Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Open accessAbstract
OBJECTIVE: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. METHODS: We examined muscle mass and strength in mice lacking osteocalcin (Ocn-/-) or its receptor in all cells (Gprc6a-/-) or specifically in myofibers (Gprc6a Mck -/-) as well as in 9 month-old WT mice receiving exogenous osteocalcin for 28 days. We also examined protein synthesis in WT and Gprc6a-/- mouse myotubes treated with osteocalcin. RESULTS: We show that osteocalcin signaling in myofibers is necessary to maintain muscle mass in older mice in part because it promotes protein synthesis in myotubes without affecting protein breakdown. We further show that treatment with exogenous osteocalcin for 28 days is sufficient to increase muscle mass of 9-month-old WT mice. CONCLUSION: This study uncovers that osteocalcin is necessary and sufficient to prevent age-related muscle loss in mice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Osteokines are novel exercise-inducible soluble factors secreted by osteocytes, osteoblasts, and osteoclasts that play an important role in the body's response to exercise, mainly including RANKL, sclerostin, osteocalcin, FGF23, Wnt3a, TGF-β, IGF-1, and PGE2.
“Osteokines, novel exercise-inducible soluble factors secreted by osteocytes, osteo blasts, and osteoclasts, play an important role in the body’s response to exercise, mainly including RANKL [127], sclerostin [128], osteocalcin [129], fibroblast growth factor 23 (FGF23) [95], Wnt3a [130], TGF-β [131], IGF-1 [132], and prostaglandin E2 (PGE2) [133] (Figure 3).”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [129]
In older mice, osteocalcin signaling in myotubes promotes protein synthesis without affecting protein breakdown via activation of the mTOR pathway, and osteocalcin is necessary and sufficient to attenuate age-related muscle loss.
“In older mice, osteocalcin signaling in the myotubes promotes protein synthesis without affecting protein breakdown via activation of the mTOR pathway, uncovering that osteocalcin is both necessary and sufficient to attenuate age-related muscle loss [129].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554 · see citing works
Self-citationRejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583 · see citing works
Bentzinger, C. F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.002 · Cited by 640 · see citing works
Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase
Shima, H., Pende, M., Chen, Y., Fumagalli, S., THOMAS, G. V., & Kozma, S. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6649 · Cited by 636 · see citing works
Endocrine Regulation of Male Fertility by the Skeleton
Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C. E., Hermo, L., Suarez, S., Roth, B. L., Ducy, P., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.004 · Cited by 628 · see citing works
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 616 · see citing works
Signaling pathways controlling skeletal muscle mass
Egerman, M. A., & Glass, D. J. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.857291 · Cited by 555 · see citing works
Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions
Oury, F., Khrimian, L., Denny, C. A., Gardin, A., Chamouni, A., Goeden, N., Huang, Y.-Y., Lee, H., Srinivas, P., Gao, X.-B., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.042 · Cited by 484 · see citing works
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 429 · see citing works
Muscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417 · see citing works
Ohanna, M., Sobering, A. K., Lapointe, T., Lorenzo, L., Praud, C., Petroulakis, E., Sonenberg, N., Kelly, P. A., Sotiropoulos, A., & Pende, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1231 · Cited by 392 · see citing works
Gharaibeh, B., Lu, A., Tebbets, J. C., Zheng, B. J., Feduska, J., Crisan, M., Péault, B., Cummins, J. H., & Huard, J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.142 · Cited by 335 · see citing works
The endocrine system and ageing
Chahal, H., & Drake, W. (2007) · The Journal of Pathology · doi:10.1002/path.2110 · Cited by 306 · see citing works
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
Oury, F., Ferron, M., Huizhen, W., Confavreux, C. B., Xu, L., Lacombe, J., Srinivas, P., Chamouni, A., Lugani, F., Lejeune, H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65952 · Cited by 276 · see citing works
Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication
Karsenty, G., & Olson, E. N. (2016) · Cell · doi:10.1016/j.cell.2016.02.043 · Cited by 274 · see citing works
Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
Wei, J., Hanna, T., Suda, N., Karsenty, G., & Ducy, P. F. (2013) · Diabetes · doi:10.2337/db13-0887 · Cited by 237 · see citing works
mTOR SignalingPreprint
Laplante, M., & Sabatini, D. M. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011593 · Cited by 235 · see citing works
Linking age-related changes in skeletal muscle mass and composition with metabolism and disease.
