CoChat
Sign Up
Cited by 35

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Reprogramming: Emerging Strategies to Rejuvenate Aging Cells and Tissues

Alle, Quentin, Le Borgne, Enora, Milhavet, Ollivier, Lemaitre, Jean-Marc·2021·International Journal of Molecular Sciences
DOI 10.3390/ijms22083990PMC PMC8070588
Open this paper in CoChat — free account

Abstract

Aging is associated with a progressive and functional decline of all tissues and a striking increase in many “age-related diseases”. Although aging has long been considered an inevitable process, strategies to delay and potentially even reverse the aging process have recently been developed. Here, we review emerging rejuvenation strategies that are based on reprogramming toward pluripotency. Some of these approaches may eventually lead to medical applications to improve healthspan and longevity.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms22083990

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Loss of epigenetic information has been proposed as a critical cause of aging that precedes many other aspects of age-related deterioration.

    “Among the hallmarks of aging, loss of epigenetic information has been proposed as a critical cause of aging that precedes many other aspects of age-related deterioration 2,[5][6][7][8] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [5]

    Section 2.2.1 identifies epigenetic alterations as one of several primary hallmarks that trigger accumulating harmful consequences; Section 2.2.2 describes later damage responses to primary hallmarks. The paper does not single out loss of epigenetic information as a critical cause that precedes many other aspects of deterioration, and instead presents aging as multifactorial. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 150

  1. Takahashi, 2006, Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Cell, 126, 663, 10.1016/j.cell.2006.07.024 · DOI · Paper page
  2. Seals, 2016, Physiological geroscience: Targeting function to increase healthspan and achieve optimal longevity, J. Physiol., 594, 2001, 10.1113/jphysiol.2014.282665 · DOI
  3. Pison, 2019, Pourquoi l’espérance de vie augmente-t-elle moins vite en France?, Popul. Sociétés, 564, 1
  4. DeSantis, 2019, Cancer statistics for adults aged 85 years and older, CA Cancer J. Clin., 69, 452, 10.3322/caac.21577 · DOI · Paper page
  5. Hazlehurst, 2016, Non-alcoholic fatty liver disease and diabetes, Metabolism, 65, 1096, 10.1016/j.metabol.2016.01.001 · DOI
  6. Birbrair, 2014, Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner, Stem Cell Res. Ther., 5, 122, 10.1186/scrt512 · DOI
  7. Espindola, 2018, Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis, Am. J. Respir. Crit. Care Med., 197, 1443, 10.1164/rccm.201707-1519OC · DOI
  8. Nastase, 2018, Targeting renal fibrosis: Mechanisms and drug delivery systems, Adv. Drug. Deliv. Rev., 129, 295, 10.1016/j.addr.2017.12.019 · DOI
  9. Lemmer, 2018, Assessment of Advanced Liver Fibrosis and the Risk for Hepatic Decompensation in Patients With Congestive Hepatopathy, Hepatology, 68, 1633, 10.1002/hep.30048 · DOI
  10. Li, 2018, Extracellular matrix remodeling and cardiac fibrosis, Matrix Biol. J. Int. Soc. Matrix Biol., 68–69, 490, 10.1016/j.matbio.2018.01.013 · DOI
  11. Palacio, 2019, Restored immune cell functions upon clearance of senescence in the irradiated splenic environment, Aging Cell, 18, e12971, 10.1111/acel.12971 · DOI · Paper page
