Sirtuin‐dependent epigenetic regulation in the maintenance of genome integrity

Untitled work

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Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

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Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

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DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

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Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State

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Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

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Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

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SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

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SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

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Epigenetic control of rDNA loci in response to intracellular energy status

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Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

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Heterochromatin Formation in Mammalian Cells

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SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

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SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1

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Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

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Genetic Analysis of Histone H4: Essential Role of Lysines Subject to Reversible Acetylation

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Activation of DNA Methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma

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PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionPreprint

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DNA-Independent PARP-1 Activation by Phosphorylated ERK2 Increases Elk1 Activity: A Link to Histone Acetylation

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The Dual Role of Sirtuins in Cancer

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Methyl-CpG-binding Protein, MeCP2, Is a Target Molecule for Maintenance DNA Methyltransferase, Dnmt1

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Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

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Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

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Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

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Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development

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SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

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30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction

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Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

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SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

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The Sirtuins Hst3 and Hst4p Preserve Genome Integrity by Controlling Histone H3 Lysine 56 Deacetylation

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MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation

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MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

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The Interaction of Alba, a Conserved Archaeal Chromatin Protein, with Sir2 and Its Regulation by Acetylation

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The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

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miR-22 represses cancer progression by inducing cellular senescence

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The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylationPreprint

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Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

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A SUPPRESSOR OF MATING-TYPE LOCUS MUTATIONS IN SACCHAROMYCES CEREVISIAE: EVIDENCE FOR AND IDENTIFICATION OF CRYPTIC MATING-TYPE LOCI

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A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

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miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells

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Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

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The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

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Isolation of microRNA targets by miRNP immunopurification

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Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis

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Histone H3-K56 acetylation is important for genomic stability in mammals

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Chromatin and the genome integrity network

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Sorting out functions of sirtuins in cancer

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The Constantly Changing Face of Chromatin

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miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

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Insights into the Role of Histone H3 and Histone H4 Core Modifiable Residues in Saccharomyces cerevisiae

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HP1 Binds Specifically to Lys26-methylated Histone H1.4, whereas Simultaneous Ser27 Phosphorylation Blocks HP1 Binding

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From Sirtuin Biology to Human Diseases: An Update

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MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1

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The histone methyltransferase SET8 is required for S-phase progression

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SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities

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Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription

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The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells

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Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1

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A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

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Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

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Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival

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E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

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Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage

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Acetylation of TAFI68, a subunit of TIF‐IB/SL1, activates RNA polymerase I transcription

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Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

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Poly(ADP-ribosyl)ated chromatin domains: access granted

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SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

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PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosisPreprint

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MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1

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miR-34a Regulates Mouse Neural Stem Cell Differentiation

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Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2

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DNA repair: PARP – another guardian angel?

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The Human Rap1 Protein Complex and Modulation of Telomere Length

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Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

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Hsa‐miR‐125b suppresses bladder cancer development by down‐regulating oncogene SIRT7 and oncogenic long non‐coding RNA MALAT1

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p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals

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PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli

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PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase

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Sirt6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine

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A Mechanism for Coordinating Chromatin Modification and Preinitiation Complex Assembly

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Inhibition of Histone Deacetylases Promotes Ubiquitin-Dependent Proteasomal Degradation of DNA Methyltransferase 1 in Human Breast Cancer Cells

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The SIRT2 Deacetylase Regulates Autoacetylation of p300

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Establishment and Maintenance of DNA Methylation Patterns in Mammals

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MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1

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Sir2 Deacetylates Histone H3 Lysine 56 to Regulate Telomeric Heterochromatin Structure in Yeast

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Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression

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Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability

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miR-195 regulates SIRT1-mediated changes in diabetic retinopathy

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MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells

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miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53

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Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

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MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regenerationPreprint

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Chromatin state marks cell-type- and gender-specific replication of the Drosophila genomePreprint

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SIRT6 in DNA repair, metabolism and ageing

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Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression

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Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

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Predicting and validating microRNA targets.

