Cited by 163Psychedelics and Drug StudiesNeuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

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The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals

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Kamilar-Britt, Philip, Bedi, Gillinder·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.08.016PMC PMC4678620

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Abstract

Users of ±3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') report prosocial effects such as sociability and empathy. Supporting these apparently unique social effects, data from controlled laboratory studies indicate that MDMA alters social feelings, information processing, and behavior in humans, and social behavior in rodents. Here, we review this growing body of evidence. In rodents, MDMA increases passive prosocial behavior (adjacent lying) and social reward while decreasing aggression, effects that may involve serotonin 1A receptor mediated oxytocin release interacting with vasopressin receptor 1A. In humans, MDMA increases plasma oxytocin and produces feelings of social affiliation. It decreases identification of negative facial expressions (cognitive empathy) and blunts responses to social rejection, while enhancing responses to others' positive emotions (emotional empathy) and increasing social approach. Thus, consistent with drug folklore, laboratory administration of MDMA robustly alters social processing in humans and increases social approach in humans and animals. Effects are consistent with increased sociability, with mixed evidence about enhanced empathy. These neurobiologically-complex prosocial effects likely motivate recreational ecstasy use.

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The “Reading the Mind in the Eyes” Test Revised Version: A Study with Normal Adults, and Adults with Asperger Syndrome or High‐functioning Autism
Baron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00715 · Cited by 4,555 · cited 1×
“Three studies investigated the effects of MDMA on emotion recognition from pictures of the eye region using the Reading the Mind in the Eyes Test (RMET), which was designed to assesssocial cognition in individuals with autism(Baron-Cohen et al., 2001).”
The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism.
Baron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Emotions Revealed: Recognizing Faces and Feelings to Improve Communication and Emotional Life
Ekman, P. (2003) · Cited by 1,599
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581 · cited 2×
“Oxytocin is thought toregulatenumeroussocial behaviors in humans and animals(Bartz et al., 2011b; Baumgartner et al., 2008; Bos et al., 2012; Dumont et al., 2009; Kirkpatrick et al., 2014a; Lee et al., 2009).”
Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations
Blair, R. J. R. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2005.06.004 · Cited by 1,365 · cited 2×
“…is dependent on both the capacity to decode others’ emotional and mental states from facial, verbal, and behavioral cues (cognitive empathy), and the spontaneous experience of emotional responses that are consistent with the affective states expressed by others(emotional empathy; Blair, 2005).”
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Oxytocin increases generosity in humans
Zak, P. J., Stanton, A. A., & Ahmadi, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001128 · Cited by 831

Show all 99 references

Research works printed but not linked: 1

Nichols, 1993, The great entactogen empathogen debate, MAPS Bull., 4, 47

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Authors: Kamilar-Britt, P., & Bedi, G.
Affiliations: New York State Psychiatric Institute (US)
Corresponding author: Bedi, Gillinder
ORCID: Kamilar-Britt, Philip
Bedi, Gillinder
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-10
Volume: 57
Pages: 433-446
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.08.016
PMC: PMC4678620
OpenAlex: W1810864195
Cited by: 163
References: 99
Citations by year: 2026: 11 · 2025: 24 · 2024: 23 · 2023: 15 · 2022: 13 · 2021: 15 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 16 · 2016: 7
FWCI: 1.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIDA (DA029679, DA034877)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: MDMA, ecstasy, prosocial behavior, sociability, empathy, social affiliation, oxytocin, vasopressin, 5-HT1A receptor, social reward, aggression, social rejection, facial expression recognition, social approach, rodents
MeSH terms: Animals, Humans, Interpersonal Relations, Social Behavior, N-Methyl-3,4-methylenedioxyamphetamine

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The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals

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