Janssen, I., & Ross, R. (2006) · PubMed · Cited by 169 · see citing works
An overview of the endocrinology of skeletal muscle
Sheffield‐Moore, M., & Urban, R. J. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.02.009 · Cited by 123 · see citing works
An ELISA-based method to quantify osteocalcin carboxylation in mice
Ferron, M., Wei, J., Yoshizawa, T., Ducy, P. F., & Karsenty, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.008 · Cited by 120 · see citing works
Aging and the Muscle-Bone Relationship
Novotny, S. A., Warren, G. L., & Hamrick, M. W. (2015) · Physiology · doi:10.1152/physiol.00033.2014 · Cited by 103 · see citing works
Towards a definition of sarcopenia — results from epidemiologic studies
Visser, M. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0202-y · Cited by 92 · see citing works
Aranı́bar, N., Vassallo, J. D., Rathmacher, J. A., Stryker, S. A., Zhang, Y., Dai, J., Janovitz, E. B., Robertson, D., Reily, M. D., Lowe‐Krentz, L. J., et al. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.11.023 · Cited by 60 · see citing works
Bross, R., Storer, T., & Bhasin, S. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00143-x · Cited by 47 · see citing works
Plant, D. R., & Lynch, G. S. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022418 · Cited by 44 · see citing works
Chung, J. H., Hwang, H., Han, C. H., Son, B. S., Kim, D. H., & Park, M. S. (2014) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.3109/15412555.2014.908835 · Cited by 42 · see citing works
Human Muscular Dystrophy: Elevation of Urinary Dimethylarginines
Lou, M. F. (1979) · Science · doi:10.1126/science.760213 · Cited by 37 · see citing works
Motor Unit Properties of Nerve-Intact Extensor Digitorum Longus Muscle Grafts In Young and Old Rats
Cederna, P. S., Asato, H., Gu, X., van der Meulen, J., Kuzon, W. M., Carlson, B. M., & Faulkner, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.6.b254 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Han, Y., You, X., Xing, W., Zhang, Z., & Zou, W. (2018) · Bone Research · doi:10.1038/s41413-018-0019-6 · Cited by 582 · see citing works
Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines
Kirk, B., Feehan, J., Lombardi, G., & Duque, G. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00599-y · Cited by 510 · see citing works
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle
Komori, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207513 · Cited by 332 · see citing works
The role of osteoblasts in energy homeostasis
Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0246-y · Cited by 292 · see citing works
Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline
Glatigny, M., Moriceau, S., Rivagorda, M., Ramos-Brossier, M., Nascimbeni, A. C., Lante, F., Shanley, M. R., Boudarene, N., Rousseaud, A., Friedman, A. K., et al. (2019) · Current Biology · doi:10.1016/j.cub.2018.12.021 · Cited by 257 · see citing works
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 262 · see citing works
Osteocalcin—A Versatile Bone-Derived Hormone
Moser, S. C., & van der Eerden, B. C. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00794 · Cited by 234 · see citing works
Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
Pagnotti, G. M., Styner, M., Uzer, G., Patel, V. S., Wright, L. E., Ness, K. K., Guise, T. A., Rubin, J. E., & Rubin, C. T. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0170-1 · Cited by 218 · see citing works
Osteocalcin and its endocrine functions
Mizokami, A., Kawakubo‐Yasukochi, T., & Hirata, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.02.001 · Cited by 209 · see citing works
Molecular Mechanisms of Skeletal Muscle Hypertrophy
Schiaffino, S., Reggiani, C., Akimoto, T., & Blaauw, B. (2020) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-200568 · Cited by 169 · see citing works
Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166 · see citing works
Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen
Lu, L., & Tian, L. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0116 · Cited by 163 · see citing works
An osteocalcin-deficient mouse strain without endocrine abnormalities
Diegel, C. R., Hann, S., Ayturk, U. M., Hu, J. C. W., Lim, K., Droscha, C. J., Madaj, Z., Foxa, G. E., Izaguirre, I., Core, V. V. A. T., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008361 · Cited by 136 · see citing works
Bone function, dysfunction and its role in diseases including critical illness
Su, N. Y., Yang, J., Xie, Y., Du, X., Chen, H., Hong, Z., & Chen, L. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.27063 · Cited by 133 · see citing works
Maurel, D., Jähn, K., & Lara-Castillo, N. (2017) · Biomedicines · doi:10.3390/biomedicines5040062 · Cited by 111 · see citing works
What is the function of osteocalcin?