  12. Bowl, 2019, Age-Related Hearing Loss, Cold Spring Harb. Perspect Med., 9, a033217, 10.1101/cshperspect.a033217 · DOI
  13. Pelletier, 2016, Vision Loss in Older Adults, Am. Fam. Physician, 94, 219
  14. Faggioli, 2012, Chromosome-specific accumulation of aneuploidy in the aging mouse brain, Hum. Mol. Genet., 21, 5246, 10.1093/hmg/dds375 · DOI · Paper page
  15. Forsberg, 2012, Age-related somatic structural changes in the nuclear genome of human blood cells, Am. J. Hum. Genet., 90, 217, 10.1016/j.ajhg.2011.12.009 · DOI · Paper page
  16. Park, 2011, Mitochondrial DNA mutations in disease and aging, J. Cell Biol., 193, 809, 10.1083/jcb.201010024 · DOI · Paper page
  17. Zhu, 2019, Telomere and its role in the aging pathways: Telomere shortening, cell senescence and mitochondria dysfunction, Biogerontology, 20, 1, 10.1007/s10522-018-9769-1 · DOI · Paper page
  18. Field, 2018, DNA Methylation Clocks in Aging: Categories, Causes, and Consequences, Mol. Cell, 71, 882, 10.1016/j.molcel.2018.08.008 · DOI
  19. Jones, 2015, DNA methylation and healthy human aging, Aging Cell, 14, 924, 10.1111/acel.12349 · DOI
  20. Laskowska, 2019, Proteomic analysis of protein homeostasis and aggregation, J. Proteom., 198, 98, 10.1016/j.jprot.2018.12.003 · DOI
  21. Klaips, 2018, Pathways of cellular proteostasis in aging and disease, J. Cell Biol., 217, 51, 10.1083/jcb.201709072 · DOI
  22. Leidal, 2018, Autophagy and the cell biology of age-related disease, Nat. Cell Biol., 20, 1338, 10.1038/s41556-018-0235-8 · DOI · Paper page
  23. Tomaru, 2012, Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities, Am. J. Pathol., 180, 963, 10.1016/j.ajpath.2011.11.012 · DOI · Paper page
  24. Abdellatif, 2018, Autophagy in Cardiovascular Aging, Circ. Res., 123, 803, 10.1161/CIRCRESAHA.118.312208 · DOI · Paper page
  25. Borghesan, 2020, A Senescence-Centric View of Aging: Implications for Longevity and Disease, Trends Cell Biol., 10, 777, 10.1016/j.tcb.2020.07.002 · DOI · Paper page
  26. Kujoth, G.C., Bradshaw, P.C., Haroon, S., and Prolla, T.A. (2007). The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet., 3. · DOI
  27. Trifunovic, 2004, Premature ageing in mice expressing defective mitochondrial DNA polymerase, Nature, 429, 417, 10.1038/nature02517 · DOI · Paper page
  28. Vermulst, 2008, DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice, Nat. Genet., 40, 392, 10.1038/ng.95 · DOI · Paper page
  29. Galluzzi, 2016, Metabolic Control of Longevity, Cell, 166, 802, 10.1016/j.cell.2016.07.031 · DOI · Paper page
  30. Chen, 2019, The Epigenetics of Stem Cell Aging Comes of Age, Trends Cell Biol., 29, 563, 10.1016/j.tcb.2019.03.006 · DOI
  31. Ren, 2017, Regulation of Stem Cell Aging by Metabolism and Epigenetics, Cell Metab., 26, 460, 10.1016/j.cmet.2017.07.019 · DOI
  32. Goldberg, 2015, Drivers of age-related inflammation and strategies for healthspan extension, Immunol. Rev., 265, 63, 10.1111/imr.12295 · DOI · Paper page
  33. Franceschi, 2014, Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases, J. Gerontol. Ser. A Biol. Sci. Med Sci., 69, S4, 10.1093/gerona/glu057 · DOI · Paper page
  34. Crooke, 2019, Immunosenescence and human vaccine immune responses, Immun. Ageing I A, 16, 25, 10.1186/s12979-019-0164-9 · DOI · Paper page
  35. Fedintsev, 2020, Stochastic non-enzymatic modification of long-lived macromolecules—A missing hallmark of aging, Ageing Res. Rev., 62, 101097, 10.1016/j.arr.2020.101097 · DOI · Paper page
