Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Multiple sclerosis

Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,699

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599

Microglia Heterogeneity in the Single-Cell Era

Masuda, T., Sankowski, R., Staszewski, O., & Prinz, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.010 · Cited by 784

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

Werneburg, S., Jung, J., Kunjamma, R. B., Ha, S.-K., Luciano, N. J., Willis, C. M., Gao, G., Biscola, N. P., Havton, L. A., Crocker, S. J., et al. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.004 · Cited by 440

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Cignarella, F., Filipello, F., Bollman, B., Cantoni, C., Locca, A., Mikesell, R., Manis, M., Ibrahim, A., Deng, L., Benitez, B. A., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02193-z · Cited by 392

NLRP3 inflammasome in neuroinflammation and central nervous system diseases

Xu, W., Huang, Y., & Zhou, R. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01275-w · Cited by 355

Fatigue, Sleep, and Autoimmune and Related Disorders

Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 281

Potential Implications of Quercetin in Autoimmune Diseases

Shen, P., Lin, W., Deng, X., Ba, X., Han, L., Chen, Z., Qin, K., Huang, Y., & Tu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689044 · Cited by 240

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system

Yang, S., Qin, C., Hu, Z.-W., Zhou, L.-Q., Yu, H.-H., Chen, M., Bosco, D. B., Wang, W., Wu, L.-J., & Tian, D.-S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105290 · Cited by 232

Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy

Gao, Z., Zhang, C., Xia, N. L., Tian, H., Li, D., Lin, J., Mei, X., & Wu, C. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.018 · Cited by 224

The Role of GPNMB in Inflammation

Saade, M., Araujo de Souza, G., Scavone, C., & Kinoshita, P. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674739 · Cited by 216

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

Pangrazzi, L., Balasco, L., & Bozzi, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093293 · Cited by 226

The mechanism of ferroptosis and its related diseases

Feng, S., Tang, D., Wang, Y., Li, X., Bao, H., Tang, C., Dong, X., Li, X., Yang, Q., Yan, Y., et al. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00142-2 · Cited by 241

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

Theoharides, T. C., Cholevas, C., Polyzoidis, K. S., & Politis, A. M. (2021) · BioFactors · doi:10.1002/biof.1726 · Cited by 227

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Yshii, L., Pasciuto, E., Bielefeld, P., Mascali, L. G., Lemaître, P., Marino, M., Dooley, J., Kouser, L., Verschoren, S., Lagou, V., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01208-z · Cited by 221

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

Wu, A., Zhou, X., Qiao, G., Yu, L., Tang, Y., Yan, L., Qiu, W., Pan, R., Yu, C., Law, B. Y. K., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101202 · Cited by 196

Efficient Strategies for Microglia Replacement in the Central Nervous System

Xu, Z., Rao, Y., Huang, Y., Zhou, T. G., Feng, R., Xiong, S., Yuan, T., Qin, S., Lu, Y., Zhou, X., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108041 · Cited by 189

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182

CSF1R signaling is a regulator of pathogenesis in progressive MS

Hagan, N., Kane, J. L. J., Grover, D., Woodworth, L. A., Madore, C., Saleh, J., Sancho, J., Liu, J., Li, Y., Proto, J. D., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03084-7 · Cited by 168

Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges

Han, J., Chiţu, V., Stanley, E. R., Wszołek, Z. K., Karrenbauer, V. D., & Harris, R. A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04225-1 · Cited by 169

The role of glial cells in multiple sclerosis disease progression

Healy, L. M., Stratton, J. A., Kuhlmann, T., & Antel, J. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00624-x · Cited by 152

miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation

Jiao, P., Wang, X.-P., Luoreng, Z.-M., Yang, J., Jia, L., Ma, Y., & Wei, D.-W. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59876 · Cited by 151

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

Wang, J., Wang, J., Wang, J., Yang, B., Weng, Q., & He, Q. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00286 · Cited by 154

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

Zelic, M., Pontarelli, F., Woodworth, L. A., Zhu, C., Mahan, A. L., Ren, Y., LaMorte, M. J., Gruber, R. C., Keane, A. M., Loring, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109112 · Cited by 138

Multiple sclerosis: molecular pathogenesis and therapeutic intervention

Boutitah-Benyaich, I., Eixarch, H., Villacieros‐Álvarez, J., Hervera, A., Cobo‐Calvo, Á., Montalbán, X., & Espejo, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02415-4 · Cited by 149

Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress

Wang, X., Li, S., Yu, J., Wang, W., Du, Z., Gao, S. P., Ma, Y., Tang, R., Liu, T., Ma, S., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116729 · Cited by 126

Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination

Ronzano, R., Roux, T., Thétiot, M., Aigrot, M., Richard, L., Lejeune, F., Mazuir, E., Vallat, J., Lubetzki, C., & Desmazières, A. (2021) · Nature Communications · doi:10.1038/s41467-021-25486-7 · Cited by 122

Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders

Luo, G., Wang, X., Cui, Y., Cao, Y., Zhao, Z., & Zhang, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02318-5 · Cited by 115

Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases

Seok, J. K., Kang, H. C., Cho, Y., Lee, H. S., & Lee, J. Y. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01307-9 · Cited by 122

Relationship between inflammation and oxidative stress and its effect on multiple sclerosis

Ramos-González, E. J., Bitzer-Quintero, O. K., Ortíz, G. G., Hernández-Cruz, J. J., & Ramírez-Jirano, L. J. (2021) · Neurología · doi:10.1016/j.nrl.2021.10.003 · Cited by 127

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Xiong, Y., Chen, J., & Li, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1125428 · Cited by 114

Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders

Paudel, Y. N., Angelopoulou, E., Semple, B. D., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00640 · Cited by 107

Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases

Sun, Y., Xia, X., Basnet, D., Zheng, J., Huang, J., & Liu, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.904152 · Cited by 105

A Richer and More Diverse Future for Microglia Phenotype

Wang, J., He, W., & Zhang, J. (2022) · Heliyon · doi:10.1016/j.heliyon.2023.e14713 · Cited by 113

Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

Bondt, M. D., Hellings, N., Opdenakker, G., & Struyf, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124558 · Cited by 104

Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression

Tayab, M. A., Islam, M. N., Chowdhury, K. A. A., & Tasnim, F. M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112668 · Cited by 100

β‐Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NF‐κB Pathways in LPS‐Exposed BV2 Cells

Sun, Y., Gao, L., Hou, W., & Wu, J. (2020) · BioMed Research International · doi:10.1155/2020/7532306 · Cited by 97

The Gut–CNS Axis in Multiple Sclerosis

Kadowaki, A., & Quintana, F. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.002 · Cited by 95

Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization

Zhou, F., Wang, X., Han, B.-Y., Tang, X., Liu, R., Ji, Q., Zhou, Z., & Zhang, L. (2021) · Molecular Pain · doi:10.1177/1744806921996520 · Cited by 96

Astrocyte-Mediated Neuroinflammation in Neurological Conditions

Zhao, Y., Huang, Y., Cao, Y., & Yang, J. H. (2024) · Biomolecules · doi:10.3390/biom14101204 · Cited by 106

Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function

Zhang, Y., Bailey, J. T., Xu, E., Singh, K., Lavaert, M., Link, V. M., D’Souza, S., Hafiz, A., Cao, J., Cao, G., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01349-1 · Cited by 91

Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Sariol, A., Mackin, S., Allred, M.-G., Ma, C., Zhou, Y., Zhang, Q., Zou, X., Abrahante, J. E., Meyerholz, D. K., & Perlman, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007814117 · Cited by 91

Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics

Ochocka, N., & Kaminska, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063027 · Cited by 97

Adipose tissue, systematic inflammation, and neurodegenerative diseases

Migliolo, L., Boleti, A. P. D. A., Cardoso, P. H. D. O., Frihling, B. E. F., Silva, P. S. E., & de Moraes, L. F. R. N. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.343891 · Cited by 94

TRP channels: a journey towards a molecular understanding of pain

Rosenbaum, T., Morales‐Lázaro, S. L., & Islas, L. D. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00611-7 · Cited by 91

The beneficial role of autophagy in multiple sclerosis: Yes or No?

Al-Kuraishy, H. M., Jabir, M. S., Al-Gareeb, A. I., Saad, H. M., Batiha, G. E., & Klionsky, D. J. (2023) · Autophagy · doi:10.1080/15548627.2023.2259281 · Cited by 89

Microglial NLRP3 inflammasome activation in multiple sclerosis

(2020) · Advances in Protein Chemistry and Structural Biology · doi:10.1016/bs.apcsb.2019.08.007 · Cited by 83

Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

Madsen, P. M., Desu, H. L., Vaccari, J. P. D. R., Florimon, Y., Ellman, D. G., Keane, R. W., Clausen, B. H., Lambertsen, K. L., & Brambilla, R. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.11.017 · Cited by 81

Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy

González, L. F., Acuña, E., Arellano, G., Morales, P., Sotomayor, P. C., Oyarzun-Ampuero, F. A., & Naves, R. F. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.019 · Cited by 80

Diversity and Function of Glial Cell Types in Multiple Sclerosis

Schirmer, L., Schafer, D. P., Bartels, T., Rowitch, D. H., & Calabresi, P. A. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.01.005 · Cited by 78

Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system

Zong, B., Yu, F., Zhang, X., Pang, Y., Zhao, W., Sun, P., & Li, L. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102026 · Cited by 82

The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 84

TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies

Malko, P., Mortadza, S. A. S., McWilliam, J., & Jiang, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00239 · Cited by 79

Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models

Geloso, M. C., & D’Ambrosi, N. (2021) · Cells · doi:10.3390/cells10030686 · Cited by 79

Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID

Theoharides, T. C., & Kempuraj, D. (2023) · Cells · doi:10.3390/cells12050688 · Cited by 82

Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination

Prineas, J. W., & Parratt, J. D. E. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab083 · Cited by 76

Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination

Yu, Z., Xue, F., Liu, W., Sun, R. X., Zhou, J., Pu, Y., Zhao, M., Sun, D., Xiang, Z., Liu, P., et al. (2022) · Advanced Science · doi:10.1002/advs.202105442 · Cited by 71

Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway

Guan, X., Wang, Y., Kai, G., Zhao, S., Huang, T., Li, Y., Xu, Y., Zhang, L., & Pang, T. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01245 · Cited by 70

Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies

Cardoso, F. D. S., Salehpour, F., Coimbra, N. C., Gonzalez-Lima, F., & da Silva, S. G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1006031 · Cited by 73

Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway

Deng, Y., Jiang, X., Deng, X., Chen, H., Xu, J., Zhang, Z., Liu, G., Zhu, Y., Yuan, C., Sun, X., et al. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.05.002 · Cited by 70

Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?

Psenicka, M. W., Smith, B. C., Tinkey, R. A., & Williams, J. L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.654284 · Cited by 73

The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases

Zhang, Y., Zou, M., Wu, H., Zhu, J., & Jin, T. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106710 · Cited by 75

The Ins and Outs of Central Nervous System Inflammation—Lessons Learned from Multiple Sclerosis

Ramaglia, V., Rojas, O. L., Naouar, I., & Gommerman, J. L. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-124155 · Cited by 72

TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway

Huang, J., Yue, Z., Yu, H., Yang, Z., Wang, Y., & Guo, B. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.03.025 · Cited by 68

(R)-ketamine ameliorates demyelination and facilitates remyelination in cuprizone-treated mice: A role of gut–microbiota–brain axis

Wang, X., Chang, L., Wan, X., Tan, Y., Qu, Y., Shan, J., Yang, Y. H., Ma, L., & Hashimoto, K. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105635 · Cited by 67

Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases

Anwar, S., Pons, V., & Rivest, S. (2020) · Cells · doi:10.3390/cells9071595 · Cited by 61

Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson’s Disease

Awogbindin, I. O., Ben‐Azu, B., Olusola, B. A., Akinluyi, E. T., Adeniyi, P. A., Paolo, T. D., & Tremblay, M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.670298 · Cited by 61

Is cyclooxygenase‐1 involved in neuroinflammation?

Ghazanfari, N., van Waarde, A., Dierckx, R., Doorduin, J., & de Vries, E. F. J. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24934 · Cited by 65

A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models

Cheng, A., Jia, W., Kawahata, K., & Fukunaga, K. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103582 · Cited by 59

Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis

Pluchino, S., Smith, J. A., & Peruzzotti‐Jametti, L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.04.005 · Cited by 59

Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities

Lyu, J., Jiang, X., Leak, R. K., Shi, Y., Hu, X., & Chen, J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00857-2 · Cited by 63

Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway

Zheng, K., Lv, B., Wu, L., Wang, C., Xu, H., Li, X., Wu, Z., Zhao, Y., & Zheng, Z. (2022) · Bioengineered · doi:10.1080/21655979.2022.2052671 · Cited by 57

Tools and Approaches for Studying Microglia In vivo

Eme‐Scolan, E., & Dando, S. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583647 · Cited by 60

Microglial innate memory and epigenetic reprogramming in neurological disorders

Martins-Ferreira, R., Leal, B., Costa, P., & Ballestar, E. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101971 · Cited by 55

Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers

Huang, Y., Driedonks, T. A. P., Cheng, L., Turchinovich, A., Rajapaksha, H., Arab, T., Powell, B. H., Pletniková, O., Redding‐Ochoa, J., Troncoso, J. C., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220322 · Cited by 58

Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

Wang, X., Eguchi, A., Yang, Y. H., Chang, L., Wan, X., Shan, J., Qu, Y., Ma, L., Mori, C., Yang, J., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105951 · Cited by 54

Gut microbiome and multiple sclerosis: New insights and perspective

Amini, M. E., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107024 · Cited by 54

Efficacy of Probiotics in Multiple Sclerosis: A Systematic Review of Preclinical Trials and Meta-Analysis of Randomized Controlled Trials

Jiang, J., Chu, C., Wu, C., Wang, C., Zhang, C., Li, T., Zhai, Q., Yu, L., Tian, F., & Chen, W. (2021) · Food & Function · doi:10.1039/d0fo03203d · Cited by 52

The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies

Brom, V. C., Burger, C., Wirtz, D. C., & Schildberg, F. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837645 · Cited by 56

Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia

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