The Intertwined Roles of Transcription and Repair Proteins
Open accessAbstract
Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to repair DNA lesions that could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point to an even more direct function of DNA repair complexes as coactivators of transcription and the unexpected role of "scheduled" DNA damage/repair at gene promoters. Paradoxically, spontaneous DNA double-strand breaks also induce ectopic transcription that is essential for repair. Thus, transcription, DNA damage, and repair may be more physically and functionally intertwined than previously appreciated.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ATR is the main regulator of nucleotide excision repair because it detects replication and transcription stress caused by UV-induced and other bulky DNA adducts.
“Although it functions in multiple DDR processes 21 ATR is the primary regulator of the nucleotide excision repair pathway due to its ability to detect the replicative and transcriptional stresses caused by UV-induced damage and other bulky DNA adducts resulting from chemical toxins and some chemotherapeutic agents 22–25.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works
Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., & Smith, A. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00392-1 · Cited by 3,255 · see citing works
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M., & Yamanaka, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00393-3 · Cited by 3,192 · see citing works
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882 · see citing works
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954 · see citing works
BRCA1 and BRCA2: different roles in a common pathway of genome protection
Roy, R., Chun, J., & Powell, S. N. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3181 · Cited by 1,479 · see citing works
Charting a dynamic DNA methylation landscape of the human genome
Ziller, M. J., Gu, H., Müller, F., Donaghey, J., Tsai, L. T.-Y., Kohlbacher, O., De Jager, P. L., Rosen, E. D., Bennett, D. A., Bernstein, B. E., et al. (2013) · Nature · doi:10.1038/nature12433 · Cited by 1,357 · see citing works
Transcription regulation and animal diversity
Levine, M., & Tjian, R. (2003) · Nature · doi:10.1038/nature01763 · Cited by 1,309 · see citing works
Self-citationSuppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301 · see citing works
MELLON, I. (1987) · Cell · doi:10.1016/0092-8674(87)90151-6 · Cited by 1,228 · see citing works
Architectural protein subclasses shape 3D organization of genomes during lineage commitment
Phillips-Cremins, J. E., Sauria, M. E. G., Sanyal, A., Gerasimova, T. I., Lajoie, B. R., Bell, J. S. K., Ong, C.-T., Hookway, T. A., Guo, C., Sun, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.053 · Cited by 1,187 · see citing works
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115 · see citing works
Active DNA demethylation: many roads lead to Rome
Wu, S. C., & Zhang, Y. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2950 · Cited by 1,054 · see citing works
Transcription-coupled DNA repair: two decades of progress and surprises
Hanawalt, P. C., & Spivak, G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2549 · Cited by 1,038 · see citing works
R Loops: From Transcription Byproducts to Threats to Genome Stability
Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029 · see citing works
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature · doi:10.1038/nature08287 · Cited by 1,028 · see citing works
DNA interstrand crosslink repair and cancer
Deans, A. J., & West, S. C. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3088 · Cited by 1,019 · see citing works
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature · doi:10.1038/nature08290 · Cited by 968 · see citing works
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Utikal, J., Polo, J., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J., & Hochedlinger, K. (2009) · Nature · doi:10.1038/nature08285 · Cited by 896 · see citing works
A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C. M., Lim, S. M., Borkent, M., Apostolou, E., Alaei, S., Cloutier, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.039 · Cited by 861 · see citing works
A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription
Ju, B., Lunyak, V. V., Perissi, V., García-Bassets, I., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (2006) · Science · doi:10.1126/science.1127196 · Cited by 842 · see citing works
Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809 · see citing works
DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor
Schaeffer, L., Roy, R., Humbert, S., Moncollin, V., Vermeulen, W., Hoeijmakers, J. H. J., Chambon, P., & Egly, J. (1993) · Science · doi:10.1126/science.8465201 · Cited by 794 · see citing works
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability
Xialu Li, C., & Manley, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.06.008 · Cited by 772 · see citing works
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
Yu, K.-F., Chédin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 767 · see citing works
Orchestrated response: a symphony of transcription factors for gene controlPreprint
Lemon, B. D., & Tjian, R. (2000) · Genes & Development · doi:10.1101/gad.831000 · Cited by 762 · see citing works
Self-citationGadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
Barreto, G., Schäfer, A., Marhold, J., Stach, D., Swaminathan, S. K., Handa, V., Doederlein, G., Maltry, N., Wu, W., Lyko, F., et al. (2007) · Nature · doi:10.1038/nature05515 · Cited by 753 · see citing works
Repair of Endogenous DNA Damage
LINDAHL, T., & BARNES, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.127 · Cited by 714 · see citing works
DNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697 · see citing works
UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex
Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.035 · Cited by 576 · see citing works
Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B.-G., Ohgi, K. A., Zhang, J., Rose, D. W., Fu, X.-D., Glass, C. K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.030 · Cited by 576 · see citing works
A Role for Small RNAs in DNA Double-Strand Break Repair
Wei, W., Ba, Z., Gao, M., Wu, Y., Ma, Y., Amiard, S., White, C. I., Danielsen, J. M. R., Yang, Y., & Qi, Y. (2012) · Cell · doi:10.1016/j.cell.2012.03.002 · Cited by 575 · see citing works
Transcriptional coactivator complexes.