  36. Yuan, Y., Li, J., He, Z., Fan, X., Mao, X., Yang, M., and Yang, D. (2021). tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases. Aging Dis. · DOI
  37. Knupp, 2018, CircRNA accumulation: A new hallmark of aging?, Mech. Ageing Dev., 173, 71, 10.1016/j.mad.2018.05.001 · DOI
  38. Conboy, 2013, Heterochronic parabiosis: Historical perspective and methodological considerations for studies of aging and longevity, Aging Cell, 12, 525, 10.1111/acel.12065 · DOI · Paper page
  39. Carlson, 2008, Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells, Nature, 454, 528, 10.1038/nature07034 · DOI
  40. Egerman, 2015, GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration, Cell Metab., 22, 164, 10.1016/j.cmet.2015.05.010 · DOI · Paper page
  41. Mao, 2015, Regenerative Medicine: Current Therapies and Future Directions, Proc. Natl. Acad. Sci. USA, 112, 14452, 10.1073/pnas.1508520112 · DOI
  42. Evans, 1981, Establishment in culture of pluripotential cells from mouse embryos, Nat. Cell Biol., 292, 154
  43. Martin, 1981, Isolation of a Pluripotent Cell Line from Early Mouse Embryos Cultured in Medium Conditioned by Teratocarcinoma Stem Cells, Proc. Natl. Acad. Sci. USA, 78, 7634, 10.1073/pnas.78.12.7634 · DOI
  44. Thomson, 1995, Isolation of a Primate Embryonic Stem Cell Line, Proc. Natl. Acad. Sci. USA, 92, 7844, 10.1073/pnas.92.17.7844 · DOI
  45. Thomson, 1998, Embryonic Stem Cell Lines Derived from Human Blastocysts, Science, 282, 1145, 10.1126/science.282.5391.1145 · DOI
  46. Eguizabal, 2019, Two decades of embryonic stem cells: A historical overview, Hum. Rep. Open, 2019, hoy024
  47. Colman, 2013, Profile of John Gurdon and Shinya Yamanaka, 2012 Nobel Laureates in Medicine or Physiology, Proc. Natl. Acad. Sci. USA, 110, 5740, 10.1073/pnas.1221823110 · DOI
  48. Gurdon, 1958, Sexually Mature Individuals of Xenopus laevis from the Transplantation of Single Somatic Nuclei, Nat. Cell Biol., 182, 64
  49. Gurdon, 1962, Adult frogs derived from the nuclei of single somatic cells, Dev. Biol., 4, 256, 10.1016/0012-1606(62)90043-X · DOI
  50. Pasque, 2013, Nuclear reprogramming, Development, 140, 2468, 10.1242/dev.092049 · DOI
  51. Takahashi, 2016, A decade of transcription factor-mediated reprogramming to pluripotency, Nat. Rev. Mol. Cell Biol., 17, 183, 10.1038/nrm.2016.8 · DOI
  52. Yamanaka, 2012, Induced Pluripotent Stem Cells: Past, Present, and Future, Cell Stem Cell, 10, 678, 10.1016/j.stem.2012.05.005 · DOI
  53. Yamanaka, 2010, Nuclear reprogramming to a pluripotent state by three approaches, Nat. Cell Biol., 465, 704
  54. Takahashi, 2007, Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, 131, 861, 10.1016/j.cell.2007.11.019 · DOI · Paper page
  55. Avilion, 2003, Multipotent cell lineages in early mouse development depend on SOX2 function, Genes Dev., 17, 126, 10.1101/gad.224503 · DOI
  56. Nichols, 1998, Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor, Cell, 95, 379, 10.1016/S0092-8674(00)81769-9 · DOI
  57. Niwa, 2000, Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells, Nat. Genet., 24, 372, 10.1038/74199 · DOI
  58. Cartwright, 2005, LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism, Development, 132, 885, 10.1242/dev.01670 · DOI
  59. Li, 2005, Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor, Blood, 105, 635, 10.1182/blood-2004-07-2681 · DOI
