host–pathogen interaction
Siméone, R., Bottai, D., & Brosch, R. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.11.003 · Cited by 250 · see citing works
Take five — Type VII secretion systems of Mycobacteria
Houben, E. N. G., Korotkov, K. V., & Bitter, W. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.11.003 · Cited by 223 · see citing works
The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation
Tan, T., Lee, W. L., Alexander, D. C., Grinstein, S., & Liu, J. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00721.x · Cited by 172 · see citing works
Social behavior and decision making in bacterial conjugation
Koraimann, G., & Wagner, M. A. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00054 · Cited by 163 · see citing works
Converse, S. E., & Cox, J. S. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.4.1238-1245.2005 · Cited by 154 · see citing works
Champion, P. A. D., Champion, M. M., Manzanillo, P. S., & Cox, J. S. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06821.x · Cited by 149 · see citing works
Shiloh, M. U., & DiGiuseppe Champion, P. A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.11.006 · Cited by 137 · see citing works
Coros, A., Callahan, B., Battaglioli, E., & Derbyshire, K. M. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06299.x · Cited by 137 · see citing works
Self-citationFlint, J. L., Kowalski, J. C., Karnati, P. K., & Derbyshire, K. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404892101 · Cited by 134 · see citing works
Self-citationGray, T. A., Krywy, J. A., Harold, J., Palumbo, M. J., & Derbyshire, K. M. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001602 · Cited by 100 · see citing works
Self-citationConjugal transfer of chromosomal DNA in <i>Mycobacterium smegmatis</i>
Parsons, L. M., Jankowski, C. S., & Derbyshire, K. M. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00818.x · Cited by 92 · see citing works
Self-citationTubercle bacilli rely on a type VII army for pathogenicity
Stoop, E. J. M., Bitter, W., & van der Sar, A. M. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.07.001 · Cited by 90 · see citing works
Raman, S., Puyang, X., Cheng, T., Young, D. C., Moody, D. B., & Husson, R. N. (2006) · Journal of Bacteriology · doi:10.1128/jb.01212-06 · Cited by 85 · see citing works
Enterococcal Sex Pheromones: Evolutionary Pathways to Complex, Two-Signal Systems
Dunny, G. M., & Berntsson, R. P. ‐. (2016) · Journal of Bacteriology · doi:10.1128/jb.00128-16 · Cited by 80 · see citing works
Derbyshire, K. M., & Gray, T. A. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.mgm2-0022-2013 · Cited by 75 · see citing works
Self-citationAgarwal, N., Woolwine, S. C., Tyagi, S. K., & Bishai, W. R. (2006) · Infection and Immunity · doi:10.1128/iai.01395-06 · Cited by 71 · see citing works
Frampton, M., & Houlston, R. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049110 · Cited by 55 · see citing works
Wang, J., Karnati, P. K., Takacs, C. M., Kowalski, J. C., & Derbyshire, K. M. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04824.x · Cited by 50 · see citing works
Self-citationDiverse regulatory circuits for transfer of conjugative elements
Singh, P. K., & Meijer, W. J. J. (2014) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12526 · Cited by 29 · see citing works
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Hall, J. P. J., Brockhurst, M. A., & Harrison, E. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0424 · Cited by 212 · see citing works
Whitney, J. C. C., Peterson, S. B., Kim, J., Pazos, M., Verster, A. J., Radey, M. C., Kulasekara, H. D., Ching, M. Q., Bullen, N. P., Bryant, D., et al. (2017) · eLife · doi:10.7554/elife.26938 · Cited by 179 · see citing works
Mycobacterium smegmatis: The Vanguard of Mycobacterial Research
Sparks, I. L., Derbyshire, K. M., Jacobs, W. R., & Morita, Y. S. (2023) · Journal of Bacteriology · doi:10.1128/jb.00337-22 · Cited by 149 · see citing works
Self-citationLaencina, L., Dubois, V., Le Moigne, V., Viljoen, A., Majlessi, L., Pritchard, J., Bernut, A., Piel, L., Roux, A.-L., Gaillard, J.-L., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713195115 · Cited by 147 · see citing works
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Ruhe, Z. C., Low, D. A., & Hayes, C. S. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115638 · Cited by 146 · see citing works
Architecture of the mycobacterial type VII secretion system
Famelis, N., Rivera-Calzada, Á., Degliesposti, G., Wingender, M., Mietrach, N., Skehel, M. J., Fernández-Leiro, R., Böttcher, B., Schlösser, A., Llorca, Ó., et al. (2019) · Nature · doi:10.1038/s41586-019-1633-1 · Cited by 117 · see citing works
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Citti, C., Dordet‐Frisoni, E., Nouvel, L., Kuo, C., & Baranowski, É. (2018) · Current Issues in Molecular Biology · doi:10.21775/cimb.029.003 · Cited by 91 · see citing works
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Orgeur, M., Sous, C., Madacki, J., & Brosch, R. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae006 · Cited by 92 · see citing works
Blending genomes: distributive conjugal transfer in mycobacteria, a sexier form of HGT
Gray, T. A., & Derbyshire, K. M. (2018) · Molecular Microbiology · doi:10.1111/mmi.13971 · Cited by 70 · see citing works