Näär, A. M., Lemon, B. D., & Tjian, R. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.475 · Cited by 571 · see citing works
Self-citationGenome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming
Song, C., Szulwach, K. E., Dai, Q., Fu, Y., Mao, S.-Q., Lin, L., Street, C., Li, Y., Poidevin, M., Wu, H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.001 · Cited by 545 · see citing works
The AID/APOBEC family of nucleic acid mutators
Conticello, S. G. (2008) · Genome biology · doi:10.1186/gb-2008-9-6-229 · Cited by 544 · see citing works
Site-specific DICER and DROSHA RNA products control the DNA-damage response
Francia, S., Michelini, F., Saxena, A., Tang, D. T. P., de Hoon, M., Anelli, V., Mione, M., Carninci, P., & di Fagagna, F. D. (2012) · Nature · doi:10.1038/nature11179 · Cited by 533 · see citing works
DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression
Perillo, B., Ombra, M. N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A., Abbondanza, C., & Avvedimento, E. V. (2008) · Science · doi:10.1126/science.1147674 · Cited by 529 · see citing works
Chevray, P. M., & Nathans, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5789 · Cited by 526 · see citing works
High‐resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome
Iacovoni, J. S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D., & Legube, G. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.38 · Cited by 515 · see citing works
Frederico, L. A., Kunkel, T. A., & Shaw, B. R. (1990) · Biochemistry · doi:10.1021/bi00462a015 · Cited by 498 · see citing works
Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics
Shen, L., Wu, H., Diep, D., Yamaguchi, S., D’Alessio, A. C., Fung, H.-L., Zhang, K., & Zhang, Y. (2013) · Cell · doi:10.1016/j.cell.2013.04.002 · Cited by 497 · see citing works
R-loop-mediated genomic instability is caused by impairment of replication fork progressionPreprint
Gan, W., Guan, Z., Liu, J., Gui, T., Shen, K., Manley, J. L., & Xialu Li, C. (2011) · Genes & Development · doi:10.1101/gad.17010011 · Cited by 459 · see citing works
A multistep damage recognition mechanism for global genomic nucleotide excision repair
Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., & Hanaoka, F. (2001) · Genes & Development · doi:10.1101/gad.866301 · Cited by 435 · see citing works
Topoisomerases facilitate transcription of long genes linked to autism
King, I. F. G., Yandava, C., Mabb, A. M., Hsiao, J. S., Huang, H., Pearson, B. L., Calabrese, J. M., Starmer, J., Parker, J. S., Magnuson, T., et al. (2013) · Nature · doi:10.1038/nature12504 · Cited by 430 · see citing works
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
Cortázar, D., Kunz, C., Selfridge, J., Lettieri, T., Saito, Y., MacDougall, E., Wirz, A., Schuermann, D., Jacobs, A. L., Siegrist, F., et al. (2011) · Nature · doi:10.1038/nature09672 · Cited by 389 · see citing works
Mechanisms of transcription-coupled DNA repair
Svejstrup, J. Q. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm703 · Cited by 380 · see citing works
Citterio, E., van den Boom, V., Schnitzler, G. R., Kanaar, R., Bonte, E. J., Kingston, R. E., Hoeijmakers, J. H. J., & Vermeulen, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7643-7653.2000 · Cited by 371 · see citing works
Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability
Mischo, H. E., Gómez‐González, B., Grzechnik, P., Rondón, A. G., Wei, W., Steinmetz, L. M., Aguilera, A., & Proudfoot, N. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.007 · Cited by 342 · see citing works
Transcriptional regulation and the role of diverse coactivators in animal cells
Roeder, R. G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.12.007 · Cited by 340 · see citing works
Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma, Y., & Hanaoka, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100855200 · Cited by 335 · see citing works
TFIIH: when transcription met DNA repair
Compe, E., & Egly, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3350 · Cited by 333 · see citing works
The connection between transcription and genomic instability
Aguilera, A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.195 · Cited by 328 · see citing works
Transcription as a source of genome instability
Kim, N., & Jinks-Robertson, S. (2012) · Nature reviews genetics · doi:10.1038/nrg3152 · Cited by 297 · see citing works
Structural visualization of key steps in human transcription initiation
He, Y., Fang, J., Taatjes, D. J., & Nogales, E. (2013) · Nature · doi:10.1038/nature11991 · Cited by 282 · see citing works
Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., & Hanaoka, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9870 · Cited by 277 · see citing works
Transcription-replication encounters, consequences and genomic instability
Helmrich, A., Ballarino, M., Nudler, E., & Tora, L. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2543 · Cited by 267 · see citing works
