Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Open accessAbstract
The nature of muscle‐bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)‐6, IL‐7, IL‐15, insulin‐like growth factor‐1, fibroblast growth factor (FGF)‐2, and β‐aminoisobutyric acid and through bone‐derived factors including FGF23, prostaglandin E 2 , transforming growth factor β, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone‐muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.
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Crosstalk exists between bone and muscle, probably mediated by secretory factors.
“Emerging data demonstrate that crosstalk exists between bone and muscle, probably mediated by secretory factors165.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [165]
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Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,637 · see citing works
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554 · see citing works
Exosomes: Extracellular organelles important in intercellular communication
Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,539 · see citing works
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works
FGF23 induces left ventricular hypertrophy
Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46122 · Cited by 2,027 · see citing works
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735 · see citing works
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350 · see citing works
Bischoff-Ferrari, H. A., Dawson‐Hughes, B., Staehelin, H. B., Orav, E. J., Stuck, A. E., Theiler, R., Wong, J. B., Egli, A., Kiel, D. P., & Henschkowski, J. (2009) · BMJ · doi:10.1136/bmj.b3692 · Cited by 1,279 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,105 · see citing works
Amaya, E., Musci, T. J., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90616-7 · Cited by 1,085 · see citing works
The role of exercise and PGC1α in inflammation and chronic disease
Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083 · see citing works
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668 · see citing works
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.025 · Cited by 638 · see citing works
New insights into the biology of osteocalcin
Zoch, M. L., Clemens, T. L., & Riddle, R. C. (2015) · Bone · doi:10.1016/j.bone.2015.05.046 · Cited by 612 · see citing works
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Li, D., Liu, J., Guo, B., Liang, C., Dang, L., Lu, C., He, X., Cheung, H. Y.-S., Xu, L., Lu, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms10872 · Cited by 588 · see citing works
Self-citationMicroRNA control of bone formation and homeostasis
Lian, J. B., Stein, G. S., van Wijnen, A. J., Stein, J. L., Hassan, M. Q., Gaur, T., & Zhang, Y. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.234 · Cited by 586 · see citing works
Kristiansen, O. P., & Mandrup-Poulsen, T. R. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s114 · Cited by 525 · see citing works
Vitamin D deficiency, muscle function, and falls in elderly people
Janssen, H. C. J. P., Samson, M., & Verhaar, H. J. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.611 · Cited by 456 · see citing works
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P., Laue, K., Ferron, M., Confavreux, C. B., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.004 · Cited by 429 · see citing works
Ferron, M., McKee, M. D., Levine, R. L., Ducy, P., & Karsenty, G. (2012) · Bone · doi:10.1016/j.bone.2011.04.017 · Cited by 414 · see citing works
Excess TGF-β mediates muscle weakness associated with bone metastases in mice
Waning, D. L., Mohammad, K. S., Reiken, S. R., Xie, W., Andersson, D. C., John, S. K., Chiechi, A., Wright, L. E., Umanskaya, A., Niewolna, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3961 · Cited by 380 · see citing works
Bone and muscle: Interactions beyond mechanical
Brotto, M. A. P., & Bonewald, L. F. (2015) · Bone · doi:10.1016/j.bone.2015.02.010 · Cited by 350 · see citing works
Aging of skeletal muscle fibers
Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R. (2015) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2015.39.2.155 · Cited by 309 · see citing works
Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
Colaianni, G., Mongelli, T., Cuscito, C., Pignataro, P., Lippo, L., Spiro, G., Notarnicola, A., Severi, I., Passeri, G., Mori, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02557-8 · Cited by 305 · see citing works
Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men
Verschueren, S., Gielen, E., O’Neill, T. W., Pye, S. R., Adams, J. E., Ward, K. A., Wu, F. C. W., Szulc, P., Laurent, M. R., Claessens, F., et al. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2057-z · Cited by 302 · see citing works
Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease
Quarles, L. D. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.02.027 · Cited by 298 · see citing works
Hassan, M. Q., MAEDA, Y. Y., Taipaleenmäki, H., Zhang, W., Jafferji, M. S., Gordon, J. A. R., Li, Z., Croce, C. M., van Wijnen, A. J., Stein, J. L., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.377515 · Cited by 296 · see citing works
Qin, Y., Peng, Y., Zhao, W., Pan, J., Ksiȩżak-Reding, H., Cardozo, C. P., Wu, Y., Pajevic, P. D., Bonewald, L. F., Bauman, W. A., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770941 · Cited by 282 · see citing works
Hiscock, N. J., Chan, S. M. H., Bisucci, T., Darby, I. A., & Febbraio, M. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-1259fje · Cited by 273 · see citing works
Hindlimb unloading: rodent analog for microgravity
Globus, R. K., & Morey, E. R. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00997.2015 · Cited by 273 · see citing works
Botulinum Toxin: Mechanism of Presynaptic Blockade
Kao, I., Drachman, D. B., & Price, D. L. (1976) · Science · doi:10.1126/science.785600 · Cited by 272 · see citing works
Weitzmann, M., Roggia, C., Toraldo, G., Weitzmann, L., & Pacifici, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15687 · Cited by 271 · see citing works
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
Quinn, L. S., Anderson, B. G., Strait-Bodey, L., Stroud, A. M., & Argilés, J. M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90506.2008 · Cited by 267 · see citing works
Dankbar, B., Fennen, M., Brunert, D., Hayer, S., Frank, S., Wehmeyer, C., Beckmann, D., Paruzel, P., Bertrand, J., Redlich, K., et al. (2015) · Nature Medicine · doi:10.1038/nm.3917 · Cited by 262 · see citing works
Nutrition and Sarcopenia: A Review of the Evidence and Implications for Preventive Strategies
Robinson, S., Cooper, C., & Aihie Sayer, A. (2012) · Journal of Aging Research · doi:10.1155/2012/510801 · Cited by 256 · see citing works
Irisin Enhances Osteoblast Differentiation In Vitro
Colaianni, G., Cuscito, C., Mongelli, T., Oranger, A., Mori, G., Brunetti, G., Colucci, S., Cinti, S., & Grano, M. (2014) · International Journal of Endocrinology · doi:10.1155/2014/902186 · Cited by 236 · see citing works
Interactions Between Muscle Tissues and Bone Metabolism
Kawao, N., & Kaji, H. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25040 · Cited by 231 · see citing works
Use it or lose it to age: A review of bone and muscle communication
Bonewald, L. F. (2018) · Bone · doi:10.1016/j.bone.2018.11.002 · Cited by 229 · see citing works
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Mera, P., Laue, K., Wei, J., Berger, J. M., & Karsenty, G. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.07.002 · Cited by 223 · see citing works
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor
Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.041 · Cited by 219 · see citing works
Osteocalcin and its endocrine functions
Mizokami, A., Kawakubo‐Yasukochi, T., & Hirata, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.02.001 · Cited by 209 · see citing works
Reginster, J., Beaudart, C., Buckinx, F., & Bruyère, O. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000230 · Cited by 207 · see citing works
Clarke, M. S. F., Khakee, R., & McNeil, P. L. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.1.121 · Cited by 204 · see citing works
Novel Role of Y1 Receptors in the Coordinated Regulation of Bone and Energy Homeostasis
Baldock, P. A. J., Allison, S. J., Lundberg, P., Lee, N. J., Slack, K., Lin, E.-J. D., Enriquez, R. F., McDonald, M. M., Zhang, L., During, M. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700644200 · Cited by 202 · see citing works
Self-citationKitase, Y., Barragan, L., Qing, H., Kondoh, S., Jiang, J. X., Johnson, M. L., & Bonewald, L. F. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.168 · Cited by 199 · see citing works
Self-citationHesse, M., Fröhlich, L. F., Zeitz, U., Lanske, B., & Erben, R. G. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.10.003 · Cited by 198 · see citing works
Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis
Sharir, A., Stern, T., Rot, C., Shahar, R., & Zelzer, E. (2011) · Development · doi:10.1242/dev.063768 · Cited by 194 · see citing works
Mendias, C. L., Gumucio, J. P., Davis, M. E., Bromley, C. W., Davis, C. S., & Brooks, S. V. (2011) · Muscle & Nerve · doi:10.1002/mus.22232 · Cited by 188 · see citing works
Allen, D. L., Cleary, A. S., Speaker, K. J., Lindsay, S. F., Uyenishi, J., Reed, J. M., Madden, M. C., & Mehan, R. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00798.2007 · Cited by 183 · see citing works
Role of muscle-derived growth factors in bone formation.