Komori, T. (2020) · Journal of Oral Biosciences · doi:10.1016/j.job.2020.05.004 · Cited by 125 · see citing works
Bone and Muscle Crosstalk in Aging
He, C., He, W., Hou, J., Chen, K., Huang, M., Yang, M., Luo, X., & Li, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.585644 · Cited by 128 · see citing works
Update on the Biology of Osteocalcin
Karsenty, G. (2017) · Endocrine Practice · doi:10.4158/ep171966.ra · Cited by 117 · see citing works
Molecular bases of the crosstalk between bone and muscle
Karsenty, G., & Mera, P. (2017) · Bone · doi:10.1016/j.bone.2017.04.006 · Cited by 116 · see citing works
Osteocalcin promotes bone mineralization but is not a hormone
Manolagas, S. C. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008714 · Cited by 117 · see citing works
Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones
Wang, J. S., Mazur, C. M., & Wein, M. N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.584147 · Cited by 110 · see citing works
Behera, J., Ison, J., Voor, M. J., & Tyagi, N. (2022) · Diabetes · doi:10.2337/db21-0573 · Cited by 112 · see citing works
Shen, W.-D., Li, X., Deng, Y., Zha, X., Pan, L., Li, Q.-M., & Luo, J. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.200 · Cited by 106 · see citing works
Exosomes and Extracellular RNA in Muscle and Bone Aging and Crosstalk
Qin, W., & Dallas, S. L. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00537-7 · Cited by 93 · see citing works
Regulation of Energy Metabolism by Bone-Derived Hormones
Mera, P., Ferron, M., & Mosialou, I. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031666 · Cited by 90 · see citing works
Regulation of Skeletal Homeostasis
Zaidi, M., Yuen, T., Sun, L., & Rosen, C. J. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00050 · Cited by 92 · see citing works
Qian, Z., Li, H., Yang, H., Yang, Q., Lu, Z., Wang, L., Chen, Y., & Li, X. (2021) · Science Advances · doi:10.1126/sciadv.abi5811 · Cited by 91 · see citing works
GPRC6A: Jack of all metabolism (or master of none)
Pi, M., Nishimoto, S. K., & Quarles, L. D. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.12.006 · Cited by 85 · see citing works
Lin, X., Brennan‐Speranza, T. C., Levinger, I., & Yeap, B. B. (2018) · Nutrients · doi:10.3390/nu10070847 · Cited by 86 · see citing works
Bone and muscle crosstalk in ageing and disease
Kirk, B., Lombardi, G., & Duque, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01088-x · Cited by 81 · see citing works
Sheng, R., Cao, M., Song, M., Wang, M., Zhang, Y., Shi, L., Xie, T., Li, Y., Wang, J., & Rui, Y. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.09.007 · Cited by 74 · see citing works
Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications
Cariati, I., Bonanni, R., Onorato, F., Mastrogregori, A., Rossi, D., Iundusi, R., Gasbarra, E., Tancredi, V., & Tarantino, U. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6020055 · Cited by 76 · see citing works
Mechanism and physical activities in bone-skeletal muscle crosstalk
Zhao, Z., Yan, K., Guan, Q., Guo, Q., & Zhao, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1287972 · Cited by 71 · see citing works
CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model
Ye, R.-S., Pi, M., Cox, J. V., Nishimoto, S. K., & Quarles, L. D. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0561-x · Cited by 68 · see citing works
ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass
Barreto, R., Kitase, Y., Matsumoto, T., Pin, F., Colston, K. C., Couch, K. E., O’Connell, T. M., Couch, M. E., Bonewald, L. F., & Bonetto, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-15040-1 · Cited by 65 · see citing works