RNA Polymerase Backtracking in Gene Regulation and Genome Instability
Nudler, E. (2012) · Cell · doi:10.1016/j.cell.2012.06.003 · Cited by 251 · see citing works
Le May, N., Mota-Fernandes, D., Vélez-Cruz, R., Iltis, I., Biard, D., & Egly, J. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.004 · Cited by 228 · see citing works
Venema, J., van Hoffen, A., Natarajan, A. T., van Zeeland, A. A., & Mullenders, L. H. F. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.3.443 · Cited by 226 · see citing works
CSB Is a Component of RNA Pol I Transcription
Bradsher, J., Auriol, J., Proietti‐De‐Santis, L., Iben, S., Vonesch, J., Grummt, I., & Egly, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00678-0 · Cited by 217 · see citing works
Apostolou, E., Ferrari, F., Walsh, R. M., Bar‐Nur, O., Stadtfeld, M., Cheloufi, S., Stuart, H. T., Polo, J. M., Ohsumi, T. K., Borowsky, M. L., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.013 · Cited by 215 · see citing works
Wei, Z., Gao, F., Kim, S., Yang, H., Lyu, J., An, W., Wang, K., & Lu, W. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.010 · Cited by 207 · see citing works
Goodrich, J. A., & Tjian, R. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2847 · Cited by 200 · see citing works
Self-citationThe enigmatic thymine DNA glycosylase
Cortázar, D., Kunz, C., Saito, Y., Steinacher, R., & Schär, P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.013 · Cited by 198 · see citing works
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
洪, 炫. (2012) · Medical Entomology and Zoology · Cited by 198 · see citing works
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway
Yamamoto, K. N., Kobayashi, S., Tsuda, M., Kurumizaka, H., Takata, M., Kono, K., Jiricny, J., Takeda, S., & Hirota, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018487108 · Cited by 197 · see citing works
DNA damage response in adult stem cells: pathways and consequences
Mandal, P. K., Blanpain, C., & Rossi, D. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3060 · Cited by 195 · see citing works
Molecular Biology of Fanconi Anemia: Implications for Diagnosis and Therapy
D’Andrea, A. D., & Grompe, M. (1997) · Blood · doi:10.1182/blood.v90.5.1725 · Cited by 194 · see citing works
Ito, S., Kuraoka, I., Chymkowitch, P., Compe, E., Takedachi, A., Ishigami, C., Coin, F., Egly, J., & Tanaka, K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.013 · Cited by 194 · see citing works
Schmitz, K., Schmitt, N., Hoffmann‐Rohrer, U., Schäfer, A., Grummt, I., & Mayer, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.015 · Cited by 192 · see citing works
Yüce, Ö., & West, S. C. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01195-12 · Cited by 189 · see citing works
Wahba, L., Gore, S. K., & Koshland, D. E. (2013) · eLife · doi:10.7554/elife.00505 · Cited by 188 · see citing works
Saxowsky, T. T., & Doetsch, P. W. (2006) · Chemical Reviews · doi:10.1021/cr040466q · Cited by 176 · see citing works
A DNA Repair Complex Functions as an Oct4/Sox2 Coactivator in Embryonic Stem Cells
Fong, Y. W., Inouye, C. J., Yamaguchi, T., Cattoglio, C., Grubisic, I., & Tjian, R. (2011) · Cell · doi:10.1016/j.cell.2011.08.038 · Cited by 164 · see citing works
Self-citationGADD45A Does Not Promote DNA Demethylation
Jin, S., Guo, C., & Pfeifer, G. P. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000013 · Cited by 161 · see citing works
DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation.
Wang, Q.-E. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki684 · Cited by 160 · see citing works
Cotranscriptional processes and their influence on genome stabilityPreprint
Xialu Li, C., & Manley, J. L. (2006) · Genes & Development · doi:10.1101/gad.1438306 · Cited by 158 · see citing works
Direct evidence for the effect of transcription on local DNA supercoiling in vivo
Rahmouni, A. R., & Wells, R. D. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90721-u · Cited by 150 · see citing works
Nucleotide excision repair: new tricks with old bricks
Kamileri, I., Karakasilioti, I., & Garinis, G. A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.06.004 · Cited by 146 · see citing works
TFIIH Plays an Essential Role in RNA Polymerase I Transcription
Iben, S., Tschochner, H., Bier, M., Hoogstraten, D., Hozák, P., Egly, J., & Grummt, I. (2002) · Cell · doi:10.1016/s0092-8674(02)00729-8 · Cited by 145 · see citing works
Overcoming reprogramming resistance of Fanconi anemia cells
Müller, L., Milsom, M. D., Harris, C. E., Vyas, R., Brumme, K. M., Parmar, K., Moreau, L. A., Schambach, A., Park, I., London, W. B., et al. (2012) · Blood · doi:10.1182/blood-2012-02-408674 · Cited by 140 · see citing works
Reaban, M. E., Lebowitz, J., & Griffin, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31881-1 · Cited by 136 · see citing works
