The DOI matches its Crossref record; 316 of the 318 references it cites were found in a registry or an index.
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder
Abstract
Incomplete response to monoaminergic antidepressants in major depressive disorder (MDD), and the phenomenon of neuroprogression, suggests a need for additional pathophysiological markers and pharmacological targets. Neuronal zinc is concentrated exclusively within glutamatergic neurons, acting as an allosteric modulator of the N-methyl D-aspartate and other receptors that regulate excitatory neurotransmission and neuroplasticity. Zinc-containing neurons form extensive associational circuitry throughout the cortex, amygdala and hippocampus, which subserve mood regulation and cognitive functions. In animal models of depression, zinc is reduced in these circuits, zinc treatment has antidepressant-like effects and dietary zinc insufficiency induces depressive behaviors. Clinically, serum zinc is lower in MDD, which may constitute a state-marker of illness and a risk factor for treatment-resistance. Marginal zinc deficiency in MDD may relate to multiple putative mechanisms underlying core symptomatology and neuroprogression (e.g. immune dysfunction, monoamine metabolism, stress response dysregulation, oxidative/nitrosative stress, neurotrophic deficits, transcriptional/epigenetic regulation of neural networks). Initial randomized trials suggest a benefit of zinc supplementation. In summary, molecular and animal behavioral data support the clinical significance of zinc in the setting of MDD.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a double-blinded, placebo controlled prospective trial, involving 489 postmenopausal elderly women, there was no effect of hormone therapy and calcitriol, either individually or in combination, on depression (55).”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [55]
In the citing paper
“Observational studies show an association between low zinc dietary intake or low zinc status and depression in adults or elderly subjects [189,190,191].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [189]
In the citing paper
“Moreover, although the proof of its implications in the oxidative mechanisms is pretty solid, some animal models studies contradicted the clinical findings [285] and therefore, there is still a need for the determination of the real benefits for the copper therapy in patients with depression [288].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [288]
Citations
Cites
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Self-citationAntidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 3,535
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,511
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,425
Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., DeRubeis, R. J., et al. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3628 · Cited by 1,292
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160
Blood, A. J., Zatorre, R. J., Bermudez, P., & Evans, A. C. (1999) · Nature Neuroscience · doi:10.1038/7299 · Cited by 1,097
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070
Trk receptors: mediators of neurotrophin action
Patapoutian, A., & Reichardt, L. F. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00208-7 · Cited by 1,070
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.
Ishii, T. M., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., Akazawa, C., Shigemoto, R., Mizuno, N., & Masu, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53849-7 · Cited by 980
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948
The role of the hippocampus in the pathophysiology of major depression
Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 891
Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836
Stimulation-induced uptake and release of zinc in hippocampal slices
Howell, G. A., Welch, M. G., & Frederickson, C. (1984) · Nature · doi:10.1038/308736a0 · Cited by 820
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Zinc in the physiology and pathology of the CNS
Sensi, S. L., Paoletti, P., Bush, A. I., & Sekler, I. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2734 · Cited by 759
Contextual fear, gestalt memories, and the hippocampus
Fanselow, M. S. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00186-2 · Cited by 752
Choi, D. W., & Koh, J. Y. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.347 · Cited by 752
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718
ZnT-3, a putative transporter of zinc into synaptic vesicles
Palmiter, R. D., Cole, T. B., Quaife, C. J., & Findley, S. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14934 · Cited by 708
The olfactory bulbectomized rat as a model of depression: An update
