The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation
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“Mutant p53 has been proven to inhibit autophagy via different mechanisms.163–166”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [163]
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“The DBD of mutant p53 interacts with the AMPKα1 and AMPKα2 subunits, whereas the NTD disturbs the interaction between AMPKα and its upstream kinase LKB1 to inhibit autophagy by preventing AMPK phosphorylation and activation.163”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [163]
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · cited 3×
“Moreover, once activated, wtp53 can, in turn, increase AMPK activity through transcriptional activation of the gene encoding the b subunit of AMPK (Feng et al., 2007) and sestrin (Budanov and Karin, 2008), providing a positive feedback effect to AMPK function.”
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308
Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633
Winder, W. W., Wilson, H. A., Hardie, D. G., Rasmussen, B. B., Hutber, C. A., Call, G. B., Clayton, R. D., Conley, L. M., Yoon, S., & Zhou, B. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.1.219 · Cited by 237
Research works printed but not linked: 36
- Acin, 2011, Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras, J. Pathol., 225, 479, 10.1002/path.2971 · DOI
- Agrawal, 2011, Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1, Science, 333, 1154, 10.1126/science.1206923 · DOI · Paper page
- Berkers, 2013, Metabolic regulation by p53 family members, Cell Metab., 18, 617, 10.1016/j.cmet.2013.06.019 · DOI · Paper page
- Bertout, 2009, Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model, Cancer Res., 69, 3213, 10.1158/0008-5472.CAN-08-4223 · DOI
- DeBerardinis, 2012, Cellular metabolism and disease: what do metabolic outliers teach us?, Cell, 148, 1132, 10.1016/j.cell.2012.02.032 · DOI · Paper page
- Esfandiari, 2007, S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet, Alcohol. Clin. Exp. Res., 31, 1231, 10.1111/j.1530-0277.2007.00407.x · DOI
- Faubert, 2013, AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo, Cell Metab., 17, 113, 10.1016/j.cmet.2012.12.001 · DOI · Paper page
- Feng, 2010, The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein, Trends Cell Biol., 20, 427, 10.1016/j.tcb.2010.03.004 · DOI · Paper page
- Fogarty, 2010, Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer, Biochim. Biophys. Acta, 1804, 581, 10.1016/j.bbapap.2009.09.012 · DOI · Paper page
- Freed-Pastor, 2012, Mutant p53: one name, many proteins, Genes Dev., 26, 1268, 10.1101/gad.190678.112 · DOI · Paper page
- Freed-Pastor, 2012, Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway, Cell, 148, 244, 10.1016/j.cell.2011.12.017 · DOI · Paper page
- Goldstein, 2012, Regulation of lipid metabolism by p53—fighting two villains with one sword, Trends Endocrinol. Metab., 23, 567, 10.1016/j.tem.2012.06.007 · DOI
- Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 · DOI · Paper page
- Hardie, 2002, Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase, Biochem. Soc. Trans., 30, 1064, 10.1042/bst0301064 · DOI · Paper page
- Hawley, 1996, Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase, J. Biol. Chem., 271, 27879, 10.1074/jbc.271.44.27879 · DOI · Paper page
- He, 2014, AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity, Mol. Cell. Biol., 34, 148, 10.1128/MCB.00670-13 · DOI
- Jones, 2005, AMP-activated protein kinase induces a p53-dependent metabolic checkpoint, Mol. Cell, 18, 283, 10.1016/j.molcel.2005.03.027 · DOI · Paper page
- Kamat, 2007, Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia, Cancer Lett., 249, 209, 10.1016/j.canlet.2006.08.017 · DOI
- Kodiha, 2007, Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK→ERK1/2 pathway, Am. J. Physiol. Cell Physiol., 293, C1427, 10.1152/ajpcell.00176.2007 · DOI
