The DNA Damage Response: Ten Years After

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Histone acetyltransferase complexes: one size doesn't fit all

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Antagonism between curcumin and the topoisomerase II inhibitor etoposide

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Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

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Regulation and Modulation of Human DNA Polymerase δ Activity and Function

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Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

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Relaxed complex scheme suggests novel inhibitors for the lyase activity of DNA polymerase beta

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Proteomics insights into DNA damage response and translating this knowledge to clinical strategies

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DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications

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Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury

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Calcium channel blockers protect against aluminium-induced DNA damage and block adaptive response to genotoxic stress in plant cells

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Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress

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The CXXC finger 5 protein is required for DNA damage-induced p53 activation

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Effects of microgravity on DNA damage response in Caenorhabditis elegans during Shenzhou-8 spaceflight

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Checkpoint kinase inhibitor synergizes with DNA‐damaging agents in G1 checkpoint‐defective neuroblastoma

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Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

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ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes

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Klotho and the Treatment of Human Malignancies

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Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide

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Regulation of human DNA polymerase delta in the cellular responses to DNA damage

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TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression

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PARP inhibitors – current status and the walk towards early breast cancer

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The Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response—Biological and Clinical Aspects

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Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

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Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

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Importance of PIKKs in NF-κB activation by genotoxic stress

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A winding road to origin discovery

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Invasive oral cancer stem cells display resistance to ionising radiation

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Multiple Functions of the Eya Phosphotyrosine Phosphatase

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RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair

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Bacillus subtilis DisA regulates RecA-mediated DNA strand exchange

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Individual Radiosensitivity in Oncological Patients: Linking Adverse Normal Tissue Reactions and Genetic Features

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Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase δ for Degradation in Response to DNA Damage

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p21Cip1 protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways

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Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology

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RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7

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Posttranscriptional regulation of gene expression—adding another layer of complexity to the DNA damage response

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Inhibition of DNA damage repair by artificial activation of PARP with siDNA

Croset, A., Cordelières, F. P., Berthault, N., Buhler, C., Sun, J., Quanz, M., & Dutreix, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt522 · Cited by 38

Mutational status of TP53 defines the efficacy of Wee1 inhibitor AZD1775 in KRAS-mutant non-small cell lung cancer

Ku, B. M., Bae, Y.-H., Koh, J., Sun, J., Lee, S., Ahn, J. S., Park, K., & Ahn, M. (2017) · Oncotarget · doi:10.18632/oncotarget.18728 · Cited by 38

Contradictory effects of mitochondria‐ and non‐mitochondria‐targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice

Wang, B., Fu, J., Yu, T., Xu, A., Qin, W., Yang, Z., Chen, Y., & Wang, H. (2017) · Hepatology · doi:10.1002/hep.29518 · Cited by 37

RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling

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Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia

Chen, Y., Tang, C. S., Zhang, M., Huang, W., Xu, Y. K., Sun, H.-Y., Yang, F., Song, L., Wang, H., Mu, L., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0458-0 · Cited by 37

hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks

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Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression

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The DNA-Damage Response to γ-Radiation Is Affected by miR-27a in A549 Cells

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Loss of H3 K79 Trimethylation Leads to Suppression of Rtt107-dependent DNA Damage Sensitivity through the Translesion Synthesis Pathway

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Arabidopsis thaliana RNase H2 Deficiency Counteracts the Needs for the WEE1 Checkpoint Kinase but Triggers Genome Instability

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Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation

Han, X., Pozo, F. M., Wisotsky, J. N., Wang, B., Jacobberger, J. W., & Zhang, Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621532 · Cited by 39

Apple Flavonoids Suppress Carcinogen‐Induced DNA Damage in Normal Human Bronchial Epithelial Cells

Vazhappilly, C. G., & Rupasinghe, H. P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1767198 · Cited by 38

The Treatment of Heterotopic Human Colon Xenograft Tumors in Mice with 5-Fluorouracil Attached to Magnetic Nanoparticles in Combination with Magnetic Hyperthermia Is More Efficient than Either Therapy Alone

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mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy

Pazhooh, R. D., Farnood, P. R., Asemi, Z., Mirsafaei, L., Yousefi, B., & Mirzaei, H. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103142 · Cited by 36

DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation

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NONO regulates the intra-S-phase checkpoint in response to UV radiation

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RAD18 lives a double life: Its implication in DNA double-strand break repair

Liu, T., Jun, H., & Junjie, C. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.016 · Cited by 38

Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism

Tian, W., Huang, J., Zhang, W., Wang, Y., Jin, R., Guo, H., Tang, Y., Wang, Y., Lai, H., & Leung, E. L. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107034 · Cited by 40

Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo

Qi, W., Zhang, W., Edwards, H. J., Chu, R. L., Madlambayan, G. J., Taub, J. W., Wang, Z., Wang, Y., Li, C., Lin, H., et al. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1095406 · Cited by 36

Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods

Chen, X., Wu, D., Zhao, Y. B., Wong, B. H. C., & Guo, L. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.11.004 · Cited by 38

Visualizing recombination intermediates with single-stranded DNA curtains

Qi, Z., & Greene, E. C. (2016) · Methods · doi:10.1016/j.ymeth.2016.03.027 · Cited by 38

USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability

Wu, M., Tu, H.-Q., Chang, Y., Tan, B., Wang, G., Zhou, J., Wang, L., Mu, R., & Zhang, W. (2016) · Oncotarget · doi:10.18632/oncotarget.11116 · Cited by 37

Caspase-2 is required for skeletal muscle differentiation and myogenesis

Boonstra, K. M., Bloemberg, D., & Quadrilatero, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.07.016 · Cited by 36

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis

Córcoles-Sáez, I., Dong, K., Johnson, A. L., Waskiewicz, E., Costanzo, M., Boone, C. M., & Cha, R. S. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.011 · Cited by 35

Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response

Gold, A., Eini, L., Nissim‐Rafinia, M., Viner‐Breuer, R., Ezer, S., Erez, K., Aqaqe, N., Hanania, R., Milyavsky, M., Meshorer, E., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0654-9 · Cited by 37

Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance

Temprine, K., Campbell, N. R., Huang, T. H., Langdon, E. M., Simon-Vermot, T., Mehta, K., Clapp, A., Chipman, M. E., & White, R. M. (2020) · Science Signaling · doi:10.1126/scisignal.aau1453 · Cited by 40

Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer

Li, W., Peng, X., Lang, J., & Xu, C. S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00631 · Cited by 36

Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors

Albert, E., & Laimins, L. A. (2020) · Viruses · doi:10.3390/v12070744 · Cited by 41

High-Throughput Sequencing of Gastric Cancer Patients: Unravelling Genetic Predispositions Towards an Early-Onset Subtype

Machlowska, J., Kapusta, P., Baj, J., Morsink, F. H. M., Wołkow, P. P., Maciejewski, R., Offerhaus, G. J. A., & Sitarz, R. (2020) · Cancers · doi:10.3390/cancers12071981 · Cited by 36

DNA Damage and Repair in Pulmonary Arterial Hypertension

Sharma, S., & Aldred, M. A. (2020) · Genes · doi:10.3390/genes11101224 · Cited by 38

Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability

Nayak, S. U., Calvo, J. A., & Cantor, S. B. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1864321 · Cited by 37

The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond

Sui, H., Hao, M., Chang, W., & Imamichi, T. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.761983 · Cited by 36

Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1

Penedos, A. R., Johnson, A. L., Strong, E., Goldman, A. S. H., Carballo, J. A., & Cha, R. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134297 · Cited by 36

UHRF1 is a genome caretaker that facilitates the DNA damage response to γ-irradiation

Mistry, H. S., Tamblyn, L., Butt, H., Sisgoreo, D., Gracias, A., Larin, M., Gopalakrishnan, K., Hande, M. P., & McPherson, J. P. (2010) · Genome Integrity · doi:10.1186/2041-9414-1-7 · Cited by 39

A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation

Cao, L., Kawai, H., Sasatani, M., Iizuka, D., Masuda, Y., Inaba, T., Suzuki, K., Ootsuyama, A., Umata, T., Kamiya, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104279 · Cited by 37

Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage

Chea, J., Zhang, S., Zhao, H. L., Zhang, Z., Lee, E. Y. C., Darżynkiewicz, Z., & Lee, M. (2012) · Cell Cycle · doi:10.4161/cc.21280 · Cited by 37

hTERT: Another brick in the wall of cancer cells

Lamy, E., Goetz, V., Erlacher, M., Herz, C., & Mersch‐Sundermann, V. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.12.005 · Cited by 37

Targeting DNA repair and the cell cycle in glioblastoma

Alexander, B. M., Pinnell, N. E., Wen, P. Y., & D’Andrea, A. D. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0765-4 · Cited by 38

The ubiquitin‐proteasome system in cancer, a major player in DNA repair. Part 1: post‐translational regulation

Vlachostergios, P. J., Patrikidou, A., Daliani, D., & Papandreou, C. N. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00824.x · Cited by 36

RNF8 deficiency results in neurodegeneration in mice

Ouyang, S., Song, Y., Tian, Y., Chen, Y., Yu, X., & Wang, D. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.010 · Cited by 35

Dissecting the role of ubiquitylation in the DNA damage response checkpoint in G2

Bassermann, F. C., & Pagano, M. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.104 · Cited by 35

Ubiquitin and SUMO signalling in DNA repair

Thomson, T. M., & Guerra‐Rebollo, M. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380116 · Cited by 34

Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition

Zhang, C., Liu, G., & Huang, M. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1302-6 · Cited by 35

Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases

Malik, D., Hsu, T., Falatoonzadeh, P., Cáceres‐del‐Carpio, J., Tarek, M., Chwa, M., Atilano, S. R., Ramírez, C., Nesburn, A. B., Boyer, D. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099003 · Cited by 36

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

Puigvert, J. C., von Stechow, L., Siddappa, R., Pines, A., Bahjat, M., Haazen, L. C. J. M., Olsen, J. V., Vrieling, H., Meerman, J. H. N., Mullenders, L. H. F., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003208 · Cited by 36

Non-coding RNAs in DNA damage response.

Liu, Y., & Lu, X. (2012) · PubMed Central · Cited by 34

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

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Functional validation of miRNAs targeting genes of DNA double-strand break repair to radiosensitize non-small lung cancer cells

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