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The tripartite synapse: roles for gliotransmission in health and disease
Abstract
In addition to being essential supporters of neuronal function, astrocytes are now recognized as active elements in the brain. Astrocytes sense and integrate synaptic activity and, depending on intracellular Ca(2+) levels, release gliotransmitters (e.g. glutamate, d-serine and ATP) that have feedback actions on neurons. Recent experimental results have raised the possibility that quantitative variations in gliotransmission might contribute to disorders of the nervous system. Here, we discuss targeted molecular genetic approaches that have demonstrated that alterations in protein expression in astrocytes can lead to serious changes in neuronal function. We also introduce the concept of 'astrocyte activation spectrum' in which enhanced and reduced gliotransmission might contribute to epilepsy and schizophrenia, respectively. The results of future experimental tests of the astrocyte activation spectrum, which relates gliotransmission to neurological and psychiatric disorders, might point to a new therapeutic target in the brain.
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“Glial/CSPG cluster abnormalities may thus represent a contributing factor to dysregulated glutamatergic transmission, and more broadly to neuron/glia interactions, in major psychoses.15, 22, 105, 106”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [22]
Citations
Cites
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529
Self-citationCurrents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004717 · Cited by 2,466
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
Tsien, R. Y. (1980) · Biochemistry · doi:10.1021/bi00552a018 · Cited by 2,261
The Fine Structure of the Nervous System.
Tennyson, V. M. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480240094019 · Cited by 1,946
Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,837
Glutamate-mediated astrocyte–neuron signalling
Parpura, V., Basarsky, T. A., Liu, F., Jeftinija, K., Jeftinija, S., & Haydon, P. G. (1994) · Nature · doi:10.1038/369744a0 · Cited by 1,768
Self-citationEpilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) · Science · doi:10.1126/science.276.5319.1699 · Cited by 1,755
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715
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Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Pathological and protective roles of glia in chronic pain
Milligan, E. D., & Watkins, L. R. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2533 · Cited by 1,443
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
Halassa, M. M., & Haydon, P. G. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135843 · Cited by 763
Self-citationEvidence for a cytokine model of cognitive function
McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760
Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability
Vezzani, A., & Viviani, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.027 · Cited by 670
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
Interaction of Microglia and Astrocytes in the Neurovascular Unit
Liu, L., Liu, J., Bao, J.-S., Bai, Q.-Q., & Wang, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01024 · Cited by 624
What Is the Role of Astrocyte Calcium in Neurophysiology?
Agulhon, C., Petravicz, J., McMullen, A. B., Sweger, E. J., Minton, S. K., Taves, S., Casper, K. B., Fiacco, T. A., & McCarthy, K. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.004 · Cited by 591
González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 541
The Indispensable Roles of Microglia and Astrocytes during Brain Development
Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516
Olabarria, M., Noristani, H. N., Verkhratsky, A., & Rodríguez, J. J. (2010) · Glia · doi:10.1002/glia.20967 · Cited by 499
Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
Newman, L. A., Korol, D. L., & Gold, P. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028427 · Cited by 492
Astrocytes in Alzheimer's Disease
Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 470
Glutamatergic Mechanisms Associated with Seizures and EpilepsyPreprint
Barker‐Haliski, M. L., & White, H. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022863 · Cited by 459
Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1
Morel, L., Regan, M., Higashimori, H., Ng, S. K., Esau, C., Vidensky, S., Rothstein, J., & Yang, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410944 · Cited by 430
Functions of astrocytes and their potential as therapeutic targets
Kimelberg, H., & Nedergaard, M. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.006 · Cited by 423
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Rodriguez, J. J., Olabarria, M., Chvátal, A., & Verkhratsky, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.172 · Cited by 409
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Bélanger, M., & Magistretti, P. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/mbelanger · Cited by 396
Astrocytes in the Epileptic Brain
Wetherington, J. P., Serrano, G. E., & Dingledine, R. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.002 · Cited by 391
Presynaptic glutamate receptors: physiological functions and mechanisms of action
Pinheiro, P. S., & Mulle, C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2379 · Cited by 368
Neurobiology of depression, fibromyalgia and neuropathic pain
Maletic, V. (2009) · Frontiers in bioscience · doi:10.2741/3598 · Cited by 384
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
Hampel, H., Caraci, F., Cuello, A. C., Caruso, G., Nisticò, R., Corbo, M., Baldacci, F., Toschi, N., Garaci, F., Chiesa, P. A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00456 · Cited by 360
“Indeed, depending on the fluctuations of intracellular Ca2+ concentrations, they release gliotransmitters, such as glutamate, D-serine, and ATP, which have feedback actions on neurons (77).”
BackgroundTREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation
Woo, D. H., Han, K.-S., Shim, J. W., Yoon, B., Kim, E., Bae, J. Y., Oh, S., Hwang, E. M., Marmorstein, A. D., Bae, Y. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.005 · Cited by 350
Men, Y., Yelick, J., Jin, S., Tian, Y., Chiang, M. S. R., Higashimori, H., Brown, E., Jarvis, R., & Yang, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-11534-w · Cited by 357
Organization and Postembryonic Development of Glial Cells in the Adult Central Brain of Drosophila
Awasaki, T., Lai, S.-L., Ito, K., & Lee, T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4844-08.2008 · Cited by 345
Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects
Karimi-Abdolrezaee, S., & Billakanti, R. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8287-4 · Cited by 331
Wu, Z., Guo, Z., Gearing, M., & Chen, G. (2014) · Nature Communications · doi:10.1038/ncomms5159 · Cited by 306
Adenosine signaling and function in glial cells
Boison, D., Chen, J., & Fredholm, B. B. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.131 · Cited by 319
Neuroglia in neurodegeneration
Heneka, M. T., Rodriguez, J. J., & Verkhratsky, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.004 · Cited by 316
Pantazopoulos, H., Woo, T.-U. W., Lim, M. P., Lange, N., & Berretta, S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.196 · Cited by 296
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Filosa, A., Paixão, S., Honsek, S. D., Carmona, M. A., Becker, L., Feddersen, B., Gaitanos, L., Rudhard, Y., Schoepfer, R., Klopstock, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2394 · Cited by 283
Astrocyte dysfunction in epilepsy
Seifert, G., Carmignoto, G., & Steinhäuser, C. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.004 · Cited by 290
Li, L., Acioglu, C., Heary, R. F., & Elkabes, S. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.10.007 · Cited by 283
Adenosine Receptors and the Central Nervous System
Sebastião, A. M., & Ribeiro, J. A. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_16 · Cited by 271
Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex
Lalo, U., Palygin, O., Rasooli-Nejad, S., Andrew, J., Haydon, P. G., & Pankratov, Y. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001747 · Cited by 270
Self-citationAstroglial cradle in the life of the synapse
Verkhratsky, A., & Nedergaard, M. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0595 · Cited by 266
Molecular comparison of GLT1 + and ALDH1L1 + astrocytes in vivo in astroglial reporter mice
Yang, Y., Vidensky, S., Jin, L., Jie, C., Lorenzini, I., Frankl, M., & Rothstein, J. D. (2010) · Glia · doi:10.1002/glia.21089 · Cited by 264
IL-6 regulation of synaptic function in the CNS
Gruol, D. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.023 · Cited by 254
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
Martini-Stoica, H., Cole, A. L., Swartzlander, D. B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D. A., Lee, V. M. Y., Trojanowski, J. Q., Liu, Z., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20172158 · Cited by 253
Ultrasonic Neuromodulation via Astrocytic TRPA1
Oh, S., Lee, J. M., Kim, H., Lee, J., Han, S., Bae, J. Y., Hong, G., Koh, W., Kwon, J., Hwang, E., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.021 · Cited by 251
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Verkhratsky, A., Sofroniew, M. V., Messing, A., deLanerolle, N. C., Rempe, D. A., Rodriguez, J. J., & Nedergaard, M. (2012) · ASN NEURO · doi:10.1042/an20120010 · Cited by 254
Human astrocytes in the diseased brain
Dossi, E., Vasile, F., & Rouach, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.001 · Cited by 250
Motori, E., Puyal, J., Toni, N., Ghanem, A., Angeloni, C., Malaguti, M., Cantelli-Forti, G., Berninger, B., Conzelmann, K.-K., Götz, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.005 · Cited by 249
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
Tobinick, E. L., & Gross, H. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-2 · Cited by 250
Harada, K., Kamiya, T., & Tsuboi, T. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00499 · Cited by 267
Fellin, T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05830.x · Cited by 245
Self-citationRole of Astrocytes in EpilepsyPreprint
Coulter, D. A., & Steinhäuser, C. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022434 · Cited by 252
