Modulation of defensive behavior by transient receptor potential vanilloid type-1 (TRPV1) channels
Abstract
The Transient Receptor Potential Vanilloid Type-1 (TRPV1) was first characterized in primary afferent fibers as a receptor for capsaicin (the pungent ingredient of chili peppers). Later on, this cation-permeable ion channel was also described in the central nervous system, where its main putative endogenous ligand is N-arachidonoyl ethanolamide (an endocannabinoid, also known as anandamide). Recent results employing genetic, pharmacological and histochemical techniques indicate that TRPV1 tonically modulate anxiety, fear and panic responses in brain regions related to defensive responses, such as the dorsal periaqueductal gray, the hippocampus and the medial prefrontal cortex. Genetic deletion or antagonism of this ion channel induces anxiolytic-like effects in several animal models. The main mechanism responsible for TRPV1-mediated effects on anxiety seems to involve facilitation of glutamatergic neurotransmission. In addition, there is evidence for interactions with other neurotransmitter systems, such as nitric oxide and endocannabinoids.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Functional expression of TRPV1 may be underestimated if TRPV1 is expressed post- and presynaptically and acts far away from its synthesis sites.
“functional expression may be underestimated if TRPV1 is expressed post and presynaptically (Aguiar et al., 2014) and acts far away from its synthesis sites (Gutierrez-Rodriguez et al., 2016; Ruehle et al., 2013).”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Aguiar et al., 2014
TRPV1 acts as an ionotropic counterpart to CB1R and promotes fear- and anxiety-related responses in rodents.
“there is growing indication that TRPV1 acts as a ionotropic counterpart to the CB1R resulting in the promotion of fear- and anxiety-related responses in rodents”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Aguiar et al., 2014
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132 · see citing works
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086 · see citing works
NITRIC OXIDE: A Physiologic Messenger Molecule
Bredt, D. S., & Snyder, S. H. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.001135 · Cited by 2,315 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
The Neuropsychology of Anxiety
Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,933 · see citing works
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.
Holzer, P. D. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06664-5 · Cited by 1,784 · see citing works
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,549 · see citing works
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462 · see citing works
A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance
McNaughton, N., & Corr, P. J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.005 · Cited by 1,308 · see citing works
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293 · see citing works
Hwang, S. W., Cho, H., Kwak, J., Lee, S.-Y., Kang, C.-J., Jung, J., Cho, S., Min, K. H., Suh, Y., Kim, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6155 · Cited by 1,047 · see citing works
Neurocognitive mechanisms of anxiety: An integrative account
Bishop, S. J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.05.008 · Cited by 976 · see citing works
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
Huang, S. M., Bisogno, T., Trevisani, M., Al‐Hayani, A., PETROCELLIS, L. D., Fezza, F., Tognetto, M., Petros, T. J., Krey, J. F., Chu, C. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122196999 · Cited by 962 · see citing works
When fear is near: threat imminence elicits prefrontal periaqueductal gray shifts in humans.
Mobbs, D., Petrovic, P., Marchant, J. L., Hassabis, D., Weiskopf, N., Seymour, B., Dolan, R. J., & Frith, C. D. (2007) · Science · doi:10.1126/science.1144298 · Cited by 951 · see citing works
Reduced fear expression after lesions of the ventral hippocampus
Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H.-A., Murison, R., Moser, E. I., & Moser, M.-B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152112399 · Cited by 912 · see citing works
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
SZALLASI, A., Cortright, D. N., Blum, C. A., & Eid, S. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2280 · Cited by 884 · see citing works
Mezey, É., Tóth, Z. E., Cortright, D. N., Arzubi, M. K., Krause, J. E., Elde, R., Guo, A., Blumberg, P. M., & Szallasi, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3655 · Cited by 850 · see citing works
Guo, A., Vulchanova, L., Wang, J., Li, X., & Elde, R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00503.x · Cited by 838 · see citing works
Vertes, R. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.027 · Cited by 811 · see citing works
Targeting the endocannabinoid system: to enhance or reduce?
