Cited by 322

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Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1

Yamano, Takashi, Zetsche, Bernd, Ishitani, Ryuichiro, Zhang, Feng, Nishimasu, Hiroshi, Nureki, Osamu·2017·Molecular Cell

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Crossref · 10.1016/j.molcel.2017.06.035

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  • LbCpf1 and AsCpf1 have higher targeting specificity in mammalian cells than SpCas9, as measured through Digenome-Seq analysis.

    “Cas12a (type-V Cpf1) from Lachnospiraceae bacterium ND2006 (LbCpf1) and Acidaminococcus sp. BV3L6 (AsCpf1) have many differences from SpCas9, but they are gaining popularity because they have higher targeting specificity in mammalian cells, as measured through Digenome-Seq analysis [74,75].”

    From Viral Delivery Systems for CRISPR (2019) · cites this paper as [75]

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Citations

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Research works printed but not linked: 36

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Metadata

Authors
Yamano, T., Zetsche, B., Ishitani, R., Zhang, F., Nishimasu, H., & Nureki, O.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2017-08
Volume
67
Issue
4
Pages
633-645.e3
ISSN
1097-2765
Cited by
322
References
9
Language
en
Funders
  • Japan Society for the Promotion of Science (15H01463, 26291010)
  • National Institutes of Health
  • Ministry of Education, Culture, Sports, Science and Technology
  • National Institute of Mental Health (1R01-MH110049, 5DP1-MH100706)
  • Japan Science and Technology Agency
  • National Institute of Diabetes and Digestive and Kidney Diseases (5R01DK097768-03)
  • Precursory Research for Embryonic Science and Technology (JPMJPR13L8)
  • Japan Agency for Medical Research and Development
  • Vallee Foundation

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