Um, S., Harbers, M., Benecke, A., Pierrat, B., Losson, R., & Chambon, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20728 · Cited by 134 · see citing works
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
Oca, R. M. D., Andreassen, P. R., Margossian, S. P., Gregory, R. C., Taniguchi, T., Wang, X., Houghtaling, S. R., Grompe, M., & D’Andrea, A. D. (2004) · Blood · doi:10.1182/blood-2003-11-3997 · Cited by 132 · see citing works
Zhang, H., Jiao, W., Sun, L., Fan, J., Chen, M., Wang, H., Xu, X., Shen, A., Li, T., Niu, B., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.012 · Cited by 130 · see citing works
5-Methylcytosine DNA Demethylation: More Than Losing a Methyl Group
Franchini, D., Schmitz, K.-M., & Petersen‐Mahrt, S. K. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155451 · Cited by 128 · see citing works
May, N. L., Fradin, D. D., Iltis, I., Bougneres, P. F., & Egly, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.050 · Cited by 120 · see citing works
Chen, D., Lucey, M. J., Phoenix, F. A., Lopez-Garcia, J., Hart, S., Losson, R., Buluwela, L., Coombes, R. C., Chambon, P., Schär, P., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304286200 · Cited by 116 · see citing works
Shifting Players and Paradigms in Cell-Specific Transcription
D’Alessio, J. A., Wright, K. J., & Tjian, R. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.011 · Cited by 115 · see citing works
Self-citationRole for topoisomerase 1 in transcription-associated mutagenesis in yeast
Lippert, M. J., Kim, N., Cho, J.-E., Larson, R. P., Schoenly, N. E., O'Shea, S. H., & Jinks-Robertson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012363108 · Cited by 97 · see citing works
Developmental regulation of transcription initiation: more than just changing the actors
Müller, F., Zaucker, A., & Tora, L. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.06.004 · Cited by 89 · see citing works
Gonzãlez, F., Georgieva, D., Vanoli, F., Shi, Z., Stadtfeld, M., Ludwig, T., Jasin, M., & Huangfu, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.005 · Cited by 82 · see citing works
True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
May, N. L., Egly, J., & Coin, F. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/616342 · Cited by 78 · see citing works
Takahashi, T. S., Burguiere-Slezak, G., van der Kemp, P. A., & Boiteux, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012582108 · Cited by 77 · see citing works
Two‐stage dynamic DNA quality check by xeroderma pigmentosum group C protein
Camenisch, U., Träutlein, D., Clement, F. C., Fei, J., Leitenstorfer, A., Ferrando‐May, E., & Naegeli, H. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.187 · Cited by 77 · see citing works
The emerging role of Polycomb repressors in the response to DNA damage
Vissers, J. H. A., van Lohuizen, M., & Citterio, E. (2012) · Journal of Cell Science · doi:10.1242/jcs.107375 · Cited by 76 · see citing works
Premature aging and cancer in nucleotide excision repair-disorders
Diderich, K. E. M., Alanazi, M. A., & Hoeijmakers, J. H. J. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.04.025 · Cited by 71 · see citing works
Factor‐independent transcription pausing caused by recognition of the RNA–DNA hybrid sequence
Bochkareva, A., Yuzenkova, Y., Tadigotla, V. R., & Zenkin, N. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.432 · Cited by 64 · see citing works
FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis
Park, E., Kim, H., Kim, J. M., Primack, B., Vidal-Cardenas, S. L., Xu, Y., Price, B. D., Mills, A. A., & D’Andrea, A. D. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.017 · Cited by 62 · see citing works
Kamileri, I., Karakasilioti, I., Sideri, A., Kosteas, T., Tatarakis, A., Talianidis, I., & Garinis, G. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114941109 · Cited by 52 · see citing works
Lin, Y., & Wilson, J. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046807 · Cited by 46 · see citing works
Interactions between DNA damage, repair, and transcription
Khobta, A., & Epe, B. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.07.014 · Cited by 35 · see citing works
Krasikova, Y. S., Rechkunova, N. I., Maltseva, E. A., Pestryakov, P. E., Petruseva, I. O., Sugasawa, K., Chen, X., Min, J., & Lavrik, O. I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444026 · Cited by 33 · see citing works
Shimizu, Y., Uchimura, Y., Dohmae, N., Saitoh, H., Hanaoka, F., & Sugasawa, K. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/805698 · Cited by 33 · see citing works
Robinson, C. E., Wu, X., Morris, D. C., & Gimble, J. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8305 · Cited by 25 · see citing works
Transcriptional regulation by coactivators in embryonic stem cells
Fong, Y. W., Cattoglio, C., Yamaguchi, T., & Tjian, R. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.04.002 · Cited by 25 · see citing works
Self-citationDNA bending by nuclear receptors.