Marzo, V. D. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2553 · Cited by 798 · see citing works
Extinction circuits for fear and addiction overlap in prefrontal cortex
Peters, J., Kalivas, P. W., & Quirk, G. J. (2009) · Learning & Memory · doi:10.1101/lm.1041309 · Cited by 736 · see citing works
Wu, L., Sweet, T.-B., & Clapham, D. E. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002725 · Cited by 591 · see citing works
Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture
Wood, J., Winter, J., James, I. F., Rang, H. P., Yeats, J. C., & Bevan, S. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03208.1988 · Cited by 559 · see citing works
Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of Prostaglandins
Moriyama, T., Higashi, T., Togashi, K., Iida, T., Segi‐Nishida, E., Sugimoto, Y., Tominaga, T., Narumiya, S., & Tominaga, M. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-3 · Cited by 551 · see citing works
Sensations Evoked by Stimulation in the Midbrain of Man
Nashold, B. S., Wilson, W. P., & Slaughter, D. G. (1969) · Journal of neurosurgery · doi:10.3171/jns.1969.30.1.0014 · Cited by 550 · see citing works
Transient receptor potential channels as therapeutic targets
Moran, M. M., McAlexander, M. A., Bı́ró, T., & SZALLASI, A. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3456 · Cited by 546 · see citing works
Cavanaugh, D. J., Chesler, A. T., Jackson, A. C., Sigal, Y. M., Yamanaka, H., Grant, R., O'Donnell, D., Nicoll, R. A., Shah, N. M., Julius, D., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6451-10.2011 · Cited by 542 · see citing works
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
Gavva, N. R., Treanor, J. J. S., Garami, A., Fang, L., Surapaneni, S., Akrami, A., Alvarez, F., Bak, A., Darling, M., Gore, A., et al. (2008) · Pain · doi:10.1016/j.pain.2008.01.024 · Cited by 527 · see citing works
Cristino, L., PETROCELLIS, L. D., Pryce, G., Baker, D., Guglielmotti, V., & Marzo, V. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.074 · Cited by 489 · see citing works
Baumann, T., Simone, D. A., Shain, C. N., & LaMotte, R. H. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.212 · Cited by 456 · see citing works
Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain
Tóth, A., Boczán, J., Kedei, N., Lizanecz, E., Bagi, Z. A., Papp, Z., Edes, I. F., Csiba, L., & Blumberg, P. M. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.003 · Cited by 452 · see citing works
Ständer, S., Moormann, C., Schumacher, M. A., Buddenkotte, J., Artuc, M., Shpacovitch, V. M., Brzoska, T., Lippert, U., Henz, B. M., Luger, T. A., et al. (2004) · Experimental Dermatology · doi:10.1111/j.0906-6705.2004.0178.x · Cited by 410 · see citing works
TRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons
Gibson, H. E., Edwards, J. G., Page, R. S., Van Hook, M. J., & Kauer, J. A. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.027 · Cited by 388 · see citing works
Clapham, D. E., Julius, D. J., Montell, C., & Schultz, G. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.6 · Cited by 385 · see citing works
The neuropsychology of anxiety
Green, S. (1983) · International Journal of Psychophysiology · doi:10.1016/0167-8760(83)90031-4 · Cited by 378 · see citing works
Release of substance P from the cat spinal cord.
Go, V. L. W., & Yaksh, T. L. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016731 · Cited by 371 · see citing works
The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro
Marsh, S. J., Stansfeld, C. E., Brown, D. A., Davey, R., & McCarthy, D. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90289-2 · Cited by 371 · see citing works
Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., & Wotjak, C. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3303-06.2007 · Cited by 359 · see citing works
Self-citationPostsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens
Grueter, B. A., Brasnjo, G., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2685 · Cited by 353 · see citing works
Chávez, A. E., Chiu, C. Q., & Castillo, P. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2684 · Cited by 351 · see citing works
PETROCELLIS, L. D., Bisogno, T., Maccarrone, M., Davis, J. B., Finazzi‐Agrò, A., & Marzo, V. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008555200 · Cited by 350 · see citing works
N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia
Chu, C. J., Huang, S. M., PETROCELLIS, L. D., Bisogno, T., Ewing, S. A., Miller, J. D., Zipkin, R. E., Daddario, N., Appendino, G., Marzo, V. D., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211231200 · Cited by 345 · see citing works
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
Sigurdsson, T., Doyère, V., Cain, C. K., & LeDoux, J. E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.022 · Cited by 325 · see citing works
Gavva, N. R., Bannon, A. W., Surapaneni, S., Hovland, D. N., Lehto, S. G., Gore, A., Juan, T., Deng, H., Han, B., Klionsky, L., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4833-06.2007 · Cited by 315 · see citing works
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
Hayes, P. D., Meadows, H. J., Gunthorpe, M. J., Harries, M. H., Duckworth, M. D., Cairns, W. J., Harrison, D. C., Clarke, C. E., Ellington, K., Prinjha, R. K., et al. (2000) · Pain · doi:10.1016/s0304-3959(00)00353-5 · Cited by 308 · see citing works
Southall, M. D., Li, T., Gharibova, L. S., Pei, Y., Nicol, G. D., & Travers, J. B. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040675 · Cited by 295 · see citing works
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
Maccarrone, M., Rossi, S., Bari, M., Chiara, V. D., Fezza, F., Musella, A., Gasperi, V., Prosperetti, C., Bernardi, G., Finazzi‐Agrò, A., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2042 · Cited by 293 · see citing works
Maione, S., Bisogno, T., de Novellis, V., Palazzo, E., Cristino, L., Valenti, M., Petrosino, S., Guglielmotti, V., Rossi, F., & Marzo, V. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093286 · Cited by 293 · see citing works