Essex, A. L., Pin, F., Huot, J. R., Bonewald, L. F., Plotkin, L. I., & Bonetto, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00809 · Cited by 63 · see citing works
Potential Role for Osteocalcin in the Development of Atherosclerosis and Blood Vessel Disease
Tacey, A., Qaradakhi, T., Brennan‐Speranza, T. C., Hayes, A., Zulli, A., & Levinger, I. (2018) · Nutrients · doi:10.3390/nu10101426 · Cited by 64 · see citing works
Sellami, M., Bragazzi, N. L., Aboghaba, B., & Elrayess, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631873 · Cited by 61 · see citing works
Bone Control of Muscle Function
Battafarano, G., Rossi, M., Marampon, F., Minisola, S., & Fattore, A. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041178 · Cited by 64 · see citing works
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P. A., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., de Cabo, R., Campisi, J., Cuervo, A. M., et al. (2020) · Aging · doi:10.18632/aging.202454 · Cited by 59 · see citing works
Rahimi, G. R. M., Niyazi, A., & Alaee, S. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05592-w · Cited by 59 · see citing works
Novel insights into the complex architecture of osteoporosis molecular genetics
Saad, F. A. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14231 · Cited by 55 · see citing works
Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases
Colaianni, G., Storlino, G., Sanesi, L., Colucci, S. C., & Grano, M. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00600-8 · Cited by 61 · see citing works
Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs
He, T., Qin, L., Chen, S., Huo, S., Li, J., Zhang, F., Yi, W., Mei, Y., & Xiao, G. (2025) · Bone Research · doi:10.1038/s41413-025-00424-1 · Cited by 58 · see citing works
Nowicki, J. K., & Jakubowska‐Pietkiewicz, E. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1895 · Cited by 53 · see citing works
Mou, K., Chan, S. M. H., & Vlahos, R. (2024) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2024.108635 · Cited by 51 · see citing works
Guo, X., Shan, C., Hou, Y., Zhu, G., Tao, B., Sun, L., Zhao, H., Ning, G., Li, S., & Liu, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00343 · Cited by 48 · see citing works
Smith, C., Tacey, A., Mesinovic, J., Scott, D. S., Lin, X., Brennan‐Speranza, T. C., Lewis, J. R., Duque, G., & Levinger, I. (2020) · Bone · doi:10.1016/j.bone.2020.115766 · Cited by 49 · see citing works
Poggiogalle, E., Donini, L. M., Lenzi, A., Chiesa, C., & Pacifico, L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i10.1747 · Cited by 47 · see citing works
Skeletal energy homeostasis: a paradigm of endocrine discovery
Suchacki, K. J., Roberts, F. L., Lovdel, A., Farquharson, C., Morton, N. M., MacRae, V. E., & Cawthorn, W. P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0147 · Cited by 45 · see citing works
Li, X., Jiang, C., Zheng, C., Hong, C.-Z., Pan, L., Li, Q.-M., Luo, J., & Zha, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08192 · Cited by 46 · see citing works
Body Protein Sparing in Hibernators: A Source for Biomedical Innovation
Bertile, F., Habold, C., Maho, Y. L., & Giroud, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.634953 · Cited by 46 · see citing works
Bone circuitry and interorgan skeletal crosstalk
Zaidi, M., Kim, S.-M., Mathew, M., Korkmaz, F., Sultana, F., Miyashita, S., Gumerova, A. A., Frolinger, T., Moldavski, O., Barak, O., et al. (2023) · eLife · doi:10.7554/elife.83142 · Cited by 45 · see citing works