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Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.

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miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

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miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in human fibrosarcoma cells

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A miR‐34a‐SIRT6 axis in the squamous cell differentiation network

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Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

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The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

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A chromosomal SIR2 homologue with both histone NAD‐dependent ADP‐ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei

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PARP1 Is a TRF2-associated Poly(ADP-Ribose)Polymerase and Protects Eroded Telomeres

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Structure of the SET domain histone lysine methyltransferase Clr4

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Sirtuins in stress response: guardians of the genome

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Sirtuins in neurodegenerative diseases: an update on potential mechanisms

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Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis

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SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

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The world of protein acetylation

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Epigenetics and depression

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The Substrate Specificity of Sirtuins

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SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

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SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms

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Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

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Functions and mechanisms of plant histone deacetylases

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Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress

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Histone Modifications in Alzheimer’s Disease

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AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

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Sirtuins and DNA damage repair: SIRT7 comes to play

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HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis

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Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

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Dissecting bipolar disorder complexity through epigenomic approach

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Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development

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BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

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The functional genomic studies of resveratrol in respect to its anti-cancer effects

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SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer

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PWR/HDA9/ABI4 Complex Epigenetically Regulates ABA Dependent Drought Stress Tolerance in Arabidopsis

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Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases

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The Role of Histone Protein Acetylation in Regulating Endothelial Function

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Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging

Hekmatimoghaddam, S., Firoozabadi, A. D., Zare‐Khormizi, M. R., & Pourrajab, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.001 · Cited by 62 · see citing works

Canonical and Noncanonical Actions of Arabidopsis Histone Deacetylases in Ribosomal RNA Processing

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Decoding the Rosetta stone of mitonuclear communication

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Resveratrol Attenuates Chronic Unpredictable Mild Stress-Induced Alterations in the SIRT1/PGC1α/SIRT3 Pathway and Associated Mitochondrial Dysfunction in Mice

Tabassum, S., Misrani, A. A., Huang, H., Zhang, Z.-Y., Li, Q.-W., & Long, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03395-8 · Cited by 55 · see citing works

LC–MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes

Tanabe, K., Liu, J., Kato, D., Kurumizaka, H., Yamatsugu, K., Kanai, M., & Kawashima, S. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-21060-2 · Cited by 53 · see citing works

A Molecular Perspective on Sirtuin Activity

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Grape seed proanthocyanidins improves mitochondrial function and reduces oxidative stress through an increase in sirtuin 3 expression in EA.hy926 cells in high glucose condition

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A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation

Bhatiya, M., Pathak, S., Jothimani, G., Duttaroy, A. K., & Banerjee, A. (2023) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-023-00669-w · Cited by 51 · see citing works

A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance

Goutham, G., Manikandan, R., Manikandan, B., Raman, T., Chinnasamy, A., Arumugam, M., Setzer, W. N., Daglia, M., Nabavi, S. F., & Nabavi, S. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.141 · Cited by 45 · see citing works

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Jęśko, H. M., & Strosznajder, R. P. (2016) · Folia Neuropathologica · doi:10.5114/fn.2016.62531 · Cited by 44 · see citing works

Roles of vitamins in stem cells

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Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition

Wang, F., Zhao, J., Liu, D., Zhao, T., Lu, Z., Zhu, L., Cao, L., Yang, J., Jin, J., & Cai, Y. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1235654 · Cited by 42 · see citing works

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters

Palomer, E., Martín‐Flores, N., Jolly, S., Vargas, P. P., Benvegnù, S., Podpolny, M., Teo, S., Vaher, K., Saito, T., Saido, T. C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01492-z · Cited by 42 · see citing works

Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma

Ma, K., Lu, N., Zou, F., & Meng, F. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172670 · Cited by 41 · see citing works