Nardulli, A. M., & Shapiro, D. J. (1993) · PubMed · Cited by 24 · see citing works
Brief Report: Impaired Cell Reprogramming in Nonhomologous End Joining Deficient Cells
Molina-Estévez, F. J., Lozano, M. L., Navarro, S., Torres, Y., Grabundžija, I., Ivics, Z., Samper, E., Bueren, J. A., & Güenechea, G. (2013) · Stem Cells · doi:10.1002/stem.1406 · Cited by 13 · see citing works
Transitions for Regulating Early Transcription
Michel, M., & Cramer, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.050 · Cited by 12 · see citing works
eNERgizing Pluripotent Gene Transcription
Etchegaray, J., & Mostoslavsky, R. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.09.004 · Cited by 4 · see citing works
Impaired cell reprogramming in non-homologous end joining deficient cells
Molina-Estevez, F. J., Lozano, M. L., Navarro, S., et al. (2013) · MDC Repository (Max-Delbrueck-Center for Molecular Medicine) · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065 · see citing works
Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair
Fleming, A. M., Ding, Y., & Burrows, C. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619809114 · Cited by 364 · see citing works
Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
Breiling, A., & Lyko, F. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0016-6 · Cited by 353 · see citing works
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Kumar, S., Chinnusamy, V., & Mohapatra, T. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00640 · Cited by 287 · see citing works
Hu, J., Adar, S., Selby, C. P., Lieb, J. D., & Sancar, A. (2015) · Genes & Development · doi:10.1101/gad.261271.115 · Cited by 249 · see citing works
Cell cycle regulation of human DNA repair and chromatin remodeling genes
Mjelle, R., Hegre, S. A., Aas, P. A., Slupphaug, G., Drabløs, F., Sætrom, P., & Krokan, H. E. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.03.007 · Cited by 203 · see citing works
Transcriptional elongation requires DNA break-induced signalling
Bunch, H., Lawney, B. P., Lin, Y., Asaithamby, A., Murshid, A., Wang, Y. E., Chen, B. P. C., & Calderwood, S. K. (2015) · Nature Communications · doi:10.1038/ncomms10191 · Cited by 203 · see citing works
Not breathing is not an option: How to deal with oxidative DNA damage
Markkanen, E. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.09.007 · Cited by 192 · see citing works
DSBCapture: in situ capture and sequencing of DNA breaks
Lensing, S. V., Marsico, G., Hänsel‐Hertsch, R., Lam, E. Y. N., Tannahill, D., & Balasubramanian, S. (2016) · Nature Methods · doi:10.1038/nmeth.3960 · Cited by 155 · see citing works
At the intersection of DNA damage and immune responses
Bednarski, J. J., & Sleckman, B. P. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0135-6 · Cited by 154 · see citing works
Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters
Fleming, A. M., & Burrows, C. J. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b11050 · Cited by 152 · see citing works
8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis
Fleming, A. M., & Burrows, C. J. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.06.009 · Cited by 142 · see citing works
Ligand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
Puc, J., Koźbiał, P., Li, W., Tan, Y., Liu, Z., Suter, T., Ohgi, K. A., Zhang, J., Aggarwal, A. K., & Rosenfeld, M. G. (2015) · Cell · doi:10.1016/j.cell.2014.12.023 · Cited by 139 · see citing works
Formation and processing of DNA damage substrates for the hNEIL enzymes
Fleming, A. M., & Burrows, C. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.030 · Cited by 127 · see citing works
Amente, S., Di Palo, G., Scala, G., Castrignanò, T., Gorini, F., Cocozza, S., Moresano, A., Pucci, P., Ma, B., Stepanov, I., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1152 · Cited by 123 · see citing works
APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer
Periyasamy, M., Patel, H., Lai, C., Nguyen, V. T. M., Nevedomskaya, E., Harrod, A., Russell, R., Reményi, J., Ochocka, A. M., Thomas, R. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.066 · Cited by 110 · see citing works
RNA Processing and Genome Stability: Cause and Consequence
Wickramasinghe, V. O., & Venkitaraman, A. R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.001 · Cited by 107 · see citing works
Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models
Wheeler, V. C., & Dion, V. (2021) · Journal of Huntington s Disease · doi:10.3233/jhd-200426 · Cited by 83 · see citing works
Active DNA demethylation by DNA repair: Facts and uncertainties
Schuermann, D., Weber, A. R., & Schär, P. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.013 · Cited by 82 · see citing works
Human NEIL3 Gene Expression Regulated by Epigenetic-Like Oxidative DNA Modification
Fleming, A. M., Zhu, J., Manage, S. A. H., & Burrows, C. J. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01847 · Cited by 68 · see citing works
Transcription and DNA Damage: Holding Hands or Crossing Swords?
