The DNA Damage Response: Ten Years After

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Molecular mechanism of nucleotide excision repair

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Histone acetyltransferase complexes: one size doesn't fit all

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Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells

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Distinct mechanisms contribute to acquired cisplatin resistance of urothelial carcinoma cells

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Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication

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A FACS-Optimized Screen Identifies Regulators of Genome Stability in Candida albicans

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The ‘Pushmi-Pullyu’ of DNA REPAIR: Clinical Synthetic Lethality

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DNA-damage checkpoints: location, location, location

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The ubiquitin‐proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation

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REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts

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Theory of the Origin, Evolution, and Nature of Life

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New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

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Ubiquitylation in DNA double-strand break repair

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Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage

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Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability

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DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR

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Albicanol modulates oxidative stress and the p53 axis to suppress profenofos induced genotoxicity in grass carp hepatocytes

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Lysine Crotonylation: An Emerging Player in DNA Damage Response

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DNA Damage during G2 Phase Does Not Affect Cell Cycle Progression of the Green Alga Scenedesmus quadricauda

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Unraveling DNA damage response-signaling networks through systems approaches

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Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues

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Minichromosome Maintenance 2 Bound with Retroviral Gp70 Is Localized to Cytoplasm and Enhances DNA-Damage-Induced Apoptosis

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Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics

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Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells

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ZNF185 is a p53 target gene following DNA damage

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RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration

Guo, Z., Tian, Y., Guo, Y., Li, B., Liu, X., Xie, K., Song, Y., & Wang, D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00392 · Cited by 18

Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus

González‐Arzola, K., Guerra‐Castellano, A., Rivero‐Rodríguez, F., Casado‐Combreras, M. Á., Pérez‐Mejías, G., Dı́az-Quintana, A., Díaz‐Moreno, I., & la Rosa, M. Á. D. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13176 · Cited by 20

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin’s lymphoma and testicular cancer cells

Constantin, D., & Widmann, C. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03231-0 · Cited by 17

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

Lin, Y., Li, J., Zhao, H., McMahon, A., McGhee, K., & Yan, S. (2023) · eLife · doi:10.7554/elife.82324 · Cited by 18

DNA repair during in utero development: A review of the current state of knowledge, research needs, and potential application in risk assessment

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Involvement of p29 in DNA damage responses and Fanconi anemia pathway

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DNA Damage Response in Neonatal and Adult Stromal Cells Compared With Induced Pluripotent Stem Cells

Liedtke, S., Biebernick, S., Radke, T. F., Stapelkamp, D., Coenen, C., Zaehres, H., Fritz, G., & Kögler, G. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0209 · Cited by 19

APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death

Wang, Y., Wu, S., Zheng, S., Wang, S., Wali, A., Ezhilarasan, R., Sulman, E. P., Koul, D., & Yung, W. K. A. (2017) · Oncotarget · doi:10.18632/oncotarget.17348 · Cited by 19

A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining

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Dodging the bullet: therapeutic resistance mechanisms in pediatric cancers

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Flavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency

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Contextualizing Autophagy during Gametogenesis and Preimplantation Embryonic Development

Moura, M. T., Latorraca, L. B., & de Paula-Lopes, F. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126313 · Cited by 19

PARP inhibitors for metastatic castration-resistant prostate cancer: Biological rationale and current evidence

Bieńkowski, M., Tomasik, B., Braun, M., & Jassem, J. (2022) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2022.102359 · Cited by 19

P50, the Small Subunit of DNA Polymerase Delta, Is Required for Mediation of the Interaction of Polymerase Delta Subassemblies with PCNA

Wang, Y., Zhang, Q., Chen, H., Li, X., Mai, W., Chen, K., Zhang, S., Lee, E. Y. C., Lee, M., & Zhou, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027092 · Cited by 18

The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

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Characterization of nuclear PTEN and its post translational modifications

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Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors

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DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation

Zhu, G., Fan, Z., Ding, M., Mu, L., Liang, J. B., Ding, Y., Fu, Y., Huang, B., & Wu, W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.553388 · Cited by 19

Predicting Response to Chemotherapy With Early-Stage Lung Cancer

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In SilicoNanodosimetry: New Insights into Nontargeted Biological Responses to Radiation

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Chek2 DNA Damage Response Pathway and Inherited Breast Cancer Risk

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The Atr Protein Kinase Controls UV-Dependent Upregulation of p16INK4A Through Inhibition of Skp2-Related Polyubiquitination/Degradation

Al‐Khalaf, H. H., Hendrayani, S., & Aboussekhra, A. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0506 · Cited by 18

Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer

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Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition

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Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses

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Histone lysine methylation exhibits a distinct distribution during spermatogenesis in pigs

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Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression

Patil, M., Pabla, N., Ding, H., & Dong, Z. (2013) · Cell Cycle · doi:10.4161/cc.25624 · Cited by 18

Hepatitis C Virus NS5B Protein Delays S Phase Progression in Human Hepatocyte-derived Cells by Relocalizing Cyclin-dependent Kinase 2-interacting Protein (CINP)

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Time‐varying magnetic fields of 60 Hz at 7 mT induce DNA double‐strand breaks and activate DNA damage checkpoints without apoptosis

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Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks

Woo, T.-T., Chuang, C.-N., Higashide, M., Shinohara, A., & Wang, T. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa587 · Cited by 18

BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response

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Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest

Liou, J.-S., Wu, Y., Yen, W., Tang, Y.-S., Kakadiya, R., Su, T., & Yih, L. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.028 · Cited by 17

Menin stimulates homology‐directed DNA repair

Gallo, A., Agnese, S., Esposito, I., Galgani, M., & Avvedimento, V. E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.032 · Cited by 16

DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression

Kshirsagar, M. P., Jiang, W., & Shih, I. (2011) · Journal of Oncology · doi:10.1155/2012/621685 · Cited by 17

A new in vitro system for activating the cell cycle checkpoint

Wang, J., Engle, S. E., & Zhang, Y. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14753 · Cited by 17

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

Helbig, L., Damrot, J., Hülsenbeck, J., Köberle, B., Brozović, A., Osmak, M., Fiket, Ž., Kaina, B., & Fritz, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190645 · Cited by 17

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis

Waskiewicz, E., Vasiliou, M., Córcoles-Sáez, I., & Rita, S. (2021) · Communications Biology · doi:10.1038/s42003-021-01884-x · Cited by 17

Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease

Kisby, G. E., & Spencer, P. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.752153 · Cited by 17

DNA Repair and Resistance to Cancer Therapy

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RAD001 (everolimus) induces dose-dependent changes to cell cycle regulation and modifies the cell cycle response to vincristine

Saunders, P. O., Weiss, J., Welschinger, R., Baraz, R., Bradstock, K. F., & Bendall, L. J. (2012) · Oncogene · doi:10.1038/onc.2012.498 · Cited by 17

Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1

Liu, X., & Ladias, J. A. A. (2013) · Biochemistry · doi:10.1021/bi400714v · Cited by 16

ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot

Sun, J., Oma, Y., Harata, M., Kono, K., Shima, H., Kinomura, A., Ikura, T., Suzuki, H., Mizutani, S., Kanaar, R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013554 · Cited by 17

A glance at … telomeres, oxidative stress, antioxidants, and biological aging

Glade, M. J., & Meguid, M. M. (2015) · Nutrition · doi:10.1016/j.nut.2015.05.018 · Cited by 17

Cell-line dependent effects of hypoxia prior to irradiation in squamous cell carcinoma lines

Hauth, F., Toulany, M., Zips, D., & Menegakis, A. (2017) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2017.06.001 · Cited by 19

AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair

Moyal, L., Goldfeiz, N., Gorovitz, B., Rephaeli, A., Tal, E., Tarasenko, N., Nudelman, A., Ziv, Y., & Hodak, E. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0500-x · Cited by 17

