Cancer cell membrane-coated siRNA-Decorated Au/MnO2 nanosensitizers for synergistically enhanced radio-immunotherapy of breast cancer
Open accessAbstract
Radiotherapy plays a critical role in the clinical treatment of breast cancer. However, the efficacy of traditional X-ray radiotherapy is greatly limited by its low tumor specificity and treatment tolerance mediated by the tumor microenvironment. Herein, we proposed a novel nano-radiotherapy sensitization strategy to design and construct a cancer cell membrane-coated siRNA-decorated Au/MnO 2 nanosensitizer (R&F@Au/MnO 2 -CM) to synergistically enhance radio-immunotherapy for breast cancer. In the integrated nanosensitizer, the cancer cell membrane (CM) derived from 4T1 breast cancer cells is utilized for targeted functionality, while Au/MnO 2 is designed to improve X-ray absorption and alleviate tumor hypoxia. Additionally, PD-L1 siRNA (R) is used to downregulate PD-L1 expression in tumor cells. In an in situ mouse model of 4T1 breast cancer, R&F@Au/MnO 2 -CM demonstrated accurate tumor identification via CM-mediated homologous targeting after intravenous injection, which was monitored in real-time through NIR-II fluorescence imaging of NIR-935 (F). Subsequently, the radiotherapy sensitivity was achieved due to the strong radiation absorption properties and oxygen generation through catalysis of Au/MnO 2 upon X-ray irradiation. Furthermore, the immunosuppressive microenvironment of the tumor is improved by downregulating PD-L1, enhancing synergistic anti-tumor effect. Our findings demonstrate a promising approach for tumor treatment by combining targeted enhanced radiotherapy with immune activation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biomimetic strategies, including cell membrane-coated nanoparticles, were reported to enhance circulation time and immune evasion.
“Biomimetic strategies, including cell membrane-coated nanoparticles, were reported to enhance circulation time and immune evasion [34,44,50,56].”
From Nanoparticle-Mediated Radiosensitization in Breast Cancer: A Systematic Review of Preclinical Evidence and Translational Challenges (2026) · cites this paper as [56]
The Results and discussion section (‘In vivo homologous targeting and anti-tumor efficiency’; page unavailable) reports a 3.79-hour blood half-life for the cell membrane-coated nanosensitizer and calls its circulation characteristics favorable. It does not show that membrane coating increased circulation time relative to an uncoated comparator or that the nanoparticles evaded immune clearance. Its discussion of immune evasion concerns tumor-cell PD-L1, not nanoparticle immune evasion. (LLM, conf=0.82)
Experimental — accuracy not yet measuredImmune-modulating strategies, including checkpoint-related approaches, were described in combination with radiotherapy in selected nanoplatforms.
“Immune-modulating strategies, including checkpoint-related approaches, were described in combination with radiotherapy in selected nanoplatforms [17,21,23,26,39,56].”
From Nanoparticle-Mediated Radiosensitization in Breast Cancer: A Systematic Review of Preclinical Evidence and Translational Challenges (2026) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848 · see citing works
The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144 · cited 1× · see citing works
“This may be one of the significant reasons why a single radiotherapy treat-ment rarely induces a strong anti-tumor immune response clinically [26, 27].”