D’Alessandro, G., & di Fagagna, F. D. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.11.002 · Cited by 66 · see citing works
Transcriptional Repressor ZBTB1 Promotes Chromatin Remodeling and Translesion DNA Synthesis
Kim, H., Dejsuphong, D., Adelmant, G., Ceccaldi, R., Yang, K., Marto, J. A., & D’Andrea, A. D. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.02.017 · Cited by 58 · see citing works
A critical role for topoisomerase IIb and DNA double strand breaks in transcription
Calderwood, S. K. (2016) · Transcription · doi:10.1080/21541264.2016.1181142 · Cited by 57 · see citing works
Combinatorial control of plant gene expression
Brkljacić, J., & Erich Grotewold, A. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.07.005 · Cited by 56 · see citing works
Single-molecule imaging of transcription at damaged chromatin
Vítor, A. C., Sridhara, S. R. C., Sabino, J. C., Afonso, A., Grosso, A. R., Martin, R. M., & de Almeida, S. F. (2019) · Science Advances · doi:10.1126/sciadv.aau1249 · Cited by 56 · see citing works
The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells
Fong, Y. W., Ho, J. J., Inouye, C. J., & Tjian, R. (2014) · eLife · doi:10.7554/elife.03573 · Cited by 54 · see citing works
Self-citationZuchegna, C., Aceto, F., Bertoni, A., Romano, A., Perillo, B., Laccetti, P., Gottesman, M. E., Avvedimento, E. V., & Porcellini, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku823 · Cited by 51 · see citing works
Redstone, S. C. J., Fleming, A. M., & Burrows, C. J. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00332 · Cited by 51 · see citing works
Dobersch, S., Rubio, K., Singh, I., Günther, S., Graumann, J., Cordero, J., Castillo‐Negrete, R., Huynh, M. B., Mehta, A., Braubach, P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21227-y · Cited by 50 · see citing works
Nathansen, J., Lukiyanchuk, V., Hein, L., Stolte, M.-I., Borgmann, K., Löck, S., Kurth, I., Baumann, M. A., Krause, M., Linge, A., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01842-1 · Cited by 50 · see citing works
Targeted DNA oxidation by LSD1–SMAD2/3 primes TGF-β1/ EMT genes for activation or repression
Pezone, A., Taddei, M. L., Tramontano, A., Dolcini, J., Boffo, F. L., Rosa, M. D., Parri, M., Stinziani, S., Comito, G., Porcellini, A., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa599 · Cited by 42 · see citing works
Adam, S., & Polo, S. E. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.07.017 · Cited by 41 · see citing works
Fischer, F., Grigolon, G., Benner, C., & Ristow, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00017.2021 · Cited by 41 · see citing works
Reprogramming transcription after DNA damage: recognition, response, repair, and restart
Lu, H., Yang, M., & Zhou, Q. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.11.010 · Cited by 40 · see citing works
Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin
Ziani, S., Nagy, Z., Alekseev, S., Soutoglou, E., Egly, J., & Coin, F. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201403096 · Cited by 40 · see citing works
The Fragile X Protein and Genome Function
Dockendorff, T. C., & Labrador, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1122-9 · Cited by 40 · see citing works
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation
Bordin, D. L., Lirussi, L., & Nilsen, H. L. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103051 · Cited by 37 · see citing works
Flach, J., Jann, J.-C., Knaflic, A., Riabov, V., Streuer, A., Altrock, E., Xu, Q., Schmitt, N., Obländer, J., Nowak, V., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.254193 · Cited by 36 · see citing works
DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription
Semer, M., Bidon, B., Larnicol, A., Caliskan, G., Catez, P., Egly, J., Coin, F., & May, N. L. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0354-y · Cited by 35 · see citing works
Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters
Piett, C. G., Pecen, T. J., Laverty, D. J., & Nagel, Z. D. (2021) · Nature Protocols · doi:10.1038/s41596-021-00577-3 · Cited by 35 · see citing works
Elevated glucose increases genomic instability by inhibiting nucleotide excision repair
Ciminera, A. K., Shuck, S. C., & Termini, J. S. (2021) · Life Science Alliance · doi:10.26508/lsa.202101159 · Cited by 33 · see citing works
Flach, K. D., Periyasamy, M., Jadhav, A., Dorjsuren, D. G., Siefert, J. C., Hickey, T. E., Opdam, M., Patel, H., Canisius, S., Wilson, D. M., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2207 · Cited by 32 · see citing works
Fleming, A. M., Manage, S. A. H., & Burrows, C. J. (2021) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.1c00031 · Cited by 32 · see citing works
Orchestral maneuvers at the damaged sites in nucleotide excision repair
Alekseev, S., & Coin, F. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1859-5 · Cited by 31 · see citing works
Gowrishankar, J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004909 · Cited by 31 · see citing works
Function of transcription factors at DNA lesions in DNA repair
Malewicz, M., & Perlmann, T. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.032 · Cited by 31 · see citing works
Fleming, A. M., Zhu, J., Ding, Y., Esders, S., & Burrows, C. J. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00041 · Cited by 29 · see citing works
Liu, Z., Lam, N., & Thiele, C. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4733 · Cited by 27 · see citing works
Mandemaker, I. K., Vermeulen, W., & Marteijn, J. A. F. (2014) · Nucleus · doi:10.4161/nucl.29085 · Cited by 27 · see citing works
Malfatti, M. C., Antoniali, G., Codrich, M., Burra, S., Mangiapane, G., Dalla, E., & Tell, G. (2019) · Mutagenesis · doi:10.1093/mutage/gez051 · Cited by 26 · see citing works
Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses
Weems, J. C., Slaughter, B. D., Unruh, J. R., Hall, S. M., McLaird, M. B., Gilmore, J. M., Washburn, M. P., Florens, L. A., Yasukawa, T., Aso, T., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.632794 · Cited by 26 · see citing works
Stress Marks on the Genome: Use or Lose?
