Amino acids and mTORC1: from lysosomes to disease

Cited by (435)

Items 101–200 of 435

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3. Regulation of autophagy by mitochondrial phospholipids in health and diseases
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4. Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease
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5. Characteristics and requirements of basal autophagy in HEK 293 cells
   Patience Musiwaro, Matthew Denman Smith, Maria Manifava, Simon A. Walker, Nicholas T. Ktistakis · 2013 · Autophagy
6. Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
   Peng, Wesley, Minakaki, Georgia, Nguyen, Maria, Krainc, Dimitri · 2019 · Neurotherapeutics
7. Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis
   Jennifer A. Hollywood, Aneta J. Przepiorski, Randall F. D’Souza, Sreevalsan Sreebhavan, Ernst Jurgen Wolvetang, Patrick T. Harrison, Alan James Davidson, Teresa M. Holm · 2020 · Journal of the American Society of Nephrology
8. Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling
   Powis, Katie, Zhang, Tianlong, Panchaud, Nicolas, Wang, Rong, Virgilio, Claudio De, Ding, Jianping · 2015 · Cell Research
9. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
   Fredrick Joseph Rosario, Peter W. Nathanielsz, Theresa L. Powell, Thomas Jansson · 2017 · Scientific Reports
10. mTOR Links Environmental Signals to T Cell Fate Decisions
    Nicole M. Chapman, Hongbo Chi · 2015 · Frontiers in Immunology
11. Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation
    Victoria E. B. Hipolito, Jacqueline A. Diaz, Kristofferson V. Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Sarić, Shannon McLaughlan, Ola Segnestam Larsson, Ivan Topisirović et al. · 2019 · PLoS Biology
12. Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy
    Stacy A. Johnson, Robert F. Spurney · 2015 · American Journal of Physiology-Renal Physiology
13. The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein
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14. The Effects of Testosterone Deprivation and Supplementation on Proteasomal and Autophagy Activity in the Skeletal Muscle of the Male Mouse: Differential Effects on High-Androgen Responder and Low-Androgen Responder Muscle Groups
    Carlo Serra, Nicolae L. Sandor, Hyeran Jang, Daniel C. Lee, Gianluca Toraldo, Tyler Guarneri, Siu Wong, Anqi Zhang, Wen Guo, Ravi Jasuja et al. · 2013 · Endocrinology
15. Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D
    Suman Mukhopadhyay, Mahesh Saqcena, Amrita Chatterjee, Avalon Garcia, María A. Frías, David A. Foster · 2015 · Journal of Biological Chemistry
16. Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
    Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding · 2017 · Nature Communications
17. The Association between Circulating Branched Chain Amino Acids and the Temporal Risk of Developing Type 2 Diabetes Mellitus: A Systematic Review & Meta-Analysis
    Imran Ramzan, Arash Ardavani, Froukje Vanweert, Aisling Mellett, Philip James Atherton, ISKANDAR RAUF IDRIS · 2022 · Nutrients
18. CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation
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19. Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation
    Bodo Clemens Melnik, Swen Malte John, Pedro Carrera‐Bastos, Gerd Schmitz · 2016 · Clinical and Translational Allergy
20. Branched‐chain amino acids modulate the expression of hepatic fatty acid metabolism‐related genes in female broiler chickens
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21. Spatial and functional separation of mTORC1 signalling in response to different amino acid sources
    Stephanie Fernandes, Danai-Dimitra Angelidaki, Julian Nüchel, Jiyoung Pan, Peter Gollwitzer, Yoav Elkis, Filippo Artoni, Sabine Wilhelm, Marija Kovacevic-Sarmiento, Constantinos Demetriades · 2024 · Nature Cell Biology
22. Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors
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23. The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism
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24. Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids
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25. Evolutionarily conserved regulation of TOR signalling
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26. Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic Rewiring
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27. Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
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28. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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29. Regulation of mTOR by phosphatidic acid
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30. Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling
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31. Autophagy is required for G 1 /G 0 quiescence in response to nitrogen starvation in Saccharomyces cerevisiae
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32. Stress and Obesity as Risk Factors in Cardiovascular Diseases: A Neuroimmune Perspective
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33. Altered mTOR signalling in nephropathic cystinosis
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34. Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine
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35. Vacuolar H+-ATPase: An Essential Multitasking Enzyme in Physiology and Pathophysiology
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36. mTOR and metabolic regulation of conventional and regulatory T cells
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37. Rag GTPase in amino acid signaling
    Joungmok Kim, Eunjung Kim · 2016 · Amino Acids
38. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis
    Qiang Shao, Mei Yang, Liang Chen, Li Ma, Wei Zhang, Zhiwen Jiang, Jun Luo, Jae‐Kyung Lee, Chengyu Liang, Jian‐Fu Chen · 2019 · Autophagy
39. Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
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40. Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts
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41. The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo
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42. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation
    Tatyana Danyukova, Khandsuren Ariunbat, Melanie Thelen, Nahal Brocke‐Ahmadinejad, Sara Mole, Stephan Storch · 2018 · Human Molecular Genetics
43. Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion
    Kai Jin, Toshihiro Imada, Ryuji Hisamura, Masataka Ito, Haruki Toriumi, Kenji F. Tanaka, Shigeru Nakamura, Kazuo Tsubota · 2020 · American Journal Of Pathology