BackgroundImmunologic Correlates of the Abscopal Effect in a Patient with Melanoma
Postow, M. A., Callahan, M. K., Barker, C. A., Yamada, Y. J., Yuan, J. D., Kitano, S., Mu, Z., Rasalan, T. S., Adamow, M. J., Ritter, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112824 · Cited by 2,087 · see citing works
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
Garcia-Diaz, A., Shin, D. S., Moreno, B. H., Saco, J., Escuin-Ordinas, H., Rodriguez, G. A., Zaretsky, J. M., Sun, L., Hugo, W., Wang, X., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.031 · Cited by 1,942 · see citing works
Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752 · see citing works
The use of gold nanoparticles to enhance radiotherapy in mice
Hainfeld, J. F., Slatkin, D. N., & Smilowitz, H. M. (2004) · Physics in Medicine and Biology · doi:10.1088/0031-9155/49/18/n03 · Cited by 1,644 · see citing works
Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery
Fang, R. H., Hu, C. J., Luk, B. T., Gao, W., Copp, J. A., Tai, Y., O’Connor, D. E., & Zhang, L. (2014) · Nano Letters · doi:10.1021/nl500618u · Cited by 1,509 · see citing works
Lee, Y., Auh, S. L., Wang, Y., Burnette, B., Wang, Y., Meng, Y., Beckett, M., Sharma, R., Chin, R., Tu, T., et al. (2009) · Blood · doi:10.1182/blood-2009-02-206870 · Cited by 1,324 · see citing works
-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
Kinner, A., Wu, W., Staudt, C., & Iliakis, G. E. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn550 · Cited by 1,249 · see citing works
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037 · see citing works
Self-citationCD44: Structure, Function and Association with the Malignant Process
Naor, D., Sionov, R. V., & Ish‐Shalom, D. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60101-3 · Cited by 1,020 · see citing works
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995 · see citing works
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 968 · see citing works
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
McLaughlin, M., Patin, E. C., Pedersen, M., Wilkins, A. C., Dillon, M. T., Melcher, A. A., & Harrington, K. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0246-1 · Cited by 901 · see citing works
Chen, Z., Zhao, P., Luo, Z., Zheng, M., Tian, H., Gong, P., Gao, G., Pan, H., Liu, L., Ma, A.-Q., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b04695 · Cited by 898 · see citing works
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865 · see citing works
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Sato, H., Niimi, A., Yasuhara, T., Permata, T. B. M., Hagiwara, Y., Isono, M., Nuryadi, E., Sekine, R., Oike, T., Kakoti, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01883-9 · Cited by 710 · see citing works
Li, Z., Lai, X., Fu, S., Ren, L. F., Cai, H., Zhang, H., Gu, Z., Ma, X., & Luo, K. (2022) · Advanced Science · doi:10.1002/advs.202201734 · Cited by 688 · see citing works
Fan, W., Bu, W., Shen, B., He, Q., Cui, Z., Liu, Y., Zheng, X., Zhao, K., & Shi, J. (2015) · Advanced Materials · doi:10.1002/adma.201405141 · Cited by 668 · see citing works
Imaging hypoxia to improve radiotherapy outcome
Horsman, M. R., Mortensen, L. S., Petersen, J. B., Busk, M., & Overgaard, J. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.171 · Cited by 614 · see citing works
Wang, H., Mu, X., He, H., & Zhang, X. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.003 · Cited by 579 · see citing works
Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563 · see citing works
Yamaguchi, H., Hsu, J.-M., Yang, W., & Hung, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00601-9 · Cited by 507 · see citing works
Radiation therapy‐associated toxicity: Etiology, management, and prevention
Wang, K., & Tepper, J. E. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21689 · Cited by 473 · see citing works
Radiotherapy and Immunogenic Cell Death