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Jackson, M., Stevens, C. M., Zhang, L., Zgurskaya, H. I., & Niederweis, M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00869 · Cited by 68 · see citing works
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Pajuelo, D., Tak, U., Zhang, L., Danilchanka, O., Tischler, A. D., & Niederweis, M. (2021) · Nature Communications · doi:10.1038/s41467-021-26925-1 · Cited by 63 · see citing works
Yano, H., Iwamoto, T., Nishiuchi, Y., Nakajima, C., Starkova, D. A., Владиславович, М. И., Narvskaya, O. V., Yoshida, S., Arikawa, K., Nakanishi, N., et al. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx183 · Cited by 58 · see citing works
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Klein, T. A., Pazos, M., Surette, M. G., Vollmer, W., & Whitney, J. C. C. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.08.027 · Cited by 40 · see citing works
Lafuente, B. I., Ummels, R., Kuijl, C. P., Bitter, W., & Speer, A. (2021) · mBio · doi:10.1128/mbio.02983-20 · Cited by 39 · see citing works
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Ates, L. S., & Brosch, R. (2016) · Molecular Microbiology · doi:10.1111/mmi.13579 · Cited by 33 · see citing works
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Lagune, M., Petit, C., Sotomayor, F. V., Johansen, M. D., Beckham, K. S. H., Ritter, C., Girard-Misguich, F., Wilmanns, M., Kremer, L., Maurer, F. P., et al. (2021) · Microbiology · doi:10.1099/mic.0.001054 · Cited by 27 · see citing works
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Mortimer, T. D., Weber, A. M., & Pepperell, C. S. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx001 · Cited by 22 · see citing works
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Behra, P. R. K., Das, S., Pettersson, B. M. F., Shirreff, L., DuCote, T. J., Jacobsson, K.-G., Ennis, D. G., & Kirsebom, L. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-40922-x · Cited by 20 · see citing works
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Master control of protein secretion by Mycobacterium tuberculosisPreprint
Nair, R. R., Meikle, V., Dubey, S., Pavlenok, M., & Niederweis, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.13.643117 · Cited by 2 · see citing works
Brown, S. P., Blackwell, H. E., & Hammer, B. K. (2018) · Journal of Bacteriology · doi:10.1128/jb.00291-18 · Cited by 1 · see citing works
Sánchez‐Costa, M., Gola, S., Rodríguez‐Sáiz, M., Barredo, J. L., Hidalgo, A., & Berenguer, J. (2023) · Microbial Biotechnology · doi:10.1111/1751-7915.14290
Herrera, N., Odermatt, P. D., Voorhies, M., Nakagawa, R. M., Sil, A., Chang, F., & Rosenberg, O. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.17.464699 · Cited by 1 · see citing works
Type VII secretion system and its effect on Group B Streptococcus virulencePreprint
Schindler, Y., Rahav, G., Nissan, I., Valenci, G. Z., Ravins, M., Hanski, E., Ment, D., Tekes-Manova, D., & Maor, . (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.23.525132 · Cited by 1 · see citing works
Faculty Opinions recommendation of Architecture of the mycobacterial type VII secretion system.
Sherman, M. B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736726306.793566134
Origins of Organismal Complexity
Lynch, M. (2024) · doi:10.1093/oso/9780192847287.003.0024
Characterizing the function of the SigM regulon in mycobacterium smegmatis
Montgomery, S. (2020) · doi:10.54014/ewz3-j70f
Williams, G. C., Danne, J. C., Crawford, S., Homman‐Ludiye, J., Kostoulias, X., Heron, B., Islam, T., Yong, M., Gan, Y., Srikhanta, Y. N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.12.659224
An overview of Quorum sensing in Mycobacterium tuberculosis, tuberculosis and diabetes mellitus
Ali, S. A. M. (2025) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000441
Williams, G. C., Danne, J. C., Crawford, S., Homman‐Ludiye, J., Kostoulias, X., Heron, B., Islam, T., Yong, M., Gan, Y., Srikhanta, Y. N., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-10359-w
Sigma factor M induces an ESX-4-focused regulon in Mycobacterium abscessus
Canestrari, J. G., Gianola, S., Derbyshire, K. M., & Gray, T. A. (2026) · Frontiers in Tuberculosis · doi:10.3389/ftubr.2026.1797268
Self-citation
- Authors
- Gray, T. A., Clark, R. R., Boucher, N., Lapierre, P., Smith, C., & Derbyshire, K. M.
- Affiliations
- New York State Department of Health (US)
- Corresponding author
- Gray, Todd A.
- Derbyshire, Keith M.
- Venue
- Science
- Published
- 2016-10-21
- Volume
- 354
- Issue
- 6310
- Pages
- 347-350
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8324006
- OpenAlex
- W2535274628
- Cited by
- 84
- References
- 22
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 1
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI097191, R21AI07258)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- ESX secretion system, ESX-1, intercellular communication, bacterial conjugation, Mycobacterium smegmatis, gene expression regulation, co-culture
- MeSH terms
- Type VII Secretion Systems, Bacterial Proteins, Conjugation, Genetic, Mutation, Transcription, Genetic, Gene Expression Regulation, Bacterial, Mycobacterium smegmatis
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