Kelly, J. P., Wrynn, A. S., & Leonard, B. E. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00004-1 · Cited by 661
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630
Functional significance of adult neurogenesis
Kempermann, G., Wiskott, L., & Gage, F. H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.001 · Cited by 630
Liuzzi, J. P., Lichten, L. A., Rivera, S., Blanchard, R. K., Aydemir, T. B., Knutson, M. D., Ganz, T., & Cousins, R. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502257102 · Cited by 594
Meyer, J. H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A., Young, T., Praschak-Rieder, N., Wilson, A. A., & Houle, S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1209 · Cited by 585
Zinc: role in immunity, oxidative stress and chronic inflammation
Prasad, A. S. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283312956 · Cited by 560
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Schwarcz, R. M., & Pellicciari, R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034439 · Cited by 556
Altar, C. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01309-7 · Cited by 535
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529
Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., & Brundin, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.030 · Cited by 524
O’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 521
Shelton, R. C., Claiborne, J., Sidoryk-Wegrzynowicz, M., Reddy, R., Aschner, M., Lewis, D. A., & Mirnics, K. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.52 · Cited by 511
Reversible neural inactivation reveals hippocampal participation in several memory processes
Riedel, G., Micheau, J., Lam, A. G. M., Roloff, E. V. L., Martin, S. J., Bridge, H., de Hoz, L., Poeschel, B., McCulloch, J., & Morris, R. (1999) · Nature Neuroscience · doi:10.1038/13202 · Cited by 494
The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses
Vogt, K. E., Mellor, J. R., Tong, G., & Nicoll, R. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81149-6 · Cited by 491
NMDA receptor pathways as drug targets
Kemp, J. A., & McKernan, R. M. (2002) · Nature Neuroscience · doi:10.1038/nn936 · Cited by 479
Maes, M. H. J., Christophe, A. B., Delanghe, J., Altamura, C. A., Neels, H. M., & Meltzer, H. Y. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00014-1 · Cited by 452
Kubera, M., Obuchowicz, E., Goehler, L., Brzeszcz, J., & Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.026 · Cited by 443
Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200202000-00014 · Cited by 437
GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin
Holst, B., Egerod, K. L., Schild, E., Vickers, S. P., Cheetham, S. C., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck‐Sickinger, A. G., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0933 · Cited by 433
Altered Lipid Metabolism in Brain Injury and Disorders
Rao, A. M., & Hatcher, J. F. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8831-5_9 · Cited by 413
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408
Mony, L., Kew, J. N. C., Gunthorpe, M. J., & Paoletti, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00304.x · Cited by 404
Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., et al. (2009) · Science · doi:10.1126/science.1167768 · Cited by 400
Haug, F. Š. (1967) · Histochemistry and Cell Biology · doi:10.1007/bf00401978 · Cited by 393
Glycogen Synthase Kinase-3 (GSK3) in Psychiatric Diseases and Therapeutic Interventions
Jope, R. S., & Roh, M. (2006) · Current Drug Targets · doi:10.2174/1389450110607011421 · Cited by 389
Glutamate-based antidepressants: 20 years on
Skolnick, P., Popik, P., & Trullás, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.002 · Cited by 386
Capuron, L., Pagnoni, G., Drake, D. F., Woolwine, B. J., Spivey, J. R., Crowe, R. J., Votaw, J. R., Goodman, M. M., & Miller, A. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2094 · Cited by 382
Adachi, M., Barrot, M., Autry, A. E., Theobald, D., & Monteggia, L. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.019 · Cited by 380
Induction of Neuronal Apoptosis by Thiol Oxidation
Aizenman, E., Stout, A. K., Hartnett, K. A., Dineley, K. E., McLaughlin, B., & Reynolds, I. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751878.x · Cited by 376
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367
Komatsu, K., Kikuchi, K., Kojima, H., Urano, Y., & Nagano, T. (2005) · Journal of the American Chemical Society · doi:10.1021/ja050301e · Cited by 352
Maes, M. H. J., Smith, R., Christophe, A., Vandoolaeghe, E., Gastel, A. V., Neels, H. M., Demedts, P., Wauters, A., & Meltzer, H. Y. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09622.x · Cited by 351
Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat
Frederickson, C. J., Klitenick, M. A., Manton, W. I., & Kirkpatrick, J. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90858-2 · Cited by 346
Beck, F. W., Prasad, A. S., Kaplan, J., Fitzgerald, J. T., & Brewer, G. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1002 · Cited by 345
Roles of NMDA receptor activity and nitric oxide production in brain development
Contestabile, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00018-7 · Cited by 340
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
Noh, K., & Koh, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-j0001.2000 · Cited by 335
Dwivedi, Y., Rizavi, H. S., Roberts, R. C., Conley, R. C., Tamminga, C. A., & Pandey, G. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00300.x · Cited by 333
Cellular zinc sensors: MTF-1 regulation of gene expression
Andrews, G. K. (2001) · BioMetals · doi:10.1023/a:1012932712483 · Cited by 325
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319
Tissue‐specific regulation of zinc metabolism and metallothionein genes by interleukin 1
Cousins, R. J., & Leinart, A. S. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.13.2458983 · Cited by 312
You, Z., Luo, C., Zhang, W., Chen, Y., He, J., Zhao, Q., Zuo, R. M., & Wu, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.006 · Cited by 312
Tardito, D., Perez, J., Tiraboschi, E., Musazzi, L., Racagni, G., & Popoli, M. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.7 · Cited by 303
Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons
Thomas, C. G., Miller, A., & Westbrook, G. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00771.2005 · Cited by 286
Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels
HARRISON, N., & Gibbons, S. J. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90152-x · Cited by 282
Williams, H. J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L. S., Georgieva, L., Williams, N. M., Morris, D. W., Quinn, E. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.36 · Cited by 279
Sutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274
Papp, M., & Moryl, E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90516-9 · Cited by 272
Maes, M., Vandoolaeghe, E., Neels, H., Demedts, P., Wauters, A., Meltzer, H. Y., Altamura, C., & Desnyder, R. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00365-4 · Cited by 272
Mayer, M. L., Vyklický, L., & Westbrook, G. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017724 · Cited by 272
Jiang, D., Sullivan, P. G., Sensi, S. L., Steward, O., & Weiss, J. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108834200 · Cited by 265
Casacalenda, N., Perry, J. C., & Looper, K. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1354 · Cited by 256
Wilcock, G. K., Ballard, C. G., Cooper, J. A., & Loft, H. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0302 · Cited by 253
A zinc-sensing receptor triggers the release of intracellular Ca 2+ and regulates ion transport
Hershfinkel, M., Moran, A., Grossman, N., & Sekler, I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201193398 · Cited by 253
Stress, Depression and Hippocampal Apoptosis
Lucassen, P. J., Heine, V. M., Müller, M. B., van der Beek, E. M., Wiegant, V. M., de Kloet, E. R., Joëls, M., Fuchs, E., Swaab, D. F., & Czéh, B. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559273 · Cited by 253
Chapter 6 Zinc-containing neurons in hippocampus and related CNS structures
Frederickson, C. J., & Danscher, G. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61242-x · Cited by 239
The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B
Rachline, J., Perin-Dureau, F., Goff, A. L., Neyton, J., & Paoletti, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3967-04.2005 · Cited by 238
Seizures and neuronal damage in mice lacking vesicular zinc
Cole, T. B., Robbins, C. A., Wenzel, H. J., Schwartzkroin, P. A., & Palmiter, R. D. (2000) · Epilepsy Research · doi:10.1016/s0920-1211(99)00121-7 · Cited by 237
(2003) · PubMed · Cited by 236
Eren, İ., Nazıroğlu, M., & Demirdaş, A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9289-x · Cited by 234
Besser, L., Chorin, E., Sekler, I., Silverman, W. F., Atkin, S. D., Russell, J. T., & Hershfinkel, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5093-08.2009 · Cited by 228
Inflammation: A new candidate in modulating adult neurogenesis
Das, S., & Basu, A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21585 · Cited by 226
Lee, J. Y., Cole, T. B., Palmiter, R. D., & Koh, J.-Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-j0003.2000 · Cited by 222
Maes, M. H. J., D’Haese, P. C., Scharpé, S., D'Hondt, P., Cosyns, P. R., & Broe, M. E. D. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90117-1 · Cited by 218
