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The aging of ER-mitochondria communication: A journey from undifferentiated to aged cells

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CD4+ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets

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STAT3 modulates CD4 +T mitochondrial dynamics and function in aging

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Metabolic regulation of immunological aging

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The Role of T Cell Senescence in Neurological Diseases and Its Regulation by Cellular Metabolism

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Applying causal discovery to single-cell analyses using CausalCell

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“Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications

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Age-related changes in energy metabolism in peripheral mononuclear blood cells (PBMCs) and the brains of cognitively healthy seniors

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The Impact of T-cell Aging on Alloimmunity and Inflammaging

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Meta-epigenetic shifts in T cell aging and aging-related dysfunction

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Longevity, Centenarians and Modified Cellular Proteodynamics

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Basal autophagic flux measured in blood correlates positively with age in adults at increased risk of type 2 diabetes

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Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation

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Increased Efficiency of Mitochondrial Coupling With a Reduction in Other Mitochondrial Respiratory Parameters in Peripheral Blood Mononuclear Cells Is Observed in Older Adults

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A glance through the effects of CD4 + T cells, CD8 + T cells, and cytokines on Alzheimer's disease

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Mitochondrial phenotypes in purified human immune cell subtypes and cell mixturesPreprint

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Chromatin Modifications in 22q11.2 Deletion Syndrome

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Energizing Mitochondria to Prevent Mobility Loss in Aging: Rationale and Hypotheses

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An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases

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Resveratrol promotes apoptosis and G2/M cell cycle arrest of fibroblast-like synoviocytes in rheumatoid arthritis through regulation of autophagy and the serine-threonine kinase-p53 axis

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Proteostasis in T cell aging

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The immunometabolic roots of aging

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Defining Microbiota‐Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age‐Related T Cell Senescence

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The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk

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Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms

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Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapy

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Cellular senescence and cell therapy in cardiovascular diseases

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Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus

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Immunosenescence and immunotherapy in elderly patients with hepatocellular carcinoma

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Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis

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Physical Activity Modifies the Metabolic Profile of CD4 + and CD8 + T‐Cell Subtypes at Rest and Upon Activation in Older Adults

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Building the case for mitochondrial transplantation as an anti-aging cardiovascular therapy

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Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases

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Mitochondrial Oxidative Stress Regulates FOXP3+ T-Cell Activity and CD4-Mediated Inflammation in Older Adults with Frailty

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Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Kassir, M. F., Lee, H. G., Oleinik, N. V., Wofford, W., Walton, C., Atilgan, F. C., Janneh, A. H., Chakraborty, P., Calisir, K., Percin, E., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4740 · Cited by 10 · see citing works

Cell‐Type‐Specific Autophagy in Human Leukocytes

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Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment

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T-cell senescence: Unlocking the tumor immune “Dark Box” - A multidimensional analysis from mechanism to tumor immunotherapeutic intervention

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Causes and consequences of T cell DNA damage

Koufaris, C., Berger, M., & Aqeilan, R. I. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.04.006 · Cited by 8 · see citing works

Metabolic Signaling as a Driver of T Cell Aging

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Mitochondrial quality control in human ageing and longevity

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Towards understanding the mechanism of action of a polyherbal formulation using a multi-pronged strategy

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PBMCs Mitochondrial Respiration and Its Relation to Immunity, Fitness, and Metabolic Risk in the Healthy Elderly

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Statistical and machine learning methods to study human CD4+ T cell proteome profiles

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Quercetin prevents the loss of chondrogenic capacity in expansion cultured human auricular chondrocytes by alleviating mitochondrial dysfunction

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The ecto-enzyme CD38 modulates CD4T cell immunometabolic responses and participates in HIV pathogenesis

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Molecular Biomarkers of Health

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A unique inflammaging profile generated by T cells from people with obesity is metformin resistant

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CD8+ T cell aging, senescence, and related disease

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Kaempferol alleviates T-cell immunosenescence and inflammaging in aged mice via the SIRT3-LKB1-AMPK-mitophagy pathway

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Immune aging biomarkers for clinical trials

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Physical activity modifies the metabolic profile of CD4+ and CD8+ T cell subtypes at rest and upon activation in older adultsPreprint

Withnall, E., Hazeldine, J., Llibre, A., Duggal, N. A., Lord, J. M., & Sardeli, A. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.20.607078 · Cited by 2 · see citing works

Mitochondrial Bioenergetic Profiling in T Cell Subsets Associates With Functional Health in Older Adults: A Cross-sectional Analysis From the INSPIRE-T Cohort

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Preservation of Autophagy May Be a Mechanism Behind Healthy Aging

Bektas, A., Schurman, S. H., Candia, J., Santiago‐Fernández, O., Kaushik, S., Cuervo, A. M., & Ferrucci, L. (2025) · Aging Cell · doi:10.1111/acel.70246 · Cited by 2 · see citing works

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

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Lifelong Exercise as a Modulator of CD4 + T Cell Immunometabolism

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Pearson syndrome-like anemia induced by accumulation of mutant mtDNA and anemia with imbalanced white blood cell lineages induced by Drp1 deletion in a murine model

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Immune aging and pulmonary diseases

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T Cell Aging: An Important Target for Perioperative Immunomodulation

Lan, H., Xu, S., Li, H., Guo, R., Feng, Z., & Wang, Y. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s519438

Immunosenescence and CoQ10

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Defining microbiota-derived metabolite butyrate as a senomorphic: therapeutic potential in the age-related T cell senescencePreprint

Duggal, N. A., Rees, N. P., Conway, J., Dugan, B., Parker, A., & Carding, S. R. (2025) · Research Square · doi:10.21203/rs.3.rs-6419928/v1 · Cited by 1 · see citing works

Old T cells pollute with mito-litter

Heras, M. M. G. D. L., & Mittelbrunn, M. (2023) · Nature Aging · doi:10.1038/s43587-023-00412-2

CD4+ T Cells at the Center of Inflammaging

Kroemer, G., & Zitvogel, L. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.016 · Cited by 29 · see citing works

Preservation of Autophagy May Be a Mechanism Behind Healthy Aging

Bektas, A., Schurman, S. H., Candia, J., Santiago‐Fernández, O., Kaushik, S., Cuervo, A. M., & Ferrucci, L. (2025) · Aging Cell · doi:10.1111/acel.70246 · Cited by 2 · see citing works

Inheritance of old mitochondria controls early CD8 + T cell fate commitment and is regulated by autophagyPreprint

Borsa, M., Lechuga‐Vieco, A. V., Kayvanjoo, A. H., Yazicioglu, Y. F., Compeer, E. B., Richter, F. C., Bui, H. M., Dustin, M. L., Katajisto, P., & Simon, A. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.29.577412 · Cited by 5 · see citing works

Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4 + T Cells in Aging

Headley, C. A., Gautam, S., Olmo-Fontánez, A. M., Garcia‐Vilanova, A., Dwivedi, V., Akhter, A., Schami, A., Chiem, K., Ault, R., Zhang, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202303664 · Cited by 24 · see citing works