Golden, E. B., & Apétoh, L. (2014) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2014.07.005 · Cited by 463 · see citing works
Induction of HIF–1α in response to hypoxia is instantaneous
Jewell, U. R., Kvietikova, I., Scheid, A., Bauer, C., Wenger, R. H., & Gassmann, M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0732fje · Cited by 443 · see citing works
Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization
Xie, J., Gong, L., Zhu, S., Yong, Y., Gu, Z., & Zhao, Y. (2018) · Advanced Materials · doi:10.1002/adma.201802244 · Cited by 418 · see citing works
NIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 364 · see citing works
Glinsky, V. V., Glinsky, G. V., Glinskii, O. V., Huxley, V. H., Turk, J. R., Mossine, V. V., Deutscher, S. L., Pienta, K. J., & Quinn, T. P. (2004) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2003.12.009 · Cited by 266 · see citing works
Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M. M. H., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.005 · Cited by 259 · see citing works
Radiation-induced tumor immune microenvironments and potential targets for combination therapy
Guo, S., Yao, Y., Tang, Y., Xin, Z., Wu, D., Ni, C., Huang, J., Wei, Q., & Zhang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01462-z · Cited by 252 · see citing works
Karim, R., Jordanova, E. S., Piersma, S. J., Kenter, G. G., Chen, L., Boer, J. M., Melief, C. J. M., & van der Burg, S. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1652 · Cited by 250 · see citing works
Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation
Frankenberg-Schwager, M. (1989) · Radiotherapy and Oncology · doi:10.1016/0167-8140(89)90143-6 · Cited by 216 · see citing works
Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells
Sultan, A., Xie, J., LeBaron, M. J., Ealley, E. L., Nevalainen, M. T., & Rui, H. (2004) · Oncogene · doi:10.1038/sj.onc.1208203 · Cited by 197 · see citing works
Glinsky, V. V., Glinsky, G. V., Glinskii, O. V., Huxley, V. H., Turk, J. R., Mossine, V. V., Deutscher, S. L., Pienta, K. J., & Quinn, T. P. (2003) · PubMed · Cited by 186 · see citing works
Tumor hypoxia and radiotherapy: A major driver of resistance even for novel radiotherapy modalities
Beckers, C., Pruschy, M. N., & Vetrugno, I. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.11.006 · Cited by 182 · see citing works
Immune Priming of the Tumor Microenvironment by Radiation
Jiang, W., Chan, C. K. F., Weissman, I. L., Kim, B. Y. S., & Hahn, S. M. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.09.007 · Cited by 179 · see citing works
Molecular targeting of hypoxia in radiotherapy
Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 171 · see citing works
Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia
Abbasi, A. Z., Gordijo, C. R., Amini, M. A., Maeda, A., Rauth, A. M., DaCosta, R. S., & Wu, X. Y. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3475 · Cited by 121 · see citing works
Inside the hypoxic tumour: reprogramming of the DDR and radioresistance
Begg, K., & Tavassoli, M. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00311-0 · Cited by 109 · see citing works
Luo, Z., Zhu, M., Zhang, Z., Ye, F.-J., Huang, W.-H., & Luo, X.-Z. (2019) · BMC Cancer · doi:10.1186/s12885-019-5324-y · Cited by 104 · see citing works
Base excision repair regulates PD-L1 expression in cancer cells
Permata, T. B. M., Hagiwara, Y., Sato, H., Yasuhara, T., Oike, T., Gondhowiardjo, S. A., Held, K. D., Nakano, T., & Shibata, A. (2019) · Oncogene · doi:10.1038/s41388-019-0733-6 · Cited by 101 · see citing works
Zhou, Z., Liu, Y., Jiang, X.-X., Zheng, C., Luo, W., Xiang, X.-L., Qi, X., & Shen, J.-L. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.167 · Cited by 95 · see citing works
Xie, X., Hu, X., Li, Q., Yin, M., Song, H., Hu, J., Wang, L., Fan, C., & Chen, N. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c01503 · Cited by 93 · see citing works
Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.