History of Zinc as Related to Brain Function
Sandstead, H. H., Frederickson, C. J., & Penland, J. G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.496s · Cited by 214
Kozisek, M. E., Middlemas, D. S., & Bylund, D. B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.07.001 · Cited by 211
Siwek, M., Dudek, D., Paul, I. A., Sowa-Kućma, M., Zięba, A., Popik, P., Pilc, A., & Nowak, G. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.014 · Cited by 210
Chen, Y., Jiang, T., Chen, P., Ouyang, J., Xu, G., Zeng, Z., & Sun, Y. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.10.029 · Cited by 209
Qian, J., & Noebels, J. L. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089276 · Cited by 201
Metallothioneins in Brain—The Role in Physiology and Pathology
Aschner, M., Cherian, M. G., Klaassen, C. D., Palmiter, R. D., Erickson, J. C., & Bush, A. I. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8054 · Cited by 200
Insight into zinc signaling from dietary zinc deficiency
Takeda, A., & Tamano, H. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.003 · Cited by 197
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Soczynska, J. K., Mansur, R. B., Brietzke, E. M., Swardfager, W., Kennedy, S. H., Woldeyohannes, H. O., Powell, A. M., Manierka, M. S., & McIntyre, R. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.026 · Cited by 192
Self-citationRosa, A. O., Lin, J. H. X., Calixto, J. Β., Santos, A. R. S., & Rodrigues, A. L. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00069-x · Cited by 183
Enhanced Long-Term Synaptic Depression in an Animal Model of Depression
Holderbach, R., Clark, K., Moreau, J., Bischofberger, J., & Normann, C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.007 · Cited by 182
Zinc suppresses Th17 development via inhibition of STAT3 activation
Kitabayashi, C., Fukada, T., Kanamoto, M., Ohashi, W., Hojyo, S., Atsumi, T., Ueda, N., Azuma, I., Hirota, H., Murakami, M., et al. (2010) · International Immunology · doi:10.1093/intimm/dxq017 · Cited by 179
Hyrc, K. L., Handran, S. D., Rothman, S., & Goldberg, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06669.1997 · Cited by 175
Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory
Pocivavsek, A., Wu, H., Potter, M. C., Elmer, G. I., Pellicciari, R., & Schwarcz, R. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.127 · Cited by 171
Nowak, G., Szewczyk, B., Wierońska, J. M., Brański, P., Pałucha-Poniewiera, A., Pilc, A., Sadlik, K., & Piekoszewski, W. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00104-7 · Cited by 171
Chai, F., Truong-Tran, A. Q., Ho, L. H., & Zalewski, P. D. (1999) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1999.00825.x · Cited by 171
Zinc status and serum testosterone levels of healthy adults
Prasad, A. S., Mantzoros, C. S., Beck, F. W. J., Hess, J. W., & Brewer, G. J. (1996) · Nutrition · doi:10.1016/s0899-9007(96)80058-x · Cited by 167
Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease
Molina, J. A., Jiménez-Jiménez, F. J., Aguilar, M. V., Meseguer, I., Mateos-Vega, C. J., González-Muñoz, M. J., de Bustos, F., Porta, J., Ortí-Pareja, M., Zurdo, M., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050071 · Cited by 167
Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes
Rassendren, F.-A., Lory, P., Pin, J., & Nargeot, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90199-p · Cited by 167
Lai, J. S., Moxey, A. J., Nowak, G., Vashum, K. P., Bailey, K. A., & McEvoy, M. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.022 · Cited by 166
Functional implications of decreases in neurogenesis following chronic mild stress in mice
Mineur, Y. S., Belzung, C., & Crusio, W. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.045 · Cited by 166
Kosten, T. A., Galloway, M. P., Duman, R. S., Russell, D. S., & D'Sa, C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301527 · Cited by 165
Ilouz, R., Kaidanovich‐Beilin, O., Gurwitz, D., & Eldar-Finkelman, H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00636-8 · Cited by 161
Antidepressant-like properties of zinc in rodent forced swim test
Kroczka, B., Brański, P., Pałucha-Poniewiera, A., Pilc, A., & Nowak, G. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00473-7 · Cited by 161
Park, S.-E., Dantzer, R., Kelley, K. W., & McCusker, R. H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-12 · Cited by 160
Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain
Wenzel, A., Scheurer, L., Künzi, R., Fritschy, J., Möhler, H., & Benke, D. (1995) · Neuroreport · doi:10.1097/00001756-199512000-00010 · Cited by 159
McLoughlin, I. J., & Hodge, J. S. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb03077.x · Cited by 159
Zinc and depression. An update.
