Chronic inflammation and the hallmarks of aging

Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation

Zeng, X., Li, X., Li, X., Wei, C., Shi, C., Hu, K., Kong, D., Luo, Q., Xu, Y., Shan, W., et al. (2023) · Blood · doi:10.1182/blood.2022017514 · Cited by 157

COVID-19 and cellular senescence

Schmitt, C. A., Tchkonia, T., Niedernhofer, L. J., Robbins, P. D., Kirkland, J. L., & Lee, S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00785-2 · Cited by 153

MitophAging: Mitophagy in Aging and Disease

Bakula, D., & Scheibye‐Knudsen, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00239 · Cited by 152

Mechanisms and disease implications of sirtuin-mediated autophagic regulation

Lee, I. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0302-7 · Cited by 151

The Role of Exosomal microRNAs and Oxidative Stress in Neurodegenerative Diseases

Wang, X., Zhou, Y., Gao, Q., Ping, D., Wang, Y., Wu, W., Xu, L., Fang, Y., Zhang, J., & Shao, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3232869 · Cited by 151

Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism

Sadria, M., & Layton, A. T. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00706-1 · Cited by 150

Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

Mender, I., Zhang, A., Ren, Z., Han, C., Deng, Y., Siteni, S., Li, H., Zhu, J., Vemula, A., Shay, J. W., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.020 · Cited by 149

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

Mullen, P. J., Garcia, G., Purkayastha, A., Matulionis, N., Schmid, E. W., Momcilovic, M., Sen, C., Langerman, J., Ramaiah, A., Shackelford, D. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22166-4 · Cited by 149

Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection

Bellon, M., & Nicot, C. (2017) · Viruses · doi:10.3390/v9100289 · Cited by 147

A role for autophagy in Huntington's disease

Croce, K. R., & Yamamoto, A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.010 · Cited by 144

Mitophagy in neurological disorders

Zhang, L., Dai, L., & Li, D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02334-5 · Cited by 143

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Wielscher, M., Mandaviya, P. R., Kuehnel, B., Joehanes, R., Mustafa, R., Robinson, O., Zhang, Y., Bodinier, B., Walton, E., Mishra, P. P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29792-6 · Cited by 141

Aging is associated with hypermethylation of autophagy genes in macrophages

Khalil, H., Tazi, M., Caution, K., Ahmed, A. E., Kanneganti, A., Assani, K. D., Kopp, B. T., Marsh, C. B., Dakhlallah, D. A., & Amer, A. O. (2016) · Epigenetics · doi:10.1080/15592294.2016.1144007 · Cited by 140

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging

Khan, S. M., Chan, Y. T., Revelo, X. S., & Winer, D. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00267 · Cited by 140

“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases

Cai, D., & Khor, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.021 · Cited by 138

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models

Zhuang, X., Wang, S.-F., Tan, Y., Song, J., Zhu, Z., Wang, Z., Wu, M.-Y., Cai, C.-Z., Huang, Z., Tan, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2322-6 · Cited by 136

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

Dembny, P., Newman, A. G., Singh, M., Hinz, M., Szczepek, M., Krüger, C., Adalbert, R., Dzaye, O., Trimbuch, T., Wallach, T., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.131093 · Cited by 134

Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity

Rivas, D. A., McDonald, D. J., Rice, N. P., Haran, P. H., Dolnikowski, G. G., & Fielding, R. A. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00198.2015 · Cited by 132

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7

Salvi, V., Gianello, V., Busatto, S., Bergese, P., Andréoli, L., D’Oro, U., Zingoni, A., Tincani, A., Sozzani, S., & Bosisio, D. (2018) · JCI Insight · doi:10.1172/jci.insight.98204 · Cited by 130

Cell‐free DNA as a biomarker of aging

Teo, Y. V., Capri, M., Morsiani, C., Pizza, G., Faria, A. M. C., Franceschi, C., & Neretti, N. (2019) · Aging Cell · doi:10.1111/acel.12890 · Cited by 127

Cellular reprogramming and epigenetic rejuvenation

Simpson, D. J., Olova, N. N., & Chandra, T. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01158-7 · Cited by 127

The Role of Immune Cells in Oxi-Inflamm-Aging

de Toda, I. M., Ceprián, N., Cerro, E. D., & la Fuente, M. D. (2021) · Cells · doi:10.3390/cells10112974 · Cited by 124

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging · doi:10.18632/aging.102863 · Cited by 122

The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy

Xu, T., Liu, J., Li, X.-R., Yu, Y., Luo, X., Zheng, X., Cheng, Y. G., Yu, P.-Q., & Liu, Y. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02390-1 · Cited by 122

Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction

Mallavia, B., Liu, F., Lefrançais, E., Cleary, S. J., Kwaan, N., Tian, J. J., Magnen, M., Sayah, D. M., Soong, A., Chen, J., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0140oc · Cited by 118

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

Haythorne, E., Lloyd, M., Walsby-Tickle, J., Tarasov, A. I., Sandbrink, J. B., Portillo, I., Terrón-Expósito, R., Sachse, G., Cyranka, M., Rohm, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34095-x · Cited by 118

Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease

Lv, Q.-K., Tao, K., Wang, X.-B., Yao, X., Pang, M., Liu, J., Wang, F., & Liu, C. (2023) · Inflammation Research · doi:10.1007/s00011-022-01676-x · Cited by 117

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

Tang, Y., Purkayastha, S., & Cai, D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.10.002 · Cited by 115

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

Xu, P., Wang, M., Song, W.-M., Wang, Q., Yuan, G.-C., Sudmant, P. H., Zare, H., Tu, Z., Orr, M. E., & Zhang, B. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00507-7 · Cited by 114

Systemic induction of senescence in young mice after single heterochronic blood exchange

Jeon, O. H., Mehdipour, M., Gil, T.-H., Kang, M., Aguirre, N. W., Robinson, Z. R., Kato, C., Etienne, J., Lee, H. G., Alimirah, F., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00609-6 · Cited by 114

Control of immune cell function by the unfolded protein response

Conza, G. D., Ho, P., Cubillos‐Ruiz, J. R., & Huang, S. C. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00838-0 · Cited by 113

Antiaging agents: safe interventions to slow aging and healthy life span extension

Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 112

Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo

Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111

The impact of age on genetic risk for common diseases

Jiang, X., Holmes, C. C., & McVean, G. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009723 · Cited by 110

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

Ham, D. J., Börsch, A., Chojnowska, K., Lin, S., Leuchtmann, A. B., Ham, A. S., Thürkauf, M., Delezie, J., Furrer, R., Bürri, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29714-6 · Cited by 110

Role of autophagy in aging: The good, the bad, and the ugly

TABIBZADEH, S. S. (2022) · Aging Cell · doi:10.1111/acel.13753 · Cited by 107

Transmission of α-synuclein seeds in neurodegenerative disease: recent developments

Karpowicz, R. J., Trojanowski, J. Q., & Lee, V. M. ‐. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0195-z · Cited by 105

Mitochondria, immunosenescence and inflammaging: a role for mitokines?

Conte, M., Martucci, M., Chiariello, A., Franceschi, C., & Salvioli, S. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00813-0 · Cited by 105

Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

Amin, A., Perera, N. D., Beart, P. M., Turner, B. J., & Shabanpoor, F. (2020) · Cells · doi:10.3390/cells9112413 · Cited by 103

Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration

Molinero, N., Antón‐Fernández, A., Hernández, F., Ávila, J., Bartolomé, B., & Moreno-Arribas, M. V. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.02.014 · Cited by 101

The IKK‐related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists

Bodur, Ç., Kazyken, D., Huang, K., Üstünel, B. E., Siroky, K. A., Tooley, A. S., Gonzalez, I. E., Foley, D. H., Acosta-Jaquez, H. A., Barnes, T. M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696164 · Cited by 100

Inflammation‐mediated genomic instability: roles of activation‐induced cytidine deaminase in carcinogenesis

Shimizu, T., Marusawa, H., Endo, Y., & Chiba, T. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02293.x · Cited by 99

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01904-z · Cited by 99

Mechanosensing in macrophages and dendritic cells in steady-state and disease

Lee, M., Du, H., Winer, D. A., Clemente-Casares, X., & Tsai, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044729 · Cited by 99

Aging‐related Atg5 defect impairs neutrophil extracellular traps formation

Xu, F., Zhang, C., Zou, Z., Fan, E., Chen, L., Li, Y., Billiar, T. R., Wilson, M. A., Shi, X., & Fan, J. (2017) · Immunology · doi:10.1111/imm.12740 · Cited by 98

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

Wang, J., Thomas, H. R., Li, Z., Yeo, N. C., Scott, H. E., Dang, N. D.-P., Hossain, M. I., Andrabi, S. A., & Parant, J. M. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03902-6 · Cited by 98

A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo

Yan, C., Tian, X., Li, J., Liu, D., Ye, D., Xie, Z., Han, Y., & Zou, M. (2020) · Diabetes · doi:10.2337/db20-0146 · Cited by 96

