Cited by 57Ion Channels and ReceptorsCannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Modulation of defensive behavior by transient receptor potential vanilloid type-1 (TRPV1) channels

Aguiar, D.C., Moreira, F.A., Terzian, A.L., Fogaça, M.V., Lisboa, S.F., Wotjak, C.T., Guimaraes, F.S.·2014·Neuroscience & Biobehavioral Reviews

Abstract

The Transient Receptor Potential Vanilloid Type-1 (TRPV1) was first characterized in primary afferent fibers as a receptor for capsaicin (the pungent ingredient of chili peppers). Later on, this cation-permeable ion channel was also described in the central nervous system, where its main putative endogenous ligand is N-arachidonoyl ethanolamide (an endocannabinoid, also known as anandamide). Recent results employing genetic, pharmacological and histochemical techniques indicate that TRPV1 tonically modulate anxiety, fear and panic responses in brain regions related to defensive responses, such as the dorsal periaqueductal gray, the hippocampus and the medial prefrontal cortex. Genetic deletion or antagonism of this ion channel induces anxiolytic-like effects in several animal models. The main mechanism responsible for TRPV1-mediated effects on anxiety seems to involve facilitation of glutamatergic neurotransmission. In addition, there is evidence for interactions with other neurotransmitter systems, such as nitric oxide and endocannabinoids.

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Crossref · 10.1016/j.neubiorev.2014.03.026

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177 of 177 references verified0 citation errors · 0 not checkable

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  • Functional expression of TRPV1 may be underestimated if TRPV1 is expressed post- and presynaptically and acts far away from its synthesis sites.

    “functional expression may be underestimated if TRPV1 is expressed post and presynaptically (Aguiar et al., 2014) and acts far away from its synthesis sites (Gutierrez-Rodriguez et al., 2016; Ruehle et al., 2013).”

    From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Aguiar et al., 2014

  • TRPV1 acts as an ionotropic counterpart to CB1R and promotes fear- and anxiety-related responses in rodents.

    “there is growing indication that TRPV1 acts as a ionotropic counterpart to the CB1R resulting in the promotion of fear- and anxiety-related responses in rodents”

    From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Aguiar et al., 2014

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Authors
Aguiar, D. C., Moreira, F. A., Terzian, A. L., Fogaça, M. V., Lisboa, S. F., Wotjak, C. T., & Guimaraes, F. S.
Affiliations
  • Universidade Federal de Minas Gerais (BR)
  • Max Planck Institute of Psychiatry (DE)
  • Universidade de São Paulo (BR)
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2014-10
Volume
46
Pages
418-428
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2084784577
Cited by
57
References
179
Citations by year
2025: 5 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 2
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • FAPEMIG (APQ-01883-10, APQ-01038-11, APQ-04625-10)
  • FAPESP
  • (2012/17626-7)
  • CAPES
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
TRPV1, defensive behavior, anxiety, fear, panic, dorsal periaqueductal gray, hippocampus, medial prefrontal cortex, anandamide, endocannabinoids, glutamatergic neurotransmission, nitric oxide, capsaicin
MeSH terms
Animals, Anxiety, Brain, Defense Mechanisms, Disease Models, Animal, Humans, Models, Biological, TRPV Cation Channels

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