Epigenetic Regulation of Aging and its Rejuvenation

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SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Kaufmann, T., Kukolj, E., Brachner, A., Beltzung, E., Bruno, M., Kostrhon, S., Opravil, S., Hudecz, O., Mechtler, K., Warren, G., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.192633 · Cited by 40 · see citing works

The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral Infections

Alqarni, M. H., Foudah, A. I., Muharram, M. M., & Labrou, N. E. (2021) · Cells · doi:10.3390/cells10020460 · Cited by 38 · see citing works

NAD+ centric mechanisms and molecular determinants of skeletal muscle disease and aging

Wagner, S., Manickam, R., Brotto, M. A. P., & Tipparaju, S. M. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04408-1 · Cited by 39 · see citing works

Immune Cell Regulatory Pathways Unexplored as Host-Directed Therapeutic Targets for Mycobacterium tuberculosis : An Opportunity to Apply Precision Medicine Innovations to Infectious Diseases

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Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring

Tanwar, V., Adelstein, J. M., Grimmer, J. A., Youtz, D. J., Katapadi, A., Sugar, B. P., Falvo, M. J., Baer, L. A., Stanford, K. I., & Wold, L. E. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010797 · Cited by 35 · see citing works

Nuclear Sirtuins and the Aging of the Immune System

Gámez-García, A., & Vázquez, B. N. (2021) · Genes · doi:10.3390/genes12121856 · Cited by 33 · see citing works

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.

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Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Rifai, K. T., Idrissou, M., Penault-Llorca, F. M., Bignon, Y., & Bernard-Gallon, D. J. (2018) · Cancers · doi:10.3390/cancers10110409 · Cited by 33 · see citing works

SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex

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A positive feedback loop of SIRT1 and miR17HG promotes the repair of DNA double-stranded breaks

Xie, L., Huang, R., Liu, S., Wu, W., Su, A., Li, R., Liu, X. D., Lei, Y., Sun, H., Liu, X., et al. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1641388 · Cited by 32 · see citing works

A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy

Farr, G. H., Morris, M., Gómez, A. E., Pham, T. Q., Parker, E. U., Kilroy, E., Said, S., Henry, C. A., & Maves, L. (2020) · Skeletal Muscle · doi:10.1186/s13395-020-00251-4 · Cited by 33 · see citing works

Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury

Kang, Y., Kim, D., Lee, S., Kim, H., Kim, T.-B., Cho, J. A., Lee, T., & Choi, E. Y. (2024) · Advanced Science · doi:10.1002/advs.202308978 · Cited by 31 · see citing works

Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21

Li, X., Feng, L., Zhang, C., Wang, J., Wang, S., & Hu, L. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2096-0 · Cited by 30 · see citing works

SIRT7 promotes chromosome synapsis during prophase I of female meiosis

Vázquez, B. N., Blengini, C. S., Hernandez, Y., Serrano, L., & Schindler, K. (2019) · Chromosoma · doi:10.1007/s00412-019-00713-9 · Cited by 29 · see citing works

Deregulated intracellular pathways define novel molecular targets for HBV-specific CD8 T cell reconstitution in chronic hepatitis B

Montali, I., Berti, C. C., Morselli, M., Acerbi, G., Barili, V., Pedrazzi, G., Montanini, B., Boni, C., Alfieri, A., Pesci, M., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.035 · Cited by 30 · see citing works

Interplay Between Genetic and Epigenetic Mechanisms in Rheumatoid Arthritis

Frank‐Bertoncelj, M., Klein, K., & Gay, S. (2017) · Epigenomics · doi:10.2217/epi-2016-0142 · Cited by 29 · see citing works

Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation

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Modulations of Histone Deacetylase 2 Offer a Protective Effect through the Mitochondrial Apoptosis Pathway in Acute Liver Failure

Wang, Y., Yang, F., Jiao, F., Chen, Q., Zhang, W., Wang, L.-W., & Gong, Z. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8173016 · Cited by 27 · see citing works

Scientometric Analysis of SIRT6 Studies

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Could sirtuin activities modify ALS onset and progression?

