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LincRNA-p21 Suppresses Target mRNA Translation
Open accessAbstract
Mammalian long intergenic noncoding (linc)RNAs are best known for modulating transcription. Here we report a post-transcriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower lincRNA-p21 stability. Under reduced HuR levels, lincRNA-p21 accumulated in human cervical carcinoma HeLa cells, increasing its association with JUNB and CTNNB1 mRNAs and selectively lowering their translation. With elevated HuR, lincRNA-p21 levels declined, which in turn derepressed JunB and β-catenin translation and increased the levels of these proteins. We propose that HuR controls translation of a subset of target mRNAs by influencing lincRNA-p21 levels. Our findings uncover a role for lincRNA as a post-transcriptional inhibitor of translation.
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Metadata
- Authors
- Yoon, J.-H., Abdelmohsen, K., Srikantan, S., Yang, X., Martindale, J. L., De, S., Huarte, M., Zhan, M., Becker, K. G., & Gorospe, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 47
- Issue
- 4
- Pages
- 648-655
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1964113455
- Cited by
- 962
- References
- 29
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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