44. Wip1 phosphatase: between p53 and MAPK kinases pathways
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45. Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids
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46. Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS
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47. Endolysosomal Ca2+ Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!
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48. Translation regulation gets its ‘omics’ moment
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49. Discovery and development of small molecule modulators targeting glutamine metabolism
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50. Reciprocal Regulation of V-ATPase and Glycolytic Pathway Elements in Health and Disease
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51. Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism
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52. AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease
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53. Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve
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54. Targeted Metabolomic Analysis of a Mucopolysaccharidosis IIIB Mouse Model Reveals an Imbalance of Branched-Chain Amino Acid and Fatty Acid Metabolism
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55. mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication
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56. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging‐related diseases
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57. mTOR folate sensing links folate availability to trophoblast cell function
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58. Macropinosomes as units of signal transduction
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59. Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer’s Disease
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60. KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
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61. Acetate regulates milk fat synthesis through the mammalian target of rapamycin/eukaryotic initiation factor 4E signaling pathway in bovine mammary epithelial cells
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62. Emerging role for branched-chain amino acids metabolism in fibrosis
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64. mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR
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65. Arginine protects muscle cells from wasting in vitro in an mTORC1-dependent and NO-independent manner
    Daniel J. Ham, Marissa K. Caldow, Gordon Stuart Lynch, René Koopman · 2014 · Amino Acids
66. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila
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67. Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1
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68. βA3/A1-crystallin: More than a lens protein
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69. Key mediators of intracellular amino acids signaling to mTORC1 activation
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70. Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria
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72. Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma
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73. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
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74. Control of the translational machinery by amino acids
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75. Autophagy in renal tubular injury and repair
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76. RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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78. Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness
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79. Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach
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80. Metabolic regulation through the endosomal system
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81. Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids
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82. Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
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83. Deciphering the Role of the Coagulation Cascade and Autophagy in Cancer-Related Thrombosis and Metastasis
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84. Survival strategies of cancer cells: the role of macropinocytosis in nutrient acquisition, metabolic reprogramming, and therapeutic targeting
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85. p53 and rapamycin are additive
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86. Novel pharmacological modulators of autophagy: an updated patent review (2012-2015)
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87. Selective Lysosomal Transporter Degradation by Organelle Membrane Fusion
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88. Reliable Quantification of pH Variation in Live Cells Using Prussian Blue-Caged Surface-Enhanced Raman Scattering Probes
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90. MYC, Metabolic Synthetic Lethality, and Cancer
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91. Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2
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92. Ageing, cellular senescence and the impact of diet: an overview
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93. RES-529
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94. The potential mechanistic link between allergy and obesity development and infant formula feeding
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95. The IGF-1R/AKT pathway determines cell fate in response to p53
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96. Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells
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97. The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption
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98. Bolus vs. continuous feeding to optimize anabolism in neonates
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99. Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1
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100. The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer
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