Roberts, J. C., Davis, J. B., & Benham, C. D. (2003) · Brain Research · doi:10.1016/j.brainres.2003.10.001 · Cited by 286 · see citing works
Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex
Rubino, T., Realini, N., Castiglioni, C., Guidali, C., Viganò, D., Marras, E., Petrosino, S., Perletti, G., Maccarrone, M., Marzo, V. D., et al. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm161 · Cited by 283 · see citing works
Moreira, F. A., Kaiser, N., Monory, K., & Lutz, B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.005 · Cited by 282 · see citing works
Self-citationCapsaicin Binds to the Intracellular Domain of the Capsaicin-Activated Ion Channel
Jung, J., Hwang, S. W., Kwak, J., Lee, S.-Y., Kang, C.-J., Kim, W. B., Kim, D., & Oh, U. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00529.1999 · Cited by 278 · see citing works
The role of hippocampus in anxiety: intracerebral infusion studies
Engin, E., & Treit, D. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282de7929 · Cited by 267 · see citing works
Marinelli, S., Marzo, V. D., Berretta, N., Matias, I., Maccarrone, M., Bernardi, G., & Mercuri, N. B. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03136.2003 · Cited by 257 · see citing works
SZALLASI, A., & Blumberg, P. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90498-z · Cited by 252 · see citing works
Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats
Pentkowski, N. S., Blanchard, D. C., Lever, C., Litvin, Y., & Blanchard, R. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04754.x · Cited by 244 · see citing works
Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin
Szolcsányi, J., Anton, F., Reeh, P. W., & Handwerker, H. O. (1988) · Brain Research · doi:10.1016/0006-8993(88)90885-2 · Cited by 235 · see citing works
Hot flash: TRPV channels in the brain
Kauer, J. A., & Gibson, H. E. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.006 · Cited by 235 · see citing works
Schenberg, L. C., Bittencourt, A. S., Sudré, E. C. M., & Vargas, L. C. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00060-4 · Cited by 232 · see citing works
Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01712-0 · Cited by 226 · see citing works
Akbar, A., Yiangou, Y., Facer, P., Brydon, W. G., Walters, J. R. F., Anand, P., & Ghosh, S. K. (2010) · Gut · doi:10.1136/gut.2009.194449 · Cited by 219 · see citing works
Walpole, C. S. J., Bevan, S., Bovermann, G., Boelsterli, J., Breckenridge, R. J., Davies, J. W., Hughes, G. A., James, I. F., Oberer, L., Winter, J., et al. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00039a006 · Cited by 209 · see citing works
Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G. M., Drago, F., & Di Marzo, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.98 · Cited by 207 · see citing works
Jenck, F., Moreau, J.-L., & Martin, J. R. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02673-k · Cited by 206 · see citing works
The vanilloid (capsaicin) receptor: Receptor types and species differences
SZALLASI, A. (1994) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)90049-3 · Cited by 194 · see citing works
SZALLASI, A., & Blumberg, P. M. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90518-v · Cited by 185 · see citing works
Blanchard, D. C., Canteras, N. S., Markham, C. M., Pentkowski, N. S., & Blanchard, R. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.019 · Cited by 179 · see citing works
Moreira, F. A., & Wotjak, C. T. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_16 · Cited by 177 · see citing works
Polymodal activation of the endocannabinoid system in the extended amygdala
Puente, N., Cui, Y., Lassalle, O., Lafourcade, M., Georges, F., Venance, L., Grandes, P., & Manzoni, O. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2974 · Cited by 173 · see citing works
Campos, A. C., & Guimarães, F. S. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.08.017 · Cited by 172 · see citing works
Sanchez, J. F., Krause, J. E., & Cortright, D. N. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00373-6 · Cited by 169 · see citing works
Starowicz, K., Maione, S., Cristino, L., Palazzo, E., Marabese, I., Rossi, F., de Novellis, V., & Marzo, V. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3258-07.2007 · Cited by 168 · see citing works
Existence of capsaicin-sensitive glutamatergic terminals in rat hypothalamus
Sasamura, T., Sasaki, M., Tohda, C., & Kuraishi, Y. (1998) · Neuroreport · doi:10.1097/00001756-199806220-00025 · Cited by 164 · see citing works
Antistress Effect of TRPV1 Channel on Synaptic Plasticity and Spatial Memory
Li, H.-B., Mao, R., Zhang, J., Yang, Y., Cao, J., & Xu, L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.020 · Cited by 160 · see citing works
Anti-aversive role of serotonin in the dorsal periaqueductal grey matter
Schütz, M. T. B., Aguiar, J. C. D., & Graeff, F. G. (1985) · Psychopharmacology · doi:10.1007/bf00428199 · Cited by 160 · see citing works
Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus In vitro
Marinelli, S., Vaughan, C. W., Christie, M. J., & Connor, M. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022863 · Cited by 155 · see citing works
Marinelli, S., Marzo, V. D., Florenzano, F., Fezza, F., Viscomi, M. T., van der Stelt, M., Bernardi, G., Molinari, M., Maccarrone, M., & Mercuri, N. B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301118 · Cited by 155 · see citing works
Green, B. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90812-4 · Cited by 155 · see citing works
Guimarães, F. S., Carobrez, A. P., Aguiar, J. C. D., & Graeff, F. G. (1991) · Psychopharmacology · doi:10.1007/bf02244080 · Cited by 151 · see citing works
Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray
Moreira, F. A., de Aguiar, D. C., & Guimarães, F. S. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.10.013 · Cited by 149 · see citing works
Self-citationTRPV1 channels facilitate glutamate transmission in the striatum
