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Cited by 87Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsSurgical Sutures and Adhesives

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

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Zou, Chen-Yu, Li, Qian-Jin, Hu, Juan-Juan, Song, Yu-Ting, Zhang, Qing-Yi, Nie, Rong, Li-Ling, Jesse, Xie, Hui-Qi·2022·Materials Today Bio
DOI 10.1016/j.mtbio.2022.100468PMC PMC9626749
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Abstract

Uncontrolled bleeding remains as a leading cause of death in surgical, traumatic, and emergency situations. Management of the hemorrhage and development of hemostatic materials are paramount for patient survival. Owing to their inherent biocompatibility, biodegradability and bioactivity, biopolymers such as polysaccharides and polypeptides have been extensively researched and become a focus for the development of next-generation hemostatic materials. The construction of novel hemostatic materials requires in-depth understanding of the physiological hemostatic process, fundamental hemostatic mechanisms, and the effects of material chemistry/physics. Herein, we have recapitulated the common hemostatic strategies and development status of biopolymer-based hemostatic materials. Furthermore, the hemostatic mechanisms of various molecular structures (components and chemical modifications) are summarized from a microscopic perspective, and the design based on them are introduced. From a macroscopic perspective, the design of various forms of hemostatic materials, e.g., powder, sponge, hydrogel and gauze, is summarized and compared, which may provide an enlightenment for the optimization of hemostat design. It has also highlighted current challenges to the development of biopolymer-based hemostatic materials and proposed future directions in chemistry design, advanced form and clinical application.

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  • Many functional groups have recently been introduced into biopolymers to modify their physical and physiological properties, making them multifunctional and smart.

    “In addition, many functional groups have recently been introduced into biopolymers to modify their physical and physiological properties, making them multifunctional and smart [43].”

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Cited by

Sorted by citations

Authors
Zou, C.-Y., Li, Q.-J., Hu, J.-J., Song, Y.-T., Zhang, Q.-Y., Nie, R., Li-Ling, J., & Xie, H.-Q.
Affiliations
Sichuan University (CN)
ORCID
Venue
Materials Today Bio
Publisher
Elsevier BV
Published
2022-12
Volume
17
Pages
100468
ISSN
2590-0064 (ISSN-L)
DOI
10.1016/j.mtbio.2022.100468
PMC
PMC9626749
OpenAlex
W4306734854
Cited by
87
References
0
Citations by year
2026: 23 · 2025: 24 · 2024: 26 · 2023: 14
FWCI
2.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Materials Today Bio (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • West China Hospital, Sichuan University (ZYJC18002)
  • National Natural Science Foundation of China (32171351)
  • Sichuan University (MCM202104)
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
hemostatic materials, biopolymers, uncontrolled bleeding, polysaccharides, polypeptides, hemostatic mechanism, chemical modification, hydrogels, sponges, gauze, hemorrhage control

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