  60. Rauch, C., Feifel, E., Kern, G., Murphy, C., Meier, F., Parson, W., Beilmann, M., Jennings, P., Gstraunthaler, G., and Wilmes, A. (2018). Differentiation of human iPSCs into functional podocytes. PLoS ONE, 13. · DOI
  61. Song, B., Smink, A.M., Jones, C.V., Callaghan, J.M., Firth, S.D., Bernard, C.A., Laslett, A.L., Kerr, P.G., and Ricardo, S.D. (2012). The Directed Differentiation of Human iPS Cells into Kidney Podocytes. PLoS ONE, 7. · DOI
  62. Fernandopulle, 2018, Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons, Curr. Protoc. Cell Biol., 79, e51, 10.1002/cpcb.51 · DOI · Paper page
  63. Yoder, 2015, Differentiation of pluripotent stem cells into endothelial cells, Curr. Opin. Hematol., 22, 252, 10.1097/MOH.0000000000000140 · DOI
  64. Acimovic, 2014, Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools, BioMed Res. Int., 2014, 1, 10.1155/2014/512831 · DOI
  65. Deng, 2016, Molecular Mechanisms of Anti-metastatic Activity of Curcumin, Anticancer Res., 36, 5639, 10.21873/anticanres.11147 · DOI
  66. Qin, 2015, Pdxl and its role in activating Ngn3 and Pax6 to induce differentiation of iPSCs into islet β cells, Genet. Mol. Res., 14, 8892, 10.4238/2015.August.3.12 · DOI
  67. Ahmed, 2018, Induced Pluripotent Stem Cells for Primary Ciliary Dyskinesia Modeling and Personalized Medicine, Am. J. Respir. Cell Mol. Biol., 59, 672, 10.1165/rcmb.2018-0213TR · DOI
  68. Akkerman, 2017, Dawn of the organoid era, BioEssays, 39, 1600244, 10.1002/bies.201600244 · DOI
  69. Rossi, 2018, Progress and potential in organoid research, Nat. Rev. Genet., 19, 671, 10.1038/s41576-018-0051-9 · DOI · Paper page
  70. Brazovskaja, 2019, High-throughput single-cell transcriptomics on organoids, Curr. Opin. Biotechnol., 55, 167, 10.1016/j.copbio.2018.11.002 · DOI
  71. Kriegstein, 2017, The use of brain organoids to investigate neural development and disease, Nat. Rev. Neurosci., 18, 573, 10.1038/nrn.2017.107 · DOI · Paper page
  72. Heide, 2018, Brain organoids as models to study human neocortex development and evolution, Curr. Opin. Cell Biol., 55, 8, 10.1016/j.ceb.2018.06.006 · DOI
  73. Seto, 2019, Human brain development and its in vitro recapitulation, Neurosci. Res., 138, 33, 10.1016/j.neures.2018.09.011 · DOI
  74. Serra, 2019, Self-organization and symmetry breaking in intestinal organoid development, Nat. Cell Biol., 569, 66
  75. Yin, 2019, Mini-gut: A promising model for drug development, Drug Discov. Today, 24, 1784, 10.1016/j.drudis.2019.06.006 · DOI
  76. Nishinakamura, 2019, Human kidney organoids: Progress and remaining challenges, Nat. Rev. Nephrol., 15, 613, 10.1038/s41581-019-0176-x · DOI
  77. Hulot, 2019, Modeling Cardiac Arrhythmias with Organoids, J. Am. Coll. Cardiol., 73, 2325, 10.1016/j.jacc.2019.01.076 · DOI
  78. Nugraha, 2019, Human Cardiac Organoids for Disease Modeling, Clin. Pharmacol. Ther., 105, 79, 10.1002/cpt.1286 · DOI
  79. Pesl, 2013, Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells, Heart Vessel., 29, 834, 10.1007/s00380-013-0436-9 · DOI
  80. Brooks, 2019, Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo, Stem Cell Rep., 13, 891, 10.1016/j.stemcr.2019.09.009 · DOI
  81. Lee, 2017, Three-Dimensional Cell Printing of Large-Volume Tissues: Application to Ear Regeneration, Tissue Eng. Part C Methods, 23, 136, 10.1089/ten.tec.2016.0362 · DOI
  82. Liu, 2019, An integrated cell printing system for the construction of heterogeneous tissue models, Acta Biomater., 95, 245, 10.1016/j.actbio.2019.05.052 · DOI