Hamrick, M. W., McNeil, P. L., & Patterson, S. L. (2010) · PubMed · Cited by 181 · see citing works
A single ascending‐dose study of muscle regulator ace‐031 in healthy volunteers
Attie, K. M., Borgstein, N. G., Yang, Y., Condon, C. H., Wilson, D. M., Pearsall, A. E., Kumar, R., Willins, D. A., Seehra, J. S., & Sherman, M. L. (2012) · Muscle & Nerve · doi:10.1002/mus.23539 · Cited by 176 · see citing works
Hodge, B. A., Wen, Y., Riley, L. A., Zhang, X., England, J. H., Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0039-5 · Cited by 175 · see citing works
β-Aminoisobutyric Acid (α-Methyl-β-Alanine): A New Amino-Acid Obtained from Human Urine
Crumpler, H. R., Dent, C. E., Harris, H., et al. (1951) · Nature · doi:10.1038/167307a0 · Cited by 149 · see citing works
Kamel, M. A., Picconi, J. L., Lara-Castillo, N., & Johnson, M. L. (2010) · Bone · doi:10.1016/j.bone.2010.08.007 · Cited by 147 · see citing works
The skeletal muscle secretome: an emerging player in muscle–bone crosstalk
Hamrick, M. W. (2012) · BoneKEy Reports · doi:10.1038/bonekey.2012.60 · Cited by 145 · see citing works
Intrinsic muscle clock is necessary for musculoskeletal health
Schroder, E. A., Harfmann, B. D., Zhang, X., Srikuea, R., England, J. H., Hodge, B. A., Wen, Y., Riley, L. A., Yu, Q., Christie, A., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271436 · Cited by 145 · see citing works
Park, J.-J., Berggren, J. R., Hulver, M. W., Houmard, J. A., & Hoffman, E. P. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00045.2006 · Cited by 135 · see citing works
Mo, C., Romero‐Suarez, S., Bonewald, L. F., Johnson, M. L., & Brotto, M. (2012) · Recent Patents on Biotechnology · doi:10.2174/1872208311206030223 · Cited by 134 · see citing works
Serum Sclerostin Increases in Healthy Adult Men during Bed Rest
Spatz, J., Fields, E. E., Yu, E. W.-Y., Pajevic, P. D., Bouxsein, M., Sibonga, J. D., Zwart, S. R., & Smith, S. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1579 · Cited by 133 · see citing works
Interaction Between Bone and Muscle in Older Persons with Mobility Limitations
Ferrucci, L., Baroni, M., Ranchelli, A., Lauretani, F., Maggio, M. G., Mecocci, P., & Ruggiero, C. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660690 · Cited by 132 · see citing works
Clarke, M. S. F., & Feerack, D. L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.4.8647349 · Cited by 126 · see citing works
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation
Mo, C., Zhao, R., Vallejo, J. A., Igwe, O. J., Bonewald, L. F., Wetmore, L., & Brotto, M. A. P. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1026520 · Cited by 119 · see citing works
Mackinnon, E. S., Rao, A. V., Josse, R. G., & RAO, L. G. S. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1308-0 · Cited by 119 · see citing works
Biomechanical Aspects of the Muscle-Bone Interaction
Avin, K. G., Bloomfield, S. A., Gross, T. S., & Warden, S. J. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0244-x · Cited by 119 · see citing works
Jähn, K., Lara-Castillo, N., Brotto, L. S., Mo, C., Johnson, M., Brotto, M., & Bonewald, L. F. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a14 · Cited by 117 · see citing works
Genetics of the Musculoskeletal System: A Pleiotropic Approach
Karasik, D., & Kiel, D. P. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080218 · Cited by 117 · see citing works
Molecular bases of the crosstalk between bone and muscle
Karsenty, G., & Mera, P. (2017) · Bone · doi:10.1016/j.bone.2017.04.006 · Cited by 117 · see citing works
Nutrition: its role in bone health
Rizzoli, R. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.08.005 · Cited by 116 · see citing works
Osteocalcin as a hormone regulating glucose metabolism
Kanazawa, I. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i18.1345 · Cited by 115 · see citing works
