The DNA Damage Response: Ten Years After

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Histone acetyltransferase complexes: one size doesn't fit all

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Targeted alpha therapy: a comprehensive analysis of the biological effects from “local-regional-systemic” dimensions

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The role of cyclin D1 in response to long-term exposure to ionizing radiation

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Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2

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Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response

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Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage

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Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome

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USP17- and SCFβTrCP-Regulated Degradation of DEC1 Controls the DNA Damage Response

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Replication protein A (RPA) sumoylation positively influences the DNA damage checkpoint response in yeast

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The DNA damage response: The omics era and its impact

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Zygotic G2/M Cell Cycle Arrest Induced by ATM/Chk1 Activation and DNA Repair in Mouse Embryos Fertilized with Hydrogen Peroxide-Treated Epididymal Mouse Sperm

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The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

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NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels

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Pharmacogenomics in non-small-cell lung cancer chemotherapy

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PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2

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Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair

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Involvement of GLTSCR2 in the DNA Damage Response

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Prognostic implications of the subcellular localization of survivin in glioblastomas treated with radiotherapy plus concomitant and adjuvant temozolomide

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cGAS in nucleus: The link between immune response and DNA damage repair

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The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells

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Maintaining replication fork integrity in UV-irradiated Escherichia coli cells

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Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells

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Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage†

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Irradiation-induced damage and the DNA damage response

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Metformin alleviates ionizing radiation-induced senescence by restoring BARD1-mediated DNA repair in human aortic endothelial cells

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Opening the DNA repair toolbox: Localization of DNA double strand breaks to the nuclear periphery

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DNA Damage: A Sensible Mediator of the Differentiation Decision in Hematopoietic Stem Cells and in Leukemia

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Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

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Oridonin induces apoptosis in human oral cancer cells via phosphorylation of histone H2 AX

Yang, I., Shin, J., Lee, K., Kim, J., Cho, N., & Cho, S. (2017) · European Journal Of Oral Sciences · doi:10.1111/eos.12387 · Cited by 31

The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication

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Deregulated estrogen receptor signaling and DNA damage response in breast tumorigenesis

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Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition

Netterfield, T. S., Ostheimer, G. J., Tentner, A. R., Joughin, B. A., Dakoyannis, A. M., Sharma, C. D., Sorger, P. K., Janes, K. A., Lauffenburger, D. A., & Yaffe, M. B. (2022) · Cell Systems · doi:10.1016/j.cels.2023.06.005 · Cited by 32

Cyclin E Is Stabilized in Response to Replication Fork Barriers Leading to Prolonged S Phase Arrest

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Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers

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DNA double‐strand breaks induce the expression of flavin‐containing monooxygenase and reduce root meristem size in A rabidopsis thaliana

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Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation

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Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction

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The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast

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Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library

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Crosstalk between the DNA damage response pathway and microRNAs

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Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress

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Estrogen Receptor Signaling in Radiotherapy: From Molecular Mechanisms to Clinical Studies

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Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer

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CRISPR/Cas9: targeted genome editing for the treatment of hereditary hearing loss

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ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis

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Regulation of DNA duplication by the mTOR signaling pathway

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Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection

Gusho, E., & Laimins, L. A. (2021) · Viruses · doi:10.3390/v13071390 · Cited by 30

Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection

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Artemis Regulates Cell Cycle Recovery from the S Phase Checkpoint by Promoting Degradation of Cyclin E

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Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1

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Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair

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DNA damage dependent activation of checkpoint kinase-1 and mitogen-activated protein kinase-p38 are required in malabaricone C-induced mitochondrial cell death

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DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac

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And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance

Chen, Y., Liu, H., Zhang, H., Sun, C., Hu, Z., Tian, Q., Peng, C., Jiang, P., Hua, H. M., Li, X., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1212 · Cited by 33

Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells

Li, T., Cao, Y., Wei, Z., Jia, Q., Yu, S., Zhong, J., Wang, A., Woodgett, J. R., & Lu, Y. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.10.015 · Cited by 30

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery

Millán-Zambrano, G., Santos-Rosa, H., Puddu, F., Robson, S. C., Jackson, S. P., & Kouzarides, T. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.09.023 · Cited by 32

Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins inSaccharomyces cerevisiae

Cheng, E., Vaisica, J. A., Ou, J., Baryshnikova, A., Lu, Y. C., Roth, F. P., & Brown, G. W. (2012) · Genetics · doi:10.1534/genetics.112.141051 · Cited by 30

Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors

Galal, S. A., Khairat, S. H. M., Ali, H. I., Shouman, S. A., Attia, Y. M., Ali, M. M., Mahmoud, A. E. E.-D., Abdel-Halim, A. H., Fyiad, A. A., Tabll, A. A., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.023 · Cited by 29

Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX

Vougiouklakis, T., Saloura, V., Park, J.-H., Takamatsu, N., Miyamoto, T., Nakamura, Y., & Matsuo, Y. (2018) · Oncotarget · doi:10.18632/oncotarget.25806 · Cited by 29

DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

Yao, S., Feng, Y., Zhang, Y., & Feng, J. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.11.033 · Cited by 29

Next-Generation Sequencing-based genomic profiling of brain metastases of primary ovarian cancer identifies high number of BRCA-mutations

Balendran, S., Liebmann‐Reindl, S., Berghoff, A. S., Reischer, T., Popitsch, N. P., Geier, C. B., Kenner, L., Birner, P., Streubel, B., & Preusser, M. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2459-z · Cited by 29

TGFβ Promotes Genomic Instability after Loss of RUNX3

Krishnan, V., Chong, Y. L., Tan, T. Z., Kulkarni, M., Rahmat, M. B. B., Tay, L. S., Sankar, H., Jokhun, D. S., Ganesan, A., Chuang, L. S. H., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1178 · Cited by 30

Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis

Subramanian, G. N., Greaney, J., Wei, Z., Bécherel, O. J., Lavin, M. F., & Homer, H. A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201907213 · Cited by 31

Nucleotide Excision Repair: Finely Tuned Molecular Orchestra of Early Pre‐incision Events

Zhu, Q., & Wani, A. A. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12647 · Cited by 31

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

Yeung, M., & Durocher, D. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.09.005 · Cited by 32

Shaping chromatin for repair

Gospodinov, A. G., & Herceg, Z. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.10.001 · Cited by 28

Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis

Lunardi, A., Varmeh, S., Chen, M., Taulli, R., Guarnerio, J., Ala, U., Seitzer, N., Ishikawa, T., Carver, B. S., Hobbs, R. M., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-1050 · Cited by 31

RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence

López-Vicente, L., Pons, B., Coch, L., Teixidó, C., Hernández‐Losa, J., Armengol, G., & y Cajal, S. R. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr003 · Cited by 28

Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

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Enhancing the efficacy of glycolytic blockade in cancer cellsviaRAD51 inhibition

Wilson, J. J., Chow, K.-H., Labrie, N. J., Branca, J. A., Sproule, T. J., Perkins, B., Wolf, E. W., Costa, M. W., Stafford, G. A., Rosales, C., et al. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1507666 · Cited by 27

DNA damage and gene expression changes in patients exposed to low-dose X-radiation during neuro-interventional radiology procedures

Visweswaran, S., Joseph, S., Vinay Hegde, S., Annalakshmi, O., Jose, M. T., & Venkatachalam, P. (2019) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2019.05.011 · Cited by 27

Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress‐targeted therapeutic inhibitors

Dias, M. H., Fonseca, C. S., Zeidler, J. D., Albuquerque, L. L., da Silva, M. S., Lopes, E. C., Reis, M. S., Noël, V., dos Santos, E. O., Prior, I. A., et al. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12402 · Cited by 26

Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c

Rivero-Rodríguez, F., Dı́az-Quintana, A., Velázquez‐Cruz, A., González‐Arzola, K., Gavilán, M. P., Velázquez‐Campoy, A., Rios, R. M., la Rosa, M. Á. D., & Díaz‐Moreno, I. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101967 · Cited by 27

The DNA damage response - from cell biology to human disease

Lam, F. C. (2022) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2021.61 · Cited by 29

UFL1, a UFMylation E3 ligase, plays a crucial role in multiple cellular stress responses

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Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites

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Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells

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Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

Abreu, C. M. C., Kumar, R., Hamilton, D. S., Dawdy, A., Creavin, K., Eivers, S. B., Finn, K., Balsbaugh, J. L., O’Connor, R., Kiely, P. A., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003310 · Cited by 30

ERCC1: Impact in Multimodality Treatment of Upper Gastrointestinal Cancer

Metzger, R., Bollschweiler, E., Hölscher, A. H., & Warnecke‐Eberz, U. (2010) · Future Oncology · doi:10.2217/fon.10.140 · Cited by 28

A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae

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B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu

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