Musella, A., Chiara, V. D., Rossi, S., Prosperetti, C., Bernardi, G., Maccarrone, M., & Centonze, D. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.09.001 · Cited by 146 · see citing works
Blanchard, R. J. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)x0001-8 · Cited by 142 · see citing works
Liapi, A., & Wood, J. N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04270.x · Cited by 142 · see citing works
Tzavara, E. T., Li, D. L., Moutsimilli, L., Bisogno, T., Marzo, V. D., Phebus, L. A., Nomikos, G. G., & Bruno Giros, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.019 · Cited by 141 · see citing works
Molecular Cloning of an N-terminal Splice Variant of the Capsaicin Receptor
Schumacher, M. A., Moff, I., Sudanagunta, S. P., & Levine, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2756 · Cited by 139 · see citing works
Marinelli, S., Pascucci, T., Bernardi, G., Puglisi‐Allegra, S., & Mercuri, N. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300615 · Cited by 137 · see citing works
Doyle, M. W., Bailey, T. W., Jin, Y., & Andresen, M. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08222.2002 · Cited by 136 · see citing works
Krarup, A. L., Ny, L., Åstrand, M., Bajor, A., Hvid‐Jensen, F., Hansen, M. B., Simrén, M., Funch-Jensen, P. M., & Drewes, A. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04629.x · Cited by 135 · see citing works
Chapter 2.4 Defensive behaviors, fear, and anxiety
Blanchard, D. C., & Blanchard, R. J. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)00005-7 · Cited by 133 · see citing works
Xing, J., & Li, J. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01023.2006 · Cited by 132 · see citing works
Inhibition of Axon Reflex Vasodilatation by Topically Applied Capsaicin
Bernstein, J. E., Swift, R. M., Soltani, K., & Lorincz, A. L. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12520912 · Cited by 130 · see citing works
Further evidence that anxiety and memory are regionally dissociated within the hippocampus
Bertoglio, L. J., Joca, S. R. L., & Guimarães, F. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.021 · Cited by 128 · see citing works
The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice
Al-Hayani, A., Wease, K. N., Ross, R. A., Pertwee, R. G., & Davies, S. N. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00145-9 · Cited by 127 · see citing works
Stjärne, P., Lundblad, L., Lundberg, J. M., & Änggård, A. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11870.x · Cited by 118 · see citing works
Casarotto, P. C., Terzian, A. L. B., Aguiar, D. C., Zangrossi, H., Guimarães, F. S., Wotjak, C. T., & Moreira, F. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.207 · Cited by 117 · see citing works
Self-citationMcGaraughty, S., Chu, K. L., Bitner, R. S., Martino, B. R., Kouhen, R. E., Han, P., Nikkel, A. L., Burgard, E. C., Faltynek, C. R., & Jarvis, M. F. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00433.2003 · Cited by 116 · see citing works
Cristino, L., Starowicz, K., De Petrocellis, L., Morishita, J., Ueda, N., Guglielmotti, V., & Di Marzo, V. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.047 · Cited by 115 · see citing works
Canteras, N. S., Resstel, L. B. M., Bertoglio, L. J., Carobrez, A. P., & Guimarães, F. S. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_7 · Cited by 114 · see citing works
Defensive behavior and hypertension induced by glutamate in the midbrain central gray of the rat.
Krieger, J. E., & Graeff, F. G. (1985) · PubMed · Cited by 113 · see citing works
Neuropharmacological mechanisms of capsaicin and related substances
Dray, A. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90393-w · Cited by 113 · see citing works
Moreira, F. A., de Aguiar, D. C., Terzian, A. L. B., Guimarães, F. S., & Wotjak, C. T. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.046 · Cited by 112 · see citing works
Self-citationTerzian, A. L. B., de Aguiar, D. C., Guimarães, F. S., & Moreira, F. A. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.11.004 · Cited by 111 · see citing works
Self-citationVyklický, L., Knotková-Urbancová, H., Vitásková, Z., Vlachová, V., Kress, M., & Reeh, P. W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.670 · Cited by 111 · see citing works
Feinmark, S. J., Begum, R., Tsvetkov, E., Goussakov, I. V., Funk, C. D., Siegelbaum, S. A., & Bolshakov, V. Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11427.2003 · Cited by 107 · see citing works
Anandamide: an endogenous activator of the vanilloid receptor
Smart, D., & Jerman, J. C. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01459-0 · Cited by 107 · see citing works
Sun, F., Guo, W., Zheng, D.-H., Zhang, C., Li, S., Liu, S., Yin, Q., Yang, H., & Shu, H. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9878-2 · Cited by 106 · see citing works
The Tissue Distribution and Functional Characterization of Human VR1
Cortright, D. N., Crandall, M., Sanchez, J. F., Zou, T., Krause, J. E., & White, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4482 · Cited by 102 · see citing works
de Aguiar, D. C., Terzian, A. L. B., Guimarães, F. S., & Moreira, F. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1532-5 · Cited by 101 · see citing works
Self-citationBarthó, L., Stein, C., & Herz, A. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00175710 · Cited by 100 · see citing works
de Lago, E., de Miguel, R., Lastres‐Becker, I., Ramos, J. A., & Fernández‐Ruíz, J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.02.016 · Cited by 100 · see citing works
Hong, S., Zheng, G., Wu, X., Snider, N. T., Owyang, C., & Wiley, J. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.003 · Cited by 98 · see citing works
Resstel, L. B. M., Corrêa, F. M. D. A., & Guimarães, F. S. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm232 · Cited by 96 · see citing works
General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1
Cornett, P. M., Matta, J. A., & Ahern, G. P. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.049684 · Cited by 95 · see citing works
Panic Disorder: Is the PAG Involved?