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

Jiang, H., Westerterp, M., Wang, C., Zhu, Y., & Ai, D. (2014) · Diabetologia · doi:10.1007/s00125-014-3350-5 · Cited by 95

Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles

Weilner, S., Keider, V., Winter, M., Harreither, E., Salzer, B., Weiß, F., Schraml, E., Messner, P., Pietschmann, P., Hildner, F., et al. (2016) · Aging · doi:10.18632/aging.100865 · Cited by 95

Immunologic impact of the intestine in metabolic disease

Winer, D. A., Winer, S., Dranse, H. J., & Lam, T. K. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88879 · Cited by 95

The CD38 glycohydrolase and the NAD sink: implications for pathological conditions

Zeidler, J. D., Hogan, K. A., Agorrody, G., Peclat, T., Kashyap, S., Kanamori, K. S., Gomez, L. S., Mazdeh, D. Z., Warner, G. M., Thompson, K. L., et al. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00451.2021 · Cited by 95

Aging-induced IL27Ra signaling impairs hematopoietic stem cells

He, H., Xu, P., Zhang, X., Liao, M., Dong, Q., Cong, T., Tang, B., Yang, X., Ye, M., Chang, Y., et al. (2020) · Blood · doi:10.1182/blood.2019003910 · Cited by 94 · cited 1×

Diminished immune responses with aging predispose older adults to common and uncommon influenza complications

Keilich, S. R., Bartley, J. M., & Haynes, L. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103992 · Cited by 92

Extensive accumulation of misfolded protein aggregates during natural aging and senescence

Cuanalo-Contreras, K., Schulz, J., Mukherjee, A., Park, K.-W., Armijo, E., & Soto, C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1090109 · Cited by 92

mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

Guillén, C., & Benito, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00621 · Cited by 91

Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis

Mayer‐Hamblett, N., Kronmal, R. A., Gibson, R. L., et al. (2011) · Pediatric Pulmonology · doi:10.1002/ppul.21525 · Cited by 90

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase

Yoneyama, Y., Inamitsu, T., Chida, K., Iemura, S., Natsume, T., Maeda, T., Hakuno, F., & Takahashi, S. (2018) · iScience · doi:10.1016/j.isci.2018.06.006 · Cited by 90

PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis

Nam, B. Y., Jhee, J. H., Park, J., Kim, S., Kim, G., Park, J. T., Yoo, T., Kang, S., Yu, J., & Han, S. H. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04480-3 · Cited by 89

ROS networks: designs, aging, Parkinson’s disease and precision therapies

Kolodkin, A. N., Sharma, R. P., Colangelo, A. M., Ignatenko, A., Martorana, F., Jennen, D. G. J., Briedé, J. J., Brady, N. R., Barberis, M., Mondeel, T. D. G. A., et al. (2020) · npj Systems Biology and Applications · doi:10.1038/s41540-020-00150-w · Cited by 89

T Cell Immunosenescence in Aging, Obesity, and Cardiovascular Disease

Shirakawa, K., & Sano, M. (2021) · Cells · doi:10.3390/cells10092435 · Cited by 89

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Chen, Z., Amro, E. M., Becker, F. R., Hölzer, M., Rasa, S. M. M., Njeru, S. N., Han, B., Sanzo, S. D., Chen, Y.-L., Tang, D., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181505 · Cited by 88

Role of Proteasomes in Inflammation

Goetzke, C. C., Ebstein, F., & Kallinich, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081783 · Cited by 88

SIRT6 is a key regulator of mitochondrial function in the brain

Smirnov, D., Eremenko, E., Stein, D., Kaluski, S., Jasińska, W., Cosentino, C., Martínez-Pastor, B., Brotman, Y., Mostoslavsky, R., Khrameeva, E. E., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-022-05542-w · Cited by 88

Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease

Lee, M. Y., Lee, J.-H., Hyeon, S. J., Cho, H., Hwang, Y. J., Shin, J., McKee, A. C., Kowall, N. W., Kim, J., Stein, T. D., et al. (2020) · Aging Cell · doi:10.1111/acel.13153 · Cited by 87

Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype

Ieronymaki, E., Theodorakis, E. M., Lyroni, K., Vergadi, E., Lagoudaki, E. D., Al-Qahtani, A. A., Aznaourova, M., Neofotistou-Themeli, E., Eliopoulos, A. G., Vaporidi, K., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800065 · Cited by 86

The intestinal immune system and gut barrier function in obesity and ageing

Shemtov, S. J., Emani, R., Bielska, O., Covarrubias, A. J., Verdin, E. M., Andersen, J. K., & Winer, D. A. (2022) · FEBS Journal · doi:10.1111/febs.16558 · Cited by 86