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Kofuji, P., & Araque, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.025 · Cited by 249
Figley, C. R., & Stroman, P. W. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07584.x · Cited by 246
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Yang, Y., Gozen, O., Watkins, A., Lorenzini, I., Lepore, A., Gao, Y., Vidensky, S., Brennan, J., Poulsen, D., Won Park, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.010 · Cited by 237
Cohen, S. M., Tsien, R. W., GOFF, D. C., & Halassa, M. M. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.026 · Cited by 249
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Boison, D. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.002 · Cited by 224
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Florian, C., Vecsey, C. G., Halassa, M. M., Haydon, P., & Abel, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5761-10.2011 · Cited by 202
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Blackburn, D. J., Sargsyan, S. A., Monk, P. N., & Shaw, P. J. (2009) · Glia · doi:10.1002/glia.20848 · Cited by 187
Pereira, A., & Furlan, F. A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.07.001 · Cited by 177
Binder, D., Nagelhus, E., & Ottersen, O. (2012) · Glia · doi:10.1002/glia.22317 · Cited by 164
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Agulhon, C., Sun, M.-Y., Murphy, T., Myers, T., Lauderdale, K., & Fiacco, T. A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00139 · Cited by 167
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Cunha, R. A. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.026 · Cited by 163
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Lines, J., Martín, E. D., Kofuji, P., Aguilar, J., & Araque, A. (2020) · Nature Communications · doi:10.1038/s41467-020-17536-3 · Cited by 164
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Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153
Chandrasekaran, A., Avci, H. X., Leist, M., Kobolák, J., & Dinnyés, A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00215 · Cited by 159
Haroon, E., & Miller, A. H. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_40 · Cited by 153
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Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150
Albuquerque, E. X., & Schwarcz, R. M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.12.014 · Cited by 150
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Jackson, J. G., & Robinson, M. B. (2017) · Glia · doi:10.1002/glia.23252 · Cited by 153
Sano, F., Shigetomi, E., Shinozaki, Y., Tsuzukiyama, H., Saito, K., Mikoshiba, K., Horiuchi, H., Cheung, D. L., Nabekura, J., Sugita, K., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.135391 · Cited by 147
Astroglia In Neurological Diseases
Verkhratsky, A., Rodríguez, J. J., & Parpura, V. (2013) · Future Neurology · doi:10.2217/fnl.12.90 · Cited by 140
New roles for the external globus pallidus in basal ganglia circuits and behavior
Gittis, A. H., Berke, J. D., Bevan, M. D., Chan, C. S., Mallet, N., Morrow, M. M., & Schmidt, R. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3252-14.2014 · Cited by 136
Physiology of neuronal–glial networking
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Metadata
- Authors
- Halassa, M. M., Fellin, T., & Haydon, P. G.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 13
- Issue
- 2
- Pages
- 54-63
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W1977294596
- Cited by
- 852
- References
- 94
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 30 · 2023: 26 · 2022: 39 · 2021: 68 · 2020: 44 · 2019: 33 · 2018: 45 · 2017: 34 · 2016: 71 · 2015: 52 · 2014: 50 · 2013: 57 · 2012: 56
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Epilepsy Society
- Epilepsy Foundation
- National Institute of Neurological Disorders and Stroke
- UCB Pharma
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- gliotransmission, astrocytes, glutamate release, D-serine, ATP release, intracellular calcium, synaptic activity, epilepsy, schizophrenia, neurological disorders, mental illness, therapeutic target
- MeSH terms
- Adenosine Triphosphate, Animals, Astrocytes, Epilepsy, Humans, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Schizophrenia, Spinal Cord Injuries, Synapses, Receptors, N-Methyl-D-Aspartate, Neurotransmitter Agents, Glutamic Acid, Calcium Signaling
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