Tang, B. L. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0452-2 · Cited by 24 · see citing works

Lactate Metabolism and Satellite Cell Fate

Nalbandian, M., Radak, Z. O., & Takeda, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.610983 · Cited by 24 · see citing works

Epigenetic Regulators of White Adipocyte Browning

Nanduri, R. (2021) · Epigenomes · doi:10.3390/epigenomes5010003 · Cited by 23 · see citing works

The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?

Poulsen, R. C., Hearn, J. I., & Dalbeth, N. (2021) · Rheumatology · doi:10.1093/rheumatology/keab197 · Cited by 22 · see citing works

Inhibition of glioblastoma progression by Urolithin A in vitro and in vivo by regulating Sirt1-FOXO1 axis via ERK/AKT signaling pathways

Liu, C.-L., Zhao, D., Li, J.-J., Liu, S., An, J.-J., Wang, D., Hu, F.-A., Qiu, C.-Y., & Cui, M.-H. (2021) · Neoplasma · doi:10.4149/neo_2021_210623n834 · Cited by 23 · see citing works

SIRT1 expression regulates the transformation of resistant esophageal cancer cells via the epithelial-mesenchymal transition

Qin, T., Liu, W., Huo, J., Li, L., Zhang, X., Shi, X., Zhou, J., & Wang, C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.032 · Cited by 23 · see citing works

Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression

Nevoral, J., Landsmann, L., Štiavnická, M., Hošek, P., Moravec, J., Prokešová, Š., Řimnáčová, H., Koutná, E., Klein, P., Hošková, K., et al. (2019) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-019-0372-3 · Cited by 23 · see citing works

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2

Tantawy, A. H., Meng, X., Marzouk, A. A. E., Fouad, A., Abdelazeem, A. H., Youssif, B. G. M., Jiang, H. X., & Wang, M. (2021) · RSC Advances · doi:10.1039/d1ra04061h · Cited by 21 · see citing works

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation

Zheng, W., Tasselli, L., Li, T., & Chua, K. F. (2021) · Genes · doi:10.3390/genes12091460 · Cited by 21 · see citing works

Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis

Zhang, K., Sowers, M. L., Cherryhomes, E., Singh, V. K., Mishra, A., Restrepo, B. I., Khan, A., & Jagannath, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1121495 · Cited by 21 · see citing works

Grape seed proanthocyanidins prevent H 2 O 2 ‐induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells

Rigotti, M., Cerbaro, A. F., Silva, I. D. R., Agostini, F., Branco, C. S., Moura, S., & Salvador, M. M. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13147 · Cited by 21 · see citing works

Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway

Chang, Y., He, B., Wang, C., Li, W., Tao, S., Chen, J., Wang, Y., Yang, L., Wu, Y., Wu, Z., et al. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2491638 · Cited by 23 · see citing works

Epi-drugs as triple-negative breast cancer treatment

Idrissou, M., Sánchez, A., Penault-Llorca, F. M., Bignon, Y., & Bernard-Gallon, D. J. (2020) · Epigenomics · doi:10.2217/epi-2019-0312 · Cited by 20 · see citing works

Multifaced role of protein deacetylase sirtuins in neurodegenerative disease

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.047 · Cited by 20 · see citing works

Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors

Khalil, N. A., Ahmed, E., Zaher, A. F., El‐Zoghbi, M. S., & Sobh, E. A. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111926 · Cited by 20 · see citing works

The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance

de Souza, A. P., Marinho, V., & Marques, M. R. (2025) · Epigenomes · doi:10.3390/epigenomes9030023 · Cited by 19 · see citing works

Polydatin and I-CBP112 protects early bovine embryo against nicotinamide-induced mitochondrial dysfunction

