Cited by 230Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

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Defeat stress in rodents: From behavior to molecules

Hammels, Caroline, Pishva, Ehsan, De Vry, Jochen, van den Hove, Daniel L.A., Prickaerts, Jos, van Winkel, Ruud, Selten, Jean-Paul, Lesch, Klaus-Peter, Daskalakis, Nikolaos P., Steinbusch, Harry W.M., van Os, Jim, Kenis, Gunter, Rutten, Bart P.F.·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.10.006

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Abstract

Mood and anxiety disorders are prevalent conditions affecting one out of four people during lifetime. The development of high validity animal models to study these disorders has been a major challenge in the past. When considering experimental approaches for studying affective disorders, the social defeat paradigm has been shown to have etiological, predictive and face validity. Here, we explain the general principle of social defeat stress paradigms, with a strong focus on the resident-intruder model and compare different experimental settings as published to date. We discuss behavioral changes described in defeated animals as well as changes in the animal's physiological parameters. In addition, we provide an overview of the molecular adaptations that are found in animals subjected to defeat stress, with special attention to neural circuits and neuroendocrine signaling. Defeat produces specific behaviors resembling the signs and symptoms of humans with affective disorders, such as anhedonia, social avoidance, despair and anxiety. These can be linked to a wide range of physiological changes-ranging from cardiovascular changes to alterations in the immune system- or by disturbances in specific neurotransmitter systems, in particular serotonin and dopamine. The defeat stress model thus impacts on several functional domains of behavior and may mimic cardinal features of a multitude of psychiatric disorders including depression, post-traumatic stress disorder and schizophrenia. This manuscript critically reviews the core findings, strengths and limitations of the range of animal studies in this field and provides future perspectives.

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Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822
The tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,320
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415
Self-citation
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605

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Research works printed but not linked: 5

Bailey, 2007, Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, R1180, 10.1152/ajpregu.00307.2007 · DOI · Paper page
Foster, 2006, Social defeat increases food intake, body mass, and adiposity in Syrian hamsters, Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, R1284, 10.1152/ajpregu.00437.2005 · DOI
Kinn, 2008, A double exposure to social defeat induces sub-chronic effects on sleep and open field behaviour in rats, Physiol. Behav., 95, 553, 10.1016/j.physbeh.2008.07.031 · DOI
Kudryavtseva, 1991, Social model of depression in mice of C57BL/6J strain, Pharmacol. Biochem. Behav., 38, 315, 10.1016/0091-3057(91)90284-9 · DOI · Paper page
Watt, 2009, Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults, Behav. Neurosci., 123, 564, 10.1037/a0015752 · DOI

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The good and the bad
Stein, D. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90239-7.00009-2
References
(2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90239-7.00013-4
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Kirmayer, L. J., Worthman, C. M., Kitayama, S., Lemelson, R., & Cummings, C. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108695374.013

Authors: Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., van Os, J., Kenis, G., & Rutten, B. P. F.
Affiliations: Maastricht University (NL)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Rutten, Bart P.F.
ORCID: Pishva, Ehsan
Prickaerts, Jos
Selten, Jean-Paul
Lesch, Klaus-Peter
Daskalakis, Nikolaos P.
Steinbusch, Harry W.M.
Rutten, Bart P.F.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-12
Volume: 59
Pages: 111-140
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.10.006
OpenAlex: W2175484872
Cited by: 230
References: 229
Citations by year: 2026: 9 · 2025: 16 · 2024: 18 · 2023: 12 · 2022: 18 · 2021: 28 · 2020: 50 · 2019: 28 · 2018: 14 · 2017: 17 · 2016: 20
FWCI: 1.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Lirias (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Funders: Netherlands Organisation for Scientific Research (916.11.086)
European Community's Seventh Framework Program
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: social defeat stress, depression, post-traumatic stress disorder, schizophrenia, anhedonia, social avoidance, neuroendocrine signaling, serotonin, dopamine, immune system alterations, cardiovascular changes, neural circuits, face validity
MeSH terms: Animals, Anxiety Disorders, Behavior, Animal, Depression, Disease Models, Animal, Humans, Social Behavior, Stress, Psychological

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Defeat stress in rodents: From behavior to molecules

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