Del‐Ben, C. M., & Graeff, F. G. (2009) · Neural Plasticity · doi:10.1155/2009/108135 · Cited by 92 · see citing works
Chung, J. M., Lee, K. H., Hori, Y., & Willis, W. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)90509-8 · Cited by 92 · see citing works
Pharmacological characterization of vanilloid receptor located in the brain
Szabó, T. G., Bı́ró, T., Gonzalez, A. F., Palkovits, M., & Blumberg, P. M. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00313-8 · Cited by 90 · see citing works
de Novellis, V., Vita, D., Gatta, L., Luongo, L., Bellini, G., De Chiaro, M., Marabese, I., Siniscalco, D., Boccella, S., Piscitelli, F., et al. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-7 · Cited by 90 · see citing works
Fogaça, M. V., de Aguiar, D. C., Moreira, F. A., & Guimarães, F. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.03.007 · Cited by 89 · see citing works
Self-citationEffects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors
Kasckow, J., Mulchahey, J. J., & Geracioti, T. D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.10.007 · Cited by 89 · see citing works
TRPV1 channels control synaptic plasticity in the developing superior colliculus
Maione, S., Cristino, L., Al, M., Georgiou, A. L., Starowicz, K., Salt, T. E., & Marzo, V. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.171900 · Cited by 88 · see citing works
Steenland, H. W., Ko, S. W., Wu, L., & Zhuo, M. (2006) · Molecular Pain · doi:10.1186/1744-8069-2-34 · Cited by 88 · see citing works
Molchanov, M. L., & es, F. G. X. E. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0941-x · Cited by 85 · see citing works
Li, D., Chen, S.-R., & Pan, H. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00171.2004 · Cited by 85 · see citing works
SZALLASI, A. (1995) · PubMed · Cited by 83 · see citing works
Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1
Zschenderlein, C. A., Gebhardt, C., Halbach, O. V. B. U., Kulisch, C., & Albrecht, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016116 · Cited by 78 · see citing works
Watanabe, N., Horie, S., Michael, G. J., Spina, D., Page, C. P., & Priestley, J. V. (2005) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2004.12.002 · Cited by 74 · see citing works
The acute effects of capsaicin on rat primary afferents and spinal neurons
Williams, J. T., & Zieglagänsberger, W. (1982) · Brain Research · doi:10.1016/0006-8993(82)90679-5 · Cited by 72 · see citing works
Modeling panic disorder in rodents
Moreira, F. A., Gobira, P. H., Viana, T. G., Vicente, M. A., Zangrossi, H., & Graeff, F. G. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1610-1 · Cited by 70 · see citing works
Self-citationHalogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists
Appendino, G., Harrison, S., PETROCELLIS, L. D., Daddario, N., Bianchi, F., Moriello, A. S., Trevisani, M., Benvenuti, F., Geppetti, P., & Marzo, V. D. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705387 · Cited by 69 · see citing works
Kawahara, H., Drew, G., Christie, M., & Vaughan, C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01157.x · Cited by 67 · see citing works
Tang, H., Inoue, A., Oshita, K., & Nakata, Y. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.076 · Cited by 67 · see citing works
Anandamide – the other side of the coin
Zygmunt, P. M., Julius, D. J., Marzo, V. D., & Högestätt, E. D. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01430-3 · Cited by 66 · see citing works
Matsumoto, K., Hosoya, T., Tashima, K., Namiki, T., Murayama, T., & Horie, S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.024 · Cited by 66 · see citing works
Santos, C. J. P. A., Stern, C. A. J., & Bertoglio, L. J. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283095234 · Cited by 60 · see citing works
Liao, H., Lee, H., Ho, Y., & Chiou, L. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01214.x · Cited by 56 · see citing works
Lisboa, S. F. D. S., & Guimarães, F. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.008 · Cited by 54 · see citing works
Self-citationHakimizadeh, E., Oryan, S., Moghaddam, A. H., Shamsizadeh, A., & Roohbakhsh, A. (2012) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Bennion, D. M., Jensen, T., Walther, C., Hamblin, J., Wallmann, A., Couch, J., Blickenstaff, J., Castle, M., Dean, L., Beckstead, S., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.018 · Cited by 52 · see citing works
Maione, S., Starowicz, K., Cristino, L., Guida, F., Palazzo, E., Luongo, L., Rossi, F., Marabese, I., de Novellis, V., & Marzo, V. D. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91225.2008 · Cited by 51 · see citing works
Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat
Tóth, A., Kedei, N., Wang, Y., & Blumberg, P. M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00310-2 · Cited by 50 · see citing works
Capsaicin augments synaptic transmission in the rat medial preoptic nucleus
Karlsson, U., Sundgren‐Andersson, A. K., Johansson, S., & Krupp, J. (2005) · Brain Research · doi:10.1016/j.brainres.2004.10.064 · Cited by 48 · see citing works
Terzian, A. L. B., dos Reis, D. G., Guimarães, F. S., Corrêa, F. M. D. A., & Resstel, L. B. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3211-9 · Cited by 46 · see citing works
Self-citationQuantitative estimation of the effects of capsaicin on the mouse primary sensory neurons
Hiura, A., & Sakamoto, Y. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90200-x · Cited by 46 · see citing works