Rossi, M., Battafarano, G., Pepe, J., Minisola, S., & Fattore, A. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184502 · Cited by 44 · see citing works
Role of myokines and osteokines in cancer cachexia
Pin, F., Bonewald, L. F., & Bonetto, A. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211009213 · Cited by 43 · see citing works
Osteocalcin and its forms across the lifespan in adult men
Smith, C., Voisin, S. A. C., Saedi, A. A., Phu, S., Brennan‐Speranza, T. C., Parker, L., Eynon, N., Hiam, D., Yan, X., Scott, D. S., et al. (2019) · Bone · doi:10.1016/j.bone.2019.115085 · Cited by 42 · see citing works
Osteocalcin and its forms respond similarly to exercise in males and females
Hiam, D., Landen, S., Jacques, M., Voisin, S. A. C., Alvarez‐Romero, J., Byrnes, E., Chubb, P., Levinger, I., & Eynon, N. (2020) · Bone · doi:10.1016/j.bone.2020.115818 · Cited by 41 · see citing works
Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease
Zhang, L., & Sun, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724911 · Cited by 42 · see citing works
Muscle-Bone Crosstalk in Chronic Kidney Disease: The Potential Modulatory Effects of Exercise
Leal, D. V., Ferreira, A., Watson, E. L., Wilund, K. R., & Viana, J. L. (2021) · Calcified Tissue International · doi:10.1007/s00223-020-00782-4 · Cited by 40 · see citing works
A Pound of Flesh: What Cachexia Is and What It Is Not
Berardi, E., Madaro, L., Lozanoska‐Ochser, B., Adamo, S., Thorrez, L., Bouché, M., & Coletti, D. (2021) · Diagnostics · doi:10.3390/diagnostics11010116 · Cited by 40 · see citing works
Saeki, C., & Tsubota, A. (2021) · Life · doi:10.3390/life11090899 · Cited by 40 · see citing works
Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)
Díaz-Franco, M. C., de León, R. F.-D., & Villafán-Bernal, J. R. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9627 · Cited by 41 · see citing works
Metabolic Health and Disease: A Role of Osteokines?
Shimonty, A., Bonewald, L. F., & Huot, J. R. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01093-0 · Cited by 38 · see citing works
Updated concept of sarcopenia based on muscle–bone relationship
Yakabe, M., Hosoi, T., Akishita, M., & Ogawa, S. (2019) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-019-01048-2 · Cited by 36 · see citing works
Lin, X., Parker, L., McLennan, E. D., Zhang, X., Hayes, A., McConell, G. K., Brennan‐Speranza, T. C., & Levinger, I. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00330 · Cited by 37 · see citing works
Lin, X., Parker, L., McLennan, E. D., Hayes, A., McConell, G. K., Brennan‐Speranza, T. C., & Levinger, I. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3731 · Cited by 35 · see citing works
Metabolic phenotype in the mouse model of osteogenesis imperfecta
Boraschi-Diaz, I., Tauer, J. T., Rifai, O. A., Guillemette, D., Lefebvre, G., Rauch, F., Ferron, M., & Komarova, S. V. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0335 · Cited by 33 · see citing works
Chalhoub, D., Boudreau, R. M., Greenspan, S. L., Newman, A. B., Zmuda, J. M., Frank-Wilson, A. W., Nagaraj, N., Hoffman, A. R., Lane, N. E., Stefanick, M. L., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3458 · Cited by 33 · see citing works
The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
Lu, W., Xiao, W., Xie, W., Fu, X., Pan, L., Jin, H., Yu, Y., Zhang, Y., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.735374 · Cited by 33 · see citing works
Adipogenic progenitors in different organs: Pathophysiological implications