Bokhari, B. T., & Sharma, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020364 · Cited by 26 · see citing works
Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response
Wei, F., Peng, H., Zhang, X., Hu, H., Jiang, D., Yin, A., Wen, L., Zheng, L., He, J., Mei, W., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24517 · Cited by 25 · see citing works
Non-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage Signaling
Francia, S. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00320 · Cited by 25 · see citing works
Tomasini, P. P., Guecheva, T. N., Leguisamo, N. M., Péricart, S., Brunac, A., Hoffmann, J., & Saffi, J. (2021) · Cancers · doi:10.3390/cancers13133130 · Cited by 24 · see citing works
Super hotspots and super coldspots in the repair of UV-induced DNA damage in the human genome
Jiang, Y., Li, W., Lindsey‐Boltz, L. A., Yang, Y., Li, Y., & Sancar, A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100581 · Cited by 24 · see citing works
Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23 · see citing works
Intrinsically disordered proteins and phenotypic switching: Implications in cancer
Kulkarni, V., & Kulkarni, P. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.03.013 · Cited by 23 · see citing works
Spotlight on histone H2A variants: From B to X to Z
Herchenröther, A., Wunderlich, T. M., Lan, J., & Hake, S. B. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.025 · Cited by 22 · see citing works
The yeast Hot1 transcription factor is critical for activating a single target gene,STL1
Bai, C. G., Tesker, M., & Engelberg, D. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-12-1626 · Cited by 22 · see citing works
DNA Glycosylases Define the Outcome of Endogenous Base Modifications
Lirussi, L., & Nilsen, H. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210307 · Cited by 20 · see citing works
Role of genome guardian proteins in transcriptional elongation
Bunch, H. (2016) · FEBS Letters · doi:10.1002/1873-3468.12152 · Cited by 20 · see citing works
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1
Cao, J., Cao, C., Lin, J., Li, S., He, L., Han, K., Chen, J., Li, S., Wang, X., Xie, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113654 · Cited by 18 · see citing works
Cancer-associated transcription factors in DNA damage response
Kciuk, M., Gielecińska, A., Kołat, D., Kałuzińska‐Kołat, Ż., & Kontek, R. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188757 · Cited by 18 · see citing works
Fleming, A. M., & Burrows, C. J. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103789 · Cited by 17 · see citing works
Alemasova, E. E., & Lavrik, O. I. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-2-4-16 · Cited by 17 · see citing works
Duan, Z., Andrews, N. P., Chen, C., Fan, M., Wang, J., Shen, J., Li, J. J., & Chen, H. (2019) · Oncology Reports · doi:10.3892/or.2019.7418 · Cited by 16 · see citing works
Goncalves, M. B. C. V., Moehlin, J., Clarke, E. E., Grist, J., Hobbs, C., Carr, A. M., Jack, J., Mendoza-Parra, M. A., & Corcoran, J. P. T. (2019) · iScience · doi:10.1016/j.isci.2019.09.020 · Cited by 15 · see citing works
Manage, S. A. H., Zhu, J., Fleming, A. M., & Burrows, C. J. (2023) · RSC Chemical Biology · doi:10.1039/d2cb00233g · Cited by 15 · see citing works
Global DNA 5-hydroxymethylcytosine level and its chromosomal distribution in four rye species
Kalinka, A., Starczak, M., Gackowski, D., Stępień, E., & Achrem, M. (2023) · Journal of Experimental Botany · doi:10.1093/jxb/erad102 · Cited by 13 · see citing works
Penrad‐Mobayed, M., Perrin, C., Herman, L., Todeschini, A., Nigon, F., Cosson, B., Caburet, S., & Veitia, R. A. (2019) · The FASEB Journal · doi:10.1096/fj.201901573r · Cited by 13 · see citing works
Vizoso‐Vázquez, Á., Maceiras, M. L., Fernández-Leiro, R., Rico‐Díaz, A., Becerra, M., & Cerdán, M. E. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.11.005 · Cited by 11 · see citing works
Perfecting DNA double-strand break repair on transcribed chromatin
Tan, X. Y., & Huen, M. S. Y. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190094 · Cited by 11 · see citing works
Choi, E., Vodnala, M., Zerbato, M., Wang, J., Ho, J. J., Inouye, C. J., Ding, L., & Fong, Y. W. (2021) · Science Advances · doi:10.1126/sciadv.abk2775 · Cited by 11 · see citing works
Self-citationStagni, V., Orecchia, S., Mignini, L., Beji, S., Antonioni, A., Caggiano, C., Barilà, D., Bielli, P., & Sette, C. (2022) · Cancers · doi:10.3390/cancers14163847 · Cited by 11 · see citing works
Low complexity domains, condensates, and stem cell pluripotency
Vodnala, M., Choi, E., & Fong, Y. W. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i5.416 · Cited by 9 · see citing works
Self-citationRubio-Peña, K., Fontrodona, L., Aristizábal-Corrales, D., Torres, S., Cornes, E., García-Rodríguez, F. J., Serrat, X., González-Knowles, D., Foissac, S., Porta-de-la-Riva, M., et al. (2015) · RNA · doi:10.1261/rna.053397.115 · Cited by 9 · see citing works