A myostatin and activin decoy receptor enhances bone formation in mice
Bialek, P., Parkington, J. D., Li, X., Gavin, D., Wallace, C. E., Zhang, J., Root, A. R., Yan, G., Warner, L., Seeherman, H. J., et al. (2013) · Bone · doi:10.1016/j.bone.2013.12.002 · Cited by 111 · see citing works
LeBrasseur, N. K., Achenbach, S. J., Melton, L. J., Amin, S., & Khosla, S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1666 · Cited by 109 · see citing works
Crosstalk Between MLO‐Y4 Osteocytes and C2C12 Muscle Cells Is Mediated by the Wnt/β‐Catenin Pathway
Huang, J. M., Romero‐Suarez, S., Lara, N., Mo, C., Kaja, S., Brotto, L. S., Dallas, S. L., Johnson, M. L., Jähn, K., Bonewald, L. F., et al. (2017) · JBMR Plus · doi:10.1002/jbm4.10015 · Cited by 107 · see citing works
Huang, J. M., Hsu, Y., Mo, C., de Abreu, E. L., Kiel, D. P., Bonewald, L. F., Brotto, M., & Karasik, D. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2200 · Cited by 99 · see citing works
Deletion of Connexin43 in Osteoblasts/Osteocytes Leads to Impaired Muscle Formation in Mice
Shen, H., Grimston, S. K., Civitelli, R., & Thomopoulos, S. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2389 · Cited by 95 · see citing works
The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
Kim, S. Y., Won, C. W., Kim, B.-S., Choi, H. R., & Moon, M. Y. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.7.995 · Cited by 95 · see citing works
Liu, S.-F., Gao, F., Wen, L., Ouyang, M., Wang, Y., Wang, Q., Luo, L., & Jian, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000481752 · Cited by 87 · see citing works
Influence of Extensive Muscle Injury on Fracture Healing in Rat Tibia
Utvåg, S. E., Grundnes, O., Rindal, D. B., et al. (2003) · Journal of Orthopaedic Trauma · doi:10.1097/00005131-200307000-00007 · Cited by 86 · see citing works
Roles of Irisin in the Linkage from Muscle to Bone During Mechanical Unloading in Mice
Kawao, N., Moritake, A., Tatsumi, K., & Kaji, H. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0387-3 · Cited by 79 · see citing works
Harcourt, L. J., Schertzer, J. D., Ryall, J. G., & Lynch, G. S. (2006) · Neuromuscular Disorders · doi:10.1016/j.nmd.2006.08.012 · Cited by 77 · see citing works
Djaafar, S., Pierroz, D. D., Chicheportiche, R., Zheng, X. X., Ferrari, S., & Ferrari‐Lacraz, S. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27645 · Cited by 61 · see citing works
Role of Irisin on the bone–muscle functional unit
Colaianni, G., & Grano, M. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.134 · Cited by 57 · see citing works
Feng, S., Madsen, S. H., Viller, N. N., Neutzsky-Wulff, A. V., Geisler, C., Karlsson, L., & Söderström, K. (2015) · Immunology · doi:10.1111/imm.12449 · Cited by 52 · see citing works
Econs, M. J., Friedman, N. E., Rowe, P. S., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5167 · Cited by 51 · see citing works
Gorski, J. P., Huffman, N. T., Vallejo, J. A., Brotto, L. S., Chittur, S. V., Breggia, A., Stern, A. R., Huang, J. M., Mo, C., Seidah, N. G., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686626 · Cited by 48 · see citing works
The genetic pleiotropy of musculoskeletal aging
Karasik, D., & Cohen, M. W. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00303 · Cited by 41 · see citing works
Warden, S. J., Galley, M. R., Richard, J. S., George, L. A., Dirks, R. C., Guildenbecher, E. A., Judd, A. M., Robling, A. G., & Fuchs, R. K. (2013) · Bone · doi:10.1016/j.bone.2013.01.043 · Cited by 38 · see citing works
Payne, K. A., Meszaros, L. B., Phillippi, J. A., & Huard, J. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0738 · Cited by 38 · see citing works
Bivariate Genome-Wide Linkage Analysis of Femoral Bone Traits and Leg Lean Mass: Framingham Study
Karasik, D., Zhou, Y., Cupples, L. A., Hannan, M. T., Kiel, D. P., & Demissie, S. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081222 · Cited by 36 · see citing works
Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model
Regan, J. N., MIKESELL, C. D., Reiken, S. R., Xu, H., Marks, A. R., Mohammad, K. S., Guise, T. A., & Waning, D. L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00358 · Cited by 36 · see citing works
Self-citationThe Role of Prostaglandins in Bone Formation
Harada, S.-I., Balena, R., Rodan, G. A., & Rodan, S. B. (1995) · Connective Tissue Research · doi:10.3109/03008209509010823 · Cited by 35 · see citing works
Mechanically Loaded Myotubes Affect Osteoclast Formation
Juffer, P., Jaspers, R. T., Klein‐Nulend, J., & Bakker, A. D. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9813-8 · Cited by 32 · see citing works
Neuronal control of bone and muscle
Houweling, P. J., Kulkarni, R. N., & Baldock, P. A. J. (2015) · Bone · doi:10.1016/j.bone.2015.05.006 · Cited by 31 · see citing works
Wacker, M., Touchberry, C. D., Silswal, N., Brotto, L. S., Elmore, C. J., Bonewald, L. F., Andresen, J. J., & Brotto, M. A. P. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00173 · Cited by 30 · see citing works
The Role of Sclerostin in the Pathophysiology of Sclerosing Bone Dysplasias
van Lierop, A. H., Hamdy, N. A. T., van Bezooijen, R. L., Löwik, C. W. G. M., & Papapoulos, S. E. (2011) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-011-9123-5 · Cited by 23 · see citing works
D7-brane moduli vs. F-theory cycles in elliptically fibred threefolds
Braun, A. P., Gerigk, S., Hebecker, A., et al. (2010) · Nuclear Physics B · doi:10.1016/j.nuclphysb.2010.04.008 · Cited by 14 · see citing works
Kido, S., Hashimoto, Y., Segawa, H., et al. (2012) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2012.04.435 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [63]Krause A, Speacht T, Govey P, Sarcopenia and increased body fat in sclerostin deficient mice. J Bone Miner Res. 2014; 29: S8– S9.
Cited by
Sorted by citations
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Interactions between Muscle and Bone—Where Physics Meets Biology
Herrmann, M., Engelke, K., Ebert, R., Müller-Deubert, S., Rudert, M., Ziouti, F., Jundt, F., Felsenberg, D., & Jakob, F. (2020) · Biomolecules · doi:10.3390/biom10030432 · Cited by 197 · see citing works
Research progress on sarcopenia in the musculoskeletal system
Mao, X., Lv, K., Qi, W., Cheng, W., Li, T., Sun, Y., Jin, H., Pan, H., & Wang, D. (2025) · Bone Research · doi:10.1038/s41413-025-00455-8 · Cited by 37 · see citing works
Self-citation
- Authors
- Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P.
- Affiliations
- Northwestern Polytechnical University (CN)
- Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences Northwestern Polytechnical University Xi'an Shaanxi China
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Xu, HuiYun
- Shang, Peng
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2019-05-20
- Volume
- 120
- Issue
- 9
- Pages
- 14262-14273
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- PMC
- PMC7331460
- OpenAlex
- W2945445715
- Cited by
- 166
- References
- 101
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 32 · 2023: 32 · 2022: 28 · 2021: 20 · 2020: 11 · 2019: 2
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Natural Science Foundation of China (81772409)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- muscle-bone crosstalk, sarcopenia, osteoporosis, myokines, myostatin, irisin, fibroblast growth factor 23, osteocalcin, sclerostin, exosomes, aging, circadian rhythm, nervous system, nutrition, therapeutic target
- MeSH terms
- Fibroblast Growth Factor-23, Aging, Bone and Bones, Circadian Rhythm, Humans, Muscle Proteins, Nervous System Physiological Phenomena, Protein Binding, Signal Transduction, Osteocalcin, Muscle, Skeletal
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