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

Yan, S., & Willis, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.144 · Cited by 16

Structure of the Human TELO2-TTI1-TTI2 Complex

Kim, Y., Park, J., Joo, S. Y., Kim, B., Jo, A., Lee, H., & Cho, Y. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167370 · Cited by 15

Nucleotide Excision Repair: Insights into Canonical and Emerging Functions of the Transcription/DNA Repair Factor TFIIH

Zachayus, A., Loup-Forest, J., Cura, V., & Poterszman, A. (2025) · Genes · doi:10.3390/genes16020231 · Cited by 18

Biomarkers in lung oncology

Rosell, R., Vergnenégre, A., Liu, B., Cobo, M., Massutí, B., Wei, J., Molina‐Vila, M. Á., Costa, C., Queralt, C., & Tarón, M. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.05.003 · Cited by 16

γH2A-Binding Protein Brc1 Affects Centromere Function in Fission Yeast

Lee, S. Y., Rozenzhak, S., & Russell, P. R. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01654-12 · Cited by 16

ATM Signals miRNA Biogenesis through KSRP

Liu, Y., & Liu, Q. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.027 · Cited by 16

Influence of Human p53 on Plant Development

Ma, H., Song, T., Wang, T., & Wang, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162840 · Cited by 16

Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast

Diao, L., Chen, C., Dennehey, B. K., Pal, S., Wang, P., Shen, Z.-J., Deem, A. K., & Tyler, J. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180556 · Cited by 19

DNA Damage by an essential enzyme: A delicate balance act on the tightrope

Nitiss, K. C., Nitiss, J. L., & Hanakahi, L. A. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102639 · Cited by 16

Radiation Response of Murine Embryonic Stem Cells

Hellweg, C. E., Shinde, V., Srinivasan, S. P., Henry, M., Rotshteyn, T., Baumstark‐Khan, C., Schmitz, C., Feles, S., Spitta, L. F., Hemmersbach, R., et al. (2020) · Cells · doi:10.3390/cells9071650 · Cited by 16

Oat (Avena sativa) Extract against Oxidative Stress-Induced Apoptosis in Human Keratinocytes

Song, S., Lee, Y.-M., Lee, Y., & Yeum, K. (2021) · Molecules · doi:10.3390/molecules26185564 · Cited by 16

A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage

Yan, J., Menéndez, D., Yang, X.-P., Resnick, M. A., & Jetten, A. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013102 · Cited by 16

Overexpression of MN1 Confers Resistance to Chemotherapy, Accelerates Leukemia Onset, and Suppresses p53 and Bim Induction

Pardee, T. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043185 · Cited by 16

Buried territories: heterochromatic response to DNA double-strand breaks

Feng, Y.-L., Xiang, J.-F., Kong, N., Cai, X., & Xie, A. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw033 · Cited by 16

A Catalogue of Altered Salivary Proteins Secondary to Invasive Ductal Carcinoma: A Novel In Vivo Paradigm to Assess Breast Cancer Progression

Streckfus, C. F., & Bigler, L. R. (2016) · Scientific Reports · doi:10.1038/srep30800 · Cited by 17

Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

Goto, G. H., Ogi, H., Biswas, H., Ghosh, A. K., Tanaka, S., & Sugimoto, K. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006873 · Cited by 16

Adaptive resistance to trastuzumab impairs response to neratinib and lapatinib through deregulation of cell death mechanisms

Ríos‐Luci, C., Dı́az-Rodrı́guez, E., Gandullo‐Sánchez, L., Díaz-Gil, L., Ocaña, A., & Pandiella, A. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.026 · Cited by 16

Distinct influence of the anthracycline derivative doxorubicin on the differentiation efficacy of mESC-derived endothelial progenitor cells

Jahn, S. K., Hennicke, T., Kassack, M. U., Drews, L., Reichert, A. S., & Fritz, G. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118711 · Cited by 17

Fine tuning chemotherapy to match BRCA1 status

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DNA Double-Strand Breaks Come into Focus

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