Transcription-Associated Compositional Skews in Drosophila Genes
Bergman, J., Betancourt, A. J., & Vogl, C. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx200 · Cited by 7 · see citing works
Thomas, L. R., & Tansey, W. P. (2015) · The Open Access Journal of Science and Technology · doi:10.11131/2015/101124 · Cited by 7 · see citing works
Pradeep, R., Shanmugam, G., Rakshit, S., & Sarkar, K. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155026 · Cited by 6 · see citing works
Pradeep, R., Rakshit, S., Shanmugam, G., George, M., & Sarkar, K. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110204 · Cited by 5 · see citing works
Zhang, C., Lu, Y., Chen, B., Bai, Z., Zeng, Q., Hervieu, A., Licciardello, M. P., Mitsopoulos, K., Al‐Lazikani, B., Tortorici, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69679-4 · Cited by 5 · see citing works
The Role of ATP-Binding Cassette Proteins in Stem Cell Pluripotency
Saini, P., Anugula, S., & Fong, Y. W. (2023) · Biomedicines · doi:10.3390/biomedicines11071868 · Cited by 4 · see citing works
Self-citationCoupling between nucleotide excision repair and gene expression
Botto, A. E. C., Muñoz, J. C., & Muñoz, M. J. (2018) · RNA Biology · doi:10.1080/15476286.2018.1464354 · Cited by 3 · see citing works
Lun, M. P., Shannon, M. L., Keleş, S., Reisli, İ., Luche, N. M., Ryan, D., Capuder, K., Notarangelo, L. D., & Lehtinen, M. K. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.08.010 · Cited by 3 · see citing works
Creative damage unleashes transcription
Calderwood, S. K. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1154370 · Cited by 3 · see citing works
Eukaryotic Gene Expression by RNA Polymerase II
Durairaj, G., Malik, S., & Bhaumik, S. R. (2017) · Wiley eBooks · doi:10.1002/9783527697274.ch1 · Cited by 3 · see citing works
Data-driven design of targeted gene panels for estimating immunotherapy biomarkers
Bradley, J., & Cannings, T. I. (2022) · Communications Biology · doi:10.1038/s42003-022-03098-1 · Cited by 2 · see citing works
A Novel Spo11 Homologue Functions as a Positive Regulator in Cyst Differentiation in Giardia lamblia
Chen, Y.-C., Tung, S.-Y., Huang, C., Gan, S. W., Lin, B.-C., Chen, C.-W., Lin, Z., & Sun, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111902 · Cited by 2 · see citing works
RNA polymerase II drives FUS and EWSR1 exclusion from damaged chromatin
Varhoshkova, S., Sang, C. C., Antonova, L., Uzunova, S., Kirova, D. G., Aleksandrov, R., Kanemaki, M. T., Lee, H. O., & Stoynov, S. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117236 · Cited by 1 · see citing works
Regulating Transcription Traffic around DSBs
Plosky, B. S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.04.029 · Cited by 1 · see citing works
Darwinian Principles Acting on Highly Mutable Viruses
Domingo, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800837-9.00003-4 · Cited by 1 · see citing works
Mechanisms of Recurrent Chromosomal Translocations
Frock, R. L., Hu, J., & Alt, F. W. (2015) · Springer eBooks · doi:10.1007/978-3-319-19983-2_3 · Cited by 1 · see citing works
KDM4-dependent DNA breaks at active promoters facilitate +1 nucleosome evictionPreprint
Imre, L., Nánási, P. P., Szatmári, I., Kókai, E., Austin, C. A., Dombrádi, V., & Szabó, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.14.548993 · Cited by 1 · see citing works
Direct real-time correlation of protein conformation and substrate recognition
Ghoneim, M. (2015) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Darwinian principles acting on highly mutable viruses
Domingo, E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816331-3.00003-9
Stern, J. L., Rizzardi, L. F., & Gassman, N. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614488
- Authors
- Fong, Y. W., Cattoglio, C., & Tjian, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Tjian, Robert
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 52
- Issue
- 3
- Pages
- 291-302
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3919531
- OpenAlex
- W2078753112
- Cited by
- 106
- References
- 114
- Citations by year
- 2026: 4 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 12 · 2020: 5 · 2019: 15 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 9
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (R37CA025417)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- transcription, DNA repair, transcriptional fidelity, genome stability, DNA damage, transcriptional coactivator, DNA double-strand breaks, mutagenesis
- MeSH terms
- Animals, DNA, DNA Damage, DNA Repair, Humans, Promoter Regions, Genetic, Proteins, Transcription, Genetic, Genomic Instability, DNA Breaks, Double-Stranded
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review