Characterization of vanilloid receptors in the dorsal horn of pig spinal cord
SZALLASI, A., & Blumberg, P. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90982-2 · Cited by 45 · see citing works
The depolarising action of capsaicin on rat isolated sciatic nerve
Hayes, A. G., Hawcock, A. B., & Hill, R. G. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90354-0 · Cited by 43 · see citing works
John, C. S., & Currie, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.025 · Cited by 41 · see citing works
Musella, A., Chiara, V. D., Rossi, S., Cavasinni, F., Castelli, M., Cantarella, C., Mataluni, G., Bernardi, G., & Centonze, D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.058 · Cited by 41 · see citing works
Moreira, F. A., Molchanov, M. L., & Guimar�es, F. S. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1569-9 · Cited by 41 · see citing works
Self-citationResponses of anterior hypothalamic-preoptic thermosensitive neurons to locally applied capsaicin
Hori, T., Shibata, M., Kiyohara, T., Nakashima, T., & Asami, A. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90162-1 · Cited by 41 · see citing works
Hogg, S., Michan, L., & Jessa, M. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.03.009 · Cited by 40 · see citing works
PETROCELLIS, L. D., Guida, F., Moriello, A. S., Chiaro, M. D., Piscitelli, F., de Novellis, V., Maione, S., & Marzo, V. D. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2010.12.019 · Cited by 40 · see citing works
Computer analysis and quantification of periaqueductal grey-induced defence behaviour
Beckett, S. R. G., & Marsden, C. A. (1995) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)00170-l · Cited by 38 · see citing works
Benninger, F., Freund, T. F., & Hájos, N. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.008 · Cited by 35 · see citing works
Ahmed, M. K., Takumida, M., Ishibashi, T., Hamamoto, T., & Hirakawa, K. (2009) · Rhinology Journal · doi:10.4193/rhin08.155 · Cited by 34 · see citing works
Capsaicin‐induced excitation of locus coeruleus neurons
Hajós, M., Jancsó, G., & Engberg, G. (1987) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1987.tb08086.x · Cited by 33 · see citing works
SZALLASI, A., Conte, B., Goso, C., Blumberg, P. M., & Manzini, S. (1993) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00166945 · Cited by 33 · see citing works
Tonetto, L. L., Terzian, A. L. B., Bel, E. A. D., Guimarães, F. S., & Resstel, L. B. M. (2009) · Behavioral and Brain Functions · doi:10.1186/1744-9081-5-40 · Cited by 31 · see citing works
Self-citation[3H]Resiniferatoxin binding by the human vanilloid (capsaicin) receptor
Ács, G., Palkovits, M., & Blumberg, P. M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90225-9 · Cited by 30 · see citing works
Mascarenhas, D. C., Gomes, K. S., & Nunes‐de‐Souza, R. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.023 · Cited by 29 · see citing works
Lisboa, S. F. D. S., Magesto, A. C., Aguiar, J. C. D., Resstel, L. B. M., & Guimarães, F. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.008 · Cited by 29 · see citing works
Self-citationFogaça, M. V., Gomes, F. V., Moreira, F. A., Guimarães, F. S., & de Aguiar, D. C. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2927-2 · Cited by 27 · see citing works
Self-citationAlmeida‐Santos, A. F., Moreira, F. A., Guimarães, F. S., & de Aguiar, D. C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.02.012 · Cited by 27 · see citing works
Self-citationTransient receptor potential vanilloid 1 channels modulate the anxiolytic effect of diazepam
Manna, S. S. S., & Umathe, S. N. (2011) · Brain Research · doi:10.1016/j.brainres.2011.09.049 · Cited by 23 · see citing works
Horie, S., Michael, G. J., & Priestley, J. V. (2005) · Inflammopharmacology · doi:10.1163/156856005774423854 · Cited by 23 · see citing works
Butt, C. M., Pauly, J. R., & Debski, E. A. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000807)423:4 · Cited by 22 · see citing works
Yokoyama, T., Saito, T., Ohbuchi, T., Hashimoto, H., Suzuki, H., Otsubo, H., Fujihara, H., Nagatomo, T., & Ueta, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2986-09.2010 · Cited by 19 · see citing works
Moreira, F. A., & Guimar�es, F. S. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1910-y · Cited by 18 · see citing works
Self-citationUnmyelinated axon subpopulations in the rat peripheral nervous system
Chad, D. A., Rasool, C. G., Bradley, W. G., Good, P., & Reichlin, S. (1983) · Neurology · doi:10.1212/wnl.33.7.848 · Cited by 18 · see citing works
A behavioral and neural systems comparison of unconditioned and conditioned defensive behavior
Canteras, N. S., & Blanchard, D. C. (2008) · Cited by 18 · see citing works
Blockade of NMDA or NO in the dorsal premammillary nucleus attenuates defensive behaviors
de Aguiar, D. C., & Guimarães, F. S. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.034 · Cited by 15 · see citing works
Self-citationOkere, C. O., & Waterhouse, B. D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.065 · Cited by 12 · see citing works
Sensitization of Nociceptive Ion Channels by Inhaled Anesthetics—A Pain in the Gas?
Harrison, N. L., & Nau, C. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051615 · Cited by 12 · see citing works
The effect of capsaicin on C-fiber reflex and heat evoked discharge in the acute spinal cat.
Matsumiya, T., Sawa, A., & Oka, T. (1983) · PubMed · Cited by 8 · see citing works
Intracellular and voltage clamp studies of capsaicin induced effects on a sensory neuron model.
