Cited by 122Virus-based gene therapy researchRNA Interference and Gene DeliveryViral Infectious Diseases and Gene Expression in Insects

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Journey to the Center of the Cell: Tracing the Path of AAV Transduction

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Dhungel, Bijay P., Bailey, Charles G., Rasko, John E.J.·2021·Trends in Molecular Medicine

DOI 10.1016/j.molmed.2020.09.010

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Abstract

As adeno-associated virus (AAV)-based gene therapies are being increasingly approved for use in humans, it is important that we understand vector-host interactions in detail. With the advances in genome-wide genetic screening tools, a clear picture of AAV-host interactions is beginning to emerge. Understanding these interactions can provide insights into the viral life cycle. Accordingly, novel strategies to circumvent the current limitations of AAV-based vectors may be explored. Here, we summarize our current understanding of the various stages in the journey of the vector from the cell surface to the nucleus and contextualize the roles of recently identified host factors.

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Authors: Dhungel, B. P., Bailey, C. G., & Rasko, J. E. J.
Affiliations: The University of Sydney (AU)
Corresponding author: Rasko, John E.J.
ORCID: Dhungel, Bijay P.
Bailey, Charles G.
Rasko, John E.J.
Venue: Trends in Molecular Medicine
Publisher: Elsevier BV
Published: 2021-02
Volume: 27
Issue: 2
Pages: 172-184
ISSN: 1471-4914 (ISSN-L)
DOI: 10.1016/j.molmed.2020.09.010
OpenAlex: W3092811898
Cited by: 122
References: 139
Citations by year: 2026: 32 · 2025: 29 · 2024: 21 · 2023: 17 · 2022: 9 · 2021: 14
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Trends in Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: NSW Health
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Keywords: adeno-associated virus, adeno-associated virus vectors, gene therapy, vector-host interactions, viral life cycle, host factors, nuclear translocation, viral transduction, genome-wide screen
MeSH terms: Host Microbial Interactions, Dependovirus, Animals, Biological Transport, Genetic Vectors, Humans, Transduction, Genetic, Genetic Therapy, Gene Transfer Techniques, Cell Tracking

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Journey to the Center of the Cell: Tracing the Path of AAV Transduction

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