Cited by 1,705DNA Repair MechanismsCancer-related Molecular PathwaysUbiquitin and proteasome pathways

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The DNA Damage Response: Ten Years After

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Harper, J. Wade, Elledge, Stephen J.·2007·Molecular Cell

DOI 10.1016/j.molcel.2007.11.015

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Abstract

The DNA damage response (DDR), through the action of sensors, transducers, and effectors, orchestrates the appropriate repair of DNA damage and resolution of DNA replication problems, coordinating these processes with ongoing cellular physiology. In the past decade, we have witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage. These findings have important implications for aging and cancer.

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Authors: Harper, J. W., & Elledge, S. J.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Harper, J. Wade
Elledge, Stephen J.
ORCID: Harper, J. Wade
Elledge, Stephen J.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2007-12
Volume: 28
Issue: 5
Pages: 739-745
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2007.11.015
OpenAlex: W2042499074
Cited by: 1,705
References: 44
Citations by year: 2026: 39 · 2025: 50 · 2024: 51 · 2023: 51 · 2022: 86 · 2021: 70 · 2020: 79 · 2019: 69 · 2018: 77 · 2017: 78 · 2016: 92 · 2015: 116 · 2014: 107 · 2013: 133 · 2012: 147
FWCI: 7.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2055 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG011085)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: DNA damage response, DNA damage recognition, DNA damage signaling, DNA repair, DNA replication, protein phosphorylation, ubiquitin pathway, aging, cancer
MeSH terms: Animals, DNA Damage, DNA Repair, Humans, Protein Processing, Post-Translational, Ubiquitin, Ubiquitin-Protein Ligase Complexes, Proteasome Endopeptidase Complex

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The DNA Damage Response: Ten Years After

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