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85

The functions and roles of sestrins in regulating human diseases

Chen, Y., Huang, T., Yu, Z., Yu, Q., Wang, Y., Hu, J., Shi, J., & Yang, G. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00302-8 · Cited by 85

AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

Zhang, Q., Liu, S., Zhang, C., Wu, Q., Yu, X., Zhou, R., Meng, F., Wang, A., Zhang, F., Chen, S., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.10.026 · Cited by 85

Crosstalk between the Akt/mTORC1 and NF-κB signaling pathways promotes hypoxia-induced pulmonary hypertension by increasing DPP4 expression in PASMCs

Li, Y., Li, Y., Dong, L., Yang, Z., Zhang, J., Zhang, S., Niu, M., Xia, J., Gong, Y., Zhu, N., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0272-2 · Cited by 84

Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance

Revelo, X. S., Ghazarian, M., Chng, M. H. Y., Luck, H., Kim, J. H., Zeng, K., Shi, S. Y., Tsai, S. J., Lei, H., Kenkel, J. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.024 · Cited by 83

Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis

Kang, Y., Zhang, H., Zhao, Y., Wang, Y., Wang, W. T., He, Y., Zhang, W. K., Zhang, W., Zhu, X., Zhou, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.071 · Cited by 83

Lifespan of mice and primates correlates with immunoproteasome expression

Pickering, A. M., Lehr, M., & Miller, R. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80514 · Cited by 82

mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism

Collins, S. L., Oh, M. H., Sun, I., Chan‐Li, Y., Zhao, L., Powell, J. D., & Horton, M. R. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100230 · Cited by 82

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

Nath, N., Khan, M., Rattan, R., Mangalam, A. K., Makkar, R. S., de Meester, C., Bertrand, L., Singh, I., Chen, Y., Viollet, B., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.106 · Cited by 81

TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy

Shen, J.-F., Dai, Z., Li, Y., Zhu, H., & Zhao, L. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00780-y · Cited by 81

Molecular properties and regulation of NAD+ kinase (NADK)

Oka, S., Titus, A. S., Zablocki, D., & Sadoshima, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102561 · Cited by 80

Molecular mechanisms controlling age‐associated B cells in autoimmunity*

Phalke, S., Rivera‐Correa, J., Jenkins, D., Flores-Castro, D., Γιαννοπούλου, Ε., & Pernis, A. B. (2022) · Immunological Reviews · doi:10.1111/imr.13068 · Cited by 79

Regulation of the immune system by the insulin receptor in health and disease

Makhijani, P., Basso, P. J., Chan, Y. T., Chen, N., Baechle, J. J., Khan, S. M., Furman, D., Tsai, S. J., & Winer, D. A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1128622 · Cited by 79

Mitochondrial damage activates the NLRP10 inflammasome

Próchnicki, T., Vasconcelos, M. B., Robinson, K. S., Mangan, M., de Graaf, D. M., Shkarina, K., Lovotti, M., Standke, L., Kaiser, R., Stahl, R., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01451-y · Cited by 79

MicroRNA controls of cellular senescence

Suh, N. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.10.209 · Cited by 78

Muscle mitochondrial energetics predicts mobility decline in well-functioning older adults: the baltimore longitudinal study of aging

Tian, Q., Mitchell, B. A., Zampino, M., Fishbein, K. W., Spencer, R. G., & Ferrucci, L. (2022) · Aging Cell · doi:10.1111/acel.13552 · Cited by 78

Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice

Correia‐Melo, C., Birch, J., Fielder, E., Rahmatika, D., Taylor, J., Chapman, J., Lagnado, A., Carroll, B. M., Miwa, S., Richardson, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12882 · Cited by 77 · cited 2×

Targeting cellular senescence in metabolic disease

Palmer, A. K., Tchkonia, T., & Kirkland, J. L. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101601 · Cited by 76

Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis

Chen, Y., Liu, Y., Jiang, K., Wen, Z., Cao, X., & Wu, S. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.11.002 · Cited by 76

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine

Cangelosi, A. L., Puszynska, A. M., Roberts, J. M., Armani, A., Nguyen, T. P., Spinelli, J. B., Kunchok, T., Wang, B., Chan, S. H., Lewis, C. A., et al. (2022) · Science · doi:10.1126/science.abi9547 · Cited by 75

Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics

Kulkarni, A., Preeti, K., Tryphena, K. P., Srivastava, S., Singh, S. B., & Khatri, D. K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101816 · Cited by 74

IKKβ suppression of TSC1 function links the mTOR pathway with insulin resistance

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Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity

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