  83. Zhang, 2014, Block-Cell-Printing for Live Single-Cell Printing, Proc. Natl. Acad. Sci. USA, 111, 2948, 10.1073/pnas.1313661111 · DOI
  84. Yu, 2007, Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells, Science, 318, 1917, 10.1126/science.1151526 · DOI · Paper page
  85. Acimovic, I., Refaat, M.M., Moreau, A., Salykin, A., Reiken, S., Sleiman, Y., Souidi, M., Přibyl, J., Kajava, A.V., and Richard, S. (2018). Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes. J. Clin. Med., 7. · DOI
  86. Jelinkova, 2020, DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology, Front. Bioeng. Biotechnol., 8, 535, 10.3389/fbioe.2020.00535 · DOI
  87. Gatinois, 2019, Reprogramming of Human Peripheral Blood Mononuclear Cell (PBMC) from a patient suffering of a Werner syndrome resulting in iPSC line (REGUi003-A) maintaining a short telomere length, Stem Cell Res., 39, 101515, 10.1016/j.scr.2019.101515 · DOI
  88. Gatinois, 2020, iPSC line derived from a Bloom syndrome patient retains an increased disease-specific sister-chromatid exchange activity, Stem Cell Res., 43, 101696, 10.1016/j.scr.2019.101696 · DOI
  89. Zhang, 2011, A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects, Cell Stem Cell, 8, 31, 10.1016/j.stem.2010.12.002 · DOI
  90. Liu, 2011, Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome, Nat. Cell Biol., 472, 221
  91. Batista, 2011, Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells, Nat. Cell Biol., 474, 399
  92. Agarwal, 2010, Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients, Nat. Cell Biol., 464, 292
  93. Cheung, 2014, Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging, Stem Cell Rep., 2, 534, 10.1016/j.stemcr.2014.02.006 · DOI · Paper page
  94. Jung, 2012, Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia, EMBO Mol. Med., 4, 180, 10.1002/emmm.201100194 · DOI · Paper page
  95. Sasaki, K., Makiyama, T., Yoshida, Y., Wuriyanghai, Y., Kamakura, T., Nishiuchi, S., Hayano, M., Harita, T., Yamamoto, Y., and Kohjitani, H. (2016). Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia. PLoS ONE, 11. · DOI
  96. Lemons, 2016, High throughput physiological screening of iPSC-derived cardiomyocytes for drug development, Biochim. Biophys. Acta (BBA) Mol. Cell Res., 1863, 1717, 10.1016/j.bbamcr.2016.03.003 · DOI
  97. Grimm, 2015, High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes, Assay Drug Dev. Technol., 13, 529, 10.1089/adt.2015.659 · DOI
  98. Pesl, 2017, Phenotypic assays for analyses of pluripotent stem cell-derived cardiomyocytes, J. Mol. Recognit., 30, e2602, 10.1002/jmr.2602 · DOI
  99. Sharma, 2018, Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity, Nat. Protoc., 13, 3018, 10.1038/s41596-018-0076-8 · DOI
  100. Paik, 2020, Patient and Disease–Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics, Pharmacol. Rev., 72, 320, 10.1124/pr.116.013003 · DOI
  101. Perkhofer, 2018, Importance of organoids for personalized medicine, Pers. Med., 15, 461, 10.2217/pme-2018-0071 · DOI
  102. Takahashi, 2019, Organoids for Drug Discovery and Personalized Medicine, Annu. Rev. Pharmacol. Toxicol., 59, 447, 10.1146/annurev-pharmtox-010818-021108 · DOI
  103. Yokouchi, 2020, Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing, Sci. Rep., 10, 1, 10.1038/s41598-020-70401-7 · DOI
  104. Beghini, D.G., Horita, S.I., Cascabulho, C.M., Alves, L.A., and Henriques-Pons, A. (2020). Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies. Int. J. Mol. Sci., 21. · DOI
