Cited by 106DNA Repair MechanismsGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

The Intertwined Roles of Transcription and Repair Proteins

Open access
Fong, Yick W., Cattoglio, Claudia, Tjian, Robert·2013·Molecular Cell

Abstract

Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to repair DNA lesions that could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point to an even more direct function of DNA repair complexes as coactivators of transcription and the unexpected role of "scheduled" DNA damage/repair at gene promoters. Paradoxically, spontaneous DNA double-strand breaks also induce ectopic transcription that is essential for repair. Thus, transcription, DNA damage, and repair may be more physically and functionally intertwined than previously appreciated.

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Crossref · 10.1016/j.molcel.2013.10.018

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  • ATR is the main regulator of nucleotide excision repair because it detects replication and transcription stress caused by UV-induced and other bulky DNA adducts.

    “Although it functions in multiple DDR processes 21 ATR is the primary regulator of the nucleotide excision repair pathway due to its ability to detect the replicative and transcriptional stresses caused by UV-induced damage and other bulky DNA adducts resulting from chemical toxins and some chemotherapeutic agents 22–25.”

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Authors
Fong, Y. W., Cattoglio, C., & Tjian, R.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Tjian, Robert
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2013-11
Volume
52
Issue
3
Pages
291-302
ISSN
1097-2765 (ISSN-L)
OpenAlex
W2078753112
Cited by
106
References
114
Citations by year
2026: 4 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 12 · 2020: 5 · 2019: 15 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 9
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • Molecular Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Cancer Institute (R37CA025417)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
transcription, DNA repair, transcriptional fidelity, genome stability, DNA damage, transcriptional coactivator, DNA double-strand breaks, mutagenesis
MeSH terms
Animals, DNA, DNA Damage, DNA Repair, Humans, Promoter Regions, Genetic, Proteins, Transcription, Genetic, Genomic Instability, DNA Breaks, Double-Stranded

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