Vukovic, V. M., Haugland, H. K., Nicklee, T., Morrison, A. J., & Hedley, D. W. (2001) · PubMed · Cited by 91 · see citing works
Marciscano, A. E. E., Haimovitz‐Friedman, A., Lee, P. P., Tran, P. T., Tomé, W. A., Guha, C., Kong, F., Sahgal, A., Naqa, I. E., Rimner, A., et al. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.02.046 · Cited by 91 · see citing works
Basílio-de-Oliveira, R. P., & Pannain, V. L. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.6924 · Cited by 89 · see citing works
Alle, M., Sharma, G., Lee, S. H., & Kim, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01402-z · Cited by 80 · see citing works
Role of VEGF, CD105, and CD31 in the Prognosis of Colorectal Cancer Cases
Mohamed, S. Y., Mohammed, H. L., Ibrahim, H., Mohamed, E. M., & Salah, M. (2017) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-017-0014-y · Cited by 75 · see citing works
Targeting hypoxia in tumor: a new promising therapeutic strategy
Bosco, M. C., D’Orazi, G., & Bufalo, D. D. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1517-0 · Cited by 69 · see citing works
Challenges Coexist with Opportunities: Spatial Heterogeneity Expression of PD‐L1 in Cancer Therapy
Wang, Y., Zhou, Y., Yang, L., Lei, L., He, B., Cao, J., & Gao, H. (2023) · Advanced Science · doi:10.1002/advs.202303175 · Cited by 65 · see citing works
Shi, Z., Hu, C., Zheng, X., Sun, C., & Li, Q. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00519-1 · Cited by 60 · see citing works
Core–shell TaOx@MnO 2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy
Gong, F., Chen, J., Han, X., Zhao, J., Wang, M., Feng, L., Li, Y., Liu, Z., & Cheng, L. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00070k · Cited by 58 · see citing works
Hang, Q., Zeng, L., Wang, L., Nie, L., Yao, F., Teng, H., Deng, Y., Yap, S., Sun, Y., Frank, S. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24298-z · Cited by 56 · see citing works
Catalytic radiosensitization: Insights from materials physicochemistry
Wang, Y., Zhang, H., Liu, Y., Younis, M. H., Cai, W., & Bu, W. (2022) · Materials Today · doi:10.1016/j.mattod.2022.05.022 · Cited by 51 · see citing works
Re-evaluating the risk factors for radiation pneumonitis in the era of immunotherapy
Chen, F., Niu, J., Wang, M., Zhu, H., & Guo, Z. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04212-5 · Cited by 44 · see citing works
Zhou, Z., Jiang, X., Yi, L., Li, C., Wang, H., Xiong, W., Li, Z., & Shen, J. (2024) · Advanced Science · doi:10.1002/advs.202401394 · Cited by 42 · see citing works
Self-citationImaizumi, K., Suzuki, T., Kojima, M., Shimomura, M., Sakuyama, N., Tsukada, Y., Sasaki, T., Nishizawa, Y., Taketomi, A., Ito, M., et al. (2019) · Cancer Science · doi:10.1111/cas.14223 · Cited by 39 · see citing works
Wang, T., Zhang, H., Han, Y., Zheng, Q. Y., Liu, H., Han, M., & Li, Z. (2023) · Advanced Science · doi:10.1002/advs.202204961 · Cited by 39 · see citing works
Combining High-Z Sensitized Radiotherapy with CD73 Blockade to Boost Tumor Immunotherapy
Chen, Q., Chen, J., Zhang, Q., Yang, P., Gu, R., Ren, H., Dai, Y., Huang, S., Wu, J., Wu, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c11403 · Cited by 37 · see citing works
Self-citationHu, C., Man, R., Li, H., Xia, M., Yu, Z., & Tang, B. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02218 · Cited by 32 · see citing works
How the histological structure of some lung cancers shaped almost 70 years of radiobiology
Worth, K. R., Papandreou, I., & Hammond, E. M. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02041-9 · Cited by 15 · see citing works
Flagged first, then by citations
3 of the 67 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Overcoming cancer therapy resistance: From drug innovation to therapeutics
Wei, J., Lu, M., Wei, T., Fleishman, J. S., Yu, H. J., Chen, X.-L., Kong, X.-T., Sun, S., Li, N., Yang, Y., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101229 · Cited by 50 · see citing works
Yu, K., Fu, L., Cao, Y., Zeng, X., Zhang, Y., Chen, Y., Gao, J., Lu, B., Zhu, H., Gu, L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c18035 · Cited by 33 · see citing works
Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer
Zeng, M., Hu, C., Chen, T., Zhao, T., & Dai, X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s502144 · Cited by 28 · see citing works