Nowak, G., Szewczyk, B., & Pilc, A. (2005) · PubMed · Cited by 158
Pasinetti, G. M., Johnson, S. A., Oda, T., Rozovsky, I., & Finch, C. E. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903390307 · Cited by 155
Biological half-lives of zinc and manganese in rat brain
Takeda, A., Sawashita, J., & Okada, S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00916-e · Cited by 154
Zinc Modulates Bidirectional Hippocampal Plasticity by Effects on NMDA Receptors
Izumi, Y., Auberson, Y. P., & Zorumski, C. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1258-06.2006 · Cited by 152
Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease
Jiménez‐Jiménez, F. J., Molina, J. A., Aguilar, M. V., Meseguer, I., Mateos-Vega, C. J., González‐Muñoz, M. J., de Bustos, F., Martínez‐Salio, A., Pareja, M. O., Zurdo, M., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050073 · Cited by 151
Nutrient intakes and the common mental disorders in women
Jacka, F. N., Maes, M., Pasco, J. A., Williams, L. J., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.018 · Cited by 149
Zinc in Attention-Deficit/Hyperactivity Disorder
Arnold, L. E., & DiSilvestro, R. A. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.619 · Cited by 149
Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats
Dias, C. P., de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Garcia, V. A., Scalco, F. S., Guimarães, M. R., Constantino, L. D. S., Budni, P., Dal‐Pizzol, F., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.018 · Cited by 148
Nudmamud‐Thanoi, S., & Reynolds, G. P. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.09.035 · Cited by 147
Alexander, K., Wu, H., Schwarcz, R. M., & Bruno, J. P. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2539-2 · Cited by 147
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.014 · Cited by 147
Meerarani, P., Ramadass, P., Toborek, M. J., Bauer, H., Bauer, H., & Hennig, B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.81 · Cited by 146
Zinc fluxes and zinc transporter genes in chronic diseases
Devirgiliis, C., Zalewski, P. D., Perozzi, G., & Murgia, C. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.01.013 · Cited by 144
Haug, F. Š. (1974) · Anatomy and Embryology · doi:10.1007/bf00519123 · Cited by 144
Joca, S. R. L., Ferreira, F. R., & Guimarães, F. S. (2007) · Stress · doi:10.1080/10253890701223130 · Cited by 139
Zinc deficiency induces depression-like symptoms in adult rats
Tassabehji, N. M., Corniola, R. S., Alshingiti, A., & Levenson, C. W. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.06.017 · Cited by 138
Interaction of zinc with antidepressants in the tail suspension test
Cunha, M. P., Machado, D. G., Bettio, L. E. B., Capra, J. C., & Rodrigues, A. L. S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.09.006 · Cited by 137
Chronic Zinc Deficiency Alters Neuronal Function of Hippocampal Mossy Fibers
Hesse, G. W. (1979) · Science · doi:10.1126/science.224456 · Cited by 136
Frankiewicz, T., Potier, B., Bashir, Z. I., Collingridge, G. L., & Parsons, C. G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15245.x · Cited by 135
KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress
Jakobsson, J., Cordero, M. I., Bisaz, R., Groner, A. C., Busskamp, V., Bensadoun, J., Cammas, F. M., Losson, R., Mansuy, I. M., Sandi, C., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.036 · Cited by 134
Hisaoka, K., Nishida, A., Koda, T., Miyata, M., Zensho, H., Morinobu, S., Ohta, M., & Yamawaki, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00531.x · Cited by 133
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment
Siwek, M., Dudek, D., Schlegel-Zawadzka, M., Morawska, A., Piekoszewski, W., Opoka, W., Zięba, A., Pilc, A., Popik, P., & Nowak, G. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.024 · Cited by 132
The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test
Szewczyk, B., Poleszak, E., Właź, P., Wróbel, A., Blicharska, E., Cichy, A., Dybała, M., Siwek, A., Pomierny-Chamioło, L., Piotrowska, A., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.011 · Cited by 131
Buck-Koehntop, B. A., Stanfield, R. L., Ekiert, D. C., Martinez-Yamout, M. A., Dyson, H. J., Wilson, I. A., & Wright, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213726109 · Cited by 128
Antidepressant-like activity of zinc: further behavioral and molecular evidence