Erdélyi, L., Such, G., & Jancsó, G. (1987) · PubMed · Cited by 8 · see citing works
Okere, C. O., Higuchi, T., & Kaba, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01609-8 · Cited by 6 · see citing works
Flagged first, then by citations
2 of the 179 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cannabidiol as a Potential Treatment for Anxiety Disorders
Blessing, E., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0387-1 · Cited by 718 · see citing works
The endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
Self-citationThe Role of the Endocannabinoid System in Pain
Woodhams, S. G., Sagar, D. R., Burston, J. J., & Chapman, V. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-46450-2_7 · Cited by 205 · see citing works
Vilela, L., Lima, I. V. D. A., Kunsch, É. B., Pinto, H. P. P., de Miranda, A. S., Vieira, É. L. M., de Oliveira, A. C. P., Moraes, M. F. D., Teixeira, A. L., & Moreira, F. A. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.07.014 · Cited by 128 · see citing works
Self-citationLlorente‐Berzal, A., Terzian, A. L. B., Marzo, V. D., Micale, V., Viveros, M., & Wotjak, C. T. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3917-y · Cited by 107 · see citing works
Self-citationMechanisms of pruritogen‐induced activation of itch nerves in isolated mouse skin
Ru, F., Sun, H., Jurcakova, D., Herbstsomer, R. A., Meixong, J., Dong, X., & Undem, B. J. (2017) · The Journal of Physiology · doi:10.1113/jp273795 · Cited by 72 · see citing works
Lisboa, S. F., Vila-Verde, C., Rosa, J., Uliana, D. L., Stern, C. A. J., Bertoglio, L. J., Resstel, L. B., & Guimaraes, F. S. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5127-x · Cited by 54 · see citing works
Self-citationZuo, W., Zhang, Y., Xie, G., Gregor, D. M., Bekker, A., & Ye, J.-H. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.012 · Cited by 45 · see citing works
Lisboa, S. F. D. S., Borges, A. A., Nejo, P., Fassini, A., Guimarães, F. S., & Resstel, L. B. M. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.005 · Cited by 43 · see citing works
Self-citationNazıroğlu, M., Taner, A. N., Balbay, E., & Çiğ, B. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3439-0 · Cited by 43 · see citing works
Gobira, P. H., Lima, I. V. D. A., Batista, L. A., de Oliveira, A. C., Resstel, L. B. M., Wotjak, C. T., de Aguiar, D. C., & Moreira, F. A. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117691567 · Cited by 42 · see citing works
Self-citationAmiri, S., Alijanpour, S., Tirgar, F., Haj‐Mirzaian, A., Amini-Khoei, H., Rahimi-Balaei, M., Rastegar, M., Ghaderi, M., Ghazi‐Khansari, M., & Zarrindast, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.003 · Cited by 40 · see citing works
Anxiogenic-like effects induced by hemopressin in rats
Fogaça, M. V., Sonego, A. B., Rioli, V., Gozzo, F. C., Dale, C. S., Ferro, E. S., & Guimarães, F. S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.013 · Cited by 37 · see citing works
Self-citationRuggiero, R. N., Rossignoli, M. T., Ross, J. B. D., Hallak, J. E. C., Leite, J. P., & Bueno-Júnior, L. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00399 · Cited by 37 · see citing works
The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?
Kayser, R. R., Snorrason, Í., Haney, M., Lee, F. S., & Simpson, H. B. (2019) · Cannabis and Cannabinoid Research · doi:10.1089/can.2018.0049 · Cited by 35 · see citing works
Transient Receptor Potential Vanilloid 1 Function at Central Synapses in Health and Disease
Meza, R. C., Ancatén-González, C., Chiu, C. Q., & Chávez, A. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.864828 · Cited by 35 · see citing works
Back, F., & Carobrez, A. P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.032 · Cited by 33 · see citing works
Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle
Heinz, D. E., Genewsky, A. J., & Wotjak, C. T. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.010 · Cited by 32 · see citing works
Self-citationSartim, A. G., Moreira, F. A., & Joca, S. R. L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.031 · Cited by 31 · see citing works
Self-citationSartim, A. G., Sales, A. J., Guimarães, F. S., & Joca, S. R. L. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118784877 · Cited by 27 · see citing works
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors
Diniz, C. R. A. F., Biojone, C., Joca, S. R. L., Rantamäki, T., Ċastrén, E., Guimarães, F. S., & Casarotto, P. C. (2019) · PeerJ · doi:10.7717/peerj.6493 · Cited by 25 · see citing works
Cold stress-induced brain injury regulates TRPV1 channels and the PI3K/AKT signaling pathway
Liu, Y., Liu, Y., Jin, H., Cong, P., Zhang, Y., Tong, C., Shi, X., Liu, X., Tong, Z., Shi, L., et al. (2017) · Brain Research · doi:10.1016/j.brainres.2017.06.025 · Cited by 24 · see citing works
Escelsior, A., Sterlini, B., Murri, M. B., Valente, P., Amerio, A., di Brozolo, M. R., da Silva, B. P., & Amore, M. (2020) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000249 · Cited by 25 · see citing works
Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour
Newson, P. N., van den Buuse, M., Martin, S., Lynch‐Frame, A., & Chahl, L. A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.036 · Cited by 23 · see citing works
Oliveira, A. B., de Mello, M. T., Tufik, S. B., & Peres, M. F. P. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.12.018 · Cited by 22 · see citing works
Batista, P. A., Fogaça, M. V., & Guimarães, F. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.019 · Cited by 23 · see citing works
Self-citationCannabinoids, TRPV and nitric oxide: the three ring circus of neuronal excitability