  105. Li, 2015, Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas, Stem Cell Rep., 4, 143, 10.1016/j.stemcr.2014.10.013 · DOI · Paper page
  106. Long, 2018, Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing, Sci. Adv., 4, eaap9004, 10.1126/sciadv.aap9004 · DOI
  107. Okita, 2007, Generation of germline-competent induced pluripotent stem cells, Nat. Cell Biol., 448, 313
  108. Rebuzzini, 2016, Achilles’ heel of pluripotent stem cells: Genetic, genomic and epigenetic variations during prolonged culture, Cell. Mol. Life Sci., 73, 2453, 10.1007/s00018-016-2171-8 · DOI · Paper page
  109. Tosca, 2015, Genomic instability of human embryonic stem cell lines using different passaging culture methods, Mol. Cytogenet., 8, 1, 10.1186/s13039-015-0133-8 · DOI
  110. Wang, 2015, Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions, Stem Cell Res. Ther., 6, 223, 10.1186/s13287-015-0206-y · DOI
  111. Mallon, 2006, Toward xeno-free culture of human embryonic stem cells, Int. J. Biochem. Cell Biol., 38, 1063, 10.1016/j.biocel.2005.12.014 · DOI
  112. Gagliano, 2019, Microfluidic reprogramming to pluripotency of human somatic cells, Nat. Protoc., 14, 722, 10.1038/s41596-018-0108-4 · DOI
  113. Luni, 2016, High-efficiency cellular reprogramming with microfluidics, Nat. Chem. Biol., 13, 446
  114. Barry, 2015, Setting Up a Haplobank: Issues and Solutions, Curr. Stem Cell Rep., 1, 110, 10.1007/s40778-015-0011-7 · DOI
  115. Gourraud, 2012, The Role of Human Leukocyte Antigen Matching in the Development of Multiethnic “Haplobank” of Induced Pluripotent Stem Cell Lines, Stem Cells, 30, 180, 10.1002/stem.772 · DOI
  116. Jones, 2014, Improving the safety of cell therapy products by suicide gene transfer, Front. Pharmacol., 5, 254, 10.3389/fphar.2014.00254 · DOI
  117. Liang, 2018, Linking a cell-division gene and a suicide gene to define and improve cell therapy safety, Nat. Cell Biol., 563, 701
  118. Yamanaka, 2020, Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges, Cell Stem Cell, 27, 523, 10.1016/j.stem.2020.09.014 · DOI
  119. Iwanami, 2005, Transplantation of human neural stem cells for spinal cord injury in primates, J. Neurosci. Res., 80, 182, 10.1002/jnr.20436 · DOI
  120. Nori, 2011, Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice, Proc. Natl. Acad. Sci. USA, 108, 16825, 10.1073/pnas.1108077108 · DOI
  121. Chen, 2012, Restoration of auditory evoked responses by human ES-cell-derived otic progenitors, Nat. Cell Biol., 490, 278
  122. Duncan, 2017, Alzheimer’s disease, dementia, and stem cell therapy, Stem Cell Res. Ther., 8, 1, 10.1186/s13287-017-0567-5 · DOI
  123. Bonilla, 2016, An Update on Human Stem Cell-Based Therapy in Parkinson’;s Disease, Curr. Stem Cell Res. Ther., 11, 561, 10.2174/1574888X10666150531172612 · DOI
  124. Sonntag, 2018, Pluripotent stem cell-based therapy for Parkinson’s disease: Current status and future prospects, Prog. Neurobiol., 168, 1, 10.1016/j.pneurobio.2018.04.005 · DOI
  125. Hallett, 2015, Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease, Cell Stem Cell, 16, 269, 10.1016/j.stem.2015.01.018 · DOI
  126. Monville, 2019, Cell Therapy for Retinal Dystrophies: From Cell Suspension Formulation to Complex Retinal Tissue Bioengineering, Stem Cells Int., 2019, 1
  127. Morizur, 2020, Human pluripotent stem cells: A toolbox to understand and treat retinal degeneration, Mol. Cell. Neurosci., 107, 103523, 10.1016/j.mcn.2020.103523 · DOI