The roles of ultrasound-responsive nanomaterials in enhancing cancer immunotherapy
Wang, X., Wang, C., Liu, W., Thakur, A., Zhang, K., Xu, Z., & Li, J. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107975 · Cited by 24 · see citing works
Cancer Cell Membrane-Coated NPs as a Biomimetic Strategy for Precision Tumor Therapy
Lin, J., Li, W., Aboushanab, A. R., & Sun, J. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17101322 · Cited by 27 · see citing works
Tumor Microenvironment Dynamics of Triple-Negative Breast Cancer Under Radiation Therapy
Niture, S. K., Ghosh, S., Jaboin, J. J., & Seneviratne, D. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062795 · Cited by 22 · see citing works
Metal-based nanomedicines for cancer theranostics
Yu, H., Liu, J.-H., Liu, W., Niu, R., Zhang, B., Xiong, Y., Liu, Y., Wang, Y., & Zhang, H. (2025) · Military Medical Research · doi:10.1186/s40779-025-00627-x · Cited by 20 · see citing works
Research progress of multifunctional inorganic nanomaterials for tumor photothermal therapy
Wang, W., Huang, Y., Zhang, Y., Xiao, S., Luo, D., Lan, H., & Geng, P. (2025) · Nanoscale · doi:10.1039/d5nr02839f · Cited by 12 · see citing works
Gao, M., Yin, L., Zhang, B., Dong, Z., Jiang, W., Bai, Z., Zhao, X., Xu, L., Wang, N., & Peng, J. (2025) · ACS Nano · doi:10.1021/acsnano.5c01641 · Cited by 9 · see citing works
Biswal, P., Vijay, G. V., Krouse, G., Quan, P., Lakshmisha, B. M., Shahbaz, S. K., Taba, M. Y., Sabbagh, A., Cheung, L. W. T., Mackeyev, Y., et al. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00110 · Cited by 10 · see citing works
Du, Q., Wu, G., Xie, A., Wu, D., Hu, W., Lu, Q., Liu, J., Wang, J., Yang, Y., Hu, B., et al. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00926j · Cited by 7 · see citing works
Tang, R., Zeng, F., Lyu, C., Tuerheng, J., Guo, Z., He, K., & Wu, D. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18050534 · Cited by 4 · see citing works
Recent advances in small-molecule radiosensitizers for Cancer therapy
Chen, L., Yan, L., Liu, Z., & Xu, X. X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165858 · Cited by 4 · see citing works
Design of a ROS-responsive fluorescent probe for the diagnosis and imaging of breast cancer
Li, C., Liang, Q., Pan, W., Yang, Y., Shao, Q., & Fan, B. (2025) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2025.130268 · Cited by 1 · see citing works
Self-citationLunca, S., Morarasu, S., & Dimofte, G. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146522 · Cited by 2 · see citing works
“Immune-modulating strategies, including checkpoint-related approaches, were described in combination with radiotherapy in selected nanoplat-forms [17,21,23,26,39,56].”
Wang, S., Chu, Z., Li, J., Cui, J., Geng, Y., Wei, J., Liu, H., & Dong, B. (2026) · Research Square · doi:10.21203/rs.3.rs-10551593/v1
Engineering next-generation polyethylenimine vectors for efficient siRNA delivery in cancer
Singhmar, R., Jeong, J. Y., & Hong, C. A. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108833
Luncă, S., Morărașu, Ș., & Dimofte, G. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198928
- Authors
- Wang, D., Lin, S., Li, T., Yang, X., Zhong, X., Chen, Q., Jiang, G., & Li, C.
- Affiliations
- Chinese Academy of Sciences (CN)
- Second Affiliated Hospital of Soochow University (CN)
- University of Science and Technology of China (CN)
- Corresponding author
- Jiang, Guoqin
- Li, Chunyan
- Venue
- Materials Today Bio
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 29
- Pages
- 101275
- ISSN
- 2590-0064 (ISSN-L)
- PMC
- PMC11471673
- OpenAlex
- W4402878349
- Cited by
- 18
- References
- 67
- Citations by year
- 2026: 6 · 2025: 12
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Today Bio (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Key Research and Development Program of China Stem Cell and Translational Research
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- breast cancer, radioimmunotherapy, cancer cell membrane coating, tumor hypoxia, X-ray absorption, NIR-II fluorescence imaging, tumor microenvironment, 4T1 cells, targeted drug delivery, oxygen production
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