Sowa-Kućma, M., Legutko, B., Szewczyk, B., Novák, K., Znojek, P., Poleszak, E., Papp, M., Pilc, A., & Nowak, G. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0115-7 · Cited by 126
Koponen, E., Rantamäki, T., Voikar, V., Saarelainen, T., MacDonald, E., & Castrén, E. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-8468-z · Cited by 125
Ryu, M., Langkamp‐Henken, B., Chang, S.-M., Shankar, M. N., & Cousins, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117207108 · Cited by 124
Whittle, N., Lübec, G., & Singewald, N. (2008) · Amino Acids · doi:10.1007/s00726-008-0195-6 · Cited by 124
da Silva, G. D. L., Matteussi, A. S., Santos, A. R. S., Calixto, J. Β., & Rodrigues, A. L. S. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00022 · Cited by 122
Amani, R., Saeidi, S., Nazari, Z., & Nematpour, S. (2009) · Biological Trace Element Research · doi:10.1007/s12011-009-8572-x · Cited by 122
Alasaari, J., Lagus, M., Ollila, H. M., Toivola, A., Mika Kivimaki, B., Vahtera, J., Kronholm, E., Härmä, M., Puttonen, S., & Paunio, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045813 · Cited by 121
Astrocyte‐derived kynurenic acid modulates basal and evoked cortical acetylcholine release
Zmarowski, A., Wu, H., Brooks, J. M., Potter, M. C., Pellicciari, R., Schwarcz, R. M., & Bruno, J. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06594.x · Cited by 121
Targeting Glutamatergic Signaling for the Development of Novel Therapeutics for Mood Disorders
Machado‐Vieira, R., Salvadore, G., Ibrahim, L. A., Diazgranados, N., & Zarate, C. A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168010 · Cited by 118
Yamawaki, Y., Fuchikami, M., Morinobu, S., Segawa, M., Matsumoto, T., & Yamawaki, S. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.585663 · Cited by 117
Frederickson, C. J., Giblin, L. J., Rengarajan, B., Masalha, R., Frederickson, C. J., Zeng, Y., Varea, E., Koh, J., Chorin, U., Besser, L., et al. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.11.014 · Cited by 117
Stress in early life inhibits neurogenesis in adulthood
Karten, Y. J. G., Olariu, A., & Cameron, H. A. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.009 · Cited by 115
Fumagalli, F., Molteni, R., Calabrese, F., Frasca, A., Racagni, G., & Riva, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03149.x · Cited by 113
Prasad, A. S., Beck, F. W., Grabowski, S. M., Kaplan, J., & Mathog, R. H. (1997) · PubMed · Cited by 112
ZNF804a Regulates Expression of the Schizophrenia-Associated Genes PRSS16, COMT, PDE4B, and DRD2
Girgenti, M. J., Loturco, J., & Maher, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032404 · Cited by 110
Evaluating antidepressant therapies: remission as the optimal outcome.
Thase, M. E. (2003) · PubMed · Cited by 107
Marcellini, F., Giuli, C., Papa, R., Gagliardi, C., Dedoussis, G. V., Herbein, G., Fülöp, T., Monti, D., Rink, L., Jajte, J., et al. (2006) · Biogerontology · doi:10.1007/s10522-006-9048-4 · Cited by 107
Anxiety-like behavior of young rats after 2-week zinc deprivation
Takeda, A., Tamano, H., Kan, F., Itoh, H., & Oku, N. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.023 · Cited by 107
Synaptically released zinc gates long-term potentiation in fear conditioning pathways
Kodirov, S. A., Takizawa, S., Joseph, J., Kandel, E. R., Shumyatsky, G. P., & Bolshakov, V. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607131103 · Cited by 105
Noncompetitive inhibition of gamma-aminobutyric acidA channels by Zn.
Legendre, P., & Westbrook, G. L. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10881-x · Cited by 104
Mitschelen, M., Yan, H., Farley, J. A., Warrington, J. P., Han, S., Hereñú, C. B., Csiszar, A., Ungvari, Z., Bailey-Downs, L. C., Bass, C. E., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.032 · Cited by 103
Amori, L., Wu, H., Marinozzi, M., Pellicciari, R., Guidetti, P., & Schwarcz, R. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.055 · Cited by 101
Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant
Kanoni, S., Nettleton, J. A., Hivert, M., Ye, Z., van Rooij, F. J. A., Shungin, D., Sonestedt, E., Ngwa, J. S., Wojczynski, M. K., Lemaître, R. N., et al. (2011) · Diabetes · doi:10.2337/db11-0176 · Cited by 100
Wong, C. P., Magnusson, K. R., & Ho, E. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.005 · Cited by 98
Zinc exhibits an antidepressant-like effect in the forced swimming test in mice.
