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Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

Savonenko, Alena, Xu, Guilian M., Melnikova, Tatiana, Morton, Johanna L., Gonzales, Victoria, Wong, Molly P.F., Price, Donald L., Tang, Fai, Markowska, Alicja L., Borchelt, David R.·2005·Neurobiology of Disease
DOI 10.1016/j.nbd.2004.10.022
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Abstract

Transgenic mice made by crossing animals expressing mutant amyloid precursor protein (APPswe) to mutant presenilin 1 (PS1dE9) allow for incremental increases in Abeta42 production and provide a model of Alzheimer-type amyloidosis. Here, we examine cognition in 6- and 18-month old transgenic mice expressing APPswe and PS1dE9, alone and in combination. Spatial reference memory was assessed in a standard Morris Water Maze task followed by assessment of episodic-like memory in Repeated Reversal and Radial Water maze tasks. We then used factor analysis to relate changes in performance in these tasks with cholinergic markers, somatostatin levels, and amyloid burden. At 6 months of age, APPswe/PS1dE9 double-transgenic mice showed visible plaque deposition; however, all genotypes, including double-transgenic mice, were indistinguishable from nontransgenic animals in all cognitive measures. In the 18-month-old cohorts, amyloid burdens were much higher in APPswe/PS1dE9 mice with statistically significant but mild decreases in cholinergic markers (cortex and hippocampus) and somatostatin levels (cortex). APPswe/PS1dE9 mice performed all cognitive tasks less well than mice from all other genotypes. Factor and correlation analyses defined the strongest correlation as between deficits in episodic-like memory tasks and total Abeta loads in the brain. Collectively, we find that, in the APPswe/PS1dE9 mouse model, some form of Abeta associated with amyloid deposition can disrupt cognitive circ…

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Metadata

Authors
Savonenko, A., Xu, G. M., Melnikova, T., Morton, J. L., Gonzales, V., Wong, M. P. F., Price, D. L., Tang, F., Markowska, A. L., & Borchelt, D. R.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2005-04
Volume
18
Issue
3
Pages
602-617
ISSN
0969-9961
DOI
10.1016/j.nbd.2004.10.022
Cited by
346
References
8
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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