The DNA Damage Response: Ten Years After

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Targeting DNA repair mechanisms in cancer

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Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity

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Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals

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Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

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Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21

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Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control

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Cryo-EM structure of human DNA-PK holoenzyme

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DNA repair and aging: The impact of the p53 family

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The capacity of oocytes for DNA repair

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DDR-mediated crosstalk between DNA-damaged cells and their microenvironment

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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

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DNA stress checkpoint control and plant development

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Assembly of checkpoint and repair machineries at DNA damage sites

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DNA damage signalling prevents deleterious telomere addition at DNA breaks

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USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15

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hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

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The cellular response to DNA damage: A focus on MDC1 and its interacting proteins

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Mitotic catastrophe and cancer drug resistance: A link that must to be broken

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Aberrant Reactive Oxygen and Nitrogen Species Generation in Rheumatoid Arthritis (RA): Causes and Consequences for Immune Function, Cell Survival, and Therapeutic Intervention

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DNA-PK, ATM and ATR collaboratively regulate p53–RPA interaction to facilitate homologous recombination DNA repair

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Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

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Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

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Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response

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Distinct Roles of the ATR Kinase and the Mre11-Rad50-Nbs1 Complex in the Maintenance of Chromosomal Stability in Arabidopsis

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MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent of H2AX

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Parp1 promotes sleep, which enhances DNA repair in neurons

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Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates

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GEN1/Yen1 and the SLX4 complex: solutions to the problem of Holliday junction resolutionPreprint

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MRN and the race to the break

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CDK targeting of NBS1 promotes DNA‐end resection, replication restart and homologous recombination

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Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

Dorstyn, L., Puccini, J., Wilson, C. H., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2012.36 · Cited by 104

Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia

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Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis

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Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2

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Chfr and RNF8 synergistically regulate ATM activation

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Parvovirus Minute Virus of Mice Induces a DNA Damage Response That Facilitates Viral Replication

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Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer

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Dif1 Is a DNA-Damage-Regulated Facilitator of Nuclear Import for Ribonucleotide Reductase

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Inhibition of Ataxia Telangiectasia- and Rad3 -Related Function Abrogates the In Vitro and In Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133+ Tumor-Initiating Cell Fraction

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ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

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Cdk2 is required for p53-independent G2/M checkpoint control

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APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

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The ubiquitin‐ and SUMO‐dependent signaling response to DNA double‐strand breaks

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Charting the Landscape of Tandem BRCT Domain–Mediated Protein Interactions

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K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

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High mobility group (HMG) proteins: Modulators of chromatin structure and DNA repair in mammalian cells

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Selective Targeting of the G2/M Cell Cycle Checkpoint to Improve the Therapeutic Index of Radiotherapy

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DNA Damage and Pulmonary Hypertension

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Cryo-EM structure of human ATR-ATRIP complex

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USP10 inhibits genotoxic NF‐κB activation by MCPIP1‐facilitated deubiquitination of NEMO

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Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIR ON AGE cohort study

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Autophagy and senescence in fibrosing cholangiopathies

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Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM -Defective Tumors

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Targeting deubiquitinase USP28 for cancer therapy

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The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

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MBD5 and MBD6 interact with the human PR‐DUB complex through their methyl‐CpG‐binding domain

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Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

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SUMOylation-Dependent Localization of IKKɛ in PML Nuclear Bodies Is Essential for Protection against DNA-Damage-Triggered Cell Death

Renner, F., Moreno, R., & Schmitz, M. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.018 · Cited by 104

Analysis of miRNA and mRNA Expression Profiles Highlights Alterations in Ionizing Radiation Response of Human Lymphocytes under Modeled Microgravity

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PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization

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Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses

Chiba, N., Comaills, V., Shiotani, B., Takahashi, F., Shimada, T., Tajima, K., Winokur, D., Hayashida, T., Willers, H., Brachtel, E. F., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018867108 · Cited by 102

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration

Błasiak, J., Głowacki, S., Kauppinen, A., & Kaarniranta, K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022996 · Cited by 100

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

Huelsenbeck, J., Henninger, C., Schad, A., Lackner, K. J., Kaina, B., & Fritz, G. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.65 · Cited by 98

Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

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Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments

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Mammalian TIMELESS Is Required for ATM-dependent CHK2 Activation and G2/M Checkpoint Control

Yang, X., Wood, P. A., & Hrushesky, W. J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.050237 · Cited by 98

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

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Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

Liang, W., Leibowitz, B. J., Wang, X., Epperly, M. W., Greenberger, J. S., Zhang, L., & Yu, J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88410 · Cited by 96

Cell-Cycle Control and Plant Development

Inagaki, S., & Umeda, M. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00007-0 · Cited by 96

Caspase-2 as a tumour suppressor

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Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers

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Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

Xie, C., Drenberg, C. D., Edwards, H. J., Caldwell, J. T., Chen, W., Inaba, H., Xu, X., Buck, S. A., Taub, J. W., Baker, S. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079106 · Cited by 95

Cdc5L interacts with ATR and is required for the S‐phase cell‐cycle checkpoint

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Acquired Radioresistance of Cancer and the AKT/GSK3β/cyclin D1 Overexpression Cycle

Shimura, T. (2011) · Journal of Radiation Research · doi:10.1269/jrr.11098 · Cited by 96

SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism

Luna, A., Aladjem, M. I., & Kohn, K. W. (2013) · Genome Integrity · doi:10.1186/2041-9414-4-6 · Cited by 96

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

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Mechanisms of Taste Bud Cell Loss after Head and Neck Irradiation

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Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation, and Cell Cycle: Role and Targeting

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Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker‐Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bártek, J., Lukas, J., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.15 · Cited by 95

Phosphatases in the cellular response to DNA damage

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Achieving Precision Death with Cell-Cycle Inhibitors that Target DNA Replication and Repair

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Role of non-homologous end joining in V(D)J recombination

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Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks

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TheArabidopsis thalianaCheckpoint Kinase WEE1 Protects against Premature Vascular Differentiation during Replication Stress

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