Kroczka, B., Zieba, A., Dudek, D., Pilc, A., & Nowak, G. (2000) · PubMed · Cited by 97
Gallo, E. F., & Iadecola, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0374-11.2011 · Cited by 97
Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats
Meloni, D., Gambarana, C., Montis, M. G. D., Pra, P. D., Taddei, I., & Tagliamonte, A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90374-3 · Cited by 96
Sirtori, C. R., Crepaldi, G., Manzato, E., Mancini, M., Rivellese, A., Paoletti, R., Pazzucconi, F., Pamparana, F., & Stragliotto, E. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00298-0 · Cited by 95
Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression
Anttila, S., Huuhka, K., Huuhka, M., Rontu, R., Hurme, M., Leinonen, E. V. J., & Lehtimäki, T. J. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0705-9 · Cited by 95
The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
Gold, A. B., Herrmann, N., Swardfager, W., Black, S. E., Aviv, R. I., Tennen, G., Kiss, A., & Lanctôt, K. L. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-17 · Cited by 95
Self-citationMaserejian, N. N., Hall, S. A., & McKinlay, J. B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.039 · Cited by 94
Alterations in serum and brain trace element levels after antidepressant treatment
Nowak, G., & Schlegel-Zawadzka, M. (1999) · Biological Trace Element Research · doi:10.1007/bf02784278 · Cited by 93
Vitamin A and zinc metabolism in alcoholism
Russell, R. M. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.12.2741 · Cited by 93
Redmond, A. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00259-1 · Cited by 92
Joo, J., Kim, B., Lee, J.-S., Park, J.-Y., Kim, S., Yun, Y.-J., Lee, S.-H., Lee, S., Rhim, H., & Son, H. (2007) · Journal of Cell Science · doi:10.1242/jcs.002154 · Cited by 92
Szewczyk, B., Poleszak, E., Sowa-Kućma, M., Wróbel, A., Słotwiński, S., Listos, J., Właź, P., Cichy, A., Siwek, A., Dybała, M., et al. (2009) · Amino Acids · doi:10.1007/s00726-009-0412-y · Cited by 91
Ferland‐Beckham, C., & Schrader, L. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.077 · Cited by 89
Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice
Baarendse, P. J. J., van Grootheest, G., Jansen, R. F., Pieneman, A. W., Ögren, S. O., Verhage, M., & Stiedl, O. (2007) · Hippocampus · doi:10.1002/hipo.20356 · Cited by 88
Chun, S., Sun, W., Park, J., & JUNG, M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.05.005 · Cited by 86
Reichling, D. B., & MacDermott, A. B. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018746 · Cited by 85
Robertson, M. J., Schacterle, R. S., Mackin, G. A., Wilson, S. N., Bloomingdale, K. L., Ritz, J., & Komaroff, A. L. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02833.x · Cited by 85
Antepartum/postpartum depressive symptoms and serum zinc and magnesium levels.
Wójcik, J., Dudek, D., Schlegel-Zawadzka, M., Grabowska, M., Marcinek, A., Florek, E., Piekoszewski, W., Nowak, R. J., Opoka, W., & Nowak, G. (2006) · PubMed · Cited by 85
Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly
Pepersack, T., Rotsaert, P., Benoit, F., Willems, D., Fuss, M., Bourdoux, P., & Duchateau, J. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00186-8 · Cited by 84
Młyniec, K., & Nowak, G. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70762-4 · Cited by 84
pH-Dependent Inhibition of Kainate Receptors by Zinc
Mott, D. D., Benveniste, M., & Dingledine, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3567-07.2008 · Cited by 82
Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease.
