Patients with major depressive disorder exhibit reduced reward size coding in the striatum
Open accessAbstract
BACKGROUND: Anhedonia is a core symptom of major depressive disorder (MDD). While recent evidence suggests that reduced motivation for reward may be a core feature of anhedonia, the abnormalities in modulatory neural responses to variable reward amounts in MDD patients remain unclear. We investigated whether MDD patients' ability to represent variable-sized monetary rewards in the striatum is disrupted. METHODS: Twelve MDD patients and 12 healthy volunteers completed an assessment of psychometric status and participated in a functional magnetic resonance imaging (fMRI) task that involved the anticipation of financial reward (monetary incentive delay task). The size of the monetary reward was varied among trial conditions and was cued with geometric stimuli. Patients participated in additional fMRI sessions after a 6-week pharmacological treatment with escitalopram, an SSRI. RESULTS: In healthy volunteers, striatal activity increased in proportion to the size of the monetary reward during reward anticipation. This pattern was altered in MDD patients, and significant group-by-reward size interaction effects were observed in the bilateral putamen and the left ventral striatum. Reward sensitivity in motor response and striatum activity at three regions were correlated in healthy controls. In MDD patients, this neurobehavioral coupling was not observed. In addition, changes in the neural reward sensitivity parameter at the left ventral striatum in response to treatment were positively correlated with a reduction of depressive symptoms. CONCLUSIONS: Patients with MDD exhibit reduced ability to modulate neural response when adjusting for variable amount of reward. This result suggests that reward size coding in the striatum may represent a neural correlate of motivational anhedonia in MDD patients.
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Difference in VS is reduced by SSRI treatment and correlates with extent of symptom reduction.
“Importantly, this difference in the VS was reduced by SSRI treatment and correlated with the extent of symptom reduction (Takamura et al., 2017).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Takamura et al., 2017
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Circuit Mechanisms of Reward, Anhedonia, and Depression
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- Authors
- Takamura, M., Okamoto, Y., Okada, G., Toki, S., Yamamoto, T., Ichikawa, N., Mori, A., Minagawa, H., Takaishi, Y., Fujii, Y., Kaichi, Y., Akiyama, Y., Awai, K., & Yamawaki, S.
- Affiliations
- Hiroshima University (JP)
- Tokushima University (JP)
- Yoshida General Hospital (JP)
- Corresponding author
- Okamoto, Yasumasa
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 79
- Issue
- Pt B
- Pages
- 317-323
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2734508223
- Cited by
- 81
- References
- 29
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 29 · 2020: 6 · 2019: 8 · 2018: 2
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (16dm0107093h0001)
- AMED (15dm0207012h0002)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, anhedonia, striatum, ventral striatum, putamen, monetary incentive delay task, escitalopram, selective serotonin reuptake inhibitors, motivation, treatment response
- MeSH terms
- Adult, Brain Mapping, Corpus Striatum, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Reaction Time, Reward, Citalopram, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation, Anticipation, Psychological, Anhedonia
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