  128. Mandai, 2017, Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration, N. Engl. J. Med., 376, 1038, 10.1056/NEJMoa1608368 · DOI
  129. Suchy, 2018, Interspecies chimeras, Curr. Opin. Genet. Dev., 52, 36, 10.1016/j.gde.2018.05.007 · DOI
  130. Suchy, 2018, iPSC-Derived Organs In Vivo: Challenges and Promise, Cell Stem Cell, 22, 21, 10.1016/j.stem.2017.12.003 · DOI
  131. Kobayashi, 2010, Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells, Cell, 142, 787, 10.1016/j.cell.2010.07.039 · DOI
  132. Yamaguchi, 2017, Interspecies organogenesis generates autologous functional islets, Nat. Cell Biol., 542, 191
  133. Usui, 2012, Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation, Am. J. Pathol., 180, 2417, 10.1016/j.ajpath.2012.03.007 · DOI
  134. Wu, 2017, Interspecies Chimerism with Mammalian Pluripotent Stem Cells, Cell, 168, 473, 10.1016/j.cell.2016.12.036 · DOI
  135. Nishimura, 2021, Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras, Cell Stem Cell, 28, 141, 10.1016/j.stem.2020.11.019 · DOI
  136. Brons, 2007, Derivation of pluripotent epiblast stem cells from mammalian embryos, Nat. Cell Biol., 448, 191
  137. Tesar, 2007, New cell lines from mouse epiblast share defining features with human embryonic stem cells, Nat. Cell Biol., 448, 196
  138. Angeles, 2015, Hallmarks of pluripotency, Nat. Cell Biol., 525, 469
  139. Hu, 2020, Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos, Sci. Adv., 6, eaaz0298, 10.1126/sciadv.aaz0298 · DOI
  140. Kilens, 2018, Parallel derivation of isogenic human primed and naive induced pluripotent stem cells, Nat. Commun., 9, 1, 10.1038/s41467-017-02107-w · DOI
  141. Theunissen, 2016, Molecular Criteria for Defining the Naive Human Pluripotent State, Cell Stem Cell, 19, 502, 10.1016/j.stem.2016.06.011 · DOI
  142. Li, 2009, The Ink4/Arf locus is a barrier for iPS cell reprogramming, Nat. Cell Biol., 460, 1136
  143. Hayashi, 2016, BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence, Proc. Natl. Acad. Sci. USA, 113, 13057, 10.1073/pnas.1603668113 · DOI
  144. Utikal, 2009, Immortalization eliminates a roadblock during cellular reprogramming into iPS cells, Nat. Cell Biol., 460, 1145
  145. Marion, 2009, Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells, Cell Stem Cell, 4, 141, 10.1016/j.stem.2008.12.010 · DOI · Paper page
  146. Suhr, S.T., Chang, E.A., Tjong, J., Alcasid, N., Perkins, G.A., Goissis, M.D., Ellisman, M.H., Perez, G.I., and Cibelli, J.B. (2010). Mitochondrial Rejuvenation After Induced Pluripotency. PLoS ONE, 5. · DOI
  147. Abad, 2013, Reprogramming in vivo produces teratomas and iPS cells with totipotency features, Nat. Cell Biol., 502, 340
  148. Carey, 2009, Single-gene transgenic mouse strains for reprogramming adult somatic cells, Nat. Methods, 7, 56, 10.1038/nmeth.1410 · DOI
  149. Doeser, 2018, Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo, Stem Cells, 36, 1216, 10.1002/stem.2842 · DOI · Paper page
  150. Olova, 2018, Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity, Aging Cell, 18, e12877, 10.1111/acel.12877 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Alle, Q., Le Borgne, E., Milhavet, O., & Lemaitre, J.-M.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-04-13
Volume
22
Issue
8
Pages
3990
ISSN
1422-0067
DOI
10.3390/ijms22083990
PMC
PMC8070588
Cited by
35
References
38
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review