The DNA Damage Response: Ten Years After

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Molecular mechanism of nucleotide excision repair

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Histone acetyltransferase complexes: one size doesn't fit all

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Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins

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N-Doped graphene quantum dots (N-GQDs) as fluorescent probes for detection of UV induced DNA damage

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Fus3 regulates asexual development and trap morphogenesis in the nematode-trapping fungus Arthrobotrys oligospora

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Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

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MG132 inhibition of proteasome blocks high-dose UV irradiation-induced apoptosis

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Combined Genetic and Nutritional Risk Models of Triple Negative Breast Cancer

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Epimorphic regeneration in mice is p53-independent

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Chk1–cyclin A/Cdk1 axis regulates origin firing programs in mammals

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Oncogene-Induced Senescence and its Role in Tumor Suppression

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Nucleolar exit of RNF8 and BRCA1 in response to DNA damage

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Drug-induced premature senescence model in human dental follicle stem cells

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TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury

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BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2

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Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

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ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriDPreprint

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The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

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Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation

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TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition

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Trial watch – inhibiting PARP enzymes for anticancer therapy

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Terminal differentiation induction as DNA damage response in hematopoietic stem cells by GADD45A

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Pathological complete response after cisplatin neoadjuvant therapy is associated with the downregulation of DNA repair genes in BRCA1-associated triple-negative breast cancers

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Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe

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Role of deubiquitinating enzymes in DNA double-strand break repair

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Role of DNA repair in the protection against genotoxic stress

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Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in Response to DNA Damage

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Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx

Lu, Z., Wan, G., Guo, H., Zhang, X., & Lu, X. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.12.014 · Cited by 25

CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute

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TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response

Rosales, K. R., Reid, M. A., Yang, Y., Tran, T. Q., Wang, W.-I., Lowman, X. H., Pan, M., & Kong, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145938 · Cited by 24

Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer

Bonanno, L., Costa, C., Majem, M., Sanchez, J.-J., Rodríguez, I., Giménez-Capitán, A. A., Molina‐Vila, M. Á., Vergnenégre, A., Massutí, B., Favaretto, A. G., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2339-5 · Cited by 24

Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

Wu, W., Ma, B., Ye, H., Wang, T., Wang, X., Yang, J., Wei, Y., Zhu, J., & Chen, L. (2016) · Oncotarget · doi:10.18632/oncotarget.10739 · Cited by 24

Transcriptome Analysis Identifies the Dysregulation of Ultraviolet Target Genes in Human Skin Cancers

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Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation

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The Ubiquitin Conjugating Enzyme, UbcM2, Engages in Novel Interactions with Components of Cullin-3 Based E3 Ligases

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When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage

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Tandem BRCT Domains: DNA's Praetorian Guard

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CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response

Marazita, M. C., Ogara, M. F., Sonzogni, S. V., Martí, M., Dusetti, N. J., Pignataro, O. P., & Cánepa, E. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035638 · Cited by 22

Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights

Sheta, Y. S., Sarg, M. T. M., Abdulrahman, F. G., Nossier, E. S., & Husseiny, E. M. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107471 · Cited by 23

The role of cardiomyocyte senescence in cardiovascular diseases: A molecular biology update

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Reprogramming cellular senescence and aging clocks for advanced cancer immunotherapy

Yang, H., Liu, D., Qiu, L., Wang, R., Zhang, C., Yu, D., Zhong, Q., Yuki, N., Song, Z., Zhu, Τ., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02459-8 · Cited by 30

Inauhzin Sensitizes p53-Dependent Cytotoxicity and Tumor Suppression of Chemotherapeutic Agents

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Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion

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The Role of Small Noncoding RNA in DNA Double-Strand Break Repair

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Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress

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Poly(ADP-ribosyl)ation affects stabilization of Che-1 protein in response to DNA damage

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Putting the brakes on p53-driven apoptosis

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A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation

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Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs

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Essential role of Chk1 in S phase progression through regulation of RNR2 expression

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Photobiological Origins of the Field of Genomic Maintenance

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BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

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NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis

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Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair

Kciuk, M., Bukowski, K., Marciniak, B., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113934 · Cited by 23

Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell Fate

Francis, M., Daher, A. A., Azzam, P., Mroueh, M., & Zeidan, Y. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124481 · Cited by 24

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

Zhang, Y., Liu, Z., He, Q., Wu, F., Xiao, Y., Chen, W. L., Jin, Y., Yu, D., & Wang, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.696892 · Cited by 22

PARP Inhibition, a New Therapeutic Avenue in Patients with Prostate Cancer

Flippot, R., Patrikidou, A., Aldea, M. D., Colomba, É., Lavaud, P., Albiges, L. K., Naoun, N., Blanchard, P., Terlizzi, M., Garcia, C., et al. (2022) · Drugs · doi:10.1007/s40265-022-01703-5 · Cited by 22

The small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication

Ning, K., Wang, Z., Cheng, F., Yan, Z., & Qiu, J. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010578 · Cited by 22

Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage

Hu, R., Wang, E., Peng, G., Dai, H., & Lin, S. (2013) · Cell Cycle · doi:10.4161/cc.25064 · Cited by 22

Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche

Curtis, M. J., & Hays, J. B. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.10.001 · Cited by 24

Dynamics of Ionizing Radiation-Induced DNA Damage Response in Reconstituted Three-Dimensional Human Skin Tissue

Suzuki, K., Nakashima, M., & Yamashita, S. (2010) · Radiation Research · doi:10.1667/rr2007.1 · Cited by 23

Taking a Bad Turn: Compromised DNA Damage Response in Leukemia

Nilles, N., & Fahrenkrog, B. (2017) · Cells · doi:10.3390/cells6020011 · Cited by 22