Thevandavakkam, M., Schwarcz, R., Muchowski, P., & Giorgini, F. (2010) · CNS and Neurological Disorders - Drug Targets · doi:10.2174/187152710793237430 · Cited by 80
Injection of MK-801 affects ocular dominance shifts more than visual activity.
Daw, N., Gordon, B., Fox, K., Flavin, H., Kirsch, J., Beaver, C., Ji, Q.-H., Reid, S. N. M., & Czepita, D. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.1.204 · Cited by 80
G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
MacDonald, J. F., Jackson, M. F., & Beazely, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.12.006 · Cited by 79
Glasper, E. R., Llorens-Martı́n, M., Leuner, B., Gould, E., & Trejo, J. L. (2009) · Hippocampus · doi:10.1002/hipo.20672 · Cited by 79
Mossy fiber sprouting induced by repeated electroconvulsive shock seizures
Gombos, Z., Spiller, A. E., Cottrell, G. A., Racine, R. J., & Burnham, W. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01924-1 · Cited by 79
Brocardo, P. S., Assini, F. L., Franco, J. L., Pandolfo, P., Müller, Y. M. R., Takahashi, R. N., Dafré, A. L., & Rodrigues, A. L. S. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm024 · Cited by 79
Interaction of zinc with antidepressants in the forced swimming test in mice.
Szewczyk, B., Brański, P., Wierońska, J. M., Pałucha-Poniewiera, A., Pilc, A., & Nowak, G. (2002) · PubMed · Cited by 79
Cieślik, K., Klenk-Majewska, B., Danilczuk, Z., Wróbel, A., Lupina, T., & Ossowska, G. (2007) · PubMed · Cited by 78
Maes, M. H. J., Verkerk, R. M., Vandoolaeghe, E., Hunsel, F. V., Neels, H. M., Wauters, A., Demedts, P., & Scharpé, S. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf03033069 · Cited by 76
Research works printed but not linked: 3
- Maes, 1994, Hypozincemia in depression, J. Affect. Disord., 31, 135, 10.1016/0165-0327(94)90117-1 · DOI
- McLoughlin, 1990, Zinc in depressive disorder, Acta Psychiatr. Scand., 82, 451, 10.1111/j.1600-0447.1990.tb03077.x · DOI
- Yang, 2005, Serum levels of cytokine, C-reactive protein and zinc in patients with depression: changes worth paying attention to, Chin. J. Clin. Rehabil., 9, 37
Cited by
Sorted by citations
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541
Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Sarris, J., Murphy, J., Mischoulon, D., Papakostas, G. I., Fava, M., Berk, M., & Ng, C. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15091228 · Cited by 436
Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry
Selhub, E. M., Logan, A. C., & Bested, A. C. (2014) · Journal of Physiological Anthropology · doi:10.1186/1880-6805-33-2 · Cited by 280
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
Galts, C., Bettio, L. E. B., Jewett, D. C., Yang, C. C., Brocardo, P. S., Rodrigues, A. L. S., Thacker, J. S., & Gil‐Mohapel, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.002 · Cited by 276
Zinc in depression: a meta-analysis
Swardfager, W., Herrmann, N., Mazereeuw, G., Goldberger, K., Harimoto, T., & Lanctôt, K. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.008 · Cited by 246
Self-citation
Metadata
- Authors
- Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L.
- Affiliations
- Toronto Rehabilitation Institute (CA)
- University of Toronto (CA)
- University Health Network (CA)
- Sunnybrook Research Institute (CA)
- Corresponding author
- Lanctôt, Krista L.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 37
- Issue
- 5
- Pages
- 911-929
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2087435407
- Cited by
- 116
- References
- 318
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 2 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 14 · 2015: 15 · 2014: 12 · 2013: 7
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- zinc, major depressive disorder, neuroprogression, treatment-resistant depression, NMDA receptor, glutamatergic neurons, excitatory neurotransmission, neuroplasticity, zinc supplementation, serum zinc, dietary zinc deficiency, mood regulation, oxidative stress, immune dysfunction, monoamine metabolism, stress response dysregulation, epigenetic regulation
- MeSH terms
- Animals, Major Depressive Disorder, Humans, Synaptic Transmission, Neurons, Zinc, Receptors, N-Methyl-D-Aspartate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review