Cited by 329Protein Kinase Regulation and GTPase SignalingDNA Repair MechanismsPARP inhibition in cancer therapy

DNA-Independent PARP-1 Activation by Phosphorylated ERK2 Increases Elk1 Activity: A Link to Histone Acetylation

Open access
Cohen-Armon, Malka, Visochek, Leonid, Rozensal, Dana, Kalal, Adi, Geistrikh, Ilona, Klein, Rodika, Bendetz-Nezer, Sarit, Yao, Zhong +1 more·2007·Molecular Cell

Abstract

PolyADP-ribose polymerases (PARPs) catalyze a posttranslational modification of nuclear proteins by polyADP-ribosylation. The catalytic activity of the abundant nuclear protein PARP-1 is stimulated by DNA strand breaks, and PARP-1 activation is required for initiation of DNA repair. Here we show that PARP-1 also acts within extracellular signal-regulated kinase (ERK) signaling cascade that mediates growth and differentiation. The findings reveal an alternative mode of PARP-1 activation, which does not involve binding to DNA or DNA damage. In a cell-free system, recombinant PARP-1 was intensively activated and thereby polyADP-ribosylated by a direct interaction with phosphorylated ERK2, and the activated PARP-1 dramatically increased ERK2-catalyzed phosphorylation of the transcription factor Elk1. In cortical neurons treated with nerve growth factors and in stimulated cardiomyocytes, PARP-1 activation enhanced ERK-induced Elk1-phosphorylation, core histone acetylation, and transcription of the Elk1-target gene c-fos. These findings constitute evidence for PARP-1 activity within the ERK signal-transduction pathway.

Integrity signals

Registry

Crossref · 10.1016/j.molcel.2006.12.012

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cohen-Armon, M., Visochek, L., Rozensal, D., Kalal, A., Geistrikh, I., Klein, R., Bendetz-Nezer, S., Yao, Z., & Seger, R.
Affiliations
  • Tel Aviv University (IL)
  • Bar-Ilan University (IL)
  • Weizmann Institute of Science (IL)
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2007-01
Volume
25
Issue
2
Pages
297-308
ISSN
1097-2765 (ISSN-L)
OpenAlex
W2001233441
Cited by
329
References
39
Citations by year
2026: 4 · 2025: 6 · 2024: 18 · 2023: 11 · 2022: 19 · 2021: 16 · 2020: 13 · 2019: 12 · 2018: 13 · 2017: 13 · 2016: 18 · 2015: 23 · 2014: 19 · 2013: 20 · 2012: 25
FWCI
10.46
Type
journal article
Language
en
Open access
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords
PARP1, ERK2, Elk-1, histone acetylation, poly(ADP-ribosyl)ation, ERK signaling, transcriptional regulation, c-fos, nerve growth factor, cardiomyocytes, cortical neurons
MeSH terms
Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase-1, Acetylation, Animals, Base Sequence, Brain, Cell Nucleus, Cell-Free System, Cells, Cultured, DNA, Enzyme Activation, Histones, Models, Biological, Phosphorylation, Poly(ADP-ribose) Polymerases, Recombinant Proteins, Gene Expression, Genes, fos, Rats, Sprague-Dawley, Mitogen-Activated Protein Kinase 1, MAP Kinase Signaling System, RNA, Small Interfering, ets-Domain Protein Elk-1, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review