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

Liang, W., Leibowitz, B. J., Epperly, M. W., Bi, C., Li, A., Steinman, J., Wipf, P., Li, S., Zhang, L., Greenberger, J. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20370-9 · Cited by 22

Intracellular mechanism by which genotoxic stress activates yeast SAPK Mpk1

Liu, L., & Levin, D. E. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-07-0441 · Cited by 22

Response of the Green Alga Chlamydomonas reinhardtii to the DNA Damaging Agent Zeocin

Čížková, M., Slavková, M., Vítová, M., Zachleder, V., & Bišová, K. (2019) · Cells · doi:10.3390/cells8070735 · Cited by 22

PP4 phosphatase cooperates in recombinational DNA repair by enhancing double-strand break end resection

Villoria, M. T., Gutiérrez-Escribano, P., Alonso‐Rodríguez, E., Ramos, F., Merino, E., Campos, A., Montoya, A., Kramer, H., Aragón, L., & Clemente‐Blanco, A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz794 · Cited by 22

Targeting the DNA damage response (DDR) by natural compounds

van Stuijvenberg, J., Proksch, P., & Fritz, G. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115279 · Cited by 22

Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo

Gan, H., Qi, M., Chan, C., Leung, P., Ye, G., Lei, Y., Liu, A., Xue, F. S., Liu, D., Ye, W., et al. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5070 · Cited by 22

LncRNA UCA1/miR-182-5p/MGMT axis modulates glioma cell sensitivity to temozolomide through MGMT-related DNA damage pathways

Cheng, M., Wang, Q., Chen, L., Zhao, D., Tang, J. X., Xu, J., & He, Z. (2022) · Human Pathology · doi:10.1016/j.humpath.2022.02.016 · Cited by 25

Potentiation of Bleomycin in Jurkat Cells by Fungal Pycnidione

Kaneko, M., Matsuda, D., Ohtawa, M., Fukuda, T., Nagamitsu, T., Yamori, T., & Tomoda, H. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.18 · Cited by 24

The Kinase Activity of Ataxia-Telangiectasia Mutated Interferes with Adenovirus E4 Mutant DNA Replication

Gautam, D., & Bridge, E. (2013) · Journal of Virology · doi:10.1128/jvi.00376-13 · Cited by 22

Corrupting the DNA damage response: a critical role for Rad52 in tumor cell survival

Lieberman, R., & You, M. (2017) · Aging · doi:10.18632/aging.101263 · Cited by 22

DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration

Urulangodi, M., & Mohanty, A. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-019-00538-2 · Cited by 21

Opening of cohesin’s SMC ring is essential for timely DNA replication and DNA loop formation

Sakata, R., Niwa, K., Torre, D. U. L., Gu, C., Tahara, E., Takada, S., & Nishiyama, T. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108999 · Cited by 21

Aberrant Neurogliovascular Unit Dynamics in Cerebral Small Vessel Disease: A Rheological Clue to Vascular Parkinsonism

Nassir, C. M. N. C. M., Damodaran, T. K., Yusof, S. R., Norazit, A., Chilla, G. S. V. N., Huen, I., Nagaraja, B. P. K., Ibrahim, N. M., & Mustapha, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081207 · Cited by 22

ATR inhibitor AZD6738 increases the sensitivity of colorectal cancer cells to 5‑fluorouracil by inhibiting repair of DNA damage

Suzuki, T., Hirokawa, T., Maeda, A., Harata, S., Watanabe, K., Yanagita, T., Ushigome, H., Nakai, N., Maeda, Y., Shiga, K., et al. (2022) · Oncology Reports · doi:10.3892/or.2022.8289 · Cited by 21

Increased activity of CHK enhances the radioresistance of MCF-7 breast cancer stem cells

Yang, Z.-X., SUN, Y.-H., HE, J.-G., CAO, H., & Jiang, G. (2015) · Oncology Letters · doi:10.3892/ol.2015.3777 · Cited by 22

Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response

Luo, K., Yuan, J., & Lou, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.258087 · Cited by 23

Potential of protein kinase inhibitors for treating herpesvirus-associated disease

Li, R., & Hayward, S. D. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.03.005 · Cited by 21

Impaired S-Phase Arrest in Acute Myeloid Leukemia Cells with a FLT3 Internal Tandem Duplication Treated with Clofarabine

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Genome-Wide Identification of Genes Required for Yeast Growth Under Imatinib Stress: Vacuolar H + -ATPase Function Is an Important Target of This Anticancer Drug

dos Santos, S. C., & Sá‐Correia, I. (2009) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0086 · Cited by 21

An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control

Beird, H. C., Lucas, F. A. S., Hicks, S. C., Chang, K., Bertuch, A. A., & Ribes‐Zamora, A. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-664 · Cited by 21

The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells

Libério, M. S., Sadowski, M. C., Davis, R. A., Rockstroh, A., Vasireddy, R. S., Lehman, M., & Nelson, C. C. (2015) · Oncotarget · doi:10.18632/oncotarget.6267 · Cited by 21

Role of wild-type p53-induced phosphatase 1 in cancer

Wang, Z., Tian, Y., & Lin, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6685 · Cited by 19

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells

Krüger, K., Geist, K., Stuhldreier, F., Schumacher, L., Blümel, L., Remke, M., Wesselborg, S., Stork, B., Klöcker, N., Bormann, S., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.011 · Cited by 21

Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment*

Zhou, Z., Jing, C., Zhang, L., Fujita, T., Kim, H., Huang, Y., Liu, Z., & Wan, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.456962 · Cited by 21

ATP puts the brake on DNA double‐strand break repair

Hopfner, K. (2014) · BioEssays · doi:10.1002/bies.201400102 · Cited by 21

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