Yuan, Y., Xu, L., Zhang, S., Mesalam, A., Lee, K., Liu, H., Joo, M., Idrees, M., & Kong, I. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.05.007 · Cited by 19 · see citing works

Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata)

Simó‐Mirabet, P., Perera, E., Calduch-Giner, J. À., & Pérez‐Sánchez, J. (2020) · Frontiers in Zoology · doi:10.1186/s12983-020-00361-1 · Cited by 17 · see citing works

Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C

Barili, V., Vecchi, A. L., Rossi, M., Montali, I., Tiezzi, C., Penna, A., Laccabue, D., Missale, G., Fisicaro, P., & Boni, C. (2021) · Cells · doi:10.3390/cells10102563 · Cited by 18 · see citing works

Histone Modifications and Their Targeting in Lymphoid Malignancies

Fernández-Serrano, M., Winkler, R., Santos, J. C., Pannérer, M.-M. L., Buschbeck, M., & Roué, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010253 · Cited by 14 · see citing works

Identification of novel SIRT1 activators endowed with cardioprotective profile

Flori, L., Petrarolo, G., Brogi, S., Motta, C. L., Testai, L., & Calderone, V. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105930 · Cited by 15 · see citing works

Adiponectin ameliorates hypertrophic scar by inhibiting Yes-associated protein transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3

Zhang, J., Li, Y., Liu, J., Han, F., Shi, J., Wu, G., Wang, K., Shen, K., Zhao, M., Gao, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105236 · Cited by 15 · see citing works

Anti-ageing effects of FDA-approved medicines: a focused review

Thanapairoje, K., Junsiritrakhoon, S., Wichaiyo, S., Osman, M. A., & Supharattanasitthi, W. (2023) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2022-0242 · Cited by 15 · see citing works

siRNA inhibition and not chemical inhibition of Suv39h1/2 enhances pre-implantation embryonic development of bovine somatic cell nuclear transfer embryos

Jafarpour, F., Zadegan, F. G., Ostadhosseini, S., Hajian, M., Kiani‐Esfahani, A., & Nasr‐Esfahani, M. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233880 · Cited by 15 · see citing works

The interplay between histone deacetylases and rho kinases is important for cancer and neurodegeneration

Mertsch, S., & Krämer, O. H. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.05.006 · Cited by 14 · see citing works

SIRT1 Synchs Satellite Cell Metabolism with Stem Cell Fate

Díaz‐Ruiz, A., González‐Freire, M., Ferrucci, L., Bernier, M., & de Cabo, R. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.006 · Cited by 14 · see citing works

Deciphering the Epigenetic Code in Embryonic and Dental Pulp Stem Cells.

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KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma

Isohookana, J., Haapasaari, K., Soini, Y., & Karihtala, P. (2018) · Anticancer Research · doi:10.21873/anticanres.12474 · Cited by 14 · see citing works

Multifunctional activity-based chemical probes for sirtuins

Sharma, C., Donu, D., Curry, A. M., Barton, E. E., & Cen, Y. (2023) · RSC Advances · doi:10.1039/d3ra02133e · Cited by 13 · see citing works

Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition

Rymarchyk, S., Kang, W., & Cen, Y. (2021) · Biomolecules · doi:10.3390/biom11020312 · Cited by 13 · see citing works

Deciphering histone H4 lysine acetylation and methylation via sortase-mediated semisynthesis

Xiao, Y., Zou, K., Yang, J. T., & Wu, M. (2023) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2023.101638 · Cited by 13 · see citing works

TaHSP18.6 and TaSRT1 interact to confer resistance to Fusarium crown rot by regulating the auxin content in common wheat

Zhang, N., Liu, L., Li, S., Wei, Y., Ren, W., Li, M., Zhao, S., Sun, Z., Yang, X., Ren, Y. N., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500029122 · Cited by 12 · see citing works

Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1

Konada, L., Aricthota, S., Vadla, R., & Haldar, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-26476-4 · Cited by 11 · see citing works

Fusaric Acid-Induced Epigenetic Modulation of Hepatic H3K9me3 Triggers Apoptosis in Vitro and in Vivo

Ghazi, T., Nagiah, S., Dhani, S., & Chuturgoon, A. A. (2020) · Epigenomics · doi:10.2217/epi-2019-0284 · Cited by 11 · see citing works

Spatiotemporal dynamics of SIRT 1, 2 and 3 during in vitro maturation of bovine oocytes

Ferreira, A. F., Machado-Simões, J., Soares, M., Sousa, A. P., Ramalho‐Santos, J., & Almeida‐Santos, T. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.04.004 · Cited by 10 · see citing works

Effects of sirtuins on the riboflavin production in Ashbya gossypii

Kato, T., Azegami, J., Kano, M., Enshasy, H. A. E., & Park, E. Y. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11595-2 · Cited by 9 · see citing works

Nutraceuticals for Promoting Longevity

Pavlović, I., Khateb, S., Milisav, I., & Mahajna, J. A. (2020) · Current Nutraceuticals · doi:10.2174/2665978601666200213121512 · Cited by 8 · see citing works

Genetic Architecture of Depression: Where Do We Stand Now?

Ünal‐Aydın, P., Aydın, O., & Arslan, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_12 · Cited by 7 · see citing works

Two sirtuin proteins, Hst3 and Hst4, modulate asexual development, stress tolerance, and virulence by affecting global gene expression in Beauveria bassiana

Cai, Q., Li, T., Xiè, J., & Jiāng, D. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03137-23 · Cited by 6 · see citing works

Targeting ‘histone mark’: Advanced approaches in epigenetic regulation of telomere dynamics in cancer

Das, A., Giri, A. K., & Bhattacharjee, P. (2024) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2024.195007 · Cited by 6 · see citing works

Sex-divergent expression of cytochrome P450 and SIRTUIN 1–7 proteins in toxicity evaluation of a benzimidazole-derived epigenetic modulator in mice

Lee, Y. T., Tan, Y. J., Mok, P. Y., Kaur, G., Sasidharan, S., Falasca, M., & Oon, C. E. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116039 · Cited by 6 · see citing works

The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

Sgueglia, G., Longobardi, S., Valerio, D., Campitiello, M. R., Colacurci, N., Pietro, C. D., Battaglia, R., D’Hooghe, T. M., Altucci, L., & Dell’Aversana, C. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01490-0 · Cited by 7 · see citing works

Dexmedetomidine alleviates anxiety-like behaviors in female mice with musculoskeletal pain through SIRT1/p53 axis

Zhou, Q., Jiang, N., Dong, Y., & Tian, K. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110698 · Cited by 5 · see citing works

Liver Diseases: Epigenetic Mechanisms, Oxidative Stress and Use of Alpha-Lipoic Acid

Uskoković, A. S., Dinić, S., Јovanović, J. A., Poznanović, G., Vidaković, M., & Mihailović, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_112-1 · Cited by 5 · see citing works

Special Issue: Epigenetics

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DNA damage, sirtuins, and epigenetic marks

Alves-Fernandes, D. K., & Jasiulionis, M. G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91081-1.00016-9 · Cited by 1 · see citing works

Sirtuins in stress response: guardians of the genome

Bosch‐Presegué, L., & Vaquero, A. (2013) · Oncogene · doi:10.1038/onc.2013.344 · Cited by 124 · see citing works

The role of sirtuins in epigenetic regulation

Pin, Z. (2019) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.23897

Metabolism, longevity and epigenetics

Cosentino, C., & Mostoslavsky, R. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1295-3 · Cited by 34 · see citing works

Role of SIRT1 in Epigenetics

Wang, Z. A., Hsu, W. W., & Liu, W. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_1-1