Favaretto, F., Bettini, S., Busetto, L., Milan, G., & Vettor, R. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09686-6 · Cited by 33 · see citing works
Rupp, T., von Vopelius, E., Strahl, A., Oheim, R., Barvencik, F., Amling, M., & Rolvien, T. (2022) · Osteoporosis International · doi:10.1007/s00198-022-06470-3 · Cited by 33 · see citing works
The role of the musculoskeletal system in post-burn hypermetabolism
Klein, G. L. (2019) · Metabolism · doi:10.1016/j.metabol.2019.06.001 · Cited by 32 · see citing works
Vitale, J. A., Sansoni, V., Faraldi, M., Messina, C., Verdelli, C., Lombardi, G., & Corbetta, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.669704 · Cited by 32 · see citing works
Explaining divergent observations regarding osteocalcin/GPRC6A endocrine signaling
Pi, M., Nishimoto, S. K., & Darryl Quarles, L. (2021) · Endocrinology · doi:10.1210/endocr/bqab011 · Cited by 29 · see citing works
Lau, P., Vico, L., & Rittweger, J. (2022) · Biomedicines · doi:10.3390/biomedicines10020342 · Cited by 32 · see citing works
Osteocalcin and the physiology of danger
Berger, J. M., & Karsenty, G. (2021) · FEBS Letters · doi:10.1002/1873-3468.14259 · Cited by 32 · see citing works
Osteogenesis Imperfecta: Muscle–Bone Interactions when Bi-directionally Compromised
Phillips, C. L., & Jeong, Y. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0456-6 · Cited by 29 · see citing works
Parker, L., Lin, X., GARNHAM, A. P., McConell, G. K., Stepto, N. K., Hare, D. L., Byrnes, E., Ebeling, P. R., Seeman, E., Brennan‐Speranza, T. C., et al. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3574 · Cited by 29 · see citing works
INSL3 in the muscolo-skeletal system
Toni, L. D., Agoulnik, A. I., Sandri, M., Foresta, C., & Ferlin, A. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.021 · Cited by 30 · see citing works
Osteocalcin and vascular function: is there a cross-talk?
Tacey, A., Hayes, A., Zulli, A., & Levinger, I. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101205 · Cited by 29 · see citing works
Wang, B. Y., Chen, Y., Hsiao, A. W., Chen, W., Lee, C., & Lee, O. K. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13228 · Cited by 26 · see citing works
Sarcopenic obesity and osteoporosis: Research progress and hot spots
Fan, S., Cai, Y., Wei, Y., Yang, J., Gao, J., & Yang, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112544 · Cited by 27 · see citing works
Osteocalcin, a bone‐derived hormone with important andrological implications
Toni, L. D., Nisio, A. D., Rocca, M. S., Ponce, M. D. R., Ferlin, A., & Foresta, C. (2017) · Andrology · doi:10.1111/andr.12359 · Cited by 26 · see citing works
Hung, K.-C., Yao, W.-C., Liu, Y.-L., Yang, H.-J., Liao, M.-T., Chong, K., Peng, C., & Lu, K. (2023) · Biomedicines · doi:10.3390/biomedicines11072076 · Cited by 25 · see citing works
Hatakeyama, J., Inoue, S., Jiang, H., Yokoi, R., & Moriyama, H. (2024) · Bone · doi:10.1016/j.bone.2024.117314 · Cited by 25 · see citing works
Musculoskeletal Health in the Context of Spinal Cord Injury
Clark, J., & Findlay, D. M. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0400-1 · Cited by 25 · see citing works
Ginkgolide B increases healthspan and lifespan of female mice
Lee, C., Wang, B. Y., Wong, S. H., Chen, Y., Cao, Q., Hsiao, A. W., Fung, S.-H., Chen, Y.-F., Wu, H.-H., Cheng, P.-Y., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00802-0 · Cited by 24 · see citing works
Crosstalk between bone and other organs
Yuan, W., & Song, C. (2022) · Medical Review · doi:10.1515/mr-2022-0018 · Cited by 25 · see citing works