Gambino, G., Rizzo, V., Giglia, G., Ferraro, G., & Sardo, P. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01992-9 · Cited by 21 · see citing works
Lazarini-Lopes, W., Silva-Cardoso, G. K., Leite‐Panissi, C. R. A., & Garcia‐Cairasco, N. (2022) · Biomedicines · doi:10.3390/biomedicines10020416 · Cited by 21 · see citing works
Carletti, F., Gambino, G., Rizzo, V., Ferraro, G., & Sardo, P. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.09.018 · Cited by 18 · see citing works
Lagatta, D. C., Fassini, A., Terzian, A. L. B., Corrêa, F. M. D. A., & Resstel, L. B. M. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02786-5 · Cited by 16 · see citing works
Self-citationCannabinoid Receptor Type 1 in the Brain Regulates the Affective Component of Visceral Pain in Mice
Bajic, D., Monory, K., Conrad, A., Maul, C., Schmid, R. M., Wotjak, C. T., & Stein‐Thoeringer, C. K. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.041 · Cited by 16 · see citing works
Self-citationFerber, S. G., Hazani, R., Shoval, G., & Weller, A. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200429234430 · Cited by 16 · see citing works
Escelsior, A., Sterlini, B., Murri, M. B., Serafini, G., Aguglia, A., da Silva, B. P., Corradi, A. M., Valente, P., & Amore, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112734 · Cited by 16 · see citing works
Gambino, G., Gallo, D., Covelo, A., Ferraro, G., Sardo, P., & Giglia, G. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.08.025 · Cited by 15 · see citing works
Uliana, D. L., Antero, L. S., Borges‐Assis, A. B., Rosa, J., Vila-Verde, C., Lisboa, S. F. D. S., & Resstel, L. B. M. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120928201 · Cited by 15 · see citing works
Self-citationFAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats
Burman, M. A., Szolusha, K., Bind, R. H., Kerney, K., Boger, D. L., & Bilsky, E. J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.04.014 · Cited by 14 · see citing works
Sartim, A. G., Brito, B. M., Gobira, P. H., & Joca, S. R. L. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000416 · Cited by 13 · see citing works
de Medeiros, P. S., de Freitas, R. L., Silva, M. O., Coimbra, N. C., & Melo-Thomas, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.047 · Cited by 12 · see citing works
Arjmand, S., Landau, A. M., Varastehmoradi, B., Andreatini, R., Joca, S. R. L., & Wegener, G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01598-4 · Cited by 11 · see citing works
Effects of alprazolam and cannabinoid-related compounds in an animal model of panic attack
Batista, L. A., Haibara, A. S., Schenberg, L. C., & Moreira, F. A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.017 · Cited by 9 · see citing works
Self-citationA novel form of capsaicin-modified amygdala LTD mediated by TRPM1
Gebhardt, C., Halbach, O. V. B. U., Hadler, M. D., Harteneck, C., & Albrecht, D. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.09.005 · Cited by 8 · see citing works
Tang, Q., He, M., Zheng, P., Sun, M., Cao, J., Zhang, Q., He, J., Sun, R., Zhu, B., & Li, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1700282 · Cited by 6 · see citing works
Lazarini-Lopes, W., Silva-Cardoso, G. K., de Oliveira, J. A. C., Passos, L. A. C., Salgado, A. R., Demolin, D. M. R., Leite‐Panissi, C. R. A., Garcia‐Cairasco, N., & Coimbra, N. C. (2023) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2023.109160 · Cited by 5 · see citing works
Shichiri, M., Ishida, N., Aoki, Y., Koike, T., & Hagihara, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.236 · Cited by 5 · see citing works
Nascimento, G. C., Bálico, G. G., de Mattos, B. A., Pereira, M. D. S., Oliveira, I. G. C., Queiroz, M. E. C., Heck, L. C., Navegantes, L. C. C., Guimarães, F. S., & Del-Bel, E. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111456 · Cited by 5 · see citing works
Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders
Sharma, V., Sharma, P., & Singh, T. G. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02803-0 · Cited by 4 · see citing works
Roohbakhsh, A., & Shamsizadeh, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00042-1 · Cited by 3 · see citing works
TÜRKDÖNMEZ, E., Okuyucu, B., Arslan, G., Ağar, E., & Ayyıldız, M. (2025) · Neurochemical Research · doi:10.1007/s11064-024-04318-2 · Cited by 2 · see citing works
Symptomatic Responses to Low‐Level Occupational and Environmental Exposures
Linde, B., & Redlich, C. A. (2021) · Patty's Industrial Hygiene · doi:10.1002/0471435139.hyg013.pub3
de Pontes, L. R., & Ribeiro, S. T. G. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.08.001
Li, Y., Wang, G., Fang, X., Ling, Y., Zhou, C., Fang, J., Cai, R., Hu, Y., Wu, C., Zhang, S., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106235
- Authors
- Aguiar, D. C., Moreira, F. A., Terzian, A. L., Fogaça, M. V., Lisboa, S. F., Wotjak, C. T., & Guimaraes, F. S.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Max Planck Institute of Psychiatry (DE)
- Universidade de São Paulo (BR)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 46
- Pages
- 418-428
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2084784577
- Cited by
- 57
- References
- 179
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- FAPEMIG (APQ-01883-10, APQ-01038-11, APQ-04625-10)
- FAPESP
- (2012/17626-7)
- CAPES
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- TRPV1, defensive behavior, anxiety, fear, panic, dorsal periaqueductal gray, hippocampus, medial prefrontal cortex, anandamide, endocannabinoids, glutamatergic neurotransmission, nitric oxide, capsaicin
- MeSH terms
- Animals, Anxiety, Brain, Defense Mechanisms, Disease Models, Animal, Humans, Models, Biological, TRPV Cation Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review