- Lang, 2004, Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome, Cell, 119, 861, 10.1016/j.cell.2004.11.006 · DOI · Paper page
- Lee, 2012, AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells, Cancer Res., 72, 4394, 10.1158/0008-5472.CAN-12-0429 · DOI · Paper page
- Li, 2007, Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?, Oncogene, 26, 2220, 10.1038/sj.onc.1210311 · DOI · Paper page
- Li, 2011, AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice, Cell Metab., 13, 376, 10.1016/j.cmet.2011.03.009 · DOI · Paper page
- Luo, 2010, AMPK as a metabolic tumor suppressor: control of metabolism and cell growth, Future Oncol., 6, 457, 10.2217/fon.09.174 · DOI · Paper page
- Morselli, 2008, Mutant p53 protein localized in the cytoplasm inhibits autophagy, Cell Cycle, 7, 3056, 10.4161/cc.7.19.6751 · DOI · Paper page
- Muller, 2013, p53 mutations in cancer, Nat. Cell Biol., 15, 2, 10.1038/ncb2641 · DOI · Paper page
- Nicholls, 2010, Bioenergetic profile experiment using C2C12 myoblast cells, J. Vis. Exp, 10.3791/2511 · DOI · Paper page
- Okoshi, 2008, Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress, J. Biol. Chem., 283, 3979, 10.1074/jbc.M705232200 · DOI · Paper page
- Oren, 2010, Mutant p53 gain-of-function in cancer, Cold Spring Harb. Perspect. Biol., 2, a001107, 10.1101/cshperspect.a001107 · DOI · Paper page
- Sano, 2011, Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer, Clin. Cancer Res., 17, 6658, 10.1158/1078-0432.CCR-11-0046 · DOI
- Solomon, 2012, Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature, J. Cell Sci., 125, 3144
- Stommel, 1999, A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking, EMBO J., 18, 1660, 10.1093/emboj/18.6.1660 · DOI · Paper page
- Stransky, 2011, The mutational landscape of head and neck squamous cell carcinoma, Science, 333, 1157, 10.1126/science.1208130 · DOI · Paper page
- Su, 2012, TAp63 is a master transcriptional regulator of lipid and glucose metabolism, Cell Metab., 16, 511, 10.1016/j.cmet.2012.09.006 · DOI
- Tsou, 2011, A fluorescent reporter of AMPK activity and cellular energy stress, Cell Metab., 13, 476, 10.1016/j.cmet.2011.03.006 · DOI · Paper page
- Xu, 2011, Gain of function of mutant p53 by coaggregation with multiple tumor suppressors, Nat. Chem. Biol., 7, 285, 10.1038/nchembio.546 · DOI · Paper page
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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Butler, L. M., Perone, Y., Dehairs, J., Lupien, L. E., de Laat, V., Talebi, A., Loda, M., Kinlaw, W. B., & Swinnen, J. V. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.013 · Cited by 589
Gain-of-function mutant p53 in cancer progression and therapy
Zhang, C., Liu, J., Xu, D., Zhang, T., Hu, W., & Feng, Z. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa040 · Cited by 334
Clinical Overview of MDM2/X-Targeted Therapies
Burgess, A., Chia, K. M., Haupt, S., Thomas, D., Haupt, Y., & Lim, E. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00007 · Cited by 315
Soussi, T., & Wiman, K. G. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.53 · Cited by 305
Tumor suppressor p53 and metabolism
Liu, J., Zhang, C., Hu, W., & Feng, Z. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy070 · Cited by 300
Metadata
- Authors
- Zhou, G., Wang, J., Zhao, M., Xie, T.-X., Tanaka, N., Sano, D., Patel, A. A., Ward, A. M., Sandulache, V. C., Jasser, S. A., Skinner, H. D., Fitzgerald, A. L., Osman, A. A., Wei, Y., Xia, X., Songyang, Z., Mills, G. B., Hung, M.-C., Caulin, C., Liang, J., & Myers, J. N.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 54
- Issue
- 6
- Pages
- 960-974
- ISSN
- 1097-2765
- Cited by
- 235
- References
- 11
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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