Madrid, D. A., Beavers, K. M., Walkup, M. P., Ambrosius, W. T., Rejeski, W. J., Marsh, A. P., & Weaver, A. A. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112126 · Cited by 23 · see citing works
Walowski, C. O., Herpich, C., Enderle, J., Braun, W., Both, M., Hasler, M., Müller, M. J., Norman, K., & Bosy‐Westphal, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-31642-4 · Cited by 23 · see citing works
Tangseefa, P., Martin, S. K., Fitter, S., Baldock, P. A. J., Proud, C. G., & Zannettino, A. C. W. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26163 · Cited by 23 · see citing works
Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis
Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works
Lipocalin 2—A bone‐derived anorexigenic and β‐cell promoting signal: From mice to humans
Yang, Y., Liu, J., & Kousteni, S. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13504 · Cited by 22 · see citing works
The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling
Malvandi, A. M., Gerosa, L., Banfi, G., & Lombardi, G. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101367 · Cited by 22 · see citing works
Role of GPRC6A in Regulating Hepatic Energy Metabolism
Pi, M., Xu, F., Ye, R.-S., Nishimoto, S. K., Williams, R. W., Williams, R. W., Lu, L., & Quarles, L. D. (2019) · Scientific Reports · doi:10.1038/s41598-020-64384-8 · Cited by 22 · see citing works
Advance in Drug Delivery for Ageing Skeletal Muscle
Li, Y., Chen, M., Zhao, Y., Li, M., Qin, Y., Cheng, S., Yang, Y., Yin, P., Zhang, L., & Tang, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01016 · Cited by 22 · see citing works
Physical Activity, Exerkines, and Their Role in Cancer Cachexia
Bilski, J., Szlachcic, A., Ptak‐Belowska, A., & Brzozowski, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168011 · Cited by 22 · see citing works
Sarcopenia and bone health: new acquisitions for a firm liaison
Tarantino, U., Greggi, C., Visconti, V. V., Cariati, I., Bonanni, R., Gasperini, B., Nardone, I., Gasbarra, E., & Iundusi, R. (2022) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x221138354 · Cited by 21 · see citing works
Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
Hue, I., Capilla, E., Rosell-Moll, E., Balbuena-Pecino, S., Goffette, V., Gabillard, J., & Navarro, I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1155202 · Cited by 21 · see citing works
Targeting aging with the healthy skeletal system: The endocrine role of bone
Zheng, X.-Q., Lin, J.-L., Huang, J., Wu, T., & Song, C.-L. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09812-6 · Cited by 19 · see citing works
- Authors
- Mera, P., Laue, K., Wei, J., Berger, J. M., & Karsenty, G.
- Affiliations
- Columbia University Irving Medical Center (US)
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 5
- Issue
- 10
- Pages
- 1042-1047
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC5034485
- OpenAlex
- W2479847107
- Cited by
- 223
- References
- 30
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 22 · 2023: 30 · 2022: 14 · 2021: 32 · 2020: 33 · 2019: 26 · 2018: 15 · 2017: 17 · 2016: 1 · 2014: 1
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-08-01)
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH (5RO1AR045548, PO1AG032959)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- osteocalcin, muscle mass, muscle atrophy, aging, GPRC6A, muscle fibers, muscle protein synthesis, muscle protein